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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameNeuropeptide FF receptor 2
SpeciesHomo sapiens (Human)
GeneNPFFR2
SynonymNPFF2 receptor
Neuropeptide G-protein coupled receptor
GPR74
G-protein coupled receptor HLWAR77
G-protein coupled receptor 74
[ Show all ]
DiseaseN/A
Length522
Amino acid sequenceMNSFFGTPAASWCLLESDVSSAPDKEAGRERRALSVQQRGGPAWSGSLEWSRQSAGDRRRLGLSRQTAKSSWSRSRDRTCCCRRAWWILVPAADRARRERFIMNEKWDTNSSENWHPIWNVNDTKHHLYSDINITYVNYYLHQPQVAAIFIISYFLIFFLCMMGNTVVCFIVMRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCKISGLVQGISVAASVFTLVAIAVDRFQCVVYPFKPKLTIKTAFVIIMIIWVLAITIMSPSAVMLHVQEEKYYRVRLNSQNKTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYGRIGISLFRAAVPHTGRKNQEQWHVVSRKKQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIYIYPFAHWLAFGNSSVNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQLVQESTFQNPHGETLLYRKSAEKPQQELVMEELKETTNSSEI
UniProtQ9Y5X5
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5952
IUPHAR301
DrugBankN/A

Known ligands

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Total entries: 152
Page:  / 2 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
4417572D structureCHEMBL3361427C22H36N6O400.5714 / 42.7Yes
4418382D structureCHEMBL3361419C24H34N6O3454.5756 / 41.7Yes
4419172D structureCHEMBL3361412C35H52N6O5636.8388 / 46.5No
4420512D structureCHEMBL3360831C19H33N7O375.5215 / 5-0.1Yes
168962D structureCHEMBL574565C13H11F3N4O296.2536 / 22.4Yes
168982D structureCID 69536911C13H11F3N4O296.2536 / 22.4Yes
173122D structureCHEMBL2208340C22H28N6O3424.5054 / 50.5Yes
173142D structureCHEMBL2204019C22H28N6O3424.5054 / 50.5Yes
173162D structureCHEMBL2208339C22H28N6O3424.5054 / 50.5Yes
214252D structureCHEMBL572825C15H18N4O270.3363 / 22.7Yes
4425472D structureCHEMBL3361418C26H32N6O444.5834 / 43.0Yes
245222D structureCHEMBL2208309C19H28N6O5420.476 / 6-1.7No
5555872D structureRFRP-1C64H96N18O12S1341.6516 / 140.2No
5223722D structureCHEMBL3786583C76H104F9N19O231822.7635 / 23N/ANo
4427892D structureCHEMBL3361420C23H32N6O2424.5495 / 41.7Yes
353192D structureCHEMBL2208074C23H30N6O4454.5315 / 60.3No
402292D structureCHEMBL2208297C30H33N7O3539.644 / 62.8No
468482D structureCHEMBL573738C13H14N4O242.2823 / 21.9Yes
493732D structureCHEMBL388586C41H51FN10O6798.9218 / 92.4No
580662D structureCHEMBL2208295C26H30N6O3474.5654 / 51.9Yes
5233762D structureCHEMBL508974C32H38N6O6602.6927 / 63.4No
637032D structureCHEMBL2208311C25H29N7O3475.5535 / 51.0Yes
4443522D structureCHEMBL3361414C37H48N6O5656.8288 / 47.5No
4446512D structureCHEMBL3361429C26H32N6O444.5834 / 43.0Yes
745832D structureCHEMBL2208076C24H30N6O4466.5425 / 60.8No
760262D structureCHEMBL2208070C25H34N6O5498.5846 / 50.6Yes
4455052D structureCHEMBL3360836C20H27N5337.4713 / 32.3Yes
971792D structureCHEMBL2208075C23H30N6O5470.536 / 7-0.1No
4456332D structureCHEMBL3352907C34H50N6O5622.8118 / 46.1No
1112862D structureCHEMBL2208333C23H30N6O4454.5315 / 50.7Yes
1166782D structureCHEMBL2208308C21H33N7O3431.5415 / 6-1.1No
1171102D structureCHEMBL573519C14H14F3N5309.2965 / 22.1Yes
1179842D structureCHEMBL2208312C25H29N7O3475.5535 / 51.3Yes
1222962D structureCHEMBL2208080C26H36N6O3480.6134 / 52.4Yes
4784702D structureNeuropeptide FFC54H76N14O101081.2912 / 12-0.3No
5559802D structureAC1NQ0SCC54H76N14O101081.2912 / 12-0.3No
1375952D structureCHEMBL2208314C23H28N8O3464.535 / 60.6No
4472482D structureCHEMBL3361424C24H33N5O407.5623 / 32.6Yes
1416852D structureCHEMBL2208078C29H32N6O4528.6135 / 52.0No
4475872D structureCHEMBL3361436C29H35N5O469.6333 / 33.9Yes
1500432D structure311309-27-0C45H72N14O10969.15912 / 11-2.5No
