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GLASS

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Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
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Ligand

Name	VERAPAMIL
Molecular formula	C27H38N2O4
IUPAC name	2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile
Molecular weight	454.611
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	3.8
Synonyms	delta-365 AB00053495 SPBio_001820 DSSTox_RID_79636 Isoptin (Salt/Mix) alpha-((N-Methyl-N-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylacetonitrile Tox21_110300 FT-0603225 KBio2_000233 BDBM81939 Verapamil (Na-Ca chanel blocker) IDI1_000399 KBio3_002823 Bio1_001403 Verapamilum Lopac0_001237 BSPBio_000242 Verpamil (A+/-)-Verapamil hydrochloride NCGC00016083-07 Calan (TN) 1394-EP2275420A1 NCGC00016083-16 CCG-205311 1394-EP2298779A1 NCGC00024710-08 Covera-HS 2-(3,4-Dimethoxyphenyl)-5-((2-(3,4-dimethoxyphenyl)ethyl)(methyl)amino)-2-isopropylpentanenitrile, (+/-)- NSC272366 CP-165331 / CP-16533-1 5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile r,s-verapamil SCHEMBL13287282 DivK1c_000399 AC-16016 Spectrum4_000906 EINECS 260-462-6 Isoptine AN-41629 Valeronitrile, 5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropyl- HMS1791L15 KBio2_004911 Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)- Verapamil [USAN:BAN:INN] Isoptimo KBioGR_002343 Bosoptin (TN) vera\|A (+/-) verapamil MLS006011414 C-22537 1007128-78-0 NCGC00016083-10 Cardiagutt 1394-EP2280008A2 NCGC00016083-20 1394-EP2301936A1 NCI60_020143 CP 16533-1 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile Prestwick0_000141 D-365 52-53-9 7482-85-1 SGTNSNPWRIOYBX-UHFFFAOYSA-N DSSTox_CID_21152 Akilen (Salt/Mix) STK538085 Finoptin KB-243163 Apo-Verap Veramex HMS3402L15 KBio3_000465 Bio1_000425 Verapamilo L001330 BRD-A09533288-001-02-7 Verelan PM (2R)-2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-isopropylpentanenitrile NCGC00016083-05 Calan 1394-EP2272972A1 NCGC00016083-14 CAS_52-53-9 1394-EP2298765A1 NCGC00024710-06 Cordilox 1394-EP2316832A1 NSC 135784 CP-16533-1 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl]methylamino}-2-(methy lethyl)pentanenitrile Prestwick3_000141 Dignover AB00053495-20 SPBio_002181 DTXSID9041152 Isoptin (TN) alpha-(3-((2-(3,4-Dimethoxyphenyl)ethyl)-methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile Tox21_110300_1 Geangin KBio2_002343 Benzeneacetonitrile, .alpha.-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-.alpha.-(1-methylethyl)- Verapamil (USAN/INN) IDI1_033983 KBioGR_000233 Bio2_000233 Verapamilum [INN-Latin] LS-174 BSPBio_001513 (R)-(+)-Verapamil Hydrochloride NCGC00016083-08 Calan SR 1394-EP2277865A1 NCGC00016083-17 CCRIS 6749 1394-EP2301923A1 NCGC00024710-09 Covera-HS (Salt/Mix) 2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-(1-methylethyl) pentanenitrile NSC_62969 CTK8D7130 5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile SBI-0051204.P003 52V114 SCHEMBL16742 dl-Verapamil AC1L1DV5 Spectrum5_001786 F2173-0851 Isotopin Ansyr Vasolan HMS1989L15 KBio2_005369 Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-, (+-)- Verapamil [USAN:INN:BAN] Isoptin KBioSS_000233 BP-21223 Verelan (+/-)-VERAPAMIL MolPort-000-721-258 C07188 1394-EP2270011A1 NCGC00016083-11 Cardibeltin 1394-EP2298742A1 NCGC00024710-04 CHEMBL6966 1394-EP2305648A1 NINDS_000399 CP 16533-1 (Verapamil) 2-(3,4-Dimethoxyphenyl)-5-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]-2-isopropylpentanenitrile # Prestwick1_000141 D02356 SMR001550201 DSSTox_GSID_41152 AKOS005468962 Tarka FT-0080127 KBio1_000399 Arpamyl I06-0063 KBio3_000466 Bio1_000914 Verapamilo [INN-Spanish] Lekoptin BRD-A09533288-003-05-6 Verexamil (?)