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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameRelaxin receptor 2
SpeciesHomo sapiens (Human)
GeneRXFP2
SynonymRXFPR2
RXFP2
relaxin/insulin like family peptide receptor 2
relaxin receptor 2
Relaxin family peptide receptor 2
[ Show all ]
DiseaseN/A
Length754
Amino acid sequenceMIVFLVFKHLFSLRLITMFFLLHFIVLINVKDFALTQGSMITPSCQKGYFPCGNLTKCLPRAFHCDGKDDCGNGADEENCGDTSGWATIFGTVHGNANSVALTQECFLKQYPQCCDCKETELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRIFVWVIAFITCFGNLFVIGMRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRGQYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPFSNIRPGKRQTSVILICIWMAGFLIAVIPFWNKDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKILSLFRVEIPDTMTSWIVIFFLPVNSALNPILYTLTTNFFKDKLKQLLHKHQRKSIFKIKKKSLSTSIVWIEDSSSLKLGVLNKITLGDSIMKPVS
UniProtQ8WXD0
Protein Data Bank2m96
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 2m96.
BioLiPBL0278456
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1628482
IUPHARN/A
DrugBankN/A

Known ligands

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Total entries: 354
Page:  / 4 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
2122D structureBAS 04995413C23H27N5O4437.56 / 20.7Yes
2892D structureethyl 6-(5-{[(8-bromo-5-methyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio]methyl}-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-6-oxohexanoateC22H23BrN6O4S547.4288 / 22.0No
2982D structureBAS 00662566C8H12N4O3S244.2695 / 30.2Yes
11462D structure868968-75-6C20H18N6O3S422.4638 / 12.0Yes
29042D structureAC1N8RBEC19H21N5O5S2463.5279 / 11.7Yes
53342D structureAC1NLL93C16H16ClN3O5S397.837 / 11.7Yes
71932D structureAC1MQQCVC21H23N5O6S473.5048 / 11.9Yes
82292D structureMLS001029173C24H31N7O3S497.6188 / 21.9Yes
5575162D structure2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N'-[(E)-(4-hydroxy-3-methoxyphenyl)methylidene]acetohydrazideC17H18N6O5386.3687 / 20.2Yes
95202D structureBAS 09528148C10H14N2O2S226.2944 / 11.9Yes
109452D structureAC1ORZTAC15H18N4O5S366.3926 / 2-1.0Yes
114102D structure852168-54-8C15H17N7O3S2407.4679 / 11.2Yes
135542D structureMLS002154012C18H25N5NaO9P509.38812 / 2N/ANo
144522D structureSMR000046898C20H19N7O3S2469.5389 / 12.0Yes
148142D structureMLS001095782C22H25ClN6O3456.9317 / 11.8Yes
173202D structureAC1NB7KMC18H21N3O6S2439.5018 / 10.4Yes
5220012D structureCHEMBL3719005C20H14F3N3O2385.3466 / 24.0Yes
175532D structureMLS000936813C20H22N6O4S2474.5548 / 21.0Yes
5220122D structureCHEMBL3715676C22H15F3N4O2424.3836 / 34.6Yes
190322D structureMLS000936863C19H19N5O3S397.4536 / 12.0Yes
193452D structure5-[(5,7-dioxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)methyl]-N-isopropyl-2-methoxybenzenesulfonamideC18H19N3O5S389.4267 / 11.4Yes
197112D structureN-(5-chloro-2-methylphenyl)-4-(5,7-dioxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)butanamideC18H16ClN3O3357.7944 / 12.3Yes
