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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameMelanin-concentrating hormone receptor 2
SpeciesHomo sapiens (Human)
GeneMCHR2
SynonymG-protein coupled receptor 145
melanin-concentrating hormone receptor 2
MCHR-2
MCH2R
MCH2 receptor
[ Show all ]
DiseaseN/A
Length340
Amino acid sequenceMNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
UniProtQ969V1
Protein Data BankN/A
GPCR-HGmod modelQ969V1
3D structure modelThis predicted structure model is from GPCR-EXP Q969V1.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5038
IUPHAR281
DrugBankN/A

Known ligands

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Total entries: 298
Page:  / 3 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
4142D structureCHEMBL217751C19H16F3N3O359.3526 / 23.8Yes
7942D structureCHEMBL1934127C28H28ClN3O458.0022 / 25.4No
15712D structureCHEMBL540930C31H29ClF4N4O2601.0437 / 25.0No
49312D structureCHEMBL1934105C28H26N2O406.5291 / 05.9No
50102D structureCHEMBL377270C31H28F4N4O548.5867 / 26.2No
62312D structureCHEMBL268938C33H25F4N5O583.5917 / 16.5No
75152D structureCHEMBL198724C30H30Cl2N4O2549.4964 / 15.9No
91492D structureCHEMBL213873C27H28F3N3O467.5366 / 16.5No
95192D structureCHEMBL212671C31H34F2N4O3S580.6958 / 15.1No
123102D structureCHEMBL1934118C28H30N2O2426.563 / 24.0Yes
123112D structureCHEMBL1934124C28H30N2O2426.563 / 24.0Yes
215522D structureCHEMBL216510C21H20IN3O457.3153 / 24.6Yes
219512D structureCHEMBL197026C24H25F3N4O3474.4849 / 24.7Yes
224292D structureCHEMBL214843C21H20ClN3O365.8613 / 24.6Yes
226632D structureCHEMBL198945C29H28Cl2N4O3551.4685 / 24.8No
226652D structureCHEMBL372551C29H28Cl2N4O3551.4685 / 24.8No
243582D structureCHEMBL216342C21H20ClN3O365.8613 / 24.6Yes
245082D structureCHEMBL1934126C28H28FN3O441.553 / 24.8Yes
252992D structureCHEMBL372721C26H28Cl2N4O483.4373 / 15.3No
5223482D structureAZD-1979C25H26N4O5462.5068 / 02.0Yes
268992D structureCHEMBL412831C23H22F3N3O413.4446 / 25.2No
278162D structureCHEMBL214585C25H23FN2O5450.4667 / 13.5Yes
295002D structureCHEMBL197429C28H28ClFN4O491.0074 / 15.6No
317412D structureCHEMBL384848C23H24F3N3O415.466 / 15.5No
330132D structureCHEMBL371099C30H30Cl2N4O3565.4955 / 24.7No
330142D structureCHEMBL198562C30H30Cl2N4O3565.4955 / 24.7No
365552D structureCHEMBL385957C25H22ClN3O415.9213 / 25.8No
366752D structureCHEMBL211672C31H25F5N4548.5618 / 17.2No
373382D structureCHEMBL190842C30H35F4N5O557.6388 / 15.1No
453952D structureCHEMBL378180C32H32ClF3N4O581.087 / 26.7No
463512D structureCHEMBL215662C24H24F3N3O427.4716 / 15.4No
483352D structureCHEMBL215586C21H21N3O2347.4184 / 33.6Yes
485182D structureCHEMBL217462C24H27N3O373.53 / 25.3No
529622D structureCHEMBL1934121C30H33N3O451.6142 / 15.0Yes
531292D structureCHEMBL199274C30H30Cl2N4O2549.4964 / 15.6No
538632D structureCHEMBL365055C22H27F3N4O4468.4778 / 33.8Yes
565062D structureCHEMBL182554C29H34N4O4502.6155 / 34.5No
610082D structureCHEMBL209089C32H33F2N3O513.6335 / 16.5No
615102D structureCHEMBL1934102C28H28N2392.5461 / 06.2No
626732D structureCHEMBL209059C30H29F2N3O3517.5776 / 15.4No
654722D structureCHEMBL87370C20H16F3N3O371.3636 / 24.1Yes
665602D structureCHEMBL208573C29H22F4N4O518.5167 / 15.8No
687172D structureCHEMBL196567C23H23Cl2N3O4476.3546 / 15.0Yes
717922D structureCHEMBL211504C30H31Cl3FN3O574.9464 / 27.5No
724892D structureCHEMBL384547C23H20F3N3O411.4286 / 24.8Yes
