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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	PF-3893787
Molecular formula	C13H22N6
IUPAC name	4-N-(cyclopropylmethyl)-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidine-2,4-diamine
Molecular weight	262.361
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	1.1
Synonyms	CHEMBL1915540 GTPL8985 ZPL-389 BDBM50356884 PF-03893787 ZPL3893787 D02DTQ SCHEMBL12604990 N'-(cyclopropylmethyl)-6-[(3R)-3-methylaminopyrrolidin-1-yl]pyrimidine-2,4-diamine ZPL-3893787 PF-3826719 2,4-Pyrimidinediamine, N4-(cyclopropylmethyl)-6-((3R)-3-(methylamino)-1-pyrrolidinyl)- D65H9YE9VU UNII-D65H9YE9VU 943057-12-3 PF 3893787 ZPL389 [ Show all ]
Inchi Key	ISBHYKVAFKTATD-SNVBAGLBSA-N
Inchi ID	InChI=1S/C13H22N6/c1-15-10-4-5-19(8-10)12-6-11(17-13(14)18-12)16-7-9-2-3-9/h6,9-10,15H,2-5,7-8H2,1H3,(H3,14,16,17,18)/t10-/m1/s1
PubChem CID	24745335
ChEMBL	CHEMBL1915540
IUPHAR	8985
BindingDB	50356884
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
140557	Histamine H3 receptor	Q9Y5N1	HRH3	Homo sapiens (Human)	445
140554	Histamine H4 receptor	Q9H3N8	HRH4	Homo sapiens (Human)	390
140555	Histamine H4 receptor	Q91ZY2	Hrh4	Mus musculus (Mouse)	391
140556	Histamine H4 receptor	Q91ZY1	Hrh4	Rattus norvegicus (Rat)	391

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