5258352D structureCHEMBL3786309C65H91N17O161366.5518 / 18-3.9No
1517192D structureCHEMBL2208331C22H26Cl2N6O3493.3894 / 51.9Yes
4477492D structureCHEMBL3361434C23H29Cl2N5O462.4193 / 33.5Yes
4478652D structureCHEMBL3361416C22H30N6O394.5234 / 41.8Yes
4478782D structureCHEMBL3361421C22H28Cl2N6O463.4074 / 43.0Yes
1576882D structureCHEMBL2165922C12H20N4220.322 / 21.4Yes
4479992D structureCHEMBL3361423C23H31N5O393.5353 / 32.3Yes
1615162D structureCHEMBL2208059C24H30N6O4466.5425 / 60.8No
1645112D structureCHEMBL2208073C23H30N6O4454.5315 / 60.3No
1707382D structureCHEMBL2208328C21H27N7O3425.4935 / 5-0.6Yes
5561722D structureBDBM50368404C112H174N36O272456.8533 / 41-3.6No
4487202D structureCHEMBL3361417C23H32N6O408.554 / 41.2Yes
4487452D structureCHEMBL3360834C29H39N7O501.6795 / 52.7No
1788622D structureBIBP3226C27H31N5O3473.5774 / 52.5Yes
5561882D structureCHEMBL44246C27H31N5O3473.5774 / 52.5Yes
4487632D structureCHEMBL3361435C27H33N5O443.5953 / 33.5Yes
1833162D structureCHEMBL2208081C22H29N7O4455.5196 / 5-0.1Yes
4489642D structureCHEMBL3361415C38H50N6O5670.8558 / 47.4No
1927702D structureCHEMBL2208316C23H30N6O3438.5324 / 50.4Yes
1927732D structureSCHEMBL7535795C23H30N6O3438.5324 / 50.4Yes
1927742D structureCHEMBL2208317C23H30N6O3438.5324 / 50.4Yes
1983832D structureCHEMBL2208301C30H35N7O3S573.7166 / 52.5No
1992232D structureCHEMBL2208327C21H27N7O3425.4935 / 5-0.4Yes
4497122D structureCHEMBL3361413C37H48N6O5656.8288 / 47.5No
2085072D structureCHEMBL573518C13H11F3N4S312.3146 / 23.0Yes
2231832D structureCHEMBL1672379C40H64N12O11889.02513 / 12-5.0No
2279362D structureCHEMBL2208067C24H32N6O3452.5594 / 50.8Yes
2375582D structureSCHEMBL7560327C24H29N7O3463.5424 / 61.1No
5564162D structurePrRP24-31C42H67N13O9898.0811 / 10-1.8No
2443122D structureCHEMBL2208320C28H32N6O3500.6034 / 52.3No
2443132D structureCHEMBL2208338C28H32N6O3500.6034 / 52.3No
2443162D structureCHEMBL2208337C28H32N6O3500.6034 / 52.3No
4513552D structureCHEMBL3361410C23H32N6O408.554 / 41.5Yes
2490912D structureSCHEMBL7528463C22H27ClN6O3458.9474 / 51.3Yes
2525342D structurePeptide analogue, 19C42H52FN9O5781.9347 / 83.4No
2561982D structureCHEMBL2208065C26H44N6O3488.6774 / 53.4Yes
2577702D structureCHEMBL2208062C23H29N7O3451.5315 / 50.0Yes
2650802D structureCHEMBL2208323C28H32N6O3500.6034 / 52.3No
2650832D structureCHEMBL2208322C28H32N6O3500.6034 / 52.3No
2650852D structureCHEMBL2208321C28H32N6O3500.6034 / 52.3No
4524812D structureCHEMBL3361428C23H32N6O408.554 / 42.2Yes
2777842D structureCHEMBL2208298C23H28N8O3464.535 / 60.2No
2786222D structureCHEMBL2208299C29H34N6O3514.634 / 52.3No
2786232D structureCHEMBL2208319C29H34N6O3514.634 / 52.3No
2786252D structureCHEMBL2208318C29H34N6O3514.634 / 52.3No
2793302D structureAC1MCKWVC8H8Cl2N4231.082 / 21.9Yes
2793322D structureCHEMBL572531C8H8Cl2N4231.082 / 21.9Yes
2875832D structureCHEMBL2208332C22H26Cl2N6O3493.3894 / 51.9Yes
4531432D structureCHEMBL3361426C15H24N6O304.3984 / 5-0.2Yes
4531552D structureCHEMBL3361431C22H29BrN6O473.4194 / 42.5Yes
2928822D structureCHEMBL574353C10H10ClF3N4278.6635 / 22.2Yes
2943472D structureCHEMBL2208304C24H30N6O3450.5434 / 51.1Yes
2943492D structureCHEMBL2208303C24H30N6O3450.5434 / 51.1Yes
2943502D structureCHEMBL2208302C24H30N6O3450.5434 / 51.1Yes
2947722D structureCHEMBL2208066C20H32N6O3404.5154 / 50.2Yes
2950162D structureCHEMBL2208326C28H32N6O3500.6034 / 52.3No
2950192D structureCHEMBL2208325C28H32N6O3500.6034 / 52.3No
2950212D structureCHEMBL2208324C28H32N6O3500.6034 / 52.3No
4534142D structureCHEMBL3361433C27H33N5O443.5953 / 33.5Yes

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