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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameProstaglandin D2 receptor 2
SpeciesHomo sapiens (Human)
GenePTGDR2
SynonymCD294
prostaglandin D2 receptor 2
PGD2 receptor
Gpr44
G-protein coupled receptor 44
[ Show all ]
DiseaseAsthma; Chronic obstructive pulmonary disease
Asthma
Allergy
Allergic rhinitis
Allergic asthma
[ Show all ]
Length395
Amino acid sequenceMSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
UniProtQ9Y5Y4
Protein Data Bank6d27, 6d26
GPCR-HGmod modelQ9Y5Y4
3D structure modelThis structure is from PDB ID 6d27.
BioLiPBL0428440, BL0428439
Therapeutic Target DatabaseT61722
ChEMBLCHEMBL5071
IUPHAR339
DrugBankBE0003561

Known ligands

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Total entries: 3106
Page:  / 32 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
5359092D structureSCHEMBL1939501C17H15ClN2O5S394.8266 / 13.0Yes
6672D structureCHEMBL3685873C24H27N3O3405.4984 / 24.0Yes
6752D structureCHEMBL1917395C16H9ClF2O3322.6925 / 14.3Yes
9022D structureCHEMBL384979C18H12Br2N2O4480.1125 / 14.2Yes
9062D structureCHEMBL1914491C20H15ClO6S418.8446 / 13.5Yes
9462D structureSCHEMBL509214C23H21F3N2O2414.4286 / 15.2No
10572D structureCHEMBL2387690C21H17N3O2343.3864 / 13.7Yes
5359442D structureSCHEMBL1940119C19H19ClN2O4S406.8815 / 13.0Yes
12092D structureCHEMBL409714C20H15Cl2FN2O4437.2485 / 12.5Yes
12122D structureCHEMBL260013C20H15Cl2FN2O4437.2485 / 12.5Yes
12132D structureSpiro-indolinone analogue, 90C20H15Cl2FN2O4437.2485 / 12.5Yes
12232D structureSCHEMBL2463331C18H16F2N4O2358.3497 / 22.9Yes
12242D structureSCHEMBL2464762C18H16F2N4O2358.3497 / 22.9Yes
5173242D structureCHEMBL3916780C27H24FNO6477.4887 / 14.1Yes
5173252D structureCHEMBL3975186C25H21ClFNO4453.8945 / 15.0Yes
13762D structureSCHEMBL507891C22H21F3N2O4S466.4758 / 13.7Yes
15222D structureCHEMBL1088284C25H17F3N2O2434.4187 / 15.0Yes
5359602D structureCHEMBL3904360C28H26FNO5475.5166 / 14.1Yes
5173272D structureCHEMBL3955736C30H29F2NO4505.5626 / 15.6No
21782D structureCHEMBL2011457C24H20N2O4400.4344 / 13.8Yes
5173282D structureCHEMBL3891887C31H34FNO4503.6145 / 16.0No
24272D structureCHEMBL3686004C23H23BrFN3O3488.3575 / 24.6Yes
30152D structureCHEMBL361311C25H24N2O4S448.5375 / 24.4Yes
40842D structureCHEMBL2036021C17H17N5O307.3574 / 12.5Yes
41202D structureCHEMBL585385C27H26Cl2N2O7S593.4728 / 35.2No
5173392D structureCHEMBL3901887C28H27F2NO4479.5246 / 14.8Yes
41682D structureCHEMBL1689125C23H27ClN2O4430.9295 / 11.4Yes
41732D structureCHEMBL2181755C22H23ClFNO4419.8775 / 14.8Yes
5173412D structureCHEMBL3927763C28H27F2NO4479.5246 / 14.8Yes
43582D structureCHEMBL2048166C17H16N2O2S312.3874 / 13.8Yes
44482D structureCHEMBL507198C24H25FN2O3408.4734 / 24.6Yes
4419052D structureCHEMBL3338267C27H26N4O2438.5314 / 15.1No
54472D structureCHEMBL3685923C25H29N3O3419.5254 / 24.5Yes
55512D structureCHEMBL3685924C25H27Cl2N3O3488.4094 / 25.7No
56122D structureCHEMBL2042237C23H17ClN4O6480.8617 / 22.2Yes
57932D structureCHEMBL3685907C21H29N3O3371.4814 / 23.5Yes
58082D structureCHEMBL3093599C31H22N2O4486.5275 / 25.7No
59312D structureCHEMBL2030117C16H18Cl2N2O2341.2323 / 14.2Yes
5574512D structureBDBM233337C31H32ClNO5534.0495 / 27.3No
5574522D structureBDBM233338C31H32ClNO5534.0495 / 27.3No
61582D structureCHEMBL2204471C22H16F3N3O3427.3837 / 13.4Yes
5574542D structureSCHEMBL1569723C31H24Cl3NO6612.8846 / 27.7No
4419502D structureCHEMBL3338278C21H17ClN4O2392.8435 / 13.6Yes
66362D structureCHEMBL590399C25H20ClNO3S449.9495 / 16.1No
