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References

W Chan, H Zhang, J Yang, J Brender, J Hur, A Ozgur, Y Zhang. GLASS: a comprehensive database for experimentally-validated GPCR-ligand associations. Bioinformatics, 31: 3035-3042 (2015). [PDF] [Support Information] [Database]

Class A

1.) 5-hydroxytryptamine receptor 1B (n = 2)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
4IAQ
Homo sapiens (Human) (P28222)Crystal structure of the chimeric protein of 5-ht1b-bril in complex with dihydroergotamine (psi community target) X-Ray Diffraction2.82013-03-13Wang, C.; Jiang, Y.; Ma, J.; Wu, H.; Wacker, D.; Katritch, V.; Han, G.W.; Liu, W.; Huang, X.P.; Vardy, E.; Mccorvy, J.D.; Gao, X.; Zhou, X.E.; Melcher, K.; Zhang, C.; Bai, F.; Yang, H.; Yang, L.; Jiang, H.; Roth, B.L.; Cherezov, V.; Stevens, R.C.; Xu, H.E. Science 2013, 340, 610 (PMID: 23519210)
4IAR
Homo sapiens (Human) (P28222)Crystal structure of the chimeric protein of 5-ht1b-bril in complex with ergotamine (psi community target) X-Ray Diffraction2.72013-03-13Wang, C.; Jiang, Y.; Ma, J.; Wu, H.; Wacker, D.; Katritch, V.; Han, G.W.; Liu, W.; Huang, X.P.; Vardy, E.; Mccorvy, J.D.; Gao, X.; Zhou, X.E.; Melcher, K.; Zhang, C.; Bai, F.; Yang, H.; Yang, L.; Jiang, H.; Roth, B.L.; Cherezov, V.; Stevens, R.C.; Xu, H.E. Science 2013, 340, 610 (PMID: 23519210)
2.) 5-hydroxytryptamine receptor 2B (n = 3)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
5TVN
Homo sapiens (Human) (P41595)Crystal structure of the lsd-bound 5-ht2b receptor X-Ray Diffraction2.92017-02-01Wacker, D.; Wang, S.; Mccorvy, J.D.; Betz, R.M.; Venkatakrishnan, A.J.; Levit, A.; Lansu, K.; Schools, Z.L.; Che, T.; Nichols, D.E.; Shoichet, B.K.; Dror, R.O.; Roth, B.L. Cell 2017, 168, 377 (PMID: 28129538)
4NC3
Homo sapiens (Human) (P41595)Crystal structure of the 5-ht2b receptor solved using serial femtosecond crystallography in lipidic cubic phase. X-Ray Diffraction2.82013-12-18Liu, W.; Wacker, D.; Gati, C.; Han, G.W.; James, D.; Wang, D.; Nelson, G.; Weierstall, U.; Katritch, V.; Barty, A.; Zatsepin, N.A.; Li, D.; Messerschmidt, M.; Boutet, S.; Williams, G.J.; Koglin, J.E.; Seibert, M.M.; Wang, C.; Shah, S.T.; Basu, S.; Fromme, R.; Kupitz, C.; Rendek, K.N.; Grotjohann, I.; Fromme, P.; Kirian, R.A.; Beyerlein, K.R.; White, T.A.; Chapman, H.N.; Caffrey, M.; Spence, J.C.; Stevens, R.C.; Cherezov, V. Science 2013, 342, 1521 (PMID: 24357322)
4IB4
Homo sapiens (Human) (P41595)Crystal structure of the chimeric protein of 5-ht2b-bril in complex with ergotamine X-Ray Diffraction2.72013-03-13Wacker, D.; Wang, C.; Katritch, V.; Han, G.W.; Huang, X.P.; Vardy, E.; Mccorvy, J.D.; Jiang, Y.; Chu, M.; Siu, F.Y.; Liu, W.; Xu, H.E.; Cherezov, V.; Roth, B.L.; Stevens, R.C. Science 2013, 340, 615 (PMID: 23519215)
3.) Adenosine receptor A1 (n = 1)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
5UEN
Homo sapiens (Human) (P30542)Crystal structure of the human adenosine a1 receptor a1ar-bril in complex with the covalent antagonist du172 at 3.2a resolution X-Ray Diffraction3.22017-03-01Glukhova, A.; Thal, D.M.; Nguyen, A.T.; Vecchio, E.A.; Jorg, M.; Scammells, P.J.; May, L.T.; Sexton, P.M.; Christopoulos, A. Cell 2017, 168, 867 (PMID: 28235198)
4.) Adenosine receptor A2a (n = 25)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
3UZC
Homo sapiens (Human) (P29274)Thermostabilised adenosine a2a receptor in complex with 4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol X-Ray Diffraction3.342012-03-21Congreve, M.; Andrews, S.P.; Dore, A.S.; Hollenstein, K.; Hurrell, E.; Langmead, C.J.; Mason, J.S.; Ng, I.W.; Tehan, B.; Zhukov, A.; Weir, M.; Marshall, F.H. J Med Chem 2012, 55, 1898 (PMID: 22220592)
3PWH
Homo sapiens (Human) (P29274)Thermostabilised adenosine a2a receptor X-Ray Diffraction3.32011-09-07Dore, A.S.; Robertson, N.; Errey, J.C.; Ng, I.; Hollenstein, K.; Tehan, B.; Hurrell, E.; Bennett, K.; Congreve, M.; Magnani, F.; Tate, C.G.; Weir, M.; Marshall, F.H. Structure 2011, 19, 1283 (PMID: 21885291)
4EIY
Homo sapiens (Human) (P29274)Crystal structure of the chimeric protein of a2aar-bril in complex with zm241385 at 1.8a resolution X-Ray Diffraction1.82012-07-25Liu, W.; Chun, E.; Thompson, A.A.; Chubukov, P.; Xu, F.; Katritch, V.; Han, G.W.; Roth, C.B.; Heitman, L.H.; Ijzerman, A.P.; Cherezov, V.; Stevens, R.C. Science 2012, 337, 232 (PMID: 22798613)
3QAK
Homo sapiens (Human) (P29274)Agonist bound structure of the human adenosine a2a receptor X-Ray Diffraction2.712011-03-09Xu, F.; Wu, H.; Katritch, V.; Han, G.W.; Jacobson, K.A.; Gao, Z.G.; Cherezov, V.; Stevens, R.C. Science 2011, 332, 322 (PMID: 21393508)
5IU4
Homo sapiens (Human) (P29274)Crystal structure of stabilized a2a adenosine receptor a2ar-star2-bril in complex with zm241385 at 1.7a resolution X-Ray Diffraction1.722016-06-29Segala, E.; Guo, D.; Cheng, R.K.; Bortolato, A.; Deflorian, F.; Dore, A.S.; Errey, J.C.; Heitman, L.H.; Ijzerman, A.P.; Marshall, F.H.; Cooke, R.M. J Med Chem 2016, 59, 6470 (PMID: 27312113)
3RFM
Homo sapiens (Human) (P29274)Thermostabilised adenosine a2a receptor in complex with caffeine X-Ray Diffraction3.62011-09-07Dore, A.S.; Robertson, N.; Errey, J.C.; Ng, I.; Hollenstein, K.; Tehan, B.; Hurrell, E.; Bennett, K.; Congreve, M.; Magnani, F.; Tate, C.G.; Weir, M.; Marshall, F.H. Structure 2011, 19, 1283 (PMID: 21885291)
3EML
Homo sapiens (Human) (P29274)The 2.6 a crystal structure of a human a2a adenosine receptor bound to zm241385. X-Ray Diffraction2.62008-10-14Jaakola, V.P.; Griffith, M.T.; Hanson, M.A.; Cherezov, V.; Chien, E.Y.; Lane, J.R.; Ijzerman, A.P.; Stevens, R.C. Science 2008, 322, 1211 (PMID: 18832607)
5K2D
Homo sapiens (Human) (P29274)1.9a angstrom a2a adenosine receptor structure with mr phasing using xfel data X-Ray Diffraction1.92016-09-21Batyuk, A.; Galli, L.; Ishchenko, A.; Han, G.W.; Gati, C.; Popov, P.A.; Lee, M.Y.; Stauch, B.; White, T.A.; Barty, A.; Aquila, A.; Hunter, M.S.; Liang, M.; Boutet, S.; Pu, M.; Liu, Z.J.; Nelson, G.; James, D.; Li, C.; Zhao, Y.; Spence, J.C.; Liu, W.; Fromme, P.; Katritch, V.; Weierstall, U.; Stevens, R.C.; Cherezov, V. Sci Adv 2016, 2, 00292 (PMID: 27679816)
5IU7
Homo sapiens (Human) (P29274)Crystal structure of stabilized a2a adenosine receptor a2ar-star2-bril in complex with compound 12c at 1.9a resolution X-Ray Diffraction1.92016-06-29Segala, E.; Guo, D.; Cheng, R.K.; Bortolato, A.; Deflorian, F.; Dore, A.S.; Errey, J.C.; Heitman, L.H.; Ijzerman, A.P.; Marshall, F.H.; Cooke, R.M. J Med Chem 2016, 59, 6470 (PMID: 27312113)
2YDV
Homo sapiens (Human) (P29274)Thermostabilised human a2a receptor with neca bound X-Ray Diffraction2.62011-05-18Lebon, G.; Warne, T.; Edwards, P.C.; Bennett, K.; Langmead, C.J.; Leslie, A.G.W.; Tate, C.G. Nature 2011, 474, 521 (PMID: 21593763)
4UHR
Homo sapiens (Human) (P29274)Thermostabilised human a2a receptor with cgs21680 bound X-Ray Diffraction2.62015-04-08Lebon, G.; Edwards, P.C.; Leslie, A.G.W.; Tate, C.G. Mol Pharmacol 2015, 87, 907 (PMID: 25762024)
5K2A
Homo sapiens (Human) (P29274)2.5 angstrom a2a adenosine receptor structure with sulfur sad phasing using xfel data X-Ray Diffraction2.52016-09-21Batyuk, A.; Galli, L.; Ishchenko, A.; Han, G.W.; Gati, C.; Popov, P.A.; Lee, M.Y.; Stauch, B.; White, T.A.; Barty, A.; Aquila, A.; Hunter, M.S.; Liang, M.; Boutet, S.; Pu, M.; Liu, Z.J.; Nelson, G.; James, D.; Li, C.; Zhao, Y.; Spence, J.C.; Liu, W.; Fromme, P.; Katritch, V.; Weierstall, U.; Stevens, R.C.; Cherezov, V. Sci Adv 2016, 2, 00292 (PMID: 27679816)
3VG9
Homo sapiens (Human) (P29274)Crystal structure of human adenosine a2a receptor with an allosteric inverse-agonist antibody at 2.7 a resolution X-Ray Diffraction2.72012-02-01Hino, T.; Arakawa, T.; Iwanari, H.; Yurugi-Kobayashi, T.; Ikeda-Suno, C.; Nakada-Nakura, Y.; Kusano-Arai, O.; Weyand, S.; Shimamura, T.; Nomura, N.; Cameron, A.D.; Kobayashi, T.; Hamakubo, T.; Iwata, S.; Murata, T. Nature 2012, 482, 237 (PMID: 22286059)
3UZA
Homo sapiens (Human) (P29274)Thermostabilised adenosine a2a receptor in complex with 6-(2,6-dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine X-Ray Diffraction3.272012-03-21Congreve, M.; Andrews, S.P.; Dore, A.S.; Hollenstein, K.; Hurrell, E.; Langmead, C.J.; Mason, J.S.; Ng, I.W.; Tehan, B.; Zhukov, A.; Weir, M.; Marshall, F.H. J Med Chem 2012, 55, 1898 (PMID: 22220592)
5IU8
