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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	GUANFACINE
Molecular formula	C9H9Cl2N3O
IUPAC name	N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide
Molecular weight	246.091
Hydrogen bond acceptor	1
Hydrogen bond donor	2
XlogP	2.0
Synonyms	EN300-243924 Guanfacine (INN) INJOMKTZOLKMBF-UHFFFAOYSA-N LS-174236 NCGC00015469-03 NSC_3519 SPD 503 API0026077 BSPBio_000377 CHEMBL862 FT-0669067 Guanfacine [INN:BAN] L013430 N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide NCGC00015469-06 Prestwick2_000339 AC1L1G4B UNII-30OMY4G3MK Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro- CAS-29110-48-3 D08031 DTXSID9046944 Guanfacina [INN-Spanish] Guanfacinum [INN-Latin] Lopac-G-1043 NCGC00015469-01 NCGC00024950-02 30OMY4G3MK SCHEMBL35094 AKOS030255657 BRD-K32830106-003-03-0 CHEBI:5558 Estulic (Salt/Mix) Guanfacine hydrochloride (Salt/Mix) J-017394 MRF-0000019 NCGC00015469-04 Prestwick0_000339 AB0109150 Tenex (Salt/Mix) BCP09647 C07037 CS-2787 GTPL522 Guanfacine-13C-15N3 LON 798 (Salt/Mix) N-amidino-2-(2,6-dichlorophenyl)acetamide NCGC00015469-07 29110-47-2 Prestwick3_000339 ACM1189924284 ZINC3872738 Benzeneacetamide,N-(aminoiminomethyl)-2,6-dichloro- CAS_29110-47-2 EINECS 249-442-8 HY-17416A Lopac0_000519 NCGC00015469-02 NCGC00024950-03 SPBio_002298 AKOS030526130 BRD-K32830106-003-11-3 Estulic (TN) Guanfacine Monohydrochloride L000286 N-(Diaminomethyliden)-2-(2,6-dichlorophenyl)acetamid NCGC00015469-05 (2,6-dichlorophenylacetyl)-guanidine Prestwick1_000339 AB01563079_01 Tocris-1030 BDBM81984 C9H9Cl2N3O CTK8G0105 Guanfacina Guanfacinum Lon798 N-carbamimidoyl-2-(2,6-dichlorophenyl)acetamide NCGC00024950-01 29110-48-3 (mono-hydrochloride) SC-73499 AJ-46369 [(2,6-dichlorophenyl)acetyl]guanidine BPBio1_000415 CCG-204609 DB01018 [ Show all ]
Inchi Key	INJOMKTZOLKMBF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H9Cl2N3O/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13/h1-3H,4H2,(H4,12,13,14,15)
PubChem CID	3519
ChEMBL	CHEMBL862
IUPHAR	522
BindingDB	81984
DrugBank	DB01018
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
137325	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
137327	5-hydroxytryptamine receptor 2B	P41595	HTR2B	Homo sapiens (Human)	481
137319	5-hydroxytryptamine receptor 2C	P28335	HTR2C	Homo sapiens (Human)	458
447098	Alpha-1A adrenergic receptor	P43140	Adra1a	Rattus norvegicus (Rat)	466
137318	Alpha-2A adrenergic receptor	P08913	ADRA2A	Homo sapiens (Human)	450
137322	Alpha-2A adrenergic receptor	Q01338	Adra2a	Mus musculus (Mouse)	450
137321	Alpha-2B adrenergic receptor	P18089	ADRA2B	Homo sapiens (Human)	450
137317	Alpha-2C adrenergic receptor	P18825	ADRA2C	Homo sapiens (Human)	462
137326	Alpha-2C adrenergic receptor	P22086	Adra2c	Rattus norvegicus (Rat)	458
137323	D(1A) dopamine receptor	P21728	DRD1	Homo sapiens (Human)	446
137324	Muscarinic acetylcholine receptor M1	P08482	Chrm1	Rattus norvegicus (Rat)	460

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