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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameRelaxin receptor 1
SpeciesHomo sapiens (Human)
GeneRXFP1
SynonymRelaxin family peptide receptor 1
RX1
relaxin/insulin like family peptide receptor 1
relaxin receptor 1
RXFPR1
[ Show all ]
DiseaseAcute heart failure
Length757
Amino acid sequenceMTSGSVFFYILIFGKYFSHGGGQDVKCSLGYFPCGNITKCLPQLLHCNGVDDCGNQADEDNCGDNNGWSLQFDKYFASYYKMTSQYPFEAETPECLVGSVPVQCLCQGLELDCDETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKEMIHRFWYNYRQRKSMDSKGQKTYAPSFIWVEMWPLQEMPPELMKPDLFTYPCEMSLISQSTRLNSYS
UniProtQ9HBX9
Protein Data Bank2jm4
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 2jm4.
BioLiPBL0101296
Therapeutic Target DatabaseT73696
ChEMBLCHEMBL1293316
IUPHAR351
DrugBankN/A

Known ligands

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Total entries: 4862
Page:  / 49 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
182D structureN-[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]-2-ethoxybenzamideC21H22N4O4S426.4917 / 23.0Yes
2132D structureBAS 04995413C23H27N5O4437.56 / 20.7Yes
2152D structure3,6-dichloro-1-benzothiophene-2-carboxylic acidC9H4Cl2O2S247.0893 / 14.1Yes
2212D structureSMR000066873C16H20N4O6364.3588 / 11.1Yes
2872D structureethyl 6-(5-{[(8-bromo-5-methyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio]methyl}-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-6-oxohexanoateC22H23BrN6O4S547.4288 / 22.0No
3002D structureBAS 00662566C8H12N4O3S244.2695 / 30.2Yes
4242D structureMLS000065772C13H15N3OS3325.4636 / 14.0Yes
4502D structureMLS000686201C17H18N6O2S370.4317 / 11.0Yes
4912D structureethyl 2-[4-(cyanomethyl)-3-oxo-3,4-dihydro-2-quinoxalinyl]acetateC14H13N3O3271.2765 / 01.1Yes
4952D structure4-[(6,7-diethoxy-4-oxo-2-thioxo-1,4-dihydroquinazolin-3(2H)-yl)methyl]-N-(3-methoxypropyl)benzamideC24H29N3O5S471.5726 / 22.9Yes
5592D structureCHEMBL1472919C24H28FN3O3S457.5645 / 14.0Yes
5632D structure2-amino-3-benzoyl-N-(2-chlorophenyl)indolizine-1-carboxamideC22H16ClN3O2389.8393 / 25.5No
6742D structureMLS001159884C20H25N3O4S403.4976 / 12.7Yes
7312D structureCHEMBL1486479C18H16BrN5382.2654 / 14.6Yes
7832D structureCHEMBL1524350C28H29N3O4471.5574 / 13.7Yes
10762D structureAC1MTBBIC24H26N2O5S2486.6017 / 14.5Yes
11222D structureMLS001218130C14H20N6OS320.4156 / 22.6Yes
11472D structure868968-75-6C20H18N6O3S422.4638 / 12.0Yes
12142D structure1h-naphtho[2,3-d]imidazole-4,9-dioneC11H6N2O2198.1813 / 11.7Yes
13482D structure2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-(2-morpholinoethyl)acetamideC20H21N3O4367.4055 / 11.2Yes
15022D structureCHEMBL1396454C22H15F2N5387.3946 / 14.8Yes
16592D structure6-bromo-N-[(1-ethyl-3-methyl-1H-pyrazol-4-yl)methyl]-2-(4-methylphenyl)quinoline-4-carboxamideC24H23BrN4O463.3793 / 14.7Yes
16942D structureCHEMBL1562390C17H13ClFN5341.7745 / 15.3No
18912D structureOprea1_767840C23H16FNO4389.3825 / 15.5No