Homo sapiens (Human) (P29274)Crystal structure of stabilized a2a adenosine receptor a2ar-star2-bril in complex with compound 12f at 2.0a resolution X-Ray Diffraction2.02016-06-29Segala, E.; Guo, D.; Cheng, R.K.; Bortolato, A.; Deflorian, F.; Dore, A.S.; Errey, J.C.; Heitman, L.H.; Ijzerman, A.P.; Marshall, F.H.; Cooke, R.M. J Med Chem 2016, 59, 6470 (PMID: 27312113)
2YDO
Homo sapiens (Human) (P29274)Thermostabilised human a2a receptor with adenosine bound X-Ray Diffraction3.02011-05-18Lebon, G.; Warne, T.; Edwards, P.C.; Bennett, K.; Langmead, C.J.; Leslie, A.G.W.; Tate, C.G. Nature 2011, 474, 521 (PMID: 21593763)
3VGA
Homo sapiens (Human) (P29274)Crystal structure of human adenosine a2a receptor with an allosteric inverse-agonist antibody at 3.1 a resolution X-Ray Diffraction3.12012-02-01Hino, T.; Arakawa, T.; Iwanari, H.; Yurugi-Kobayashi, T.; Ikeda-Suno, C.; Nakada-Nakura, Y.; Kusano-Arai, O.; Weyand, S.; Shimamura, T.; Nomura, N.; Cameron, A.D.; Kobayashi, T.; Hamakubo, T.; Iwata, S.; Murata, T. Nature 2012, 482, 237 (PMID: 22286059)
4UG2
Homo sapiens (Human) (P29274)Thermostabilised human a2a receptor with cgs21680 bound X-Ray Diffraction2.62015-04-08Lebon, G.; Edwards, P.C.; Leslie, A.G.W.; Tate, C.G. Mol Pharmacol 2015, 87, 907 (PMID: 25762024)
5IUB
Homo sapiens (Human) (P29274)Crystal structure of stabilized a2a adenosine receptor a2ar-star2-bril in complex with compound 12x at 2.1a resolution X-Ray Diffraction2.12016-06-29Segala, E.; Guo, D.; Cheng, R.K.; Bortolato, A.; Deflorian, F.; Dore, A.S.; Errey, J.C.; Heitman, L.H.; Ijzerman, A.P.; Marshall, F.H.; Cooke, R.M. J Med Chem 2016, 59, 6470 (PMID: 27312113)
5K2C
Homo sapiens (Human) (P29274)1.9 angstrom a2a adenosine receptor structure with sulfur sad phasing and phase extension using xfel data X-Ray Diffraction1.92016-09-21Batyuk, A.; Galli, L.; Ishchenko, A.; Han, G.W.; Gati, C.; Popov, P.A.; Lee, M.Y.; Stauch, B.; White, T.A.; Barty, A.; Aquila, A.; Hunter, M.S.; Liang, M.; Boutet, S.; Pu, M.; Liu, Z.J.; Nelson, G.; James, D.; Li, C.; Zhao, Y.; Spence, J.C.; Liu, W.; Fromme, P.; Katritch, V.; Weierstall, U.; Stevens, R.C.; Cherezov, V. Sci Adv 2016, 2, 00292 (PMID: 27679816)
5UIG
Homo sapiens (Human) (P29274)Crystal structure of adenosine a2a receptor bound to a novel triazole-carboximidamide antagonist X-Ray Diffraction3.52017-02-08Sun, B.; Bachhawat, P.; Chu, M.L.; Wood, M.; Ceska, T.; Sands, Z.A.; Mercier, J.; Lebon, F.; Kobilka, T.S.; Kobilka, B.K. Proc Natl Acad Sci U S A 2017, 114, 2066 (PMID: 28167788)
3REY
Homo sapiens (Human) (P29274)Thermostabilised adenosine a2a receptor in complex with xac X-Ray Diffraction3.312011-09-07Dore, A.S.; Robertson, N.; Errey, J.C.; Ng, I.; Hollenstein, K.; Tehan, B.; Hurrell, E.; Bennett, K.; Congreve, M.; Magnani, F.; Tate, C.G.; Weir, M.; Marshall, F.H. Structure 2011, 19, 1283 (PMID: 21885291)
5K2B
Homo sapiens (Human) (P29274)2.5 angstrom a2a adenosine receptor structure with mr phasing using xfel data X-Ray Diffraction2.52016-09-21Batyuk, A.; Galli, L.; Ishchenko, A.; Han, G.W.; Gati, C.; Popov, P.A.; Lee, M.Y.; Stauch, B.; White, T.A.; Barty, A.; Aquila, A.; Hunter, M.S.; Liang, M.; Boutet, S.; Pu, M.; Liu, Z.J.; Nelson, G.; James, D.; Li, C.; Zhao, Y.; Spence, J.C.; Liu, W.; Fromme, P.; Katritch, V.; Weierstall, U.; Stevens, R.C.; Cherezov, V. Sci Adv 2016, 2, 00292 (PMID: 27679816)
5G53
Homo sapiens (Human) (P29274)Structure of the adenosine a2a receptor bound to an engineered g protein X-Ray Diffraction3.42016-08-03Carpenter, B.; Nehme, R.; Warne, T.; Leslie, A.G.W.; Tate, C.G. Nature 2016, 536, 104 (PMID: 27462812)
5IUA
Homo sapiens (Human) (P29274)Crystal structure of stabilized a2a adenosine receptor a2ar-star2-bril in complex with compound 12b at 2.2a resolution X-Ray Diffraction2.22016-06-29Segala, E.; Guo, D.; Cheng, R.K.; Bortolato, A.; Deflorian, F.; Dore, A.S.; Errey, J.C.; Heitman, L.H.; Ijzerman, A.P.; Marshall, F.H.; Cooke, R.M. J Med Chem 2016, 59, 6470 (PMID: 27312113)
5.) Beta-1 adrenergic receptor (n = 18)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
4AMI
Meleagris gallopavo (Common turkey) (P07700)Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist bucindolol X-Ray Diffraction3.22012-05-23Warne, T.; Edwards, P.C.; Leslie, A.G.; Tate, C.G. Structure 2012, 20, 841 (PMID: 22579251)
2YCZ
Meleagris gallopavo (Common turkey) (P07700)Turkey beta1 adrenergic receptor with stabilising mutations and bound antagonist iodocyanopindolol X-Ray Diffraction3.652011-06-01Moukhametzianov, R.; Warne, T.; Edwards, P.C.; Serrano-Vega, M.J.; Leslie, A.G.; Tate, C.G.; Schertler, G.F. Proc Natl Acad Sci USA 2011, 108, 8228 (PMID: 21540331)
3ZPR
Meleagris gallopavo (Common turkey) (P07700)Thermostabilised turkey beta1 adrenergic receptor with 4-methyl-2-(piperazin-1-yl) quinoline bound X-Ray Diffraction2.72013-04-03Christopher, J.; Brown, J.; Dore, A.; Errey, J.; Koglin, M.; Marshall, F.H.; Myszka, D.; Rich, R.L.; Tate, C.G.; Tehan, B.; Warne, T.; Congreve, M. J Med Chem 2013, 56, 3446 (PMID: 23517028)
5F8U
Meleagris gallopavo (Common turkey) (P07700)Ligand occupancy in crystal structure of beta1-adrenergic receptor previously submitted by huang et al X-Ray Diffraction3.352015-12-23Leslie, A.G.W.; Warne, T.; Tate, C.G. Nat Struct Mol Biol 2015, 22, 941 (PMID: 26643842)
4GPO
Meleagris gallopavo (Common turkey) (P07700)Oligomeic turkey beta1-adrenergic g protein-coupled receptor X-Ray Diffraction3.52013-02-27Huang, J.; Chen, S.; Zhang, J.J.; Huang, X.Y. Nat Struct Mol Biol 2013, 20, 419 (PMID: 23435379)
2Y03
Meleagris gallopavo (Common turkey) (P07700)Turkey beta1 adrenergic receptor with stabilising mutations and bound agonist isoprenaline X-Ray Diffraction2.852011-01-12Warne, A.; Moukhametzianov, R.; Baker, J.G.; Nehme, R.; Edwards, P.C.; Leslie, A.G.W.; Schertler, G.F.X.; Tate, C.G. Nature 2011, 469, 241 (PMID: 21228877)
4BVN
Meleagris gallopavo (Common turkey) (P07700)Ultra-thermostable beta1-adrenoceptor with cyanopindolol bound X-Ray Diffraction2.12014-04-02Miller-Gallacher, J.L.; Nehme, R.; Warne, T.; Edwards, P.C.; Schertler, G.F.X.; Leslie, A.G.W.; Tate, C.G. PLoS One 2014, 9, 92727 (PMID: 24663151)
2YCX
Meleagris gallopavo (Common turkey) (P07700)Turkey beta1 adrenergic receptor with stabilising mutations and bound antagonist cyanopindolol X-Ray Diffraction3.252011-06-01Moukhametzianov, R.; Warne, T.; Edwards, P.C.; Serrano-Vega, M.J.; Leslie, A.G.; Tate, C.G.; Schertler, G.F. Proc Natl Acad Sci USA 2011, 108, 8228 (PMID: 21540331)
3ZPQ
Meleagris gallopavo (Common turkey) (P07700)Thermostabilised turkey beta1 adrenergic receptor with 4-( piperazin-1-yl)-1h-indole bound (compound 19) X-Ray Diffraction2.82013-04-03Christopher, J.; Brown, J.; Dore, A.; Errey, J.; Koglin, M.; Marshall, F.H.; Myszka, D.; Rich, R.L.; Tate, C.G.; Tehan, B.; Warne, T.; Congreve, M. J Med Chem 2013, 56, 3446 (PMID: 23517028)
2VT4
Meleagris gallopavo (Common turkey) (P07700)Turkey beta1 adrenergic receptor with stabilising mutations and bound cyanopindolol X-Ray Diffraction2.72008-06-24Warne, A.; Serrano-Vega, M.J.; Baker, J.G.; Moukhametzianov, R.; Edwards, P.C.; Henderson, R.; Leslie, A.G.W.; Tate, C.G.; Schertler, G.F.X. Nature 2008, 454, 486 (PMID: 18594507)
2Y04
Meleagris gallopavo (Common turkey) (P07700)Turkey beta1 adrenergic receptor with stabilising mutations and bound partial agonist salbutamol X-Ray Diffraction3.052011-01-12Warne, A.; Moukhametzianov, R.; Baker, J.G.; Nehme, R.; Edwards, P.C.; Leslie, A.G.W.; Schertler, G.F.X.; Tate, C.G. Nature 2011, 469, 241 (PMID: 21228877)
2Y01
Meleagris gallopavo (Common turkey) (P07700)Turkey beta1 adrenergic receptor with stabilising mutations and bound partial agonist dobutamine (crystal dob102) X-Ray Diffraction2.62011-03-30Warne, A.; Moukhametzianov, R.; Baker, J.G.; Nehme, R.; Edwards, P.C.; Leslie, A.G.W.; Schertler, G.F.X.; Tate, C.G. Nature 2011, 469, 241 (PMID: 21228877)
5A8E
Meleagris gallopavo (Common turkey) (P07700)Thermostabilised beta1-adrenoceptor with rationally designed inverse agonist 7-methylcyanopindolol bound X-Ray Diffraction2.42015-09-30Sato, T.; Baker, J.; Warne, T.; Brown, G.; Leslie, A.; Congreve, M.; Tate, C. Mol Pharmacol 2015, 88, 1024 (PMID: 26385885)
4AMJ
Meleagris gallopavo (Common turkey) (P07700)Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist carvedilol X-Ray Diffraction2.32012-05-23Warne, T.; Edwards, P.C.; Leslie, A.G.; Tate, C.G. Structure 2012, 20, 841 (PMID: 22579251)
2YCW
