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GLASS

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Check the ligand table for details.
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Ligand

Name	loratadine
Molecular formula	C22H23ClN2O2
IUPAC name	ethyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
Molecular weight	382.888
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	5.2
Synonyms	CHEBI:6538 KBio2_007112 Claratyne Decongestant Claritin reditab 11-[N-(ethoxycarbonyl)-4-piperidylidene]-8-chloro-6,11-dihydro-5H-benzo-[5,6]cyclohepta[1,2-b]pyridine Clarityne Dy Repetabs D06ABF AB00053224-16 DTXSID2023224 ACT04775 ethyl 4-{13-chloro-4-azatricyclo[9.4.0.0;{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene}piperidine-1-carboxylate Alavert, Claritin, Loratadine FT-0627976 BBL010757 HMS3268M16 Bonalerg HY-17043 Q-100833 Lorastine s1358 Loratadine Redidose SCHEMBL4596 Loratadine, United States Pharmacopeia (USP) Reference Standard Spectrum3_000740 Lorfast SR-01000075968-6 MFCD00672869 TL8005389 NCGC00015619-02 Velodan NCGC00015619-10 NCGC00023125-07 KS-1079 NSC758628 Lomilan (TN) J10034 Children's Claritin KBioSS_001976 Claritin 1-Piperidenecarboxylic acid, 4-(8-chloro-5,6-duhydro-11H-benzo [5,6]cyclohepta[1,2-b]-pyridin-11-ylidene)-, ethyl ester Claritine (TN) 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cycloheptal[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester CPD000058255 7AJO3BO7QN DivK1c_000792 AB0012486 ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate AK-88666 FC1275 AllergyX (TN) HMS2051G11 BCP9000858 HMS3654L17 BSPBio_002300 Loracert Rhinase SBI-0050659.P003 Loratadine [USAN:USP:INN:BAN] SMR000058255 Loratadinum Spectrum_001496 Lowadina SW197416-3 MLS001148466 Tox21_110185 NCGC00015619-05 Z1741979837 NCGC00015619-13 NCI60_041473 L0223 Oprea1_027965 CCG-100786 KBio2_001976 Claratyne Claritin Hives Relief 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester Clarityne 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acidethyl ester CTK8G0633 8-Chloro-6,11-dihydro-11-(1-ethoxycarbonyl-4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine DSSTox_GSID_23224 AC-2086 ethyl 4-(8-chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)piperidine-1-carboxylate Alavert Fristamin Anhissen HMS2235G23 BIDD:GT0198 HSDB 3578 Polaratyne Loranox Roletra Loratadine for system suitability, European Pharmacopoeia (EP) Reference Standard Sch-29851 Loratadine, European Pharmacopoeia (EP) Reference Standard SPECTRUM1503712 Loratyne SR-01000075968-3 M-5196 Talorat Dy NC00036 Tox21_500680 NCGC00015619-08 ZINC537931 NCGC00023125-05 NSC-758628 Lesidas KBio3_001520 Clarinase Claritin Reditabs Clarityne-D 794L755 AB00053224_17 Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylate Aerotina ethyl 4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene}piperidine-1-carboxylate Alavert;Claritin GTPL7216 BCP0726000007 HMS3371D13 BRD-K82795137-001-02-3 I14-0747 REGID_for_CID_3957 Loratadina SAM001246987 Loratadine Wyeth Brand Sensibit Loratadine,(S) Spectrum4_000177 Lorfast (TN) ST2413201 MLS000069647 Tocris-1944 NCGC00015619-03 Versal NCGC00015619-11 NCGC00255171-01 L 9664 Nularef Lopac-L-9664 JCCNYMKQOSZNPW-UHFFFAOYSA-N Civeran Klaritin Claritin (TN) 1-Piperidenecarboxylic acid,6-duhydro-11H-benzo [5,6]cyclohepta[1,2-b]-pyridin-11-ylidene)-, ethyl ester Clarityn 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester Cronopen 8-chloro-11-(1-ethoxycarbonyl-4-piperidylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine DL-436 AB06849 Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidine)-1-piperidinecarboxylate AKOS005499513 Flonidan