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Ligand

Namemethadone
Molecular formulaC21H27NO
IUPAC name6-(dimethylamino)-4,4-diphenylheptan-3-one
Molecular weight309.453
Hydrogen bond acceptor2
Hydrogen bond donor0
XlogP3.9
Synonymsdl-Methadone
Dolophine
Phenadone
Amidone
Adanon
[ Show all ]
Inchi KeyUSSIQXCVUWKGNF-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H27NO/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15,17H,5,16H2,1-4H3
PubChem CID4095
ChEMBLCHEMBL651
IUPHAR5458
BindingDB82507
DrugBankDB00333

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Known GPCRs

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Total entries: 12
Page:  / 1 

GLASS IDNameUniProtGeneSpeciesLength
344630D(1A) dopamine receptorQ95136DRD1Bos taurus (Bovine)446
556891D(2) dopamine receptorP20288DRD2Bos taurus (Bovine)444
344623Delta-type opioid receptorP41143OPRD1Homo sapiens (Human)372
344626Delta-type opioid receptorP33533Oprd1Rattus norvegicus (Rat)372
462193Delta-type opioid receptorP79291OPRD1Sus scrofa (Pig)228
344625Kappa-type opioid receptorP41145OPRK1Homo sapiens (Human)380
344628Kappa-type opioid receptorP41144OPRK1Cavia porcellus (Guinea pig)380
344629Kappa-type opioid receptorP34975Oprk1Rattus norvegicus (Rat)380
531235Mas-related G-protein coupled receptor member X2Q96LB1MRGPRX2Homo sapiens (Human)330
344622Mu-type opioid receptorP35372OPRM1Homo sapiens (Human)400
344624Mu-type opioid receptorP33535Oprm1Rattus norvegicus (Rat)398
344627Mu-type opioid receptorP97266OPRM1Cavia porcellus (Guinea pig)98

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