Meleagris gallopavo (Common turkey) (P07700)Turkey beta1 adrenergic receptor with stabilising mutations and bound antagonist carazolol X-Ray Diffraction3.02011-06-01Moukhametzianov, R.; Warne, T.; Edwards, P.C.; Serrano-Vega, M.J.; Leslie, A.G.; Tate, C.G.; Schertler, G.F. Proc Natl Acad Sci USA 2011, 108, 8228 (PMID: 21540331)
2Y02
Meleagris gallopavo (Common turkey) (P07700)Turkey beta1 adrenergic receptor with stabilising mutations and bound agonist carmoterol X-Ray Diffraction2.62011-01-12Warne, A.; Moukhametzianov, R.; Baker, J.G.; Nehme, R.; Edwards, P.C.; Leslie, A.G.W.; Schertler, G.F.X.; Tate, C.G. Nature 2011, 469, 241 (PMID: 21228877)
2YCY
Meleagris gallopavo (Common turkey) (P07700)Turkey beta1 adrenergic receptor with stabilising mutations and bound antagonist cyanopindolol X-Ray Diffraction3.152011-06-08Moukhametzianov, R.; Warne, T.; Edwards, P.C.; Serrano-Vega, M.J.; Leslie, A.G.W.; Tate, C.G.; Schertler, G.F.X. Proc Natl Acad Sci USA 2011, 108, 8228 (PMID: 21540331)
2Y00
Meleagris gallopavo (Common turkey) (P07700)Turkey beta1 adrenergic receptor with stabilising mutations and bound partial agonist dobutamine (crystal dob92) X-Ray Diffraction2.52011-01-12Warne, A.; Moukhametzianov, R.; Baker, J.G.; Nehme, R.; Edwards, P.C.; Leslie, A.G.W.; Schertler, G.F.X.; Tate, C.G. Nature 2011, 469, 241 (PMID: 21228877)
6.) Beta-2 adrenergic receptor (n = 20)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
2R4R
Homo sapiens (Human) (P07550)Crystal structure of the human beta2 adrenoceptor X-Ray Diffraction3.42007-11-06Rasmussen, S.G.F.; Choi, H.J.; Rosenbaum, D.M.; Kobilka, T.S.; Thian, F.S.; Edwards, P.C.; Burghammer, M.; Ratnala, V.R.; Sanishvili, R.; Fischetti, R.F.; Schertler, G.F.; Weis, W.I.; Kobilka, B.K. Nature 2007, 450, 383 (PMID: 17952055)
4QKX
Homo sapiens (Human) (P07550)Structure of beta2 adrenoceptor bound to a covalent agonist and an engineered nanobody X-Ray Diffraction3.32014-07-23Weichert, D.; Kruse, A.C.; Manglik, A.; Hiller, C.; Zhang, C.; Hubner, H.; Kobilka, B.K.; Gmeiner, P. Proc Natl Acad Sci USA 2014, 111, 10744 (PMID: 25006259)
5D5B
Homo sapiens (Human) (P07550)In meso x-ray crystallography structure of the beta2-adrenergic receptor at 100 k X-Ray Diffraction3.82016-01-13Huang, C.Y.; Olieric, V.; Ma, P.; Howe, N.; Vogeley, L.; Liu, X.; Warshamanage, R.; Weinert, T.; Panepucci, E.; Kobilka, B.; Diederichs, K.; Wang, M.; Caffrey, M. Acta Crystallogr D Struct Biol 2016, 72, 93 (PMID: 26894538)
4GBR
Homo sapiens (Human) (P07550)N-terminal t4 lysozyme fusion facilitates crystallization of a g protein coupled receptor X-Ray Diffraction3.992012-10-24Zou, Y.; Weis, W.I.; Kobilka, B.K. PLoS One 2012, 7, 46039 (PMID: 23056231)
2R4S
Homo sapiens (Human) (P07550)Crystal structure of the human beta2 adrenoceptor X-Ray Diffraction3.42007-11-06Rasmussen, S.G.F.; Choi, H.J.; Rosenbaum, D.M.; Kobilka, T.S.; Thian, F.S.; Edwards, P.C.; Burghammer, M.; Ratnala, V.R.; Sanishvili, R.; Fischetti, R.F.; Schertler, G.F.; Weis, W.I.; Kobilka, B.K. Nature 2007, 450, 383 (PMID: 17952055)
3KJ6
Homo sapiens (Human) (P07550)Crystal structure of a methylated beta2 adrenergic receptor-fab complex X-Ray Diffraction3.42010-02-16Bokoch, M.P.; Zou, Y.; Rasmussen, S.G.; Liu, C.W.; Nygaard, R.; Rosenbaum, D.M.; Fung, J.J.; Choi, H.J.; Thian, F.S.; Kobilka, T.S.; Puglisi, J.D.; Weis, W.I.; Pardo, L.; Prosser, R.S.; Mueller, L.; Kobilka, B.K. Nature 2010, 463, 108 (PMID: 20054398)
2RH1
Homo sapiens (Human) (P07550)High resolution crystal structure of human b2-adrenergic g protein-coupled receptor. X-Ray Diffraction2.42007-10-30Cherezov, V.; Rosenbaum, D.M.; Hanson, M.A.; Rasmussen, S.G.; Thian, F.S.; Kobilka, T.S.; Choi, H.J.; Kuhn, P.; Weis, W.I.; Kobilka, B.K.; Stevens, R.C. Science 2007, 318, 1258 (PMID: 17962520)
3NY8
Homo sapiens (Human) (P07550)Crystal structure of the human beta2 adrenergic receptor in complex with the inverse agonist ici 118,551 X-Ray Diffraction2.842010-08-11Wacker, D.; Fenalti, G.; Brown, M.A.; Katritch, V.; Abagyan, R.; Cherezov, V.; Stevens, R.C. J Am Chem Soc 2010, 132, 11443 (PMID: 20669948)
3PDS
Homo sapiens (Human) (P07550)Irreversible agonist-beta2 adrenoceptor complex X-Ray Diffraction3.52011-01-12Rosenbaum, D.M.; Zhang, C.; Lyons, J.A.; Holl, R.; Aragao, D.; Arlow, D.H.; Rasmussen, S.G.F.; Choi, H.J.; Devree, B.T.; Sunahara, R.K.; Chae, P.S.; Gellman, S.H.; Dror, R.O.; Shaw, D.E.; Weis, W.I.; Caffrey, M.; Gmeiner, P.; Kobilka, B.K. Nature 2011, 469, 236 (PMID: 21228876)
5D6L
Homo sapiens (Human) (P07550)Beta2ar-t4l -cim X-Ray Diffraction3.22016-08-17Ma, P.; Caffrey, M. To Be Published (PMID: N/A)
5D5A
Homo sapiens (Human) (P07550)In meso in situ serial x-ray crystallography structure of the beta2-adrenergic receptor at 100 k X-Ray Diffraction2.482016-01-13Huang, C.Y.; Olieric, V.; Ma, P.; Howe, N.; Vogeley, L.; Liu, X.; Warshamanage, R.; Weinert, T.; Panepucci, E.; Kobilka, B.; Diederichs, K.; Wang, M.; Caffrey, M. Acta Crystallogr D Struct Biol 2016, 72, 93 (PMID: 26894538)
4LDE
Homo sapiens (Human) (P07550)Structure of beta2 adrenoceptor bound to bi167107 and an engineered nanobody X-Ray Diffraction2.792013-09-25Ring, A.M.; Manglik, A.; Kruse, A.C.; Enos, M.D.; Weis, W.I.; Garcia, K.C.; Kobilka, B.K. Nature 2013, 502, 575 (PMID: 24056936)
3P0G
Homo sapiens (Human) (P07550)Structure of a nanobody-stabilized active state of the beta2 adrenoceptor X-Ray Diffraction3.52011-01-19Rasmussen, S.G.; Choi, H.J.; Fung, J.J.; Pardon, E.; Casarosa, P.; Chae, P.S.; Devree, B.T.; Rosenbaum, D.M.; Thian, F.S.; Kobilka, T.S.; Schnapp, A.; Konetzki, I.; Sunahara, R.K.; Gellman, S.H.; Pautsch, A.; Steyaert, J.; Weis, W.I.; Kobilka, B.K. Nature 2011, 469, 175 (PMID: 21228869)
5JQH
Homo sapiens (Human) (P07550)Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, nb60 X-Ray Diffraction3.22016-07-13Staus, D.P.; Strachan, R.T.; Manglik, A.; Pani, B.; Kahsai, A.W.; Kim, T.H.; Wingler, L.M.; Ahn, S.; Chatterjee, A.; Masoudi, A.; Kruse, A.C.; Pardon, E.; Steyaert, J.; Weis, W.I.; Prosser, R.S.; Kobilka, B.K.; Costa, T.; Lefkowitz, R.J. Nature 2016, 535, 448 (PMID: 27409812)
4LDO
Homo sapiens (Human) (P07550)Structure of beta2 adrenoceptor bound to adrenaline and an engineered nanobody X-Ray Diffraction3.22013-09-25Ring, A.M.; Manglik, A.; Kruse, A.C.; Enos, M.D.; Weis, W.I.; Garcia, K.C.; Kobilka, B.K. Nature 2013, 502, 575 (PMID: 24056936)
3SN6
Homo sapiens (Human) (P07550)Crystal structure of the beta2 adrenergic receptor-gs protein complex X-Ray Diffraction3.22011-07-20Rasmussen, S.G.; Devree, B.T.; Zou, Y.; Kruse, A.C.; Chung, K.Y.; Kobilka, T.S.; Thian, F.S.; Chae, P.S.; Pardon, E.; Calinski, D.; Mathiesen, J.M.; Shah, S.T.; Lyons, J.A.; Caffrey, M.; Gellman, S.H.; Steyaert, J.; Skiniotis, G.; Weis, W.I.; Sunahara, R.K.; Kobilka, B.K. Nature 2011, 477, 549 (PMID: 21772288)
3D4S
Homo sapiens (Human) (P07550)Cholesterol bound form of human beta2 adrenergic receptor. X-Ray Diffraction2.82008-06-17Hanson, M.A.; Cherezov, V.; Griffith, M.T.; Roth, C.B.; Jaakola, V.P.; Chien, E.Y.; Velasquez, J.; Kuhn, P.; Stevens, R.C. Structure 2008, 16, 897 (PMID: 18547522)
3NY9
Homo sapiens (Human) (P07550)Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist X-Ray Diffraction2.842010-08-11Wacker, D.; Fenalti, G.; Brown, M.A.; Katritch, V.; Abagyan, R.; Cherezov, V.; Stevens, R.C. J Am Chem Soc 2010, 132, 11443 (PMID: 20669948)
4LDL
Homo sapiens (Human) (P07550)Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody X-Ray Diffraction3.12013-09-25Ring, A.M.; Manglik, A.; Kruse, A.C.; Enos, M.D.; Weis, W.I.; Garcia, K.C.; Kobilka, B.K. Nature 2013, 502, 575 (PMID: 24056936)
3NYA
Homo sapiens (Human) (P07550)Crystal structure of the human beta2 adrenergic receptor in complex with the neutral antagonist alprenolol X-Ray Diffraction3.162010-08-11Wacker, D.; Fenalti, G.; Brown, M.A.; Katritch, V.; Abagyan, R.; Cherezov, V.; Stevens, R.C. J Am Chem Soc 2010, 132, 11443 (PMID: 20669948)
7.) C-C chemokine receptor type 2 (n = 1)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
5T1A
Homo sapiens (Human) (P41597)Structure of cc chemokine receptor 2 with orthosteric and allosteric antagonists X-Ray Diffraction2.812016-12-14Zheng, Y.; Qin, L.; Zacarias, N.V.; Devries, H.; Han, G.W.; Gustavsson, M.; Dabros, M.; Zhao, C.; Cherney, R.J.; Carter, P.; Stamos, D.; Abagyan, R.; Cherezov, V.; Stevens, R.C.; Ijzerman, A.P.; Heitman, L.H.; Tebben, A.; Kufareva, I.; Handel, T.M. Nature 2016, 540, 458 (PMID: 27926736)