19472D structureethyl 3-(4-(N,N-bis(2-methoxyethyl)sulfamoyl)benzamido)-5-phenylthiophene-2-carboxylateC26H30N2O7S2546.6539 / 14.1No
20042D structureCHEMBL1515521C23H25N3O6S471.5287 / 21.8Yes
5215062D structureCHEMBL3715244C28H28F3N3O3511.5457 / 25.9No
20862D structureASN 04426639C16H25N5O3S367.4686 / 00.9Yes
21762D structureCHEMBL1357046C19H17ClN4O2S400.8815 / 14.9Yes
22342D structureSMR000634331C26H30N4O5S510.6097 / 13.1No
23272D structureMLS002161239C19H17NO5339.3475 / 13.3Yes
23372D structureCHEMBL1474245C24H22ClN3O3S467.9684 / 15.5No
23962D structureCHEMBL1554375C18H17F3N2O3S398.47 / 12.7Yes
24282D structureCHEMBL1336578C18H14F3N3O2S2425.4449 / 14.6Yes
29032D structureAC1N8RBEC19H21N5O5S2463.5279 / 11.7Yes
29462D structure8-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-2-methyl-8,9-dihydropyrazolo[1,5-a]quinazolin-6(7H)-oneC25H22FN3O3431.4676 / 03.9Yes
29852D structureAC1OSKCMC20H23N3OS353.4844 / 14.5Yes
30352D structureCHEMBL1338308C22H20FN5OS421.4946 / 13.7Yes
33892D structureCHEMBL1516117C22H21FN2O3380.4194 / 14.3Yes
33952D structureN-[3-(6-methyl[1,2,4]triazolo[3,4-a]phthalazin-3-yl)phenyl]acetamideC18H15N5O317.3524 / 12.2Yes
36542D structure2-(3-Cyano-6-methoxy-quinolin-2-ylsulfanyl)-N-cyclopropyl-acetamideC16H15N3O2S313.3755 / 12.6Yes
5215502D structureCHEMBL3715203C22H18F3N3O5S493.4579 / 24.2Yes
38692D structureCHEMBL1433681C20H18ClN3OS383.8944 / 14.6Yes
40112D structure5-(4-fluorophenyl)-4-(furan-2-ylcarbonyl)-3-hydroxy-1-[5-(methylsulfanyl)-1,3,4-thiadiazol-2-yl]-1,5-dihydro-2H-pyrrol-2-oneC18H12FN3O4S2417.4299 / 13.7Yes
42022D structureMLS000072923C24H24N6O3444.4956 / 20.7Yes
42842D structureCHEMBL1331538C27H26N2O6474.5136 / 25.5No
45262D structureMLS001043278C25H14O7426.387 / 23.6Yes
48812D structureMLS000727578C23H21BrN4O449.3523 / 04.2Yes
51602D structureCHEMBL1472621C26H24BrClN4O3S587.9176 / 36.1No
51862D structureCHEMBL1593216C18H20ClN3O2S377.8874 / 23.7Yes
53062D structureN-[5-(1,3-benzothiazol-2-yl)-2-methylphenyl]-2-phenoxyacetamideC22H18N2O2S374.4584 / 15.3No
53322D structureAC1NLL93C16H16ClN3O5S397.837 / 11.7Yes
53982D structureMLS000925214C20H21NO4S371.4515 / 03.3Yes
5574292D structureCHEMBL1355684C24H17N3O5S459.4767 / 34.1Yes
55722D structureMLS000516332C13H14N4O4S2354.3997 / 30.7Yes
58042D structureMLS000624282C19H21N7O3S427.4838 / 00.8Yes
58062D structureCHEMBL1514741C27H22N4O418.53 / 25.4No
59302D structureCHEMBL1436510C22H19NO5S409.4566 / 14.2Yes
59332D structureSCHEMBL1549396C29H26N2O6498.5357 / 15.1No
63022D structureCHEMBL1314411C24H30N4OS422.5915 / 16.0No
63702D structureAC1NPW2SC14H11BrCl2N2O3406.0574 / 01.9Yes
63742D structureCHEMBL1518991C18H16ClF3N2O4S448.8418 / 13.4Yes
64322D structure3-(3-methoxypropyl)-2-thioxo-2,3-dihydro[1]benzothieno[3,2-d]pyrimidin-4(1H)-oneC14H14N2O2S2306.3984 / 12.8Yes
68272D structureSMR000363287C17H19ClN2O7S2462.9168 / 03.2Yes
