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Ligand

NameTalnetant
Molecular formulaC25H22N2O2
IUPAC name3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide
Molecular weight382.463
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP5.7
Synonyms174636-32-9
SB-223412
Talnetant [INN]
UNII-CZ3T9T146K
SB 223412
[ Show all ]
Inchi KeyBIAVGWDGIJKWRM-FQEVSTJZSA-N
Inchi IDInChI=1S/C25H22N2O2/c1-2-20(17-11-5-3-6-12-17)27-25(29)22-19-15-9-10-16-21(19)26-23(24(22)28)18-13-7-4-8-14-18/h3-16,20,28H,2H2,1H3,(H,27,29)/t20-/m0/s1
PubChem CID5311424
ChEMBLCHEMBL10188
IUPHAR2132
BindingDB50051293
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Known GPCRs

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Total entries: 11
Page:  / 1 

GLASS IDNameUniProtGeneSpeciesLength
442612Adenosine receptor A1P30542ADORA1Homo sapiens (Human)326
442614Adenosine receptor A3P0DMS8ADORA3Homo sapiens (Human)318
442610Gastrin/cholecystokinin type B receptorP32239CCKBRHomo sapiens (Human)447
442613Kappa-type opioid receptorP41145OPRK1Homo sapiens (Human)380
24272Mu-type opioid receptorP35372OPRM1Homo sapiens (Human)400
24267Neuromedin-K receptorP29371TACR3Homo sapiens (Human)465
24268Neuromedin-K receptorP30098TACR3Cavia porcellus (Guinea pig)440
24271Neuromedin-K receptorP16177Tacr3Rattus norvegicus (Rat)452
442611Prostaglandin E2 receptor EP4 subtypeP35408PTGER4Homo sapiens (Human)488
24270Substance-K receptorP21452TACR2Homo sapiens (Human)398
24269Substance-P receptorP25103TACR1Homo sapiens (Human)407

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