8.) C-C chemokine receptor type 5 (n = 1)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
4MBS
Homo sapiens (Human) (P51681)Crystal structure of the ccr5 chemokine receptor X-Ray Diffraction2.712013-09-11Tan, Q.; Zhu, Y.; Li, J.; Chen, Z.; Han, G.W.; Kufareva, I.; Li, T.; Ma, L.; Fenalti, G.; Li, J.; Zhang, W.; Xie, X.; Yang, H.; Jiang, H.; Cherezov, V.; Liu, H.; Stevens, R.C.; Zhao, Q.; Wu, B. Science 2013, 341, 1387 (PMID: 24030490)
9.) C-C chemokine receptor type 9 (n = 1)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
5LWE
Homo sapiens (Human) (P51686)Crystal structure of the human cc chemokine receptor type 9 (ccr9) in complex with vercirnon X-Ray Diffraction2.82016-12-07Oswald, C.; Rappas, M.; Kean, J.; Dore, A.S.; Errey, J.C.; Bennett, K.; Deflorian, F.; Christopher, J.A.; Jazayeri, A.; Mason, J.S.; Congreve, M.; Cooke, R.M.; Marshall, F.H. Nature 2016, 540, 462 (PMID: 27926729)
10.) C-X-C chemokine receptor type 1 (n = 1)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
2LNL
Homo sapiens (Human) (P25024)Structure of human cxcr1 in phospholipid bilayers Solid-State NMRN/A2012-10-17Park, S.H.; Das, B.B.; Casagrande, F.; Tian, Y.; Nothnagel, H.J.; Chu, M.; Kiefer, H.; Maier, K.; Deangelis, A.A.; Marassi, F.M.; Opella, S.J. Nature 2012, 491, 779 (PMID: 23086146)
11.) C-X-C chemokine receptor type 4 (n = 6)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
3OE8
Homo sapiens (Human) (P61073)Crystal structure of the cxcr4 chemokine receptor in complex with a small molecule antagonist it1t in p1 spacegroup X-Ray Diffraction3.12010-10-27Wu, B.; Chien, E.Y.; Mol, C.D.; Fenalti, G.; Liu, W.; Katritch, V.; Abagyan, R.; Brooun, A.; Wells, P.; Bi, F.C.; Hamel, D.J.; Kuhn, P.; Handel, T.M.; Cherezov, V.; Stevens, R.C. Science 2010, 330, 1066 (PMID: 20929726)
3OE6
Homo sapiens (Human) (P61073)Crystal structure of the cxcr4 chemokine receptor in complex with a small molecule antagonist it1t in i222 spacegroup X-Ray Diffraction3.22010-10-27Wu, B.; Chien, E.Y.; Mol, C.D.; Fenalti, G.; Liu, W.; Katritch, V.; Abagyan, R.; Brooun, A.; Wells, P.; Bi, F.C.; Hamel, D.J.; Kuhn, P.; Handel, T.M.; Cherezov, V.; Stevens, R.C. Science 2010, 330, 1066 (PMID: 20929726)
4RWS
Homo sapiens (Human) (P61073)Crystal structure of cxcr4 and viral chemokine antagonist vmip-ii complex (psi community target) X-Ray Diffraction3.12015-02-11Qin, L.; Kufareva, I.; Holden, L.G.; Wang, C.; Zheng, Y.; Zhao, C.; Fenalti, G.; Wu, H.; Han, G.W.; Cherezov, V.; Abagyan, R.; Stevens, R.C.; Handel, T.M. Science 2015, 347, 1117 (PMID: 25612609)
3OE9
Homo sapiens (Human) (P61073)Crystal structure of the chemokine cxcr4 receptor in complex with a small molecule antagonist it1t in p1 spacegroup X-Ray Diffraction3.12010-10-27Wu, B.; Chien, E.Y.; Mol, C.D.; Fenalti, G.; Liu, W.; Katritch, V.; Abagyan, R.; Brooun, A.; Wells, P.; Bi, F.C.; Hamel, D.J.; Kuhn, P.; Handel, T.M.; Cherezov, V.; Stevens, R.C. Science 2010, 330, 1066 (PMID: 20929726)
3ODU
Homo sapiens (Human) (P61073)The 2.5 a structure of the cxcr4 chemokine receptor in complex with small molecule antagonist it1t X-Ray Diffraction2.52010-10-27Wu, B.; Chien, E.Y.; Mol, C.D.; Fenalti, G.; Liu, W.; Katritch, V.; Abagyan, R.; Brooun, A.; Wells, P.; Bi, F.C.; Hamel, D.J.; Kuhn, P.; Handel, T.M.; Cherezov, V.; Stevens, R.C. Science 2010, 330, 1066 (PMID: 20929726)
3OE0
Homo sapiens (Human) (P61073)Crystal structure of the cxcr4 chemokine receptor in complex with a cyclic peptide antagonist cvx15 X-Ray Diffraction2.92010-10-27Wu, B.; Chien, E.Y.; Mol, C.D.; Fenalti, G.; Liu, W.; Katritch, V.; Abagyan, R.; Brooun, A.; Wells, P.; Bi, F.C.; Hamel, D.J.; Kuhn, P.; Handel, T.M.; Cherezov, V.; Stevens, R.C. Science 2010, 330, 1066 (PMID: 20929726)
12.) Cannabinoid receptor 1 (n = 2)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
5U09
Homo sapiens (Human) (P21554)High-resolution crystal structure of the human cb1 cannabinoid receptor X-Ray Diffraction2.62016-12-07Shao, Z.; Yin, J.; Chapman, K.; Grzemska, M.; Clark, L.; Wang, J.; Rosenbaum, D.M. Nature 2016 (PMID: 27851727)
5TGZ
Homo sapiens (Human) (P21554)Crystal structure of the human cannabinoid receptor cb1 X-Ray Diffraction2.82016-11-02Hua, T.; Vemuri, K.; Pu, M.; Qu, L.; Han, G.W.; Wu, Y.; Zhao, S.; Shui, W.; Li, S.; Korde, A.; Laprairie, R.B.; Stahl, E.L.; Ho, J.H.; Zvonok, N.; Zhou, H.; Kufareva, I.; Wu, B.; Zhao, Q.; Hanson, M.A.; Bohn, L.M.; Makriyannis, A.; Stevens, R.C.; Liu, Z.J. Cell 2016, 167, 750 (PMID: 27768894)
13.) D(3) dopamine receptor (n = 1)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
3PBL
Homo sapiens (Human) (P35462)Structure of the human dopamine d3 receptor in complex with eticlopride X-Ray Diffraction2.892010-11-03Chien, E.Y.; Liu, W.; Zhao, Q.; Katritch, V.; Han, G.W.; Hanson, M.A.; Shi, L.; Newman, A.H.; Javitch, J.A.; Cherezov, V.; Stevens, R.C. Science 2010, 330, 1091 (PMID: 21097933)
14.) Delta-type opioid receptor (n = 4)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
4EJ4
Mus musculus (Mouse) (P32300)Structure of the delta opioid receptor bound to naltrindole X-Ray Diffraction3.42012-05-16Granier, S.; Manglik, A.; Kruse, A.C.; Kobilka, T.S.; Thian, F.S.; Weis, W.I.; Kobilka, B.K. Nature 2012, 485, 400 (PMID: 22596164)
4RWD
Homo sapiens (Human) (P41143)Xfel structure of the human delta opioid receptor in complex with a bifunctional peptide X-Ray Diffraction2.72015-01-14Fenalti, G.; Zatsepin, N.A.; Betti, C.; Giguere, P.; Han, G.W.; Ishchenko, A.; Liu, W.; Guillemyn, K.; Zhang, H.; James, D.; Wang, D.; Weierstall, U.; Spence, J.C.; Boutet, S.; Messerschmidt, M.; Williams, G.J.; Gati, C.; Yefanov, O.M.; White, T.A.; Oberthuer, D.; Metz, M.; Yoon, C.H.; Barty, A.; Chapman, H.N.; Basu, S.; Coe, J.; Conrad, C.E.; Fromme, R.; Fromme, P.; Tourwe, D.; Schiller, P.W.; Roth, B.L.; Ballet, S.; Katritch, V.; Stevens, R.C.; Cherezov, V. Nat Struct Mol Biol 2015, 22, 265 (PMID: 25686086)
4N6H
Homo sapiens (Human) (P41143)1.8 a structure of the human delta opioid 7tm receptor (psi community target) X-Ray Diffraction1.82013-12-25Fenalti, G.; Giguere, P.M.; Katritch, V.; Huang, X.P.; Thompson, A.A.; Cherezov, V.; Roth, B.L.; Stevens, R.C. Nature 2014, 506, 191 (PMID: 24413399)
4RWA
Homo sapiens (Human) (P41143)Synchrotron structure of the human delta opioid receptor in complex with a bifunctional peptide (psi community target) X-Ray Diffraction3.282015-01-14Fenalti, G.; Zatsepin, N.A.; Betti, C.; Giguere, P.; Han, G.W.; Ishchenko, A.; Liu, W.; Guillemyn, K.; Zhang, H.; James, D.; Wang, D.; Weierstall, U.; Spence, J.C.; Boutet, S.; Messerschmidt, M.; Williams, G.J.; Gati, C.; Yefanov, O.M.; White, T.A.; Oberthuer, D.; Metz, M.; Yoon, C.H.; Barty, A.; Chapman, H.N.; Basu, S.; Coe, J.; Conrad, C.E.; Fromme, R.; Fromme, P.; Tourwe, D.; Schiller, P.W.; Roth, B.L.; Ballet, S.; Katritch, V.; Stevens, R.C.; Cherezov, V. Nat Struct Mol Biol 2015, 22, 265 (PMID: 25686086)
15.) Free fatty acid receptor 1 (n = 1)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
4PHU
Homo sapiens (Human) (O14842)Crystal structure of human gpr40 bound to allosteric agonist tak-875 X-Ray Diffraction2.332014-07-16Srivastava, A.; Yano, J.; Hirozane, Y.; Kefala, G.; Gruswitz, F.; Snell, G.; Lane, W.; Ivetac, A.; Aertgeerts, K.; Nguyen, J.; Jennings, A.; Okada, K. Nature 2014, 513, 124 (PMID: 25043059)
16.) G-protein coupled receptor homolog US28 (n = 2)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
4XT3
Human cytomegalovirus (strain AD169) (HHV-5) (P69332)Structure of a viral gpcr bound to human chemokine cx3cl1 X-Ray Diffraction3.82015-03-04Burg, J.S.; Ingram, J.R.; Venkatakrishnan, A.J.; Jude, K.M.; Dukkipati, A.; Feinberg, E.N.; Angelini, A.; Waghray, D.; Dror, R.O.; Ploegh, H.L.; Garcia, K.C. Science 2015, 347, 1113 (PMID: 25745166)
4XT1
Human cytomegalovirus (strain AD169) (HHV-5) (P69332)Structure of a nanobody-bound viral gpcr bound to human chemokine cx3cl1 X-Ray Diffraction2.892015-03-04Burg, J.S.; Ingram, J.R.; Venkatakrishnan, A.J.; Jude, K.M.; Dukkipati, A.; Feinberg, E.N.; Angelini, A.; Waghray, D.; Dror, R.O.; Ploegh, H.L.; Garcia, K.C. Science 2015, 347, 1113 (PMID: 25745166)
17.) Histamine H1 receptor (n = 1)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
3RZE
