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GPCR

NameMelanin-concentrating hormone receptor 1
SpeciesMus musculus (Mouse)
GeneMchr1
SynonymMCH1R
SLC-1 {ECO:0000303|PubMed:11159839}
MCH-1R
somatostatin receptor-like protein
MCHR-1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length353
Amino acid sequenceMDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
UniProtQ8JZL2
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4730
IUPHARN/A
DrugBankN/A

Known ligands

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Total entries: 145
Page:  / 2 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
36632D structureCHEMBL216192C28H32N4O3472.5894 / 34.5Yes
5216102D structureCHEMBL3786346C25H26N4O4446.5077 / 02.5Yes
91752D structureCHEMBL434747C30H40ClFN4O2543.1245 / 16.8No
92582D structureCHEMBL196390C28H31N5O2469.5894 / 24.5Yes
137402D structureCHEMBL188937C23H28N2O5412.4866 / 13.4Yes
5220322D structureCHEMBL3787261C25H28N4O5464.5228 / 12.2Yes
211092D structureCHEMBL380509C28H33F5N4O536.5918 / 15.1No
253002D structureCHEMBL372721C26H28Cl2N4O483.4373 / 15.3No
5223512D structureAZD-1979C25H26N4O5462.5068 / 02.0Yes
270832D structureCHEMBL229715C29H36ClFN4O511.0824 / 16.4No
366762D structureCHEMBL211672C31H25F5N4548.5618 / 17.2No
373372D structureCHEMBL190842C30H35F4N5O557.6388 / 15.1No
394112D structureCHEMBL373887C34H36N4O4564.6865 / 36.1No
441332D structureCHEMBL424720C30H35N3O3485.6284 / 25.0Yes
5229272D structureCHEMBL3787170C22H23FN4O4426.4488 / 02.6Yes
479932D structureCHEMBL424836C28H31N5O3485.5885 / 33.9Yes
505952D structureCHEMBL383432C28H33ClF4N4O2569.0428 / 15.9No
588622D structureCHEMBL197210C28H31N5O2469.5894 / 34.8Yes
613222D structureCHEMBL208025C29H32F4N4O2544.5958 / 14.9No
661062D structureCHEMBL206831C28H31F4N5O529.5848 / 24.3No
665592D structureCHEMBL208573C29H22F4N4O518.5167 / 15.8No
708012D structureCHEMBL215279C29H33N3O3471.6014 / 24.8Yes
723542D structureCHEMBL425013C28H29N5O2467.5734 / 04.3Yes
5238022D structureUS8685958, 5C26H28N4O5476.5338 / 02.5Yes
842182D structureCHEMBL585664C27H28F2N4O3494.5438 / 02.3Yes
901552D structureCHEMBL229823C28H35Cl2N5O528.5224 / 16.6No
915212D structureCHEMBL205979C28H36ClFN4O3S563.1296 / 14.0No
5241842D structureCHEMBL3787134C22H24N4O4408.4587 / 02.5Yes
927182D structureCHEMBL214177C24H31N3O3409.534 / 23.6Yes
959462D structureCHEMBL215841C23H29N3O3395.5034 / 23.2Yes
972702D structureCHEMBL372291C26H27N5O2441.5354 / 24.1Yes
1068602D structureCHEMBL381162C25H32ClFN4OS491.0665 / 14.4Yes
1069662D structureCHEMBL433596C27H24F4N4O2512.5098 / 24.5No
5246502D structureCHEMBL3785343C25H28N4O4448.5237 / 02.8Yes
1119472D structureCHEMBL203445C28H31F4N5O529.5848 / 14.4No
1165832D structureCHEMBL204881C29H36F4N4O2548.6278 / 15.0No
1213862D structureCHEMBL191393C27H24F4N4O2512.5098 / 24.5No
1217032D structureCHEMBL388972C31H41Cl2N5O4S650.667 / 24.6No
1224752D structureCHEMBL229462C24H30ClFN4OS477.0395 / 23.7Yes
1281682D structureCHEMBL206616C28H33F5N4O536.5918 / 15.1No
1290632D structureCHEMBL206195C28H33ClF4N4O2569.0428 / 15.9No
1305022D structureCHEMBL203166C28H30F4N4O2530.5688 / 24.6No
1311892D structureCHEMBL215418C28H31BrN4O3551.4854 / 35.2No
1340972D structureCHEMBL187296C22H26N2O2350.4623 / 13.9Yes
1434362D structureCHEMBL229988C28H34ClFN4O2513.0545 / 25.0No
1450922D structureCHEMBL186825C28H30N2O4458.5585 / 14.6Yes
