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Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
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Ligand

Name	15532-75-9
Molecular formula	C11H13F3N2
IUPAC name	1-[3-(trifluoromethyl)phenyl]piperazine
Molecular weight	230.234
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	2.3
Synonyms	ST50213745 BSPBio_002579 UPCMLD0ENAT5654924:001 CTK0H5716 FT-0629725 (3-Trifluoromethylphenyl)piperazine KBio2_000707 1-(3-trifluoromethyl-phenyl)piperazine KS-00000IX8 1-(m-trifluoromethylphenyl)piperazine MFCD00005959 3-trifluoro methylphenylpiperazine N-(alpha,alpha,alpha-trifluoro-m-tolyl)-piperazine 4-(3-trifluoromethylphenyl)piperazine NSC 128882 AJ-09273 SCHEMBL231692 AX8018584 TFMPP CC-03643 ZINC56464 DB-024584 InChI=1/C11H13F3N2/c12-11(13,14)9-2-1-3-10(8-9)16-6-4-15-5-7-16/h1-3,8,15H,4-7H2 1-(3-(trifluoromethyl)phenyl) piperazine KBio3_001799 1-(alpha, alpha, alpha-trifluoro-m-tolyl)piperazine Legal E [Street Name] 1-[3-(Trifluoromethyl)phenyl]piperazine N-(3-trifluoromethylphenyl)piperazine 3-trifluoromethylphenylpiperazine N-[3-(trifluoromethyl) phenyl]-piperazine AB00053672-06 PIP077 AM20060396 Spectrum3_000970 Biomol-NT_000117 BRD-K94887716-001-01-5 TS-03280 CHEMBL274866 EINECS 239-574-4 KB-63878 1-(3-Trifluoromethyl-phenyl)-piperazine KKIMDKMETPPURN-UHFFFAOYSA- 1-(alpha,alpha,alpha-trifluoro-meta-tolyl)piperazine m-trifluoromethylphenylpiperazine 25R3ONU51C N-(alpha, alpha, alphatrifluoro-m-tolyl)piperazine 4-(3-trifluoromethyl-phenyl)-piperazine NCGC00163171-02 AC1Q4ISO RTR-006492 API0003456 Spectrum_000227 STK397247 C-30470 VP70305 D0B9JP GTPL115 KBio2_003275 1-(3-Trifluoromethylphenyl)-piperazine KSC175O1N 1-[3-(trifluoromethyl)-phenyl]-piperazine N-(-(3-Trifluoromethyl)phenyl)piperazine 3-trifluoromethyl phenyl piperazine N-(alpha,alpha,alpha-trifluoro-m-tolyl)piperazine NSC-128882 AK-33456 SPBio_001506 BBL020111 TL8001167 CHEBI:83536 ZX-BK000802 DivK1c_000823 J-503381 1-(3-(Trifluoromethyl)phenyl)piperazine KBioGR_001480 1-(alpha,alpha,alpha-Trifluoro-m-tolyl)piperazine Legal X [Street Name] N-(alpha, alpha, alpha-trifluoro-m-tolyl)-piperazine 4-(3-(trifluoromethyl)phenyl)piperazine N-[3-(trifluoromethyl)phenyl]piperazine AC1L1HUH Piperazine, 1-[3-(trifluoromethyl)phenyl]- AN-17206 Spectrum4_001090 BPBio1_000221 BRD-K94887716-003-02-9 UNII-25R3ONU51C CS-W007879 EN300-33997 (3-Trifluoromethylphenyl) piperazine KBio1_000823 1-(3-Trifluoromethyl-phenyl)-piperazine(TFMPP) KKIMDKMETPPURN-UHFFFAOYSA-N 1-(m-Trifluoromethylphenyl) piperazine MCULE-5364362451 3-(1-Piperazinyl)benzotrifluoride N-(alpha,alpha,alpha-Trifluoro-3-tolyl)piperazine 4-(3-trifluoromethyl-phenyl)piperazine NINDS_000823 AE-641/01084056 SBB040459 ARP-0235 ST24026866 T-6427 C-4804 W3382 D0V5HV IDI1_000823 1(-(3-Trifluoromethyl)phenyl)piperazine KBio2_005843 1-(3-Trifluoromethylphenyl)piperazine L001047 1-[3-(trifluoromethyl)phenyl]-piperazine N-(3-trifluoromethylphenyl)-piperazine 3-trifluoromethylphenyl piperazine N-(m-Trifluoromethylphenyl)piperazine AB0002091 NSC128882 AKOS000120334 Spectrum2_001573 BDBM50007406 BR-33456 TR-006492 [3-(trifluoromethyl)phenyl]piperazine DTXSID10165876 Jsp003042 1-(3-trifluoromethyl)phenylpiperazine KBioSS_000707 1-(alpha,alpha,alpha-Trifluoro-m-tolyl)piperazine, analytical standard, 96% LS-184023 N-(alpha, alpha, alpha-trifluoro-m-tolyl)piperazine 4-(3-trifluoromethyl- phenyl)-piperazine NCGC00163171-01 AC1Q4ISN PubChem20946 ANW-21561 Spectrum5_001131 [ Show all ]
Inchi Key	KKIMDKMETPPURN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H13F3N2/c12-11(13,14)9-2-1-3-10(8-9)16-6-4-15-5-7-16/h1-3,8,15H,4-7H2
PubChem CID	4296
ChEMBL	CHEMBL274866
IUPHAR	115
BindingDB	50007406
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
171165	5-hydroxytryptamine receptor 1A	P19327	Htr1a	Rattus norvegicus (Rat)	422
171166	5-hydroxytryptamine receptor 1B	P28222	HTR1B	Homo sapiens (Human)	390
171168	5-hydroxytryptamine receptor 1B	P28564	Htr1b	Rattus norvegicus (Rat)	386
171167	5-hydroxytryptamine receptor 1D	P28221	HTR1D	Homo sapiens (Human)	377
171174	5-hydroxytryptamine receptor 1D	P11614	HTR1D	Canis lupus familiaris (Dog)	377
171181	5-hydroxytryptamine receptor 1D	P28565	Htr1d	Rattus norvegicus (Rat)	374
171170	5-hydroxytryptamine receptor 1E	P28566	HTR1E	Homo sapiens (Human)	365
171177	5-hydroxytryptamine receptor 1F	P30939	HTR1F	Homo sapiens (Human)	366
171182	5-hydroxytryptamine receptor 1F	Q02284	Htr1f	Mus musculus (Mouse)	366
171171	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
556151	5-hydroxytryptamine receptor 2A	P14842	Htr2a	Rattus norvegicus (Rat)	471
171162	5-hydroxytryptamine receptor 2B	P41595	HTR2B	Homo sapiens (Human)	481
171163	5-hydroxytryptamine receptor 2B	P30994	Htr2b	Rattus norvegicus (Rat)	479
171160	5-hydroxytryptamine receptor 2C	P28335	HTR2C	Homo sapiens (Human)	458
171169	5-hydroxytryptamine receptor 2C	P08909	Htr2c	Rattus norvegicus (Rat)	460
171172	5-hydroxytryptamine receptor 5A	P30966	Htr5a	Mus musculus (Mouse)	357
171175	5-hydroxytryptamine receptor 5B	P31387	Htr5b	Mus musculus (Mouse)	370
171161	5-hydroxytryptamine receptor 6	Q9R1C8	Htr6	Mus musculus (Mouse)	440
171164	5-hydroxytryptamine receptor 6	P50406	HTR6	Homo sapiens (Human)	440
171173	5-hydroxytryptamine receptor 6	P31388	Htr6	Rattus norvegicus (Rat)	436