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Ligand

NameSpiroxatrine
Molecular formulaC22H25N3O3
IUPAC name8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Molecular weight379.46
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP3.1
Synonyms1054-88-2
Spiroxatrinum
Spiroxatrine [INN]
SPIROXAMIDE
Spiroxatrine (R 5188)
[ Show all ]
Inchi KeyJVGBTTIJPBFLTE-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H25N3O3/c26-21-22(25(16-23-21)17-6-2-1-3-7-17)10-12-24(13-11-22)14-18-15-27-19-8-4-5-9-20(19)28-18/h1-9,18H,10-16H2,(H,23,26)
PubChem CID5268
ChEMBLCHEMBL300555
IUPHAR53
BindingDB50020192
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Known GPCRs

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Total entries: 22
Page:  / 2 

GLASS IDNameUniProtGeneSpeciesLength
1608355-hydroxytryptamine receptor 1AP08908HTR1AHomo sapiens (Human)422
1608455-hydroxytryptamine receptor 1AP19327Htr1aRattus norvegicus (Rat)422
1608435-hydroxytryptamine receptor 1BP28564Htr1bRattus norvegicus (Rat)386
1608495-hydroxytryptamine receptor 1DP28221HTR1DHomo sapiens (Human)377
1608545-hydroxytryptamine receptor 2AP28223HTR2AHomo sapiens (Human)471
1608405-hydroxytryptamine receptor 2BP30994Htr2bRattus norvegicus (Rat)479
1608415-hydroxytryptamine receptor 2BP41595HTR2BHomo sapiens (Human)481
554088Alpha-1A adrenergic receptorP35348ADRA1AHomo sapiens (Human)466
554089Alpha-1B adrenergic receptorP35368ADRA1BHomo sapiens (Human)520
554090Alpha-1D adrenergic receptorP25100ADRA1DHomo sapiens (Human)572
160832Alpha-2A adrenergic receptorP08913ADRA2AHomo sapiens (Human)450
160842Alpha-2A adrenergic receptorP18871ADRA2ASus scrofa (Pig)450
160844Alpha-2A adrenergic receptorP22909Adra2aRattus norvegicus (Rat)450
160851Alpha-2A adrenergic receptorQ28838ADRA2ABos taurus (Bovine)452
160834Alpha-2B adrenergic receptorP18089ADRA2BHomo sapiens (Human)450
160838Alpha-2B adrenergic receptorO77715ADRA2BDidelphis virginiana (North American opossum)382
160839Alpha-2B adrenergic receptorP19328Adra2bRattus norvegicus (Rat)453
160853Alpha-2B adrenergic receptorO77830ADRA2BOryctolagus cuniculus (Rabbit)394
160833Alpha-2C adrenergic receptorP18825ADRA2CHomo sapiens (Human)462
160837Alpha-2C adrenergic receptorP22086Adra2cRattus norvegicus (Rat)458

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