1456852D structureCHEMBL441886C23H29ClFN5OS478.0276 / 23.1Yes
5258042D structureCHEMBL3787333C22H24N4O3392.4596 / 02.9Yes
1506042D structureCHEMBL196599C27H29N5O2455.5624 / 34.4Yes
1541092D structureCHEMBL214535C32H33N3O3507.6344 / 25.6No
1566012D structureCHEMBL390290C25H29ClFN3O2S490.0345 / 14.9Yes
1586002D structureCHEMBL229223C29H34ClFN4O2525.0655 / 25.1No
1607742D structureCHEMBL193583C29H32N4O2468.6014 / 24.3Yes
1699582D structureCHEMBL197054C28H30N6O3498.5875 / 33.0Yes
1703662D structureCHEMBL195914C28H27N5O2465.5574 / 04.3Yes
1704642D structureCHEMBL190068C27H30ClFN4O2497.0115 / 24.3Yes
1704662D structureCHEMBL193164C27H30ClFN4O2497.0115 / 24.3Yes
1704702D structureCHEMBL193260C27H30ClFN4O2497.0115 / 24.3Yes
1734892D structureCHEMBL189496C20H20Cl2N2O3407.2914 / 14.4Yes
1780452D structureCHEMBL187503C28H27N3O3453.5425 / 14.4Yes
1803412D structureCHEMBL363336C27H28N2O3428.5324 / 14.7Yes
1842322D structureCHEMBL374844C25H29Cl2N5O486.4414 / 25.3No
1847522D structureCHEMBL377843C32H28F4N4544.5987 / 17.1No
1849262D structureCHEMBL384626C29H34N4O3486.6164 / 24.7Yes
5270222D structureCHEMBL3786272C23H26N4O4422.4857 / 02.9Yes
1913252D structureCHEMBL378019C31H37F4N5O571.6658 / 15.7No
5272622D structureCHEMBL3786841C26H28N4O5476.5338 / 02.4Yes
2046542D structureCHEMBL186333C21H21F3N2O4422.4048 / 14.3Yes
2060852D structureCHEMBL383798C26H27N5O2441.5354 / 24.1Yes
2077512D structureCHEMBL211820C30H26Cl2N4513.4663 / 17.4No
2080072D structureCHEMBL372570C27H29N5O2455.5624 / 24.1Yes
2112872D structureCHEMBL383340C29H37ClFN5O2542.0965 / 23.9No
2214752D structureCHEMBL215958C30H33N3O3483.6124 / 25.2No
4504582D structureCHEMBL229290C28H36ClFN4O3S563.1296 / 24.0No
2283082D structureCHEMBL373886C34H36N4O3548.6874 / 36.2No
2297062D structureCHEMBL196115C29H33N5O3499.6155 / 24.4Yes
2332312D structureCHEMBL375520C29H36ClFN4O2527.0815 / 25.4No
2332332D structureCHEMBL229112C29H36ClFN4O2527.0815 / 25.4No
2344692D structureCHEMBL214280C28H31ClN4O3507.0314 / 35.2No
2366722D structureCHEMBL216561C30H36N4O2484.6444 / 35.1No
2407992D structureCHEMBL196991C26H34N6O446.5994 / 23.1Yes
2414492D structureCHEMBL426292C26H27N5O2441.5354 / 24.1Yes
2433052D structureCHEMBL229461C24H26ClFN4OS473.0075 / 14.9Yes
2454362D structureCHEMBL179501C28H30N4O2454.5744 / 14.3Yes
2480702D structureCHEMBL425744C27H29N5O2455.5624 / 24.1Yes
2491402D structureCHEMBL205397C26H28ClFN4O2482.9845 / 23.8Yes
2502302D structureCHEMBL381810C27H34ClFN4O485.0444 / 14.7Yes
2546322D structureCHEMBL382668C30H34F4N4O542.6237 / 16.1No
2592392D structureCHEMBL382631C27H28F4N4O2516.5418 / 24.1No
5289692D structureCHEMBL3670644C26H28N4O5476.5338 / 02.5Yes
5291262D structureUS8685958, 8C25H26N4O4446.5077 / 02.4Yes
2658162D structureCHEMBL365714C28H30N2O4458.5585 / 14.6Yes
2677012D structureCHEMBL374843C28H33ClF2N4O515.0465 / 16.0No
2721162D structureCHEMBL441726C24H26Cl2FN5O490.4045 / 24.8Yes
5292892D structureCHEMBL3785663C24H24N4O4432.487 / 02.1Yes
2733412D structureCHEMBL384247C28H31N3O4473.5735 / 25.1No
2741252D structureCHEMBL185688C28H30N2O4458.5585 / 14.6Yes
2795462D structureCHEMBL382177C27H33ClF2N4O503.0355 / 14.8No
2816502D structureCHEMBL186469C21H24N2O4368.4335 / 13.1Yes
5296012D structureCHEMBL3786311C26H30N4O5478.5498 / 02.8Yes

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