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GPCR

NameProbable G-protein coupled receptor 139
SpeciesHomo sapiens (Human)
GeneGPR139
SynonymG(q)-coupled orphan receptor GPRg1
G-protein-coupled receptor PGR3
GPR139
GPRG1
DiseaseN/A
Length353
Amino acid sequenceMEHTHAHLAANSSLSWWSPGSACGLGFVPVVYYSLLLCLGLPANILTVIILSQLVARRQKSSYNYLLALAAADILVLFFIVFVDFLLEDFILNMQMPQVPDKIIEVLEFSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWTEDYISTSVHHVLIWIHCFTVYLVPCSIFFILNSIIVYKLRRKSNFRLRGYSTGKTTAILFTITSIFATLWAPRIIMILYHLYGAPIQNRWLVHIMSDIANMLALLNTAINFFLYCFISKRFRTMAAATLKAFFKCQKQPVQFYTNHNFSITSSPWISPANSHCIKMLVYQYDKNGKPIKVSP
UniProtQ6DWJ6
Protein Data BankN/A
GPCR-HGmod modelQ6DWJ6
3D structure modelThis predicted structure model is from GPCR-EXP Q6DWJ6.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3632455
IUPHAR130
DrugBankN/A

Known ligands

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Total entries: 105
Page:  / 2 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
5574332D structureCHEMBL3976282C24H30N4OS2454.6516 / 15.5No
5532722D structure3,3-difluoro-4-(4-methoxyphenyl)-1-phenylazetidin-2-oneC16H13F2NO2289.2824 / 03.2Yes
5575322D structure(S)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamideC18H18N4O2322.3684 / 13.2Yes
4643332D structureCHEMBL3633714C19H22N2O3326.3963 / 22.8Yes
4643342D structureCHEMBL3633715C19H22N2O3326.3963 / 22.8Yes
4644392D structureCHEMBL3633895C18H20N2O3312.3693 / 22.4Yes
4644402D structureCHEMBL3633881C18H20N2O3312.3693 / 22.4Yes
4647282D structureCHEMBL3633891C17H19ClN2O302.8022 / 23.3Yes
5579352D structure(S)-2-(6-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethoxy)phenyl)ethyl)acetamideC18H14F4N4O3410.3299 / 14.1Yes
5579672D structure(S)-2-(7-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamideC19H20N4O3352.3945 / 13.1Yes
5579722D structure(S)-2-(8-fluoro-6-methyl-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(p-tolyl)ethyl)acetamideC19H19FN4O2354.3855 / 13.6Yes
5580032D structure(S)-2-(6,8-dimethyl-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-methoxyphenyl)ethyl)acetamideC20H22N4O3366.4215 / 13.5Yes
5582362D structure(S)-N-(1-(4-chlorophenyl)ethyl)-2-(4-oxobenzo[d][1,2,3]triazin-3 (4H)-yl)acetamideC17H15ClN4O2342.7834 / 13.4Yes
5583182D structure(S)-N-(1-(2-fluoro-4-(trifluoromethyl)phenyl)ethyl)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamideC19H16F4N4O3424.3569 / 13.8Yes
5584452D structureSCHEMBL17767211C19H18F2N4O4404.3748 / 13.7Yes
5534642D structureL-phenylalanineC9H11NO2165.1923 / 2-1.5Yes
5587412D structureN-(3-chlorophenethyl)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamideC17H15ClN4O2342.7834 / 13.5Yes
5588762D structureSCHEMBL17767031C19H20N4O3352.3945 / 13.1Yes
5589942D structureSCHEMBL17767119C18H16F2N4O2358.3496 / 13.4Yes
5594872D structureSCHEMBL17767056C18H17FN4O2340.3585 / 13.3Yes
5597402D structureSCHEMBL17767021C19H20N4O3352.3945 / 13.1Yes
5598572D structure(S)-N-(1-(4-methoxyphenyl)ethyl)-2-(7-methyl-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamideC19H20N4O3352.3945 / 13.1Yes
5599932D structure(S)-N-(1-(4-methoxyphenyl)ethyl)-2-(4-oxo-6-(trifluoromethyl)benzo[d][1,2,3]triazin-3 (4H)-yl)acetamideC19H17F3N4O3406.3658 / 13.7Yes
5600042D structureSCHEMBL17766994C19H19FN4O2354.3855 / 13.6Yes
5600732D structure(S)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethyl)phenyl)ethyl)acetamideC18H15F3N4O2376.3397 / 13.7Yes
5601102D structureSCHEMBL17767089C19H16F4N4O4440.35510 / 14.1Yes
5601392D structureN-(4-chlorophenethyl)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamideC17H15ClN4O2342.7834 / 13.5Yes
5604222D structure(S)-2-(7-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethyl)phenyl)ethyl)acetamideC19H17F3N4O3406.3658 / 13.7Yes
