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Check the ligand table for details.
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Ligand

Name	nortriptyline
Molecular formula	C19H21N
IUPAC name	N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine
Molecular weight	263.384
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	4.5
Synonyms	SPBio_002287 UNII-BL03SY4LXB PHVGLTMQBUFIQQ-UHFFFAOYSA-N SBI-0050843.P004 Lopac-N-7261 5-(3-(Methylamino)propylidene)dibenzo(a,e)cyclohepta(1,5)diene N-Methyl-3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yliden)propylamin AB00052061_16 NCGC00014483-08 AN-22230 NCGC00024261-06 AVENTYL HCL Noritren BSPBio_000068 Nortriptylin hydrochloride CHEMBL445 Nortryptyline Desitriptilina Pamelor (TN) GTPL2404 (2)10,11-Dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-.delta.5.gamma.-propylamine KBio2_004089 10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-Delta(5,gamma)-propylamine Spectrum3_000526 ZINC1530741 Prestwick2_000254 Sensival Lumbeck 5-[3-(Methylamino)propylidene]dibenzo[a,E]cyclohepta[1,5]diene NCGC00014483-03 AKOS022507396 NCGC00014483-11 Ateben hydrochloride NCIOpen2_004361 BIDD:PXR0187 Nortrilen CAS-894-71-3 Nortriptyline (INN) NSC-757234 Desmethylamitriptyline HMS500H13 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl- KBioGR_000870 3-(10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-methylpropylamine Sesaval Spectrum_001041 PDSP2_001788 Psychostyl (Salt/Mix) 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine methyl({3-[(2E)-tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene]propyl})amine 72-69-5 NCGC00014483-06 Altilev NCGC00024261-04 Aventyl (TN) NINDS_000151 BRD-K91263825-003-03-2 Nortriptilina [DCIT] CHEBI:7640 Nortriptylinum [INN-Latin] Demethylamitriptyline NSC78248 EINECS 200-788-8 KBio1_000151 10,11-Dihydro-N-methyl-5H-dibenzo(a,d)cycloheptane-.DELTA.,.gamma.-propylamine KUC112478N SPECTRUM1500442 US8629135, SW-02 Prestwick0_000254 SCHEMBL34527 Lopac0_000868 5-(3-Methylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene NCGC00014483 AC1L1IED NCGC00014483-09 API0003635 NCI169453 Aventyl hydrochloride Norpress (TN) BSPBio_002111 nortriptylina D04WFD Norzepine Desitriptyline Pamelor hydrochloride HMS1920B20 KBio2_006657 Spectrum4_000455 Prestwick3_000254 Sensival Ventyl 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine methyl({3-[(2E)-tricyclo[9.4.0.0;{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene]propyl})amine 5H-Dibenzo(a,d)cycloheptene-delta(sup 5),gamma-propylamine, 10,11-dihydro-N-methyl- NCGC00014483-04 Allegron NCGC00014483-12 Avantyl NCIStruc1_000856 BL03SY4LXB Nortrilen (TN) CCG-38266 Nortriptyline [INN:BAN] DB00540 NSC169453 DivK1c_000151 HSDB 3371 10,11-Dihydro-5-(3-methylaminopropylidene)-5H-dibenzo(a,d)(1,4)cycloheptene KBioSS_001521 SPBio_001093 SR-01000000223-4 Pharmakon1600-01500442 QTL1_000063 3-(5,6-dihydrodibenzo[[?],[?]][7]annulen-11-ylidene)-N-methyl-propan-1-amine MRF-0000480 AB00052061 NCGC00014483-07 Amitryptyline, demethyl- NCGC00024261-05 Aventyl allegron Noramitriptyline BRN 2216786 Nortriptylene hydrochloride Nortryptiline Demethylamitryptyline Pamelor EN300-57709 KBio2_001521 10,11-Dihydro-N-methyl-5H-dibenzo(a,d)cycloheptene-delta(5,gamma)-propylamine Lilly 38489 Spectrum2_000997 Vividyl Prestwick1_000254 Sensaval LS-60753 5-(alpha-Methylaminopropylidene)dibenzo(a,d)cyclohepta(1,4)diene NCGC00014483-02 Acetexa NCGC00014483-10 Ateben NCI60_001354 BDBM112777 Nortab hydrochloride C07274 D08288 NSC-169453 Desmethylamitriptylin PDSP1_001805 HMS2091J20 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-methyl- KBio3_001611 21B Sensoval (TN) Spectrum5_001377 Psychostyl 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methylpropylamine methyl({3-[(2E)-tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene]propyl})amine 5H-Dibenzo[a,d]cycloheptene-.DELTA.5,.gamma.-propylamine, 10,11-dihydro-N-methyl- NCGC00014483-05 Allegron (TN) NCGC00024261-03 Aventyl NCIStruc2_000700 BPBio1_000076 Nortriptilina CCRIS 9175 Nortriptylinum Demethylamitriptylene NSC757234 DTXSID9023384 IDI1_000151 10,11-Dihydro-5-(3-methylaminopropylidene)-5H-dibenzo[a,d][1,4]cycloheptene KSC-315-028- [ Show all ]
Inchi Key	PHVGLTMQBUFIQQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3
PubChem CID	4543
ChEMBL	CHEMBL445
IUPHAR	N/A
BindingDB	112777
DrugBank	DB00540
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
260138	5-hydroxytryptamine receptor 1A	P19327	Htr1a	Rattus norvegicus (Rat)	422
260153	5-hydroxytryptamine receptor 1A	P08908	HTR1A	Homo sapiens (Human)	422
260141	5-hydroxytryptamine receptor 1B	P28564	Htr1b	Rattus norvegicus (Rat)	386
260152	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
556489	5-hydroxytryptamine receptor 2A	P14842	Htr2a	Rattus norvegicus (Rat)	471
260165	5-hydroxytryptamine receptor 2B	P41595	HTR2B	Homo sapiens (Human)	481
260134	5-hydroxytryptamine receptor 2C	P08909	Htr2c	Rattus norvegicus (Rat)	460
260135	5-hydroxytryptamine receptor 2C	P28335	HTR2C	Homo sapiens (Human)	458
260139	5-hydroxytryptamine receptor 6	P31388	Htr6	Rattus norvegicus (Rat)	436
260144	5-hydroxytryptamine receptor 6	P50406	HTR6	Homo sapiens (Human)	440
260151	Alpha-1A adrenergic receptor	P35348	ADRA1A	Homo sapiens (Human)	466
260157	Alpha-1A adrenergic receptor	P43140	Adra1a	Rattus norvegicus (Rat)	466
260142	Alpha-1B adrenergic receptor	P15823	Adra1b	Rattus norvegicus (Rat)	515
260146	Alpha-1B adrenergic receptor	P35368	ADRA1B	Homo sapiens (Human)	520
260158	Alpha-1D adrenergic receptor	P25100	ADRA1D	Homo sapiens (Human)	572
260163	Alpha-2A adrenergic receptor	P08913	ADRA2A	Homo sapiens (Human)	450
260150	Alpha-2B adrenergic receptor	P18089	ADRA2B	Homo sapiens (Human)	450
260143	Alpha-2C adrenergic receptor	P18825	ADRA2C	Homo sapiens (Human)	462
461476	Beta-2 adrenergic receptor	P07550	ADRB2	Homo sapiens (Human)	413
260161	Beta-3 adrenergic receptor	P13945	ADRB3	Homo sapiens (Human)	408