Homo sapiens (Human) (P35367)Structure of the human histamine h1 receptor in complex with doxepin X-Ray Diffraction3.12011-06-15Shimamura, T.; Shiroishi, M.; Weyand, S.; Tsujimoto, H.; Winter, G.; Katritch, V.; Abagyan, R.; Cherezov, V.; Liu, W.; Han, G.W.; Kobayashi, T.; Stevens, R.C.; Iwata, S. Nature 2011, 475, 65 (PMID: 21697825)
18.) Kappa-type opioid receptor (n = 1)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
4DJH
Homo sapiens (Human) (P41145)Structure of the human kappa opioid receptor in complex with jdtic X-Ray Diffraction2.92012-03-21Wu, H.; Wacker, D.; Mileni, M.; Katritch, V.; Han, G.W.; Vardy, E.; Liu, W.; Thompson, A.A.; Huang, X.P.; Carroll, F.I.; Mascarella, S.W.; Westkaemper, R.B.; Mosier, P.D.; Roth, B.L.; Cherezov, V.; Stevens, R.C. Nature 2012, 485, 327 (PMID: 22437504)
19.) Lysophosphatidic acid receptor 1 (n = 3)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
4Z35
Homo sapiens (Human) (Q92633)Crystal structure of human lysophosphatidic acid receptor 1 in complex with ono-9910539 X-Ray Diffraction2.92015-06-03Chrencik, J.E.; Roth, C.B.; Terakado, M.; Kurata, H.; Omi, R.; Kihara, Y.; Warshaviak, D.; Nakade, S.; Asmar-Rovira, G.; Mileni, M.; Mizuno, H.; Griffith, M.T.; Rodgers, C.; Han, G.W.; Velasquez, J.; Chun, J.; Stevens, R.C.; Hanson, M.A. Cell 2015, 161, 1633 (PMID: 26091040)
4Z36
Homo sapiens (Human) (Q92633)Crystal structure of human lysophosphatidic acid receptor 1 in complex with ono-3080573 X-Ray Diffraction2.92015-06-03Chrencik, J.E.; Roth, C.B.; Terakado, M.; Kurata, H.; Omi, R.; Kihara, Y.; Warshaviak, D.; Nakade, S.; Asmar-Rovira, G.; Mileni, M.; Mizuno, H.; Griffith, M.T.; Rodgers, C.; Han, G.W.; Velasquez, J.; Chun, J.; Stevens, R.C.; Hanson, M.A. Cell 2015, 161, 1633 (PMID: 26091040)
4Z34
Homo sapiens (Human) (Q92633)Crystal structure of human lysophosphatidic acid receptor 1 in complex with ono9780307 X-Ray Diffraction3.02015-06-03Chrencik, J.E.; Roth, C.B.; Terakado, M.; Kurata, H.; Omi, R.; Kihara, Y.; Warshaviak, D.; Nakade, S.; Asmar-Rovira, G.; Mileni, M.; Mizuno, H.; Griffith, M.T.; Rodgers, C.; Han, G.W.; Velasquez, J.; Chun, J.; Stevens, R.C.; Hanson, M.A. Cell 2015, 161, 1633 (PMID: 26091040)
20.) Mu-type opioid receptor (n = 2)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
4DKL
Mus musculus (Mouse) (P42866)Crystal structure of the mu-opioid receptor bound to a morphinan antagonist X-Ray Diffraction2.82012-03-21Manglik, A.; Kruse, A.C.; Kobilka, T.S.; Thian, F.S.; Mathiesen, J.M.; Sunahara, R.K.; Pardo, L.; Weis, W.I.; Kobilka, B.K.; Granier, S. Nature 2012, 485, 321 (PMID: 22437502)
5C1M
Mus musculus (Mouse) (P42866)Crystal structure of active mu-opioid receptor bound to the agonist bu72 X-Ray Diffraction2.12015-08-05Huang, W.; Manglik, A.; Venkatakrishnan, A.J.; Laeremans, T.; Feinberg, E.N.; Sanborn, A.L.; Kato, H.E.; Livingston, K.E.; Thorsen, T.S.; Kling, R.C.; Granier, S.; Gmeiner, P.; Husbands, S.M.; Traynor, J.R.; Weis, W.I.; Steyaert, J.; Dror, R.O.; Kobilka, B.K. Nature 2015, 524, 315 (PMID: 26245379)
21.) Muscarinic acetylcholine receptor M1 (n = 1)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
5CXV
Homo sapiens (Human) (P11229)Structure of the human m1 muscarinic acetylcholine receptor bound to antagonist tiotropium X-Ray Diffraction2.72016-03-09Thal, D.M.; Sun, B.; Feng, D.; Nawaratne, V.; Leach, K.; Felder, C.C.; Bures, M.G.; Evans, D.A.; Weis, W.I.; Bachhawat, P.; Kobilka, T.S.; Sexton, P.M.; Kobilka, B.K.; Christopoulos, A. Nature 2016, 531, 335 (PMID: 26958838)
22.) Muscarinic acetylcholine receptor M2 (n = 3)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
4MQT
Homo sapiens (Human) (P08172)Structure of active human m2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator ly2119620 X-Ray Diffraction3.72013-11-27Kruse, A.C.; Ring, A.M.; Manglik, A.; Hu, J.; Hu, K.; Eitel, K.; Hubner, H.; Pardon, E.; Valant, C.; Sexton, P.M.; Christopoulos, A.; Felder, C.C.; Gmeiner, P.; Steyaert, J.; Weis, W.I.; Garcia, K.C.; Wess, J.; Kobilka, B.K. Nature 2013, 504, 101 (PMID: 24256733)
3UON
Homo sapiens (Human) (P08172)Structure of the human m2 muscarinic acetylcholine receptor bound to an antagonist X-Ray Diffraction3.02012-02-01Haga, K.; Kruse, A.C.; Asada, H.; Yurugi-Kobayashi, T.; Shiroishi, M.; Zhang, C.; Weis, W.I.; Okada, T.; Kobilka, B.K.; Haga, T.; Kobayashi, T. Nature 2012, 482, 547 (PMID: 22278061)
4MQS
Homo sapiens (Human) (P08172)Structure of active human m2 muscarinic acetylcholine receptor bound to the agonist iperoxo X-Ray Diffraction3.52013-11-27Kruse, A.C.; Ring, A.M.; Manglik, A.; Hu, J.; Hu, K.; Eitel, K.; Hubner, H.; Pardon, E.; Valant, C.; Sexton, P.M.; Christopoulos, A.; Felder, C.C.; Gmeiner, P.; Steyaert, J.; Weis, W.I.; Garcia, K.C.; Wess, J.; Kobilka, B.K. Nature 2013, 504, 101 (PMID: 24256733)
23.) Muscarinic acetylcholine receptor M3 (n = 4)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
4U14
Rattus norvegicus (Rat) (P08483)Structure of the m3 muscarinic acetylcholine receptor bound to the antagonist tiotropium crystallized with disulfide-stabilized t4 lysozyme (dst4l) X-Ray Diffraction3.572014-11-26Thorsen, T.S.; Matt, R.; Weis, W.I.; Kobilka, B.K. Structure 2014, 22, 1657 (PMID: 25450769)
4U16
Rattus norvegicus (Rat) (P08483)M3-mt4l receptor bound to nms X-Ray Diffraction3.72014-11-26Thorsen, T.S.; Matt, R.; Weis, W.I.; Kobilka, B.K. Structure 2014, 22, 1657 (PMID: 25450769)
4DAJ
Rattus norvegicus (Rat) (P08483)Structure of the m3 muscarinic acetylcholine receptor X-Ray Diffraction3.42012-02-22Kruse, A.C.; Hu, J.; Pan, A.C.; Arlow, D.H.; Rosenbaum, D.M.; Rosemond, E.; Green, H.F.; Liu, T.; Chae, P.S.; Dror, R.O.; Shaw, D.E.; Weis, W.I.; Wess, J.; Kobilka, B.K. Nature 2012, 482, 552 (PMID: 22358844)
4U15
Rattus norvegicus (Rat) (P08483)M3-mt4l receptor bound to tiotropium X-Ray Diffraction2.82014-11-26Thorsen, T.S.; Matt, R.; Weis, W.I.; Kobilka, B.K. Structure 2014, 22, 1657 (PMID: 25450769)
24.) Muscarinic acetylcholine receptor M4 (n = 1)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
5DSG
Homo sapiens (Human) (P08173)Structure of the m4 muscarinic acetylcholine receptor (m4-mt4l) bound to tiotropium X-Ray Diffraction2.62016-03-16Thal, D.M.; Sun, B.; Feng, D.; Nawaratne, V.; Leach, K.; Felder, C.C.; Bures, M.G.; Evans, D.A.; Weis, W.I.; Bachhawat, P.; Kobilka, T.S.; Sexton, P.M.; Kobilka, B.K.; Christopoulos, A. Nature 2016, 531, 335 (PMID: 26958838)
25.) Neurotensin receptor type 1 (n = 8)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
4BV0
Rattus norvegicus (Rat) (P20789)High resolution structure of evolved agonist-bound neurotensin receptor 1 mutant without lysozyme fusion X-Ray Diffraction3.12014-01-29Egloff, P.; Hillenbrand, M.; Klenk, C.; Batyuk, A.; Heine, P.; Balada, S.; Schlinkmann, K.M.; Scott, D.J.; Schuetz, M.; Plueckthun, A. Proc Natl Acad Sci USA 2014, 111, E655 (PMID: 24453215)
4GRV
Rattus norvegicus (Rat) (P20789)The crystal structure of the neurotensin receptor nts1 in complex with neurotensin (8-13) X-Ray Diffraction2.82012-10-17White, J.F.; Noinaj, N.; Shibata, Y.; Love, J.; Kloss, B.; Xu, F.; Gvozdenovic-Jeremic, J.; Shah, P.; Shiloach, J.; Tate, C.G.; Grisshammer, R. Nature 2012, 490, 508 (PMID: 23051748)
5T04
Rattus norvegicus (Rat) (P20789)Structure of constitutively active neurotensin receptor X-Ray Diffraction3.32016-12-21Krumm, B.E.; Lee, S.; Bhattacharya, S.; Botos, I.; White, C.F.; Du, H.; Vaidehi, N.; Grisshammer, R. Sci Rep 2016, 6, 38564 (PMID: 27924846)
4BUO
Rattus norvegicus (Rat) (P20789)High resolution structure of thermostable agonist-bound neurotensin receptor 1 mutant without lysozyme fusion X-Ray Diffraction2.752014-01-29Egloff, P.; Hillenbrand, M.; Klenk, C.; Batyuk, A.; Heine, P.; Balada, S.; Schlinkmann, K.M.; Scott, D.J.; Schuetz, M.; Plueckthun, A. Proc Natl Acad Sci USA 2014, 111, E655 (PMID: 24453215)
4BWB
Rattus norvegicus (Rat) (P20789)Structure of evolved agonist-bound neurotensin receptor 1 mutant without lysozyme fusion X-Ray Diffraction3.572014-01-29Egloff, P.; Hillenbrand, M.; Klenk, C.; Batyuk, A.; Heine, P.; Balada, S.; Schlinkmann, K.M.; Scott, D.J.; Schuetz, M.; Plueckthun, A. Proc Natl Acad Sci USA 2014, 111, E655 (PMID: 24453215)
3ZEV
Rattus norvegicus (Rat) (P20789)Structure of thermostable agonist-bound neurotensin receptor 1 mutant without lysozyme fusion X-Ray Diffraction3.02014-01-29Egloff, P.; Hillenbrand, M.; Klenk, C.; Batyuk, A.; Heine, P.; Balada, S.; Schlinkmann, K.M.; Scott, D.J.; Schuetz, M.; Plueckthun, A. Proc Natl Acad Sci USA 2014, 111, E655 (PMID: 24453215)
