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Ligand

Namebuspirone
Molecular formulaC21H31N5O2
IUPAC name8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione
Molecular weight385.512
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP2.6
Synonyms36505-84-7
Buspironum
Buspirona
Ansial
Buspironum [INN-Latin]
[ Show all ]
Inchi KeyQWCRAEMEVRGPNT-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
PubChem CID2477
ChEMBLCHEMBL49
IUPHAR36
BindingDB50001859
DrugBankDB00490

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Known GPCRs

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Total entries: 29
Page:  / 2 

GLASS IDNameUniProtGeneSpeciesLength
2883085-hydroxytryptamine receptor 1AP08908HTR1AHomo sapiens (Human)422
2883095-hydroxytryptamine receptor 1AP19327Htr1aRattus norvegicus (Rat)422
2883075-hydroxytryptamine receptor 1BP28564Htr1bRattus norvegicus (Rat)386
2883125-hydroxytryptamine receptor 1DP28221HTR1DHomo sapiens (Human)377
2883275-hydroxytryptamine receptor 1DP28565Htr1dRattus norvegicus (Rat)374
2883305-hydroxytryptamine receptor 1DP79400HTR1DSus scrofa (Pig)291
2883135-hydroxytryptamine receptor 2AP28223HTR2AHomo sapiens (Human)471
2883165-hydroxytryptamine receptor 2AP14842Htr2aRattus norvegicus (Rat)471
2883205-hydroxytryptamine receptor 2AQ75Z89HTR2ABos taurus (Bovine)470
2883105-hydroxytryptamine receptor 2BP41595HTR2BHomo sapiens (Human)481
2883155-hydroxytryptamine receptor 2CP08909Htr2cRattus norvegicus (Rat)460
2883215-hydroxytryptamine receptor 2CP28335HTR2CHomo sapiens (Human)458
5565965-hydroxytryptamine receptor 4Q62758Htr4Rattus norvegicus (Rat)406
2883255-hydroxytryptamine receptor 6Q9R1C8Htr6Mus musculus (Mouse)440
5547065-hydroxytryptamine receptor 7P32304Htr7Mus musculus (Mouse)448
5547075-hydroxytryptamine receptor 7P32305Htr7Rattus norvegicus (Rat)448
288323Alpha-1A adrenergic receptorP18130ADRA1ABos taurus (Bovine)466
453070Alpha-1A adrenergic receptorP43140Adra1aRattus norvegicus (Rat)466
288326Alpha-1D adrenergic receptorP25100ADRA1DHomo sapiens (Human)572
288328Alpha-2A adrenergic receptorQ28838ADRA2ABos taurus (Bovine)452

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