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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	CHEMBL257405
Molecular formula	C25H29ClN6O3Si
IUPAC name	(1S,2R,3S,4R,5S)-4-[6-[(3-chlorophenyl)methylamino]-2-(2-trimethylsilylethynyl)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Molecular weight	525.081
Hydrogen bond acceptor	7
Hydrogen bond donor	4
XlogP	None
Synonyms	BDBM50377684
Inchi Key	RDYPNVDYKVTREJ-YZSDQEEOSA-N
Inchi ID	InChI=1S/C25H29ClN6O3Si/c1-27-24(35)25-11-16(25)19(20(33)21(25)34)32-13-29-18-22(28-12-14-6-5-7-15(26)10-14)30-17(31-23(18)32)8-9-36(2,3)4/h5-7,10,13,16,19-21,33-34H,11-12H2,1-4H3,(H,27,35)(H,28,30,31)/t16-,19-,20+,21+,25+/m1/s1
PubChem CID	44449058
ChEMBL	CHEMBL257405
IUPHAR	N/A
BindingDB	50377684
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
293839	Adenosine receptor A1	P30542	ADORA1	Homo sapiens (Human)	326
293842	Adenosine receptor A1	Q60612	Adora1	Mus musculus (Mouse)	326
293841	Adenosine receptor A2a	Q60613	Adora2a	Mus musculus (Mouse)	410
293843	Adenosine receptor A2a	P29274	ADORA2A	Homo sapiens (Human)	412
293840	Adenosine receptor A3	Q61618	Adora3	Mus musculus (Mouse)	319
453326	Adenosine receptor A3	P0DMS8	ADORA3	Homo sapiens (Human)	318

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