5604262D structure(S)-2-(4-oxo-6-(trifluoromethyl)benzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamideC19H17F3N4O2390.3667 / 14.1Yes
5604722D structure(S)-2-(5-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamideC18H17FN4O2340.3585 / 13.3Yes
5605332D structureSCHEMBL17767032C18H14F4N4O3410.3299 / 14.1Yes
4775072D structureCHEMBL3633888C17H16ClFN2O2334.7753 / 23.2Yes
4788692D structureCHEMBL3633716C19H22N2O4342.3954 / 31.8Yes
5539472D structureD04ZMMC20H19N3O4365.3894 / 33.3Yes
4793952D structureCHEMBL3633892C17H19ClN2O302.8022 / 23.2Yes
5615452D structure(S)-2-(6-chloro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-methoxyphenyl)ethyl)acetamideC18H17ClN4O3372.8095 / 13.4Yes
5617822D structureSCHEMBL17767152C19H17F3N4O2390.3667 / 14.2Yes
5622532D structure(S)-2-(6-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamideC18H17FN4O2340.3585 / 13.3Yes
5624872D structure(S)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamideC19H20N4O3352.3945 / 13.1Yes
4833992D structureCHEMBL3633890C19H22N2O4342.3954 / 22.4Yes
5625622D structure(S)-N-(1-(2-fluoro-4-(trifluoromethyl)phenyl)ethyl)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamideC18H14F4N4O2394.338 / 13.8Yes
5627272D structure(S)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3 (4H)-yl)-N-(1-(4-methoxyphenyl)ethyl)acetamideC19H20N4O4368.3936 / 12.8Yes
4846062D structureTC-O 9311C20H19N3O4365.3894 / 33.3Yes
5630432D structure(S)-2-(7-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-methoxyphenyl)ethyl)acetamideC19H20N4O4368.3936 / 12.8Yes
5631982D structure(S)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethoxy)phenyl)ethyl)acetamideC19H17F3N4O4422.3649 / 14.0Yes
5633932D structure(S)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethoxy)phenyl)propyl)acetamideC19H17F3N4O3406.3658 / 14.5Yes
5634622D structure(S)-2-(7-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethoxy)phenyl)ethyl)acetamideC19H17F3N4O4422.3649 / 14.0Yes
5635632D structure(S)-2-(6-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethoxy)phenyl)ethyl)acetamideC19H17F3N4O4422.3649 / 14.0Yes
5635712D structureSCHEMBL17767147C19H20N4O2336.3954 / 13.5Yes
5638832D structure(S)-2-(6-methyl-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamideC19H20N4O2336.3954 / 13.5Yes
5639642D structure(S)-2-(6-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamideC19H20N4O3352.3945 / 13.1Yes
5640192D structure(S)-N-(1-(4-methoxyphenyl)ethyl)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamideC18H18N4O3338.3675 / 12.8Yes
4896642D structureCHEMBL3633896C17H17ClN2O2316.7852 / 23.1Yes
2157442D structureJNJ-63533054C17H17ClN2O2316.7852 / 23.1Yes
5642282D structureN-(2-chloro-4-methoxyphenethyl)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamideC18H17ClN4O3372.8095 / 13.5Yes
5642642D structure(S)-2-(8-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamideC18H17FN4O2340.3585 / 13.3Yes
5643152D structure(R)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(2-phenylpropyl)acetamideC18H18N4O2322.3684 / 13.2Yes
4908192D structureCHEMBL3633885C17H16Cl2N2O2351.2272 / 23.7Yes
4913372D structureAC1LTB7CC17H18N2O2282.3432 / 22.4Yes
5645962D structureSCHEMBL17767153C18H15F3N4O3392.3388 / 13.8Yes
4920062D structureCHEMBL3633884C17H16Cl2N2O2351.2272 / 23.7Yes
4921412D structureCHEMBL3633894C17H17NO2S299.3883 / 13.6Yes
4926242D structureCHEMBL3633883C18H17F3N2O3366.346 / 23.6Yes
5648702D structure(S)-2-(6,8-dichloro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-methoxyphenyl)ethyl)acetamideC18H16Cl2N4O3407.2515 / 14.0Yes
5649982D structure(S)-N-(1-(4-methoxyphenyl)ethyl)-2-(6-methyl-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamideC19H20N4O3352.3945 / 13.1Yes
