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Name | Sphingosine 1-phosphate receptor 5 |
---|---|
Species | Homo sapiens (Human) |
Gene | S1PR5 |
Synonym | Sphingosine 1-phosphate receptor Edg-8 S1P5 S1P receptor Edg-8 S1P5 receptor S1P receptor 5 [ Show all ] |
Disease | Multiple scierosis |
Length | 398 |
Amino acid sequence | MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD |
UniProt | Q9H228 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9H228 |
3D structure model | This predicted structure model is from GPCR-EXP Q9H228. |
BioLiP | N/A |
Therapeutic Target Database | T50089 |
ChEMBL | CHEMBL2274 |
IUPHAR | 279 |
DrugBank | BE0002432 |
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GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
---|---|---|---|---|---|---|
2172 | SR-02000000242 | C19H15Cl2NO2 | 360.234 | 2 / 1 | 5.8 | No |
3501 | CHEMBL377828 | C26H29N3O3 | 431.536 | 6 / 2 | 3.0 | Yes |
4347 | CHEMBL537632 | C20H31N3O2 | 345.487 | 4 / 4 | 3.2 | Yes |
5084 | CYM50199 | C14H12BrCl2NO2 | 377.059 | 3 / 0 | 5.2 | No |
5485 | CHEMBL224571 | C23H19ClF3NO3S | 481.914 | 8 / 1 | 3.1 | Yes |
441924 | CHEMBL211407 | C21H21ClN2O4 | 400.859 | 6 / 1 | 4.4 | Yes |
7683 | CHEMBL196534 | C25H27N3O3 | 417.509 | 6 / 1 | 2.9 | Yes |
10101 | CHEMBL226612 | C20H34FN2O5P | 432.473 | 7 / 4 | 2.2 | Yes |
10694 | CHEMBL206940 | C21H21ClN2O4 | 400.859 | 6 / 1 | 5.0 | Yes |
11002 | CHEMBL334038 | C19H33N2O5P | 400.456 | 6 / 4 | 1.3 | Yes |
521799 | CHEMBL3739440 | C20H31NO3 | 333.472 | 4 / 1 | 2.7 | Yes |
13210 | CHEMBL1916399 | C22H15F3N4O5 | 472.38 | 11 / 1 | 3.2 | No |
13504 | CHEMBL224005 | C24H22F3NO3S | 461.499 | 8 / 1 | 2.9 | Yes |
17994 | CHEMBL210301 | C20H21N3O4 | 367.405 | 7 / 1 | 3.6 | Yes |
548107 | CHEMBL3883621 | C24H23NO2S | 389.513 | 4 / 2 | 3.2 | Yes |
19542 | CHEMBL211689 | C21H19F3N2O4 | 420.388 | 9 / 1 | 4.8 | Yes |
20108 | CHEMBL241052 | C21H20N4O4 | 392.415 | 8 / 1 | 3.1 | Yes |
442458 | CHEMBL3359519 | C24H24F3NO4 | 447.454 | 7 / 1 | 4.8 | Yes |
21031 | CHEMBL324358 | C15H33N2O5P | 352.412 | 6 / 4 | 0.2 | Yes |
21321 | CHEMBL224599 | C23H19BrF3NO3S | 526.368 | 8 / 1 | 3.2 | No |
519800 | CHEMBL3769933 | C21H24ClN5O3S | 461.965 | 8 / 1 | 1.3 | Yes |
442562 | CHEMBL3401388 | C29H34FN3O4 | 507.606 | 6 / 2 | 5.7 | No |
23016 | CHEMBL1081654 | C18H22N4O2 | 326.4 | 5 / 3 | 3.5 | Yes |
522256 | SCHEMBL3042662 | C17H15Cl2NO2 | 336.212 | 3 / 1 | 1.7 | Yes |
26761 | CHEMBL208838 | C25H25F2N3O3 | 453.49 | 8 / 2 | 2.0 | Yes |
27287 | CHEMBL190529 | C19H29N3O | 315.461 | 3 / 3 | 4.0 | Yes |
27833 | CHEMBL364950 | C20H32N3O3PS | 425.528 | 6 / 4 | 4.8 | Yes |