-alpha-[3-[[2-(3,4-Dimethoxyphenyl)ethyl](methyl)amino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile NCGC00016083-06 Calan (Salt/Mix) 1394-EP2272973A1 NCGC00016083-15 CC-35584 1394-EP2298776A1 NCGC00024710-07 Cordilox (Salt/Mix) 1394-EP2316833A1 NSC 272306NA CP-165331 36622-29-4 Quasar DB00661 SC-17292 Dilacoran AB00053495_21 Spectrum2_001740 EINECS 200-145-1 Isoptin SR alpha-Isopropyl-alpha-((N-methyl-N-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylacetonitrile Univer GTPL2406 KBio2_002801 Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino) propyl)-3,4-dimethoxy-alpha-(1-methylethyl)- Verapamil AL Iproveratril KBioGR_001372 Bio2_000713 Veraptin (+-)-Verapamil MCULE-3016077278 BSPBio_002358 .alpha.-((N-Methyl-N-homoveratryl)-.gamma.-aminopropyl)-3,4-dimethoxyphenylacetonitrile NCGC00016083-09 Calcan 1394-EP2277872A1 NCGC00016083-18 CHEBI:77733 1394-EP2301931A1 NCGC00344584-01 Covera-hs (TN) 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-isopropyl-pentanenitrile Nu-Verap D 365 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile 56949-77-0 Securon Drosteakard Akilen ST50826367 Falicard Izoptin API0004584 Veracim HMS2089H17 KBio2_007479 Berkatens VERAPAMIL, Dexverapamil, Verapamyl hydrochloride, VERAPAMIL HYDROCHLORIDE KBioSS_002346 BPBio1_000268 Verelan (TN) (1)-3-(3,4-Dimethoxyphenyl)-6-((5,6-dimethoxyphenethyl)methylamino)hexane-3-carbonitrile NCGC00016083-04 C27H38N2O4 1394-EP2272841A1 NCGC00016083-13 CAS-52-53-9 1394-EP2298764A1 NCGC00024710-05 cMAP_000023 1394-EP2314585A1 Novo-Veramil CP-16,533-1 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Prestwick2_000141 D0R0FE [ Show all ]
Inchi Key	SGTNSNPWRIOYBX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3
PubChem CID	2520
ChEMBL	CHEMBL6966
IUPHAR	N/A
BindingDB	81939
DrugBank	DB00661
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
313945	5-hydroxytryptamine receptor 1A	P19327	Htr1a	Rattus norvegicus (Rat)	422
313943	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
313950	5-hydroxytryptamine receptor 2B	P41595	HTR2B	Homo sapiens (Human)	481
313944	5-hydroxytryptamine receptor 2C	P28335	HTR2C	Homo sapiens (Human)	458
454158	Alpha-1A adrenergic receptor	P43140	Adra1a	Rattus norvegicus (Rat)	466
551805	Alpha-1A adrenergic receptor	P35348	ADRA1A	Homo sapiens (Human)	466
313941	Alpha-1B adrenergic receptor	P15823	Adra1b	Rattus norvegicus (Rat)	515
551804	Alpha-1B adrenergic receptor	P35368	ADRA1B	Homo sapiens (Human)	520
551806	Alpha-1D adrenergic receptor	P25100	ADRA1D	Homo sapiens (Human)	572
313946	Alpha-2A adrenergic receptor	P08913	ADRA2A	Homo sapiens (Human)	450
313949	Alpha-2B adrenergic receptor	P18089	ADRA2B	Homo sapiens (Human)	450
313954	Beta-1 adrenergic receptor	Q28998	ADRB1	Sus scrofa (Pig)	468
313953	Beta-2 adrenergic receptor	Q28997	ADRB2	Sus scrofa (Pig)	418
313951	D(3) dopamine receptor	P35462	DRD3	Homo sapiens (Human)	400
313942	Glucagon-like peptide 1 receptor	P43220	GLP1R	Homo sapiens (Human)	463
313952	Histamine H2 receptor	P25021	HRH2	Homo sapiens (Human)	359
313948	Muscarinic acetylcholine receptor M2	P06199	CHRM2	Sus scrofa (Pig)	466

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