207132D structureMLS001116560C21H19N3O6S441.4588 / 11.6Yes
221292D structureAC1M7NVAC16H16N4O3312.3295 / 00.7Yes
226202D structureMLS002180522C19H21ClN2O4S408.8975 / 13.9Yes
238802D structure1-methyl-4-oxo-1,4-dihydropyrido[1,2-a]pyrrolo[2,3-d]pyrimidine-2-carboxylic acidC12H9N3O3243.2224 / 10.5Yes
248522D structure2-ChloroadenosineC10H12ClN5O4301.6878 / 4-0.1Yes
261332D structureMLS001116669C21H23N3O5S429.4917 / 02.1Yes
273612D structureMLS001030387C21H23N3O5S429.4917 / 12.4Yes
306592D structureAC1LCZ0GC12H10Br2N2OS390.0933 / 13.8Yes
319942D structureMLS002279973C13H16KN5O7S425.45711 / 1N/ANo
332632D structureMLS000624310C16H17N5O2S343.4057 / 02.4Yes
349592D structureMLS001116679C21H23N3O5S429.4917 / 02.1Yes
351282D structureCyclic AMP sodiumC10H11N5NaO6P351.19110 / 2N/AN/A
368912D structureMLS000419234C20H13FN2O3348.3335 / 13.6Yes
5226342D structureCHEMBL3718178C20H14F3N3O2385.3466 / 24.0Yes
387262D structureethyl 1-[(4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidin-2-yl)carbonyl]piperidine-4-carboxylateC19H19N3O4S385.4386 / 02.1Yes
390812D structureAC1MLIHOC14H18Cl2N2O4S381.2686 / 13.9Yes
405622D structureAC1OA8CKC25H25N3O2S431.5543 / 16.7No
426952D structureMLS001029045C19H14FN3O5S415.3958 / 11.3Yes
437752D structureMLS000551396C22H20BrClN4O3503.7816 / 13.7No
461252D structureAC1NNUS7C17H24N4O3S364.4645 / 11.2Yes
464442D structureMLS001115835C17H22N4O4346.3875 / 00.6Yes
467522D structureMLS001158116C20H21N5O6S459.4777 / 40.8Yes
503422D structureAC1O20VFC21H23N5O2377.4485 / 13.4Yes
520552D structureAC1LT9RXC18H17N3O6S403.4098 / 12.4Yes
522522D structureAC1NIFRMC19H24N6O5416.4387 / 00.5Yes
540972D structureSMR000091841C14H16N4O2S304.3686 / 22.1Yes
541352D structureASN 06396787C12H16Cl2N2O4S355.236 / 13.3Yes
590792D structureMLS000417683C22H24N4O3S2456.5797 / 13.6Yes
606342D structureMLS000771025C17H13BrF3N7452.2398 / 13.9Yes
621312D structureSMR000285085C22H25N7O4S483.5477 / 11.9Yes
681412D structureSMR000036135C16H16N4O3S344.3896 / 01.5Yes
691242D structure3-hydroxy-1-(6-methylpyridin-2-yl)-5-[4-(propan-2-yl)phenyl]-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-oneC24H22N2O3S418.5115 / 15.4No
692742D structureAC1NPE6GC16H20ClN5O3S2429.9387 / 11.8Yes
715432D structureMLS002164720C16H15N5O3325.3286 / 11.8Yes
735882D structureASN 04426602C21H26N6O4S458.5376 / 21.8Yes
745912D structureSMR000624799C17H22ClN3O5S3480.0099 / 12.2Yes
775382D structureN-(2-chloropyridin-3-yl)-2-{6-[(diethylamino)sulfonyl]-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl}acetamideC19H21ClN4O5S452.917 / 11.7Yes
5239152D structureCHEMBL3716158C22H23N3O2361.4452 / 34.7Yes
831152D structureMLS000061371C9H7ClN2O2S242.6774 / 12.6Yes
842242D structure1-{2-(ethylsulfonyl)-4-[(4-methylphenyl)sulfonyl]-1,3-thiazol-5-yl}-4-methylpiperazineC17H23N3O4S3429.5688 / 02.7Yes
843732D structureMLS001171340C16H13N5O3323.3126 / 23.3Yes