70492D structureSCHEMBL508652C27H28F3N3O3499.5347 / 25.6No
70882D structureCHEMBL1778623C19H20F3NO5S431.4269 / 13.9Yes
72892D structureCHEMBL3667616C25H17Cl2FO4S503.3655 / 16.8No
73802D structureCHEMBL1951555C25H24Cl2N2O6S551.4357 / 35.0No
75102D structureCHEMBL1689130C22H24Cl2N2O4451.3445 / 11.6Yes
80892D structureCHEMBL2181809C29H27FN2O3470.5444 / 25.2No
5173592D structureCHEMBL3930371C21H18Cl2N4O2429.3014 / 24.6Yes
5197342D structureCHEMBL3938068C26H20F2N2O4462.4536 / 23.9Yes
85002D structureCHEMBL2036031C17H16FN5O325.3475 / 12.6Yes
85062D structureCHEMBL178595C23H25FN2O4S444.5216 / 24.0Yes
86762D structureCHEMBL2387687C17H17N3O2295.3424 / 12.4Yes
5575292D structureSCHEMBL1569751C30H24N2O5492.5316 / 25.3No
5362332D structureCHEMBL3956812C27H27FN2O4462.5216 / 13.6Yes
96092D structureCHEMBL2385112C25H21ClN2O4S480.9635 / 14.8Yes
5575572D structureSCHEMBL1569975C28H25ClN2O5504.9676 / 25.2No
4420852D structureCHEMBL3338270C22H23N5O2389.4595 / 13.0Yes
98352D structureCHEMBL2048171C18H16N2O4S356.3966 / 13.3Yes
5575632D structureSCHEMBL1569620C28H25Cl2NO5526.415 / 26.2No
99542D structure2-Formylphenoxyacetic acidC9H8O4180.1594 / 10.8Yes
99652D structureCHEMBL2391507C21H17N3O3359.3854 / 23.2Yes
5362532D structureCHEMBL3948154C30H31FN2O4502.5866 / 11.7No
105692D structureCHEMBL3237229C21H20F4N2O3424.3967 / 14.0Yes
105702D structureCHEMBL3685835C23H20ClN3O4437.885 / 24.3Yes
105822D structureCHEMBL589502C22H16ClNO2S393.8854 / 16.7No
5173742D structureCHEMBL3890838C24H25ClN4O2436.944 / 14.8Yes
4642172D structureCHEMBL3673991C22H20FN3O2S409.4796 / 14.6Yes
108842D structureCHEMBL3685928C35H27N3O3537.6194 / 26.7No
111602D structureCHEMBL1081534C26H23F3N2O3468.4766 / 05.6No
111612D structureCHEMBL1081535C26H23F3N2O3468.4766 / 05.6No
112002D structureCHEMBL1778505C23H24N2O3376.4563 / 13.0Yes
114472D structureCHEMBL2048178C18H15BrN2O4S435.2926 / 14.0Yes
116012D structureCHEMBL3667613C26H18F4O5S518.4799 / 16.7No
118632D structureCHEMBL1916699C26H24F3NO5487.4758 / 15.1No
120362D structureCHEMBL605763C25H15F3N2O2S464.4628 / 15.5No
121382D structureCHEMBL3093605C24H22N2O5418.4496 / 22.7Yes
121812D structureCHEMBL1917447C17H13ClFNO4S381.8025 / 13.6Yes
124882D structureCHEMBL3093610C22H15N3O4S417.4397 / 23.4Yes
5576412D structureSCHEMBL1569471C31H24Cl3NO5596.8855 / 27.8No
126942D structureCHEMBL2042379C21H15ClN4O5S470.8847 / 12.4Yes
127422D structureSCHEMBL2444000C26H21ClN4O2S488.995 / 15.0Yes
5173862D structureCHEMBL3930697C25H25FN2O5S484.5428 / 14.2Yes
128262D structureCHEMBL2205158C27H23N3O3437.4994 / 14.3Yes
5173872D structureCHEMBL3930966C24H23ClN2O5S486.9677 / 14.9Yes
5363332D structureCHEMBL3906598C24H23ClN2O5S486.9677 / 14.9Yes
134832D structureCHEMBL2042378C23H17ClN4O5S496.9227 / 12.6Yes
134902D structureCHEMBL569772C25H24Cl2N2O7S567.4348 / 34.7No
135782D structureCHEMBL1778514C23H22ClFN2O3428.8884 / 13.7Yes
5576562D structureSCHEMBL1569470C24H17ClN2O5448.8596 / 24.2Yes
141762D structureCHEMBL1684725C20H22N2O5S2434.5257 / 12.2Yes
5173902D structureCHEMBL3890284C25H22FNO4419.4525 / 14.3Yes
5363672D structureCHEMBL3944545C31H33FN2O5532.6127 / 14.4No
146952D structureSCHEMBL8511017C20H19FN4O3382.3955 / 32.8Yes
147482D structureCHEMBL2204477C22H19FN4O3406.4176 / 12.1Yes
4646862D structureCHEMBL3674016C22H19ClFN3O3427.866 / 14.6Yes
147662D structureCHEMBL2011450C25H21FN2O4432.4516 / 13.6Yes
147912D structureCHEMBL2205150C26H21N3O3423.4724 / 14.5Yes

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