4943762D structureCHEMBL3633879C18H17N3O2307.3533 / 22.2Yes
5653322D structure(S)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-phenylethyl)acetamideC17H16N4O2308.3414 / 12.8Yes
5655162D structureSCHEMBL17767093C18H17FN4O3356.3576 / 12.9Yes
5655292D structure(S)-2-(6-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-methoxyphenyl)ethyl)acetamideC18H17FN4O3356.3576 / 12.9Yes
5658302D structure(S)-2-(6,8-dichloro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamideC18H16Cl2N4O2391.2524 / 14.4Yes
5658472D structure(S)-2-(8-methoxy-4-oxobenzo[d][1,2,3]triazin-3 (4H)-yl)-N-(1-(4-methoxyphenyl)ethyl)acetamideC19H20N4O4368.3936 / 12.8Yes
5659222D structure(S)-2-(5-methyl-4-oxobenzo[d][1,2,3]triazin-3 (4H)-yl)-N-(1-p-tolylethyl)acetamideC19H20N4O2336.3954 / 13.5Yes
5546622D structureL-tryptophanC11H12N2O2204.2293 / 3-1.1Yes
5659452D structure(S)-2-(8-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-methoxyphenyl)ethyl)acetamideC18H17FN4O3356.3576 / 12.9Yes
5661612D structure(S)-2-(6-chloro-4-oxobenzo[d][1,2,3]triazin-3 (4H)-yl)-N-(1-p-tolylethyl)acetamideC18H17ClN4O2356.814 / 13.8Yes
5663102D structure(S)-2-(8-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamideC19H20N4O3352.3945 / 13.1Yes
5664052D structure(S)-N-(1-(4-methoxyphenyl)ethyl)-2-(5-methyl-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamideC19H20N4O3352.3945 / 13.1Yes
5664662D structure(S)-2-(7-chloro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamideC18H17ClN4O2356.814 / 13.8Yes
5665302D structureN-(4-methylphenethyl)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamideC18H18N4O2322.3684 / 13.2Yes
5005972D structureAC1M48VOC17H17ClN2O2316.7852 / 23.1Yes
5668942D structureSCHEMBL17766920C18H13F5N4O3428.31910 / 14.2Yes
5010012D structureCHEMBL3633717C25H26N2O3402.4943 / 24.4Yes
5669472D structure(S)-2-(8-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethoxy)phenyl)ethyl)acetamideC19H17F3N4O4422.3649 / 14.0Yes
5670682D structure(S)-2-(6-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethyl)phenyl)ethyl)acetamideC18H14F4N4O2394.338 / 13.8Yes
5671892D structureSCHEMBL17767170C19H20N4O4368.3936 / 12.8Yes
5673092D structure(S)-N-(1-(4-methoxyphenyl)ethyl)-2-(8-methyl-4-oxobenzo[d][1,2,3]triazin-3 (4H)-yl)acetamideC19H20N4O3352.3945 / 13.1Yes
5548762D structure4-cyclohexyl-N-(2-methylphenyl)benzenesulfonamideC19H23NO2S329.4583 / 15.2No
5028452D structureCHEMBL3633878C18H20N2O2296.372 / 22.8Yes
5676062D structure(S)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3 (4H)-yl)-N-(1-(4-(trifluoromethyl)phenyl)ethyl)acetamideC19H17F3N4O3406.3658 / 13.7Yes
5044192D structureCHEMBL3633880C17H17FN2O2300.3333 / 22.5Yes
5679692D structure(S)-2-(7-methyl-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamideC19H20N4O2336.3954 / 13.5Yes
5052242D structureCHEMBL3633886C17H16Cl2N2O2351.2272 / 23.7Yes
5681032D structure(S)-2-(8-methyl-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamideC19H20N4O2336.3954 / 13.5Yes
5683432D structure(S)-N-(1-(4-methoxyphenyl)propan-2-yl)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamideC19H20N4O3352.3945 / 13.3Yes
5080682D structureCHEMBL3633889C17H16BrClN2O2395.6812 / 23.8Yes
5688552D structureSCHEMBL17766940C18H16F2N4O3374.3487 / 13.7Yes
5100692D structureCHEMBL3633721C17H17ClN2O2316.7852 / 23.1Yes
5103442D structureCHEMBL3633887C17H16Cl2N2O2351.2272 / 23.7Yes
5697342D structure(S)-2-(8-chloro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-methoxyphenyl)ethyl)acetamideC18H17ClN4O3372.8095 / 13.4Yes
5698462D structure(S)-2-(6,8-dimethyl-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamideC20H22N4O2350.4224 / 13.9Yes

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