844022D structureMLS001004634C15H13N7O5371.3138 / 20.7Yes
851892D structureN-cyclohexyl-2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetamideC15H21N5O3319.3654 / 10.8Yes
862352D structureAC1MBAV7C18H16BrN3O4418.2475 / 11.5Yes
863092D structureCBKinase1_012319C17H11ClFN5OS387.8175 / 13.0Yes
864392D structureMLS000778454C16H18N4O2S330.4065 / 02.7Yes
872632D structureMLS001232852C20H18N6O2S406.4647 / 12.4Yes
872752D structure2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N'-[(E)-(3-methoxyphenyl)methylidene]acetohydrazideC17H18N6O4370.3696 / 10.6Yes
879412D structureMLS001018867C21H18N4O4390.3996 / 12.3Yes
887802D structure5-[2-(methylsulfanyl)phenyl]-1,3,4-oxadiazol-2-ylhydrosulfideC9H8N2OS2224.2964 / 12.5Yes
901772D structureAC1N9GTRC17H20N2O4S348.4176 / 13.3Yes
904492D structure876902-22-6C14H17N3O2S2323.4296 / 12.6Yes
935882D structureMLS001124454C20H21N5O2S395.4815 / 12.3Yes
5602362D structureAC1NRKQ1C19H17FN8O3424.3967 / 20.7Yes
958122D structureAC1MFZXSC23H27N5O3421.5015 / 21.6Yes
962172D structureMLS000624306C18H13N5OS347.3966 / 02.6Yes
986372D structureASN 04426448C20H24N6O4S444.516 / 21.3Yes
999672D structure2-chloro-N-{4-[(4-methylphenyl)sulfanyl]phenyl}-4-(methylsulfonyl)benzenecarboxamideC21H18ClNO3S2431.9494 / 15.1No
1016852D structureAC1NDOC8C18H16ClN3O3357.7944 / 12.3Yes
1036412D structureOprea1_804678C19H15N5O3S393.4217 / 22.3Yes
1039042D structureAC1NAH0HC20H26N6O5430.4657 / 1-0.6Yes
1039232D structureMLS000568644C20H12O5332.3115 / 04.8Yes
1050182D structureAC1N17QHC16H14FN5O3S3439.4989 / 12.9Yes
1050432D structureAC1MFEFVC20H16N2O6S2444.4769 / 14.0Yes
1051162D structureSMR000060587C19H17N3O4S383.4226 / 12.6Yes
1058682D structureN-(4-methoxyphenyl)-4-(4-methyl-5-oxo-4,5-dihydrothieno[2,3-e][1,2,4]triazolo[4,3-a]pyrimidin-1-yl)butanamideC19H19N5O3S397.4536 / 12.0Yes
1069272D structureN-(1,1-dimethylpropyl)-5-[(5,7-dioxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)methyl]-2-methoxybenzenesulfonamideC20H23N3O5S417.487 / 12.1Yes
1074602D structure671200-24-1C16H19N3O2S2349.4676 / 12.8Yes
1077142D structureMLS000098572C18H20N4O3S372.4436 / 13.2Yes
1087222D structureAC1MJZWAC15H19N3O2S2337.4566 / 12.9Yes
1091042D structureN-[5-(dimethylsulfamoyl)-2-methoxyphenyl]-2-(1,3,4-thiadiazol-2-ylsulfanyl)acetamideC13H16N4O4S3388.4759 / 11.2Yes
1096122D structuredimethyl 4-methyl-6-morpholino-2,3-quinolinedicarboxylateC18H20N2O5344.3677 / 02.3Yes
1097322D structureAC1NIO8BC22H26N4O4S442.5347 / 12.1Yes
1098932D structuremethyl 3-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-4-hydroxy-5-nitrobenzoateC17H12N2O7356.297 / 12.3Yes
1138522D structureMLS000888996C18H15Cl2N3O4408.2356 / 52.2Yes
1160392D structureAC1NDZNHC19H22N6O6430.4217 / 20.5Yes
1164222D structureMLS000949206C15H20N4O5S2400.4688 / 00.3Yes
1183782D structureAC1MKYJMC19H22N6O4S430.4836 / 21.0Yes

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