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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameGlucose-dependent insulinotropic receptor
SpeciesHomo sapiens (Human)
GeneGPR119
SynonymG-protein coupled receptor 119
G-protein coupled receptor 2
glucose-dependent insulinotropic receptor
GPR119
G protein-coupled receptor 119
[ Show all ]
DiseaseDiabetes
Gastric cancer; Type 2 diabetes
Non-insulin dependent diabetes
Peripheral arterial disease; Type 2 diabetes
Type 2 diabetes
Length335
Amino acid sequenceMESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProtQ8TDV5
Protein Data BankN/A
GPCR-HGmod modelQ8TDV5
3D structure modelThis predicted structure model is from GPCR-EXP Q8TDV5.
BioLiPN/A
Therapeutic Target DatabaseT93788
ChEMBLCHEMBL5652
IUPHAR126
DrugBankN/A

Known ligands

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Total entries: 1429
Page:  / 15 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
1532D structureCHEMBL2058674C22H30N4O2382.5086 / 14.6Yes
3612D structureCHEMBL3260528C24H22ClN3O2419.9094 / 05.1No
4417112D structureCHEMBL3326687C22H24F2N6O6S538.52713 / 02.4No
5359472D structureSCHEMBL2586921C22H23N3O2361.4454 / 15.0Yes
14352D structureCHEMBL3113624C23H36N2O4S436.6115 / 04.2Yes
17512D structureCHEMBL2204975C24H33N5O3S471.628 / 02.8Yes
22912D structureCHEMBL2204978C24H28F3N5O3S523.57511 / 02.7No
23202D structureCHEMBL3113843C25H31N5O4S497.6147 / 03.2Yes
5215232D structureCHEMBL3716002C24H25FN2O5S472.5317 / 03.5Yes
33132D structureCHEMBL3112980C23H18Cl2N4O4S517.3818 / 05.7No
5360052D structureSCHEMBL2583224C27H32N4O3460.5786 / 14.5Yes
5574022D structureSCHEMBL15507271C23H28FN3O4429.4926 / 03.5Yes
5360342D structureCHEMBL3963533C23H28FN3O4429.4926 / 03.5Yes
5360352D structureCHEMBL3894640C23H28FN3O4429.4926 / 03.5Yes
5574032D structureSCHEMBL15507270C23H28FN3O4429.4926 / 03.5Yes
42012D structureCHEMBL2010830C24H29F3N2O3S482.5627 / 03.9Yes
47142D structureCHEMBL3113839C23H29N3O5S459.5617 / 03.4Yes
5360662D structureSCHEMBL2582970C19H14FN3O2335.3385 / 13.1Yes
5360692D structureCHEMBL3943310C23H30N4O3410.5184 / 03.3Yes
54482D structureCHEMBL2158451C20H21ClF2N4O3S470.928 / 01.9Yes
57122D structureCHEMBL1773288C23H29N5O5S487.5758 / 03.2Yes
61632D structureCHEMBL1775177C22H28N6O5S488.5639 / 01.9Yes
5361052D structureCHEMBL3926629C29H39N3O3477.6494 / 04.8Yes
5361192D structureSCHEMBL2593509C20H19N3O2333.3914 / 13.9Yes
72172D structureCHEMBL2322841C23H29FN6O6S536.57911 / 24.7No
5479752D structureCHEMBL3914281C23H29FN6O6S536.57911 / 24.7No
75192D structureCHEMBL1090879C22H37N5O4S467.6297 / 12.1Yes
5361722D structureSCHEMBL2590505C25H28N4O3432.5246 / 13.9Yes
80772D structureCHEMBL3113623C23H28N6O4S484.57510 / 03.9Yes
5361862D structureSCHEMBL2590373C25H25N5O4459.5068 / 14.2Yes
88562D structureCHEMBL3113007C25H20ClFN4O4S526.9679 / 05.3No
88862D structureCHEMBL2086689C20H19FN8O406.42510 / 01.5Yes
4420652D structureCHEMBL3354776C26H24F3N3O2467.4927 / 05.8No
93282D structureBDBM50387908C21H28N4O3384.487 / 24.9Yes
94902D structureCHEMBL1956608C18H17BrN4O385.2654 / 13.2Yes
102172D structureCHEMBL1775175C22H25N5O6S487.5319 / 01.9Yes
103302D structureCHEMBL1090559C24H39N5O5S509.6669 / 02.5No
105682D structureCHEMBL3113837C23H33FN2O6S484.5837 / 03.5Yes
4421422D structureCHEMBL3358010C23H26F4N4O6S562.53713 / 02.1No
112022D structureCHEMBL2336756C31H34FN5O4S591.70210 / 15.4No
4421452D structureCHEMBL3321825C24H26N6O2S2494.6329 / 14.3Yes
4421492D structureCHEMBL3354805C25H21F4N5O483.4719 / 22.6Yes
114162D structureCHEMBL1951033C22H31N5O6S493.57910 / 12.9Yes