4XEE
Rattus norvegicus (Rat) (P20789)Structure of active-like neurotensin receptor X-Ray Diffraction2.92015-07-29Krumm, B.E.; White, J.F.; Shah, P.; Grisshammer, R. Nat Commun 2015, 6, 7895 (PMID: 26205105)
4XES
Rattus norvegicus (Rat) (P20789)Structure of active-like neurotensin receptor X-Ray Diffraction2.62015-07-29Krumm, B.E.; White, J.F.; Shah, P.; Grisshammer, R. Nat Commun 2015, 6, 7895 (PMID: 26205105)
26.) Nociceptin receptor (n = 3)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
5DHH
Homo sapiens (Human) (P41146)The crystal structure of nociceptin/orphanin fq peptide receptor (nop) in complex with sb-612111 (psi community target) X-Ray Diffraction3.02015-10-21Miller, R.L.; Thompson, A.A.; Trapella, C.; Guerrini, R.; Malfacini, D.; Patel, N.; Han, G.W.; Cherezov, V.; Calo, G.; Katritch, V.; Stevens, R.C. Structure 2015, 23, 2291 (PMID: 26526853)
5DHG
Homo sapiens (Human) (P41146)The crystal structure of nociceptin/orphanin fq peptide receptor (nop) in complex with c-35 (psi community target) X-Ray Diffraction3.02015-10-21Miller, R.L.; Thompson, A.A.; Trapella, C.; Guerrini, R.; Malfacini, D.; Patel, N.; Han, G.W.; Cherezov, V.; Calo, G.; Katritch, V.; Stevens, R.C. Structure 2015, 23, 2291 (PMID: 26526853)
4EA3
Homo sapiens (Human) (P41146)Structure of the n/ofq opioid receptor in complex with a peptide mimetic X-Ray Diffraction3.012012-04-25Thompson, A.A.; Liu, W.; Chun, E.; Katritch, V.; Wu, H.; Vardy, E.; Huang, X.P.; Trapella, C.; Guerrini, R.; Calo, G.; Roth, B.L.; Cherezov, V.; Stevens, R.C. Nature 2012, 485, 395 (PMID: 22596163)
27.) Orexin receptor type 1 (n = 2)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
4ZJ8
Homo sapiens (Human) (O43613)Structures of the human ox1 orexin receptor bound to selective and dual antagonists X-Ray Diffraction2.752016-03-09Yin, J.; Babaoglu, K.; Brautigam, C.A.; Clark, L.; Shao, Z.; Scheuermann, T.H.; Harrell, C.M.; Gotter, A.L.; Roecker, A.J.; Winrow, C.J.; Renger, J.J.; Coleman, P.J.; Rosenbaum, D.M. Nat Struct Mol Biol 2016, 23, 293 (PMID: 26950369)
4ZJC
Homo sapiens (Human) (O43613)Structures of the human ox1 orexin receptor bound to selective and dual antagonists X-Ray Diffraction2.832016-03-09Yin, J.; Babaoglu, K.; Brautigam, C.A.; Clark, L.; Shao, Z.; Scheuermann, T.H.; Harrell, C.M.; Gotter, A.L.; Roecker, A.J.; Winrow, C.J.; Renger, J.J.; Coleman, P.J.; Rosenbaum, D.M. Nat Struct Mol Biol 2016, 23, 293 (PMID: 26950369)
28.) Orexin receptor type 2 (n = 1)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
4S0V
Homo sapiens (Human) (O43614)Crystal structure of the human ox2 orexin receptor bound to the insomnia drug suvorexant X-Ray Diffraction2.52015-01-14Yin, J.; Mobarec, J.C.; Kolb, P.; Rosenbaum, D.M. Nature 2015, 519, 247 (PMID: 25533960)
29.) P2Y purinoceptor 1 (n = 2)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
4XNW
Homo sapiens (Human) (P47900)The human p2y1 receptor in complex with mrs2500 X-Ray Diffraction2.72015-04-01Zhang, D.; Gao, Z.G.; Zhang, K.; Kiselev, E.; Crane, S.; Wang, J.; Paoletta, S.; Yi, C.; Ma, L.; Zhang, W.; Han, G.W.; Liu, H.; Cherezov, V.; Katritch, V.; Jiang, H.; Stevens, R.C.; Jacobson, K.A.; Zhao, Q.; Wu, B. Nature 2015, 520, 317 (PMID: 25822790)
4XNV
Homo sapiens (Human) (P47900)The human p2y1 receptor in complex with bptu X-Ray Diffraction2.22015-04-01Zhang, D.; Gao, Z.G.; Zhang, K.; Kiselev, E.; Crane, S.; Wang, J.; Paoletta, S.; Yi, C.; Ma, L.; Zhang, W.; Han, G.W.; Liu, H.; Cherezov, V.; Katritch, V.; Jiang, H.; Stevens, R.C.; Jacobson, K.A.; Zhao, Q.; Wu, B. Nature 2015, 520, 317 (PMID: 25822790)
30.) P2Y purinoceptor 12 (n = 3)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
4PY0
Homo sapiens (Human) (Q9H244)Crystal structure of p2y12 receptor in complex with 2mesatp X-Ray Diffraction3.12014-04-30Zhang, J.; Zhang, K.; Gao, Z.G.; Paoletta, S.; Zhang, D.; Han, G.W.; Li, T.; Ma, L.; Zhang, W.; Muller, C.E.; Yang, H.; Jiang, H.; Cherezov, V.; Katritch, V.; Jacobson, K.A.; Stevens, R.C.; Wu, B.; Zhao, Q. Nature 2014, 509, 119 (PMID: 24784220)
4PXZ
Homo sapiens (Human) (Q9H244)Crystal structure of p2y12 receptor in complex with 2mesadp X-Ray Diffraction2.52014-04-30Zhang, J.; Zhang, K.; Gao, Z.G.; Paoletta, S.; Zhang, D.; Han, G.W.; Li, T.; Ma, L.; Zhang, W.; Muller, C.E.; Yang, H.; Jiang, H.; Cherezov, V.; Katritch, V.; Jacobson, K.A.; Stevens, R.C.; Wu, B.; Zhao, Q. Nature 2014, 509, 119 (PMID: 24784220)
4NTJ
Homo sapiens (Human) (Q9H244)Structure of the human p2y12 receptor in complex with an antithrombotic drug X-Ray Diffraction2.622014-03-26Zhang, K.; Zhang, J.; Gao, Z.-G.; Zhang, D.; Zhu, L.; Han, G.W.; Moss, S.M.; Paoletta, S.; Kiselev, E.; Lu, W.; Fenalti, G.; Zhang, W.; Muller, C.E.; Yang, H.; Jiang, H.; Cherezov, V.; Katritch, V.; Jacobson, K.A.; Stevens, R.C.; Wu, B.; Zhao, Q. Nature 2014, 509, 115 (PMID: 24670650)
31.) Proteinase-activated receptor 1 (n = 1)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
3VW7
Homo sapiens (Human) (P25116)Crystal structure of human protease-activated receptor 1 (par1) bound with antagonist vorapaxar at 2.2 angstrom X-Ray Diffraction2.22012-12-12Zhang, C.; Srinivasan, Y.; Arlow, D.H.; Fung, J.J.; Palmer, D.; Zheng, Y.; Green, H.F.; Pandey, A.; Dror, R.O.; Shaw, D.E.; Weis, W.I.; Coughlin, S.R.; Kobilka, B.K. Nature 2012, 492, 387 (PMID: 23222541)
32.) Proteinase-activated receptor 2 (n = 3)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
5NJ6
Homo sapiens (Human) (P55085)Crystal structure of a thermostabilised human protease-activated receptor-2 (par2) in ternary complex with fab3949 and az7188 at 4.0 angstrom resolution X-Ray Diffraction4.02017-05-03Cheng, R.K.Y.; Fiez-Vandal, C.; Schlenker, O.; Edman, K.; Aggeler, B.; Brown, D.G.; Brown, G.A.; Cooke, R.M.; Dumelin, C.E.; Dore, A.S.; Geschwindner, S.; Grebner, C.; Hermansson, N.O.; Jazayeri, A.; Johansson, P.; Leong, L.; Prihandoko, R.; Rappas, M.; Soutter, H.; Snijder, A.; Sundstrom, L.; Tehan, B.; Thornton, P.; Troast, D.; Wiggin, G.; Zhukov, A.; Marshall, F.H.; Dekker, N. Nature 2017, 545, 112 (PMID: 28445455)
5NDD
Homo sapiens (Human) (P55085)Crystal structure of a thermostabilised human protease-activated receptor-2 (par2) in complex with az8838 at 2.8 angstrom resolution X-Ray Diffraction2.82017-05-03Cheng, R.K.Y.; Fiez-Vandal, C.; Schlenker, O.; Edman, K.; Aggeler, B.; Brown, D.G.; Brown, G.A.; Cooke, R.M.; Dumelin, C.E.; Dore, A.S.; Geschwindner, S.; Grebner, C.; Hermansson, N.O.; Jazayeri, A.; Johansson, P.; Leong, L.; Prihandoko, R.; Rappas, M.; Soutter, H.; Snijder, A.; Sundstrom, L.; Tehan, B.; Thornton, P.; Troast, D.; Wiggin, G.; Zhukov, A.; Marshall, F.H.; Dekker, N. Nature 2017, 545, 112 (PMID: 28445455)
5NDZ
Homo sapiens (Human) (P55085)Crystal structure of a thermostabilised human protease-activated receptor-2 (par2) in complex with az3451 at 3.6 angstrom resolution X-Ray Diffraction3.62017-05-03Cheng, R.K.Y.; Fiez-Vandal, C.; Schlenker, O.; Edman, K.; Aggeler, B.; Brown, D.G.; Brown, G.A.; Cooke, R.M.; Dumelin, C.E.; Dore, A.S.; Geschwindner, S.; Grebner, C.; Hermansson, N.O.; Jazayeri, A.; Johansson, P.; Leong, L.; Prihandoko, R.; Rappas, M.; Soutter, H.; Snijder, A.; Sundstrom, L.; Tehan, B.; Thornton, P.; Troast, D.; Wiggin, G.; Zhukov, A.; Marshall, F.H.; Dekker, N. Nature 2017, 545, 112 (PMID: 28445455)
33.) Rhodopsin (n = 39)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
4PXF
Bos taurus (Bovine) (P02699)Crystal structure of the active g-protein-coupled receptor opsin in complex with the finger-loop peptide derived from the full-length arrestin-1 X-Ray Diffraction2.752014-09-17Szczepek, M.; Beyriere, F.; Hofmann, K.P.; Elgeti, M.; Kazmin, R.; Rose, A.; Bartl, F.J.; Vonstetten, D.; Heck, M.; Sommer, M.E.; Hildebrand, P.W.; Scheerer, P. Nat Commun 2014, 5, 4801 (PMID: 25205354)
1U19
Bos taurus (Bovine) (P02699)Crystal structure of bovine rhodopsin at 2.2 angstroms resolution X-Ray Diffraction2.22004-10-12Okada, T.; Sugihara, M.; Bondar, A.N.; Elstner, M.; Entel, P.; Buss, V. J Mol Biol 2004, 342, 571 (PMID: 15327956)
1HZX
Bos taurus (Bovine) (P02699)Crystal structure of bovine rhodopsin X-Ray Diffraction2.82001-07-04Teller, D.C.; Okada, T.; Behnke, C.A.; Palczewski, K.; Stenkamp, R.E. Biochemistry 2001, 40, 7761 (PMID: 11425302)
3PQR