69132D structureBAS 05541665C20H17Cl2NO5422.2585 / 14.1Yes
71912D structureAC1MQQCVC21H23N5O6S473.5048 / 11.9Yes
73012D structure7-(4-bromophenyl)-8-(4-hydroxyphenyl)-1,3-dimethyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dioneC21H16BrN5O3466.2954 / 14.1Yes
73512D structureAC1OBYQCC18H12BrN5OS426.2925 / 14.3Yes
76192D structureSMR000624270C28H34N6O2486.625 / 13.3Yes
76412D structureCHEMBL1486082C17H14F2N4O3S2424.4419 / 12.7Yes
77472D structureSCHEMBL1074387C24H19FN2O2386.4265 / 04.9Yes
77732D structureMLS000094938C20H22N4O4S414.487 / 22.8Yes
79422D structureAC1OBTDFC19H15BrN4O3427.2584 / 13.3Yes
82282D structureMLS001029173C24H31N7O3S497.6188 / 21.9Yes
84042D structure2-amino-1-(3-chlorophenyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carbonitrileC17H10ClN5319.7524 / 13.9Yes
84752D structureSMR000624181C22H21BrN6O3S529.4137 / 13.2No
85862D structureN-(2,2-dimethoxyethyl)-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxamideC17H17N3O4327.345 / 10.4Yes
5575182D structure2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N'-[(E)-(4-hydroxy-3-methoxyphenyl)methylidene]acetohydrazideC17H18N6O5386.3687 / 20.2Yes
87142D structure2-[(6-bromo-1H-imidazo[4,5-b]pyridin-2-yl)sulfanyl]-N-(2,4,6-trimethylphenyl)acetamideC17H17BrN4OS405.3144 / 24.3Yes
87362D structureCHEMBL1514567C21H18N2O2S362.4474 / 04.0Yes
87492D structureN-(4-chlorobenzyl)-2,4-dioxo-3-pentyl-1,2,3,4-tetrahydroquinazoline-7-carboxamideC21H22ClN3O3399.8753 / 23.8Yes
87662D structureMLS001225433C19H17FN4O3S2432.4888 / 23.3Yes
88762D structureCHEMBL1357328C24H25ClN2O2S440.9864 / 15.7No
89022D structure7-hydroxy-3-(4-methoxyphenyl)-8-(morpholin-4-ylmethyl)chromen-2-oneC21H21NO5367.4016 / 12.6Yes
90072D structureMLS000736527C23H20N4O2S2448.5594 / 45.5No
90322D structureAC1LRK1UC17H12ClN3O309.7534 / 14.9Yes
90452D structureMLS000732565C22H21F3N4O414.4327 / 03.5Yes
90742D structureMLS000849730C14H10BrClN2O2S3449.786 / 14.9Yes
91152D structure2-(3-Cyano-quinolin-2-ylsulfanyl)-N-cyclopropyl-acetamideC15H13N3OS283.3494 / 12.7Yes
91772D structureCHEMBL1316937C25H21N3O6S491.5187 / 13.6Yes
92432D structure2-(methylsulfanyl)-5-[2-(methylsulfanyl)phenyl]-1,3,4-oxadiazoleC10H10N2OS2238.3235 / 02.8Yes
92672D structure2-(4-chloro-3-methylphenoxy)-N-{1-ethyl-2-[(4-methylpiperidin-1-yl)methyl]-1H-benzimidazol-5-yl}acetamideC25H31ClN4O2454.9994 / 14.8Yes
95212D structureBAS 09528148C10H14N2O2S226.2944 / 11.9Yes
97342D structureMLS001124504C20H21N5O3S411.486 / 11.9Yes
97362D structureN-(4-acetylphenyl)-4-(1H-tetrazol-1-yl)benzamideC16H13N5O2307.3135 / 11.6Yes
99152D structureCHEMBL1396103C18H16N2O2292.3383 / 23.1Yes
99222D structure6,4'-DIMETHOXYFLAVONEC17H14O4282.2954 / 03.5Yes
99272D structureMLS000087711C20H16BrClN2O4463.7124 / 24.6Yes
100362D structureAC1LHESSC12H15BrN4O311.1834 / 12.5Yes
100652D structureCHEMBL1590799C23H21N5O2S2463.5747 / 15.4No

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