747952D structureCHEMBL424721C22H22F3N3O401.4336 / 24.6Yes
756812D structureCHEMBL212256C28H22F4N4490.5067 / 25.9No
771542D structureCHEMBL210255C30H31Cl3FN3O574.9464 / 27.5No
792562D structureAla8,Ava14,15C50H83N17O12S21178.4416 / 16-2.7No
798492D structureCHEMBL378972C32H33F2N3O513.6335 / 16.5No
799212D structureAva14,15C52H87N17O12S31238.5617 / 16-2.1No
799222D structureD-Arg6,Ava14,15C52H87N17O12S31238.5617 / 16-2.1No
805992D structureCHEMBL197245C21H21Cl2N3O3434.3175 / 24.5Yes
808352D structureCHEMBL210343C32H33Cl2N3O546.5363 / 17.5No
837742D structureCHEMBL439358C23H22F3N3O413.4446 / 25.4No
842172D structureCHEMBL585664C27H28F2N4O3494.5438 / 02.3Yes
851542D structureCHEMBL196819C28H26Cl2N4O2521.4424 / 15.3No
891792D structureCHEMBL194408C23H26Cl2N4O2461.3875 / 15.2No
894902D structureCHEMBL195351C24H23F3N4O2456.4698 / 24.8Yes
900902D structureCHEMBL1934123C28H29N3O423.562 / 24.7Yes
900912D structureCHEMBL1934122C28H29N3O423.562 / 24.7Yes
901332D structureCHEMBL1934113C29H28N2O420.5562 / 06.3No
905932D structureCHEMBL384765C23H22F3N3O413.4446 / 25.4No
906352D structureCHEMBL425979C26H28F3N3O455.5256 / 16.4No
917112D structureCHEMBL196667C22H22Cl2N4O2445.3445 / 24.5Yes
919742D structureCHEMBL377874C35H32Cl2N4579.5693 / 18.8No
929492D structureAva9,10,Ava14,15C49H82N16O11S31167.4816 / 15-2.5No
943632D structureCHEMBL379489C33H34ClF3N4O595.1077 / 17.2No
950632D structureAoct8,9,10C53H89N19O11S21232.5416 / 16-2.9No
969642D structureCHEMBL1934128C28H28BrN3O502.4562 / 25.4No
973952D structureCHEMBL197280C27H26Cl2N4O493.4323 / 15.7No
975622D structureCHEMBL377321C28H27F2N3O459.5415 / 25.0Yes
985072D structureCHEMBL194837C22H23Cl2N3O3448.3445 / 15.0Yes
1004702D structureCHEMBL217575C24H24F3N3O427.4716 / 15.6No
1007662D structureCHEMBL211615C32H29F4N5O575.6127 / 16.5No
1022942D structureCHEMBL372803C31H31Cl2N5O3592.5215 / 24.8No
1047782D structureN-Me-Leu9C59H99N21O13S31406.7619 / 17-3.3No
1051642D structureCHEMBL1934125C28H29N3O2439.5593 / 33.8Yes
1153812D structureCHEMBL208081C29H29F2N3O3S537.6267 / 14.7No
1172392D structureCHEMBL208688C31H28F4N4O2S596.6459 / 16.4No
1175352D structureCHEMBL198689C29H28Cl2N4O2535.4694 / 15.2No
1187112D structureCHEMBL385221C25H29N3O387.5273 / 25.8No
1213872D structureCHEMBL191393C27H24F4N4O2512.5098 / 24.5No
1235602D structureCHEMBL209754C34H35F4N5589.6838 / 17.1No
1241322D structureCHEMBL386320C25H24F3N3O439.4826 / 25.9No
1256412D structureCHEMBL1934109C29H29N3O435.5712 / 05.8No
1267412D structureCHEMBL384449C31H26F4N4530.5717 / 17.1No
1289702D structureCHEMBL217614C21H19Cl2N3O400.3033 / 25.2No
1303942D structureCHEMBL386509C21H20F3N3O387.4066 / 24.4Yes
1318972D structureCHEMBL209510C31H31ClFN5528.0725 / 26.0No
1328742D structureCHEMBL1934108C28H26N2O406.5292 / 05.8No
1346322D structureCHEMBL377372C30H25F4N5531.5598 / 16.0No
1367572D structureCHEMBL209590C30H25F4N5O547.5588 / 25.1No
1396852D structureGva6,Ava9,10C53H89N19O11S31264.617 / 16-3.4No
1396922D structureCHEMBL216428C24H24F3N3O427.4716 / 25.9No
1397532D structureCHEMBL384550C21H20FN3O349.4094 / 24.1Yes
1403412D structureCHEMBL196581C24H27F3N4O3476.59 / 25.3No
1480472D structureCHEMBL215241C21H19Cl2N3O400.3033 / 25.2No
1497412D structureCHEMBL211311C35H31ClFN5O2608.1146 / 26.6No
1497472D structureCHEMBL215989C26H22F3N3O449.4776 / 16.2No

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