522405 | SCHEMBL3042200 | C19H17ClF3NO3 | 399.794 | 7 / 1 | 1.7 | Yes |
29343 | CHEMBL224799 | C24H22F3NO3S | 461.499 | 8 / 1 | 2.9 | Yes |
29518 | CHEMBL515603 | C22H23N2O6P | 442.408 | 7 / 4 | -0.5 | Yes |
32889 | CHEMBL195141 | C23H25N3O3 | 391.471 | 6 / 1 | 2.0 | Yes |
522542 | SCHEMBL3044904 | C19H21NO3 | 311.381 | 4 / 1 | 0.6 | Yes |
33612 | CHEMBL423691 | C19H38F3N2O7P | 494.489 | 11 / 5 | N/A | No |
33615 | CHEMBL332472 | C19H38F3N2O7P | 494.489 | 11 / 5 | N/A | No |
34329 | CHEMBL514302 | C20H27N2O6P | 422.418 | 7 / 4 | -1.0 | Yes |
522573 | CHEMBL3806205 | C22H36NO4P | 409.507 | 5 / 3 | 2.0 | Yes |
536972 | SCHEMBL2192987 | C24H26N4O5S | 482.555 | 9 / 1 | 3.1 | Yes |
536975 | SCHEMBL1875982 | C24H26N4O5S | 482.555 | 9 / 1 | 3.1 | Yes |
38698 | CHEMBL196149 | C23H25N3O3 | 391.471 | 6 / 1 | 1.6 | Yes |
39211 | CHEMBL187692 | C21H44NO2P | 373.562 | 3 / 2 | 4.2 | Yes |
44327 | CHEMBL1086170 | C19H34NO4P | 371.458 | 5 / 3 | 0.9 | Yes |
44580 | CYM50174 | C14H11Cl3N2O4 | 377.602 | 5 / 0 | 4.9 | Yes |
45300 | CHEMBL1779916 | C18H17NO2S | 311.399 | 3 / 1 | 4.6 | Yes |
45364 | SR-02000000239 | C19H16ClNO2 | 325.792 | 2 / 1 | 5.2 | No |
555658 | SCHEMBL15909397 | C22H21FN2O4 | 396.418 | 7 / 1 | 0.7 | Yes |
522879 | SCHEMBL3047198 | C18H25NO3 | 303.402 | 4 / 1 | 0.9 | Yes |
522963 | SCHEMBL3037318 | C18H25NO3 | 303.402 | 4 / 1 | 0.7 | Yes |
49053 | CHEMBL224800 | C24H22F3NO4S | 477.498 | 9 / 1 | 2.5 | Yes |
49310 | CHEMBL227851 | C18H31N2O4P | 370.43 | 5 / 4 | 0.5 | Yes |
49335 | CHEMBL433593 | C20H31F3N3O6P | 497.452 | 11 / 5 | N/A | No |
51565 | CHEMBL375488 | C25H24F3NO3S | 475.526 | 8 / 1 | 3.3 | Yes |
548508 | CHEMBL3883972 | C22H19NO2S | 361.459 | 4 / 2 | 2.4 | Yes |
54207 | CHEMBL3086532 | C13H16ClFN4O3S | 362.804 | 7 / 1 | 1.7 | Yes |
523145 | Kinome_2429 | C19H17ClF3NO3 | 399.794 | 7 / 1 | 1.8 | Yes |
55965 | CHEMBL115505 | C17H37N2O6P | 396.465 | 7 / 4 | 1.3 | Yes |
523178 | SCHEMBL3037819 | C18H16Cl2FNO3 | 384.228 | 5 / 1 | 1.6 | Yes |
59297 | 5-(2,5-dichlorophenyl)-N-(2,6-dimethylphenyl)furan-2-carboxamide | C19H15Cl2NO2 | 360.234 | 2 / 1 | 5.8 | No |
60416 | CHEMBL377968 | C23H20F3NO3S | 447.472 | 8 / 2 | 2.4 | Yes |
523304 | SCHEMBL3041361 | C19H27NO3 | 317.429 | 4 / 1 | 1.3 | Yes |
62271 | CHEMBL247699 | C20H34NO5P | 399.468 | 6 / 4 | 1.1 | Yes |
62274 | CHEMBL393055 | C20H34NO5P | 399.468 | 5 / 3 | 1.0 | Yes |
63879 | CHEMBL194898 | C23H23N3O3 | 389.455 | 6 / 1 | 1.8 | Yes |
64301 | CHEMBL209566 | C21H23N3O3 | 365.433 | 6 / 1 | 4.1 | Yes |
64835 | CHEMBL378300 | C24H27N3O3 | 405.498 | 6 / 2 | 2.1 | Yes |
