Zhang Lab

University of Michigan

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	2-amino-4-phosphonobutanoic acid
Molecular formula	C4H10NO5P
IUPAC name	2-amino-4-phosphonobutanoic acid
Molecular weight	183.1
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	-5.5
Synonyms	GlcN-6-P synthase inhibitor, 1 (racemic mixture) L-(+)-2-AMINO-4-PHOSPHONO-BUTYRIC ACID LS-47843 NCGC00024466-03 NSC354086 (+/-)-AP-4 Tox21_500064 2-Amino-4-phosphonobutyric acid ACM20263074 BUTYRIC ACID, 2-AMINO-4-PHOSPHONO- DL-0710 IN1534 L-2-amino-4-phosphonobutyrate NCGC00015041-03 NCI60_002523 ( inverted question mark)-2-Amino-4-phosphonobutyric acid PDSP2_000805 BDBM50004051 DL-2-Amino-4-phosphonobutyric acid FCH1114914 L -(+)-2-Amino-4-phosphono- butanoic acid Lopac0_000064 NCGC00015041-06 NSC-354086 (+/-)-2-Amino-4-phosphonobutyric acid SR-01000075414-1 2-Amino-4-phosphono-butyric acid (AP4) AC1L1D5X Butanoic acid, 2-amino-4-phosphono- D00IGI HMS3260M09 L-2-amino-4-phosphobutyric acid MFCD00013999 NCGC00024466-04 OR311226 (?)-2-Amino-4-phosphonobutyric acid 20263-07-4 AKOS015892998 C-51648 DL-2-Amino-4-phosphono-butanoic acid J-013164 L-AP4 cpd, butyric NCGC00015041-04 NSC 30079 ( inverted question mark)-AP-4 SCHEMBL56139 2 APB 6323-99-5 BN0082 CHEMBL285843 DL-AP4 FT-0625388 L -AP4 LP00064 NCGC00024466-02 NSC30079 (+/-)-2-Amino-4-phosphonobutyric acid, solid SR-01000075414-3 AC1Q6RPJ Butanoic acid, 2-amino-4-phosphono- (9CI) DDOQBQRIEWHWBT-UHFFFAOYSA-N I04-1589 L-2-amino-4-phosphonobutanoic acid MolPort-002-513-394 NCGC00260749-01 ( inverted exclamation markA)-AP-4 PDSP1_000818 (y)-2-Amino-4-phosphonobutyric acid 4-Amino Phosphonobutyrate AM807295 CCG-204159 DL-2-Amino-4-phosphonobutanoic acid (AP4) EU-0100064 KS-000024GC L000344 NCGC00015041-05 NSC-30079 (+/-)-2-AMINO-4-PHOSPHONO-BUTYRIC ACID SR-01000075414 2-Amino-4-phosphono-butyric acid Abu(P) BRN 5255932 CTK5B8255 [ Show all ]
Inchi Key	DDOQBQRIEWHWBT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)
PubChem CID	2207
ChEMBL	CHEMBL285843
IUPHAR	N/A
BindingDB	50004051
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
555686	Metabotropic glutamate receptor 1	Q13255	GRM1	Homo sapiens (Human)	1194
555687	Metabotropic glutamate receptor 2	Q14416	GRM2	Homo sapiens (Human)	872
57279	Metabotropic glutamate receptor 4	Q14833	GRM4	Homo sapiens (Human)	912
537399	Metabotropic glutamate receptor 4	P31423	Grm4	Rattus norvegicus (Rat)	912
555688	Metabotropic glutamate receptor 5	P41594	GRM5	Homo sapiens (Human)	1212
57277	Metabotropic glutamate receptor 6	P35349	Grm6	Rattus norvegicus (Rat)	871
57280	Metabotropic glutamate receptor 6	O15303	GRM6	Homo sapiens (Human)	877
57276	Metabotropic glutamate receptor 7	Q14831	GRM7	Homo sapiens (Human)	915
57275	Metabotropic glutamate receptor 8	O00222	GRM8	Homo sapiens (Human)	908
537400	Metabotropic glutamate receptor 8	P70579	Grm8	Rattus norvegicus (Rat)	908

zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218