Allertidin HMS2090O18 BDBM22876 HMS3714E09 C22H23ClN2O2 Loradex Rinolan (TN) Loratadine (JAN/USAN/INN) SC-13436 Loratadine, >=98% (HPLC), powder Sohotin Loratadinum [Latin] SR-01000075968 LP00680 Symphoral (TN) MLS001423984 Tox21_110185_1 NCGC00015619-06 ZB014352 NCGC00023125-02 NINDS_000792 Lergy Optimin CCG-39362 KBio2_004544 Claratyne Cold Claritin Hives Relief Reditab 1-piperidinecarboxylic acid,4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-,ethyl ester Clarityne (TN) 4-(8-chloro-5,6-dihydrobenzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylic acid ethyl ester D00364 AB00053224-15 DSSTox_RID_76931 AC1L1H3E ethyl 4-{13-chloro-4-azatricyclo[9.4.0.0(3),]pentadeca-1(15),3,5,7,11,13-hexaen-2-ylidene}piperidine-1-carboxylate Alavert (TN) Fristamin (TN) Bactimicina allergy HMS3262G21 Biloina HTS028367 Pylor Lorantis Roletra (TN) loratadine impurity c;4-(4,8-dichloro-5,6-dihydro-11h-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester Sch29851 Loratadine, Pharmaceutical Secondary Standard; Certified Reference Material Spectrum2_001584 Loraver SR-01000075968-4 MCULE-5073177964 Tidilor (TN) NCGC00015619-01 UNII-7AJO3BO7QN NCGC00015619-09 NCGC00023125-06 NSC721075 Lisino IDI1_000792 CHEMBL998 KBioGR_000693 Clarinase Reperabs Claritine 4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester Clarium 79794-75-5 DB00455 AB00053224_18 Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate AJ-23376 EU-0100680 Alerpriv Histaloran BCP22338 HMS3393G11 BRD-K82795137-001-10-6 Lopac0_000680 Restamine Loratadina [Spanish] Sanelor Loratadine [USAN:BAN:INN] Sinhistan Dy Loratadine-d4 Spectrum5_001650 Loritine STK574925 MLS000758260 Topcare childrens allergy relief NCGC00015619-04 Wyeth Brand of Loratadine NCGC00015619-12 NCGC00261365-01 L000667 Opera_ID_1868 KBio1_000792 CL0028 KS-00000JOZ Claritin D 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, ethyl ester Clarityn (TN) 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester CS-0887 8-chloro-6,11-dihydro-11-(1- ethoxycarbonyl-4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine DSSTox_CID_3224 AB2000066 ethyl 4-(8-chloro-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-11-ylidene)piperidine-1-carboxylate Alarin Flonidan (TN) AN-14336 HMS2093I15 Bedix Loratadina HMS502H14 CAS-79794-75-5 Loradif Rinomex Loratadine 0.1 mg/ml in Methanol Sch 29851 Loratadine, British Pharmacopoeia (BP) Reference Standard SPBio_001548 Loratidine SR-01000075968-1 LS-114660 Tadine MolPort-002-507-846 Tox21_301532 NCGC00015619-07 Zeos NCGC00023125-04 NSC-721075 Lertamine Pharmakon1600-01503712 [ Show all ]
Inchi Key	JCCNYMKQOSZNPW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
PubChem CID	3957
ChEMBL	CHEMBL998
IUPHAR	7216
BindingDB	22876
DrugBank	DB00455
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
147285	5-hydroxytryptamine receptor 2B	P41595	HTR2B	Homo sapiens (Human)	481
147286	Glucagon-like peptide 1 receptor	P43220	GLP1R	Homo sapiens (Human)	463
147283	Histamine H1 receptor	P35367	HRH1	Homo sapiens (Human)	487
147284	Histamine H1 receptor	P31390	Hrh1	Rattus norvegicus (Rat)	486
147290	Histamine H1 receptor	P70174	Hrh1	Mus musculus (Mouse)	488
147292	Histamine H1 receptor	P31389	HRH1	Cavia porcellus (Guinea pig)	488
147289	Histamine H4 receptor	Q9H3N8	HRH4	Homo sapiens (Human)	390
147288	Muscarinic acetylcholine receptor M1	P08482	Chrm1	Rattus norvegicus (Rat)	460
147291	Neuropeptide S receptor	Q6W5P4	NPSR1	Homo sapiens (Human)	371
147282	Platelet-activating factor receptor	P25105	PTAFR	Homo sapiens (Human)	342
147287	Thyrotropin receptor	P16473	TSHR	Homo sapiens (Human)	764

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