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Ligand

NameISOCLOZAPINE
Molecular formulaC18H19ClN4
IUPAC name8-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine
Molecular weight326.828
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP3.1
Synonyms1977-08-8
2-Chloro-11-(4-methyl-1-piperazinyl)-5H-benzo(b,e)(1,4)diazepine
2-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
2-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
2-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine(isoclozapine)
[ Show all ]
Inchi KeyAPOMSSAGEAOUGO-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-12-13(19)6-7-15(14)20-16-4-2-3-5-17(16)21-18/h2-7,12,20H,8-11H2,1H3
PubChem CID16104
ChEMBLCHEMBL415300
IUPHARN/A
BindingDB50010594
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Known GPCRs

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Total entries: 9
Page:  / 1 

GLASS IDNameUniProtGeneSpeciesLength
111775-hydroxytryptamine receptor 2AP14842Htr2aRattus norvegicus (Rat)471
111805-hydroxytryptamine receptor 2AP28223HTR2AHomo sapiens (Human)471
111815-hydroxytryptamine receptor 2CP08909Htr2cRattus norvegicus (Rat)460
11179D(1A) dopamine receptorP18901Drd1Rattus norvegicus (Rat)446
11178D(2) dopamine receptorP61169Drd2Rattus norvegicus (Rat)444
11183D(2) dopamine receptorP14416DRD2Homo sapiens (Human)443
11185D(3) dopamine receptorP35462DRD3Homo sapiens (Human)400
11184D(4) dopamine receptorP21917DRD4Homo sapiens (Human)467
11182Muscarinic acetylcholine receptor M1P11229CHRM1Homo sapiens (Human)460

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