64839 | CHEMBL378061 | C24H27N3O3 | 405.498 | 6 / 2 | 2.1 | Yes |
548655 | CHEMBL3884862 | C20H22N2O2S | 354.468 | 5 / 3 | 1.2 | Yes |
523456 | SCHEMBL3043580 | C17H25NO3 | 291.391 | 4 / 1 | 1.1 | Yes |
548662 | CHEMBL3883572 | C24H23NO2S | 389.513 | 4 / 2 | 3.2 | Yes |
548672 | CHEMBL3885415 | C25H23NO2S | 401.524 | 4 / 2 | 6.3 | No |
66378 | FTY720P | C20H36NO5P | 401.484 | 6 / 4 | 1.1 | Yes |
69596 | Sphingosine 1-phosphate | C18H38NO5P | 379.478 | 6 / 4 | 1.9 | Yes |
69616 | AC1NQXRG | C18H38NO5P | 379.478 | 6 / 4 | 1.9 | Yes |
555755 | SCHEMBL320988 | C24H24FNO4 | 409.457 | 6 / 1 | 1.7 | Yes |
523600 | 1-(4-phenethylbenzyl)azetidine-3-carboxylic acid | C19H21NO2 | 295.382 | 3 / 1 | 1.0 | Yes |
523615 | SCHEMBL3034532 | C18H16F3NO2 | 335.326 | 6 / 1 | 1.3 | Yes |
70983 | CHEMBL1951304 | C25H23N3O4S | 461.536 | 8 / 1 | 2.4 | Yes |
71442 | CHEMBL210316 | C21H21BrN2O4 | 445.313 | 6 / 1 | 5.0 | Yes |
71767 | CHEMBL247901 | C20H34NO5P | 399.468 | 6 / 4 | 1.1 | Yes |
71772 | CHEMBL247698 | C20H34NO5P | 399.468 | 5 / 3 | 1.0 | Yes |
523669 | SCHEMBL3044147 | C16H23NO3 | 277.364 | 4 / 1 | 0.4 | Yes |
548742 | CHEMBL3883947 | C20H19NO4S | 369.435 | 6 / 2 | 1.4 | Yes |
548751 | CHEMBL3885401 | C20H21NO2S | 339.453 | 4 / 2 | 1.9 | Yes |
75428 | CHEMBL1779911 | C21H21NO2 | 319.404 | 2 / 1 | 5.3 | No |
75648 | CHEMBL1824259 | C23H23NO | 329.443 | 1 / 1 | 4.9 | Yes |
78254 | CHEMBL563746 | C20H31N2O5P | 410.451 | 7 / 3 | 1.1 | Yes |
548803 | CHEMBL3885074 | C22H20N2O2S | 376.474 | 5 / 3 | 1.6 | Yes |
78547 | CYM50260 | C14H11Cl3FNO2 | 350.595 | 4 / 0 | 4.9 | Yes |
80343 | SR-02000000240 | C18H17NO2S | 311.399 | 3 / 1 | 4.6 | Yes |
555782 | BDBM196221 | C23H22ClFN2O4 | 444.887 | 7 / 1 | 1.7 | Yes |
82000 | CHEMBL389033 | C18H31N2O4P | 370.43 | 5 / 4 | 0.5 | Yes |
86105 | SR-02000000249 | C22H15Cl2NO2 | 396.267 | 2 / 1 | 6.7 | No |
86244 | CHEMBL589403 | C19H22N2 | 278.399 | 1 / 0 | 4.2 | Yes |
87508 | CHEMBL601062 | C21H21N3O | 331.419 | 2 / 1 | 4.1 | Yes |
524070 | SCHEMBL3043605 | C18H19NO2 | 281.355 | 3 / 1 | 0.8 | Yes |
89920 | CHEMBL187645 | C20H42NO3P | 375.534 | 4 / 2 | 3.1 | Yes |
90807 | VPC 23153, (R)-phosphoric acid mono-[2-amino-2-(6-octyl-1H-benzoimiazol-2-yl)-ethyl] ester, powder | C17H28N3O4P | 369.402 | 5 / 3 | 0.3 | Yes |
90812 | CHEMBL361915 | C17H28N3O4P | 369.402 | 6 / 4 | 0.4 | Yes |
91116 | CHEMBL603442 | C25H24N2O | 368.48 | 2 / 0 | 5.6 | No |
92687 | CHEMBL380040 | C21H21N5O3 | 391.431 | 7 / 1 | 4.1 | Yes |
92757 | CHEMBL210345 | C21H21N5O3 | 391.431 | 7 / 1 | 4.1 | Yes |
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