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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	pilocarpine
Molecular formula	C11H16N2O2
IUPAC name	(3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one
Molecular weight	208.261
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	1.1
Synonyms	Syncarpine D00525 Piloptic-3 DSSTox_RID_75984 QCHFTSOMWOSFHM-WPRPVWTQSA-N Imidazole-5-butyric acid, alpha-ethyl-beta-(hydroxymethyl)-1-methyl-, gamma-lactone SPBio_001287 KBio2_004155 (+)-Pilocarpine LS-7661 (3S-cis)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone NCGC00023339-07 3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one NCGC00023339-16 AC1L1LEF Ocusert pilo-20 AN-42585 Pilocarpine (TN) BSPBio_000498 Pilocarpine-d3 HCl (deuterated) Spectrum5_001379 Tox21_110887 DB01085 Pilostat Epicar SBB012409 Isopto carpine (TN) KBioGR_000956 (3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]oxolan-2-one Minims Pilocarpine 092P137 NCGC00023339-10 91484-73-0 NSC5746 AK116461 P.V. Carpine Liquifilm beta-Pilocarpine hydrochloride Pilocarpine Mononitrate, (3S-cis)-Isomer CAS-92-13-7 Pilokarpol SR-01000075339-11 ZINC75008 Piloptic-1/2 DSSTox_CID_1162 Prestwick2_000449 HSDB 3163 SCHEMBL15146 KBio1_000358 Lopac0_000960 (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]tetrahydrofuran-2-one NCGC00023339-03 2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3S,4R)- NCGC00023339-13 AB00053525_28 Ocusert P 20 Almocarpine BRD-K85090592-008-05-2 Pilocarpine [USP:BAN:JAN] Spectrum3_000546 Timpilo (TN) D06HLY Piloptic-4 DTXSID1021162 Salagen isopilocarpine SPBio_002437 KBio2_006723 (3S,4R)-3-Ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydrofuran-2(3H)-one MCULE-2634151840 (3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone NCGC00023339-08 NCI60_004403 Adsorbocarpine Ocusert pilo-20 (TN) AX8148055 Pilocarpine chloride BSPBio_002191 Pilocarpol Spectrum_001107 Tox21_110887_1 Pilopine HS (TN) Diocarpine (TN) Prestwick0_000449 GTPL305 SBI-0050924.P004 Isoptocarpine KBioSS_001587 (3S,4R)-3-ethyl-4-[(1-methylimidazol-5-yl)methyl]-3,4,5-trihydrofuran-2-one Miocarpine 2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S,4R)- NCGC00023339-11 92-13-7 Ocu-Carpine Akarpine Pilagan BIDD:GT0217 Pilocarpine nitrate salt CCG-205031 ST069319 Piloptic-2 DSSTox_GSID_21162 Prestwick3_000449 IDI1_000358 SDCCGMLS-0003164.P005 KBio2_001587 LS-187208 (3S,4R)-3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone NCGC00023339-06 3-Ethyl-4-(3-methyl-3H-imidazol-4-ylmethyl)dihydrofuran-2-one NCGC00023339-14 AB00053525_29 Ocusert pilo Amistura P Pilocarpine (JAN/USP) BRD-K85090592-008-15-1 Pilocarpine, Monohydrochloride, (3S-cis)-Isomer CHEMBL550 Spectrum4_000478 Tocris-0694 Piloptic-6 EINECS 202-128-4 Salagen (TN) Isopto carpine Spectrum2_001284 KBio3_001691 (3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one Mi-Pilo 01MI4Q9DI3 NCGC00023339-09 NINDS_000358 AI3-50523 Ocusert Pilo-40 BDBM50008072 Pilocarpine monohydrochloride C07474 Pilokarpin Spersacarpine UNII-01MI4Q9DI3 Piloptic-1 DivK1c_000358 Prestwick1_000449 HMS2089K17 Scheinpharm (TN) KB-207616 Lopac0_000950 (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one Miocarpine (TN) 2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S-cis)- NCGC00023339-12 AB00053525-27 Ocusert AKOS016010311 Pilocarpin BPBio1_000548 Pilocarpine [USAN:BAN:JAN] CHEBI:8207 [ Show all ]
Inchi Key	QCHFTSOMWOSFHM-WPRPVWTQSA-N
Inchi ID	InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1
PubChem CID	5910
ChEMBL	CHEMBL550
IUPHAR	305
BindingDB	50008072
DrugBank	DB01085
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
274812	Muscarinic acetylcholine receptor DM1	P16395	mAChR-A	Drosophila melanogaster (Fruit fly)	805
274813	Muscarinic acetylcholine receptor M1	P08482	Chrm1	Rattus norvegicus (Rat)	460
274815	Muscarinic acetylcholine receptor M1	P11229	CHRM1	Homo sapiens (Human)	460
274816	Muscarinic acetylcholine receptor M1	P12657	Chrm1	Mus musculus (Mouse)	460
274814	Muscarinic acetylcholine receptor M2	P08172	CHRM2	Homo sapiens (Human)	466
274817	Muscarinic acetylcholine receptor M2	P10980	Chrm2	Rattus norvegicus (Rat)	466
274819	Muscarinic acetylcholine receptor M3	P20309	CHRM3	Homo sapiens (Human)	590
274820	Muscarinic acetylcholine receptor M4	P08173	CHRM4	Homo sapiens (Human)	479
274818	Muscarinic acetylcholine receptor M5	P08912	CHRM5	Homo sapiens (Human)	532

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