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Ligand

Nameloxapine
Molecular formulaC18H18ClN3O
IUPAC name8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine
Molecular weight327.812
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP3.1
Synonyms13-chloro-10-(4-methylpiperazin-1-yl)-2-oxa-9-azatricyclo[9.4.0.0;{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaene
13-chloro-10-(4-methylpiperazin-1-yl)-2-oxa-9-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,9,12,14-heptaene
1977-10-2
2-Chloro-11-(4-methyl-1-piperazinyl)-dibenz(b,f)(1,4)oxazepine
2-Chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine
[ Show all ]
Inchi KeyXJGVXQDUIWGIRW-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3
PubChem CID3964
ChEMBLCHEMBL831
IUPHAR205
BindingDB22871
DrugBankDB00408

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Known GPCRs

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Total entries: 41
Page:  / 3 

GLASS IDNameUniProtGeneSpeciesLength
3932815-hydroxytryptamine receptor 1AP08908HTR1AHomo sapiens (Human)422
3933035-hydroxytryptamine receptor 1BP28222HTR1BHomo sapiens (Human)390
3932885-hydroxytryptamine receptor 1DP28221HTR1DHomo sapiens (Human)377
3933025-hydroxytryptamine receptor 1EP28566HTR1EHomo sapiens (Human)365
3932865-hydroxytryptamine receptor 2AP28223HTR2AHomo sapiens (Human)471
3932955-hydroxytryptamine receptor 2AP14842Htr2aRattus norvegicus (Rat)471
3932805-hydroxytryptamine receptor 2CP28335HTR2CHomo sapiens (Human)458
3933045-hydroxytryptamine receptor 2CP08909Htr2cRattus norvegicus (Rat)460
3932965-hydroxytryptamine receptor 5AP47898HTR5AHomo sapiens (Human)357
3932845-hydroxytryptamine receptor 6P50406HTR6Homo sapiens (Human)440
3932945-hydroxytryptamine receptor 6P31388Htr6Rattus norvegicus (Rat)436
3932745-hydroxytryptamine receptor 7P34969HTR7Homo sapiens (Human)479
3932935-hydroxytryptamine receptor 7P32305Htr7Rattus norvegicus (Rat)448
393310Alpha-1A adrenergic receptorP35348ADRA1AHomo sapiens (Human)466
393289Alpha-1B adrenergic receptorP35368ADRA1BHomo sapiens (Human)520
393292Alpha-2A adrenergic receptorP08913ADRA2AHomo sapiens (Human)450
393282Alpha-2B adrenergic receptorP18089ADRA2BHomo sapiens (Human)450
393309Alpha-2C adrenergic receptorP18825ADRA2CHomo sapiens (Human)462
393276Beta-1 adrenergic receptorP08588ADRB1Homo sapiens (Human)477
393305Beta-2 adrenergic receptorP07550ADRB2Homo sapiens (Human)413

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