126772D structureCID 62707005C21H28N4O2S400.5417 / 15.1No
129392D structureCHEMBL452070C18H21N5O7S451.45411 / 11.6No
5533232D structureLysophosphatidylcholine(16:0)C24H50NO7P495.6387 / 15.6No
4422052D structureCHEMBL3325849C19H22F2N4O6S472.46411 / 02.7No
142942D structureCHEMBL1951015C20H27N5O3385.4687 / 13.3Yes
142962D structureCHEMBL1684030C22H32N6O3428.5376 / 12.9Yes
5363622D structureCHEMBL3915823C30H36N4O3500.6434 / 05.2No
143722D structureCHEMBL1093453C23H38N4O5S482.648 / 03.0Yes
144072D structureCHEMBL2069548C18H15BrF2N4O421.2466 / 13.4Yes
146432D structureCHEMBL1956596C14H16BrN3O322.2064 / 23.0Yes
5363812D structureSCHEMBL2590331C24H25N3O4419.4816 / 13.7Yes
5577072D structureSCHEMBL2584661C24H25N3O4419.4816 / 13.7Yes
5363822D structureSCHEMBL2588390C24H25N3O4419.4816 / 13.7Yes
5363832D structureSCHEMBL2587935C18H14ClN3O2339.7794 / 13.6Yes
4422572D structureCHEMBL3358000C20H18F4N10O2506.42615 / 02.6No
158042D structureCHEMBL2336758C29H37N5O6S583.70410 / 14.7No
5363872D structureSCHEMBL2590129C16H13N3O2S311.3595 / 12.7Yes
5364022D structureCHEMBL3909975C23H28IN3O4537.3985 / 04.1No
165572D structureCHEMBL2086686C21H23N7O3421.4619 / 01.3Yes
168312D structureCHEMBL1773292C22H26FN5O6S507.5379 / 12.0No
173592D structureCHEMBL2181692C22H27FN4O5S478.5399 / 03.2Yes
176002D structureCHEMBL1775170C20H23N5O5S445.4948 / 02.2Yes
176062D structureCHEMBL3260513C22H18ClN3O2391.8554 / 04.5Yes
4593712D structureSCHEMBL2590670C19H17N3O2319.3644 / 13.4Yes
180662D structureCHEMBL2312505C25H31N5O3449.5557 / 04.3Yes
184402D structureCHEMBL2010836C23H25F3N6O458.4898 / 03.6Yes
186132D structureCHEMBL1771084C21H28N4O2S400.5416 / 02.8Yes
188562D structureCHEMBL1684033C21H30F2N2O3396.4795 / 13.8Yes
194312D structureCHEMBL3260542C23H21ClN2O2S424.9434 / 05.9No
5364822D structureCHEMBL3966709C24H32N4O3424.5454 / 03.1Yes
202892D structureCHEMBL3104889C23H18ClN3O5S483.9237 / 13.8Yes
4424782D structureCHEMBL3321826C24H30N4O4S2502.6488 / 04.1No
207842D structureCHEMBL3220233C22H24N8O4464.48612 / 00.7No
215432D structureCHEMBL3113017C25H19ClF2N4O4S544.95810 / 05.4No
218262D structureCHEMBL451796C20H21N7O5439.43210 / 02.8Yes
220292D structureCHEMBL1777817C22H28N4O4412.497 / 03.9Yes
5365592D structureCHEMBL3949822C22H27N3O4397.4755 / 03.3Yes
5481462D structureCHEMBL3986478C23H27N7O4465.5149 / 25.1No
231012D structureCHEMBL2204984C23H24N10O456.5149 / 02.7Yes
4425842D structureCHEMBL3354781C27H24F3N3O2479.5037 / 05.8No
240262D structureCHEMBL3260516C20H14Cl2FN3386.2513 / 05.6No
5580222D structureSCHEMBL2592501C27H32N4O3460.5786 / 14.7Yes
5365992D structureSCHEMBL2587600C27H32N4O3460.5786 / 14.7Yes
245762D structureCHEMBL1778247C22H24FN5O3S457.5249 / 13.6Yes
248162D structureCHEMBL2010843C23H29N7OS451.5937 / 02.9Yes
250102D structureCHEMBL2382408C23H30N4O5S474.5768 / 02.6Yes
256622D structureCHEMBL2010853C23H25F2N3O3S2493.5888 / 03.3Yes
4426802D structureCHEMBL3325850C20H24F2N4O6S486.49111 / 02.6No
4426832D structureCHEMBL3325851C20H24F2N4O6S486.49111 / 02.6No
272742D structureCHEMBL3112979C28H25ClN4O4S549.0428 / 05.5No
4662422D structureCHEMBL3622172C23H30FN3O4S463.5688 / 02.4Yes
5481922D structureCHEMBL3982536C21H24FN5O7S509.50911 / 13.5No
284682D structureCHEMBL1773295C22H25N7O3S467.5489 / 03.2Yes
291132D structureCHEMBL2010848C22H23F4N7O477.46810 / 02.6Yes
292202D structuren-oleoylethanolamineC20H39NO2325.5372 / 26.3No
292602D structureCHEMBL3260514C17H16ClN3O2329.7844 / 03.3Yes
4594672D structureSCHEMBL2587403C16H18N4O2298.3465 / 12.1Yes

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