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Name | AM095 free acid |
---|---|
Molecular formula | C27H24N2O5 |
IUPAC name | 2-[4-[4-[3-methyl-4-[[(1R)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetic acid |
Molecular weight | 456.498 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 2 |
XlogP | 5.0 |
Synonyms | 2-[4-[4-[3-methyl-4-[[(1R)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetic acid AM-152) D06XGC Lysophosphatidic acid antagonists (fibrotic disease), Amira {4'-[3-Methyl-4-({[(1R)-1-phenylethoxy]carbonyl}amino)-1,2-oxazol-5-yl][1,1'-biphenyl]-4-yl}acetic acid [ Show all ] |
Inchi Key | LNDDRUPAICPXIN-GOSISDBHSA-N |
Inchi ID | InChI=1S/C27H24N2O5/c1-17-25(28-27(32)33-18(2)20-6-4-3-5-7-20)26(34-29-17)23-14-12-22(13-15-23)21-10-8-19(9-11-21)16-24(30)31/h3-15,18H,16H2,1-2H3,(H,28,32)(H,30,31)/t18-/m1/s1 |
PubChem CID | 46213949 |
ChEMBL | CHEMBL2182052 |
IUPHAR | 6988 |
BindingDB | 50398127 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
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GLASS ID | Name | UniProt | Gene | Species | Length |
---|---|---|---|---|---|
191496 | Lysophosphatidic acid receptor 1 | Q92633 | LPAR1 | Homo sapiens (Human) | 364 |
554229 | Lysophosphatidic acid receptor 1 | P61793 | Lpar1 | Mus musculus (Mouse) | 364 |
486637 | Lysophosphatidic acid receptor 2 | Q9HBW0 | LPAR2 | Homo sapiens (Human) | 351 |
486638 | Lysophosphatidic acid receptor 3 | Q9UBY5 | LPAR3 | Homo sapiens (Human) | 353 |
486636 | Lysophosphatidic acid receptor 4 | Q99677 | LPAR4 | Homo sapiens (Human) | 370 |
486635 | Lysophosphatidic acid receptor 5 | Q9H1C0 | LPAR5 | Homo sapiens (Human) | 372 |
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