Bos taurus (Bovine) (P02699)Crystal structure of metarhodopsin ii in complex with a c-terminal peptide derived from the galpha subunit of transducin X-Ray Diffraction2.852011-03-09Choe, H.W.; Kim, Y.J.; Park, J.H.; Morizumi, T.; Pai, E.F.; Krauss, N.; Hofmann, K.P.; Scheerer, P.; Ernst, O.P. Nature 2011, 471, 651 (PMID: 21389988)
3C9L
Bos taurus (Bovine) (P02699)Structure of ground-state bovine rhodospin in a hexagonal crystal formX-Ray Diffraction2.652008-08-05Stenkamp, R.E. Acta Crystallogr, Sect D 2008, 64, 902 (PMID: 18645239)
2PED
Bos taurus (Bovine) (P02699)Crystallographic model of 9-cis-rhodopsin X-Ray Diffraction2.952007-10-30Nakamichi, H.; Buss, V.; Okada, T. Biophys J 2007, 92, L106 (PMID: 17449675)
1JFP
Bos taurus (Bovine) (P02699)Structure of bovine rhodopsin (dark adapted) Solution NMRN/A2001-10-05Yeagle, P.L.; Choi, G.; Albert, A.D. Biochemistry 2001, 40, 11932 (PMID: 11570894)
1L9H
Bos taurus (Bovine) (P02699)Crystal structure of bovine rhodopsin at 2.6 angstroms resolution X-Ray Diffraction2.62002-05-15Okada, T.; Fujiyoshi, Y.; Silow, M.; Navarro, J.; Landau, E.M.; Shichida, Y. Proc Natl Acad Sci USA 2002, 99, 5982 (PMID: 11972040)
2I36
Bos taurus (Bovine) (P02699)Crystal structure of trigonal crystal form of ground-state rhodopsin X-Ray Diffraction4.12006-10-17Salom, D.; Lodowski, D.T.; Stenkamp, R.E.; Trong, I.L.; Golczak, M.; Jastrzebska, B.; Harris, T.; Ballesteros, J.A.; Palczewski, K. Proc Natl Acad Sci USA 2006, 103, 16123 (PMID: 17060607)
5TE3
Bos taurus (Bovine) (P02699)Crystal structure of bos taurus opsin at 2.7 angstrom X-Ray Diffraction2.72017-03-15Gulati, S.; Jastrzebska, B.; Banerjee, S.; Placeres, A.L.; Miszta, P.; Gao, S.; Gunderson, K.; Tochtrop, G.P.; Filipek, S.; Katayama, K.; Kiser, P.D.; Mogi, M.; Stewart, P.L.; Palczewski, K. Proc Natl Acad Sci U S A 2017, 114, E2608 (PMID: 28289214)
2X72
Bos taurus (Bovine) (P02699)Crystal structure of the constitutively active e113q,n2c, d282c rhodopsin mutant with bound galphact peptide. X-Ray Diffraction3.02011-03-16Standfuss, J.; Edwards, P.C.; Dantona, A.; Fransen, M.; Xie, G.; Oprian, D.D.; Schertler, G.F.X. Nature 2011, 471, 656 (PMID: 21389983)
1GZM
Bos taurus (Bovine) (P02699)Structure of bovine rhodopsin in a trigonal crystal form X-Ray Diffraction2.652003-11-20Li, J.; Edwards, P.; Burghammer, M.; Villa, C.; Schertler, G.F.X. J Mol Biol 2004, 343, 1409 (PMID: 15491621)
2HPY
Bos taurus (Bovine) (P02699)Crystallographic model of lumirhodopsin X-Ray Diffraction2.82006-08-22Nakamichi, H.; Okada, T. Proc Natl Acad Sci USA 2006, 103, 12729 (PMID: 16908857)
3CAP
Bos taurus (Bovine) (P02699)Crystal structure of native opsin: the g protein-coupled receptor rhodopsin in its ligand-free state X-Ray Diffraction2.92008-06-24Park, J.H.; Scheerer, P.; Hofmann, K.P.; Choe, H.-W.; Ernst, O.P. Nature 2008, 454, 183 (PMID: 18563085)
3OAX
Bos taurus (Bovine) (P02699)Crystal structure of bovine rhodopsin with beta-ionone X-Ray Diffraction2.62011-01-19Makino, C.L.; Riley, C.K.; Looney, J.; Crouch, R.K.; Okada, T. Biophys J 2010, 99, 2366 (PMID: 20923672)
5TE5
Bos taurus (Bovine) (P02699)Crystal structure of bos taurus opsin regenerated with 6-carbon ring retinal chromophore X-Ray Diffraction4.012017-03-15Gulati, S.; Jastrzebska, B.; Banerjee, S.; Placeres, A.L.; Miszta, P.; Gao, S.; Gunderson, K.; Tochtrop, G.P.; Filipek, S.; Katayama, K.; Kiser, P.D.; Mogi, M.; Stewart, P.L.; Palczewski, K. Proc Natl Acad Sci U S A 2017, 114, E2608 (PMID: 28289214)
2J4Y
Bos taurus (Bovine) (P02699)Crystal structure of a rhodopsin stabilizing mutant expressed in mammalian cells X-Ray Diffraction3.42007-09-25Standfuss, J.; Xie, G.; Edwards, P.C.; Burghammer, M.; Oprian, D.D.; Schertler, G.F.X. J Mol Biol 2007, 372, 1179 (PMID: 17825322)
3DQB
Bos taurus (Bovine) (P02699)Crystal structure of the active g-protein-coupled receptor opsin in complex with a c-terminal peptide derived from the galpha subunit of transducin X-Ray Diffraction3.22008-09-23Scheerer, P.; Park, J.H.; Hildebrand, P.W.; Kim, Y.J.; Krauss, N.; Choe, H.-W.; Hofmann, K.P.; Ernst, O.P. Nature 2008, 455, 497 (PMID: 18818650)
4BEY
Bos taurus (Bovine) (P02699)Night blindness causing g90d rhodopsin in complex with gact2 peptide X-Ray Diffraction2.92013-05-08Singhal, A.; Ostermaier, M.K.; Vishnivetskiy, S.A.; Panneels, V.; Homan, K.T.; Tesmer, J.J.; Veprintsev, D.; Deupi, X.; Gurevich, V.V.; Schertler, G.F.; Standfuss, J. EMBO Rep 2013, 14, 520 (PMID: 23579341)
5DYS
Bos taurus (Bovine) (P02699)Crystal structure of t94i rhodopsin mutant X-Ray Diffraction2.32016-08-10Singhal, A.; Guo, Y.; Matkovic, M.; Schertler, G.; Deupi, X.; Yan, E.C.; Standfuss, J. EMBO Rep 2016, 17, 1431 (PMID: 27458239)
5EN0
Bos taurus (Bovine) (P02699)Crystal structure of t94i rhodopsin mutant X-Ray Diffraction2.812016-08-10Singhal, A.; Guo, Y.; Matkovic, M.; Schertler, G.; Deupi, X.; Yan, E.C.; Standfuss, J. EMBO Rep 2016, 17, 1431 (PMID: 27458239)
2I35
Bos taurus (Bovine) (P02699)Crystal structure of rhombohedral crystal form of ground-state rhodopsin X-Ray Diffraction3.82006-10-17Salom, D.; Lodowski, D.T.; Stenkamp, R.E.; Trong, I.L.; Golczak, M.; Jastrzebska, B.; Harris, T.; Ballesteros, J.A.; Palczewski, K. Proc Natl Acad Sci USA 2006, 103, 16123 (PMID: 17060607)
3C9M
Bos taurus (Bovine) (P02699)Structure of a mutant bovine rhodopsin in hexagonal crystal form X-Ray Diffraction3.42008-08-05Stenkamp, R.E. Acta Crystallogr, Sect D 2008, 64, 902 (PMID: 18645239)
4J4Q
Bos taurus (Bovine) (P02699)Crystal structure of active conformation of gpcr opsin stabilized by octylglucoside X-Ray Diffraction2.652013-10-30Park, J.H.; Morizumi, T.; Li, Y.; Hong, J.E.; Pai, E.F.; Hofmann, K.P.; Choe, H.W.; Ernst, O.P. Angew Chem Int Ed Engl 2013, 52, 11021 (PMID: 24038729)
1LN6
Bos taurus (Bovine) (P02699)Structure of bovine rhodopsin (metarhodopsin ii) Solution NMRN/A2002-07-10Choi, G.; Landin, J.; Galan, J.F.; Birge, R.R.; Albert, A.D.; Yeagle, P.L. Biochemistry 2002, 41, 7318 (PMID: 12044163)
1F88
Bos taurus (Bovine) (P02699)Crystal structure of bovine rhodopsin X-Ray Diffraction2.82000-08-04Palczewski, K.; Kumasaka, T.; Hori, T.; Behnke, C.A.; Motoshima, H.; Fox, B.A.; Letrong, I.; Teller, D.C.; Okada, T.; Stenkamp, R.E.; Yamamoto, M.; Miyano, M. Science 2000, 289, 739 (PMID: 10926528)
4BEZ
Bos taurus (Bovine) (P02699)Night blindness causing g90d rhodopsin in the active conformation X-Ray Diffraction3.32013-04-24Singhal, A.; Ostermaier, M.K.; Vishnivetskiy, S.A.; Panneels, V.; Homan, K.T.; Tesmer, J.J.; Veprintsev, D.; Deupi, X.; Gurevich, V.V.; Schertler, G.F.; Standfuss, J. EMBO Rep 2013, 14, 520 (PMID: 23579341)
2I37
Bos taurus (Bovine) (P02699)Crystal structure of a photoactivated rhodopsin X-Ray Diffraction4.152006-10-17Salom, D.; Lodowski, D.T.; Stenkamp, R.E.; Trong, I.L.; Golczak, M.; Jastrzebska, B.; Harris, T.; Ballesteros, J.A.; Palczewski, K. Proc Natl Acad Sci USA 2006, 103, 16123 (PMID: 17060607)
2G87
Bos taurus (Bovine) (P02699)Crystallographic model of bathorhodopsin X-Ray Diffraction2.62006-09-02Nakamichi, H.; Okada, T. Angew Chem Int Ed Engl 2006, 45, 4270 (PMID: 16586416)
4A4M
Bos taurus (Bovine) (P02699)Crystal structure of the light-activated constitutively active n2c,m257y,d282c rhodopsin mutant in complex with a peptide resembling the c-terminus of the galpha-protein subunit (gact) X-Ray Diffraction3.32012-01-25Deupi, X.; Edwards, P.; Singhal, A.; Nickle, B.; Oprian, D.; Schertler, G.; Standfuss, J. Proc Natl Acad Sci USA 2012, 109, 119 (PMID: 22198838)
4X1H
Bos taurus (Bovine) (P02699)Opsin/g(alpha) peptide complex stabilized by nonyl-glucoside X-Ray Diffraction2.292015-11-04Blankenship, E.; Vahedi-Faridi, A.; Lodowski, D.T. Structure 2015, 23, 2358 (PMID: 26526852)
3PXO
Bos taurus (Bovine) (P02699)Crystal structure of metarhodopsin ii X-Ray Diffraction3.02011-03-09Choe, H.W.; Kim, Y.J.; Park, J.H.; Morizumi, T.; Pai, E.F.; Krauss, N.; Hofmann, K.P.; Scheerer, P.; Ernst, O.P. Nature 2011, 471, 651 (PMID: 21389988)
3AYM
Todarodes pacificus (Japanese flying squid) (P31356)Crystal structure of the batho intermediate of squid rhodopsin X-Ray Diffraction2.82011-08-17Murakami, M.; Kouyama, T. J Mol Biol 2011, 413, 615 (PMID: 21906602)
2ZIY
Todarodes pacificus (Japanese flying squid) (P31356)Crystal structure of squid rhodopsin X-Ray Diffraction3.72008-05-06Shimamura, T.; Hiraki, K.; Takahashi, N.; Hori, T.; Ago, H.; Masuda, K.; Takio, K.; Ishiguro, M.; Miyano, M. J Biol Chem 2008, 283, 17753 (PMID: 18463093)
4WW3
Todarodes pacificus (Japanese flying squid) (P31356)Crystal structure of the lumi intermediate of squid rhodopsin X-Ray Diffraction2.82015-06-17Murakami, M.; Kouyama, T. PLoS One 2015, 10, 26970 (PMID: 26024518)
2Z73
Todarodes pacificus (Japanese flying squid) (P31356)Crystal structure of squid rhodopsin X-Ray Diffraction2.52008-05-13Murakami, M.; Kouyama, T. Nature 2008, 453, 363 (PMID: 18480818)
3AYN
Todarodes pacificus (Japanese flying squid) (P31356)Crystal structure of squid isorhodopsin X-Ray Diffraction2.72011-08-17Murakami, M.; Kouyama, T. J Mol Biol 2011, 413, 615 (PMID: 21906602)
5DGY
Homo sapiens (Human) (P08100)Crystal structure of rhodopsin bound to visual arrestin X-Ray Diffraction7.72016-03-23Zhou, X.E.; Gao, X.; Barty, A.; Kang, Y.; He, Y.; Liu, W.; Ishchenko, A.; White, T.A.; Yefanov, O.; Han, G.W.; Xu, Q.; Dewaal, P.W.; Suino-Powell, K.M.; Boutet, S.; Williams, G.J.; Wang, M.; Li, D.; Caffrey, M.; Chapman, H.N.; Spence, J.C.; Fromme, P.; Weierstall, U.; Stevens, R.C.; Cherezov, V.; Melcher, K.; Xu, H.E. Sci Data 2016, 3, 60021 (PMID: 27070998)
4ZWJ
Homo sapiens (Human) (P08100)Crystal structure of rhodopsin bound to arrestin by femtosecond x-ray laser X-Ray Diffraction3.32015-07-29Kang, Y.; Zhou, X.E.; Gao, X.; He, Y.; Liu, W.; Ishchenko, A.; Barty, A.; White, T.A.; Yefanov, O.; Han, G.W.; Xu, Q.; Dewaal, P.W.; Ke, J.; Tan, M.H.; Zhang, C.; Moeller, A.; West, G.M.; Pascal, B.D.; Vaneps, N.; Caro, L.N.; Vishnivetskiy, S.A.; Lee, R.J.; Suino-Powell, K.M.; Gu, X.; Pal, K.; Ma, J.; Zhi, X.; Boutet, S.; Williams, G.J.; Messerschmidt, M.; Gati, C.; Zatsepin, N.A.; Wang, D.; James, D.; Basu, S.; Roy-Chowdhury, S.; Conrad, C.E.; Coe, J.; Liu, H.; Lisova, S.; Kupitz, C.; Grotjohann, I.; Fromme, R.; Jiang, Y.; Tan, M.; Yang, H.; Li, J.; Wang, M.; Zheng, Z.; Li, D.; Howe, N.; Zhao, Y.; Standfuss, J.; Diederichs, K.; Dong, Y.; Potter, C.S.; Carragher, B.; Caffrey, M.; Jiang, H.; Chapman, H.N.; Spence, J.C.; Fromme, P.; Weierstall, U.; Ernst, O.P.; Katritch, V.; Gurevich, V.V.; Griffin, P.R.; Hubbell, W.L.; Stevens, R.C.; Cherezov, V.; Melcher, K.; Xu, H.E. Nature 2015, 523, 561 (PMID: 26200343)
34.) Sphingosine 1-phosphate receptor 1 (n = 2)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
3V2W
Homo sapiens (Human) (P21453)Crystal structure of a lipid g protein-coupled receptor at 3.35a X-Ray Diffraction3.352012-02-15Hanson, M.A.; Roth, C.B.; Jo, E.; Griffith, M.T.; Scott, F.L.; Reinhart, G.; Desale, H.; Clemons, B.; Cahalan, S.M.; Schuerer, S.C.; Sanna, M.G.; Han, G.W.; Kuhn, P.; Rosen, H.; Stevens, R.C. Science 2012, 335, 851 (PMID: 22344443)
3V2Y
Homo sapiens (Human) (P21453)Crystal structure of a lipid g protein-coupled receptor at 2.80a X-Ray Diffraction2.82012-02-15Hanson, M.A.; Roth, C.B.; Jo, E.; Griffith, M.T.; Scott, F.L.; Reinhart, G.; Desale, H.; Clemons, B.; Cahalan, S.M.; Schuerer, S.C.; Sanna, M.G.; Han, G.W.; Kuhn, P.; Rosen, H.; Stevens, R.C. Science 2012, 335, 851 (PMID: 22344443)
35.) Substance-P receptor (n = 3)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
2KS9
Homo sapiens (Human) (P25103)Solution conformation of substance p in water complexed with nk1r Solution NMRN/A2010-11-03Gayen, A.; Goswami, S.K.; Mukhopadhyay, C. Biochim Biophys Acta 2010 (PMID: 20937248)
2KSA
Homo sapiens (Human) (P25103)Substance p in dmpc/chaps isotropic q=0.25 bicelles as a ligand for nk1r Solution NMRN/A2010-11-03Gayen, A.; Goswami, S.K.; Mukhopadhyay, C. Biochim Biophys Acta 2010 (PMID: 20937248)
2KSB
Homo sapiens (Human) (P25103)Substance p in isotropic q=0.25 dmpc/chaps/gm1 bicelles as a ligand for nk1r Solution NMRN/A2010-11-03Gayen, A.; Goswami, S.K.; Mukhopadhyay, C. Biochim Biophys Acta 2010 (PMID: 20937248)
36.) Type-1 angiotensin II receptor (n = 2)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
4ZUD
Homo sapiens (Human) (P30556)Crystal structure of human angiotensin receptor in complex with inverse agonist olmesartan at 2.8a resolution. X-Ray Diffraction2.82015-10-07Zhang, H.; Unal, H.; Desnoyer, R.; Han, G.W.; Patel, N.; Katritch, V.; Karnik, S.S.; Cherezov, V.; Stevens, R.C. J Biol Chem 2015, 290, 29127 (PMID: 26420482)
4YAY
Homo sapiens (Human) (P30556)Xfel structure of human angiotensin receptor X-Ray Diffraction2.92015-04-22Zhang, H.; Unal, H.; Gati, C.; Han, G.W.; Liu, W.; Zatsepin, N.A.; James, D.; Wang, D.; Nelson, G.; Weierstall, U.; Sawaya, M.R.; Xu, Q.; Messerschmidt, M.; Williams, G.J.; Boutet, S.; Yefanov, O.M.; White, T.A.; Wang, C.; Ishchenko, A.; Tirupula, K.C.; Desnoyer, R.; Coe, J.; Conrad, C.E.; Fromme, P.; Stevens, R.C.; Katritch, V.; Karnik, S.S.; Cherezov, V. Cell 2015, 161, 833 (PMID: 25913193)
37.) Type-2 angiotensin II receptor (n = 3)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
5UNH
Homo sapiens (Human) (P50052)Synchrotron structure of human angiotensin ii type 2 receptor in complex with compound 2 (n-[(furan-2-yl)methyl]-n-(4-oxo-2-propyl-3-{[2'-(2h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-3,4-dihydroquinazolin-6-yl)benzamide) X-Ray Diffraction2.92017-04-05Zhang, H.; Han, G.W.; Batyuk, A.; Ishchenko, A.; White, K.L.; Patel, N.; Sadybekov, A.; Zamlynny, B.; Rudd, M.T.; Hollenstein, K.; Tolstikova, A.; White, T.A.; Hunter, M.S.; Weierstall, U.; Liu, W.; Babaoglu, K.; Moore, E.L.; Katz, R.D.; Shipman, J.M.; Garcia-Calvo, M.; Sharma, S.; Sheth, P.; Soisson, S.M.; Stevens, R.C.; Katritch, V.; Cherezov, V. Nature 2017, 544, 327 (PMID: 28379944)
5UNF
Homo sapiens (Human) (P50052)Xfel structure of human angiotensin ii type 2 receptor (monoclinic form) in complex with compound 1 (n-benzyl-n-(2-ethyl-4-oxo-3-{[2'-(2h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]) X-Ray Diffraction2.82017-04-05Zhang, H.; Han, G.W.; Batyuk, A.; Ishchenko, A.; White, K.L.; Patel, N.; Sadybekov, A.; Zamlynny, B.; Rudd, M.T.; Hollenstein, K.; Tolstikova, A.; White, T.A.; Hunter, M.S.; Weierstall, U.; Liu, W.; Babaoglu, K.; Moore, E.L.; Katz, R.D.; Shipman, J.M.; Garcia-Calvo, M.; Sharma, S.; Sheth, P.; Soisson, S.M.; Stevens, R.C.; Katritch, V.; Cherezov, V. Nature 2017, 544, 327 (PMID: 28379944)
5UNG
Homo sapiens (Human) (P50052)Xfel structure of human angiotensin ii type 2 receptor (orthorhombic form) in complex with compound 1 (n-benzyl-n-(2-ethyl-4-oxo-3-{[2'-(2h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl] methyl}-3,4-dihydroquinazolin-6-yl)thiophene-2-carboxamide) X-Ray Diffraction2.82017-04-05Zhang, H.; Han, G.W.; Batyuk, A.; Ishchenko, A.; White, K.L.; Patel, N.; Sadybekov, A.; Zamlynny, B.; Rudd, M.T.; Hollenstein, K.; Tolstikova, A.; White, T.A.; Hunter, M.S.; Weierstall, U.; Liu, W.; Babaoglu, K.; Moore, E.L.; Katz, R.D.; Shipman, J.M.; Garcia-Calvo, M.; Sharma, S.; Sheth, P.; Soisson, S.M.; Stevens, R.C.; Katritch, V.; Cherezov, V. Nature 2017, 544, 327 (PMID: 28379944)

Class B

38.) Calcitonin receptor (n = 1)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
5UZ7
Homo sapiens (Human) (P30988)Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric gs protein complex Electron Microscopy4.12017-05-03Liang, Y.L.; Khoshouei, M.; Radjainia, M.; Zhang, Y.; Glukhova, A.; Tarrasch, J.; Thal, D.M.; Furness, S.G.B.; Christopoulos, G.; Coudrat, T.; Danev, R.; Baumeister, W.; Miller, L.J.; Christopoulos, A.; Kobilka, B.K.; Wootten, D.; Skiniotis, G.; Sexton, P.M. Nature 2017 (PMID: 28437792)
39.) Corticotropin-releasing factor receptor 1 (n = 2)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
4K5Y
Homo sapiens (Human) (P34998)Crystal structure of human corticotropin-releasing factor receptor 1 (crf1r) in complex with the antagonist cp-376395 X-Ray Diffraction2.982013-07-17Hollenstein, K.; Kean, J.; Bortolato, A.; Cheng, R.K.; Dore, A.S.; Jazayeri, A.; Cooke, R.M.; Weir, M.; Marshall, F.H. Nature 2013, 499, 438 (PMID: 23863939)
4Z9G
Homo sapiens (Human) (P34998)Crystal structure of human corticotropin-releasing factor receptor 1 (crf1r) in complex with the antagonist cp-376395 in a hexagonal setting with translational non-crystallographic symmetry X-Ray Diffraction3.182016-06-29Dore, A.S.; Bortolato, A.; Hollenstein, K.; Cheng, R.K.Y.; Read, R.J.; Marshall, F.H. To Be Published (PMID: N/A)
40.) Glucagon receptor (n = 2)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
5EE7
Homo sapiens (Human) (P47871)Crystal structure of the human glucagon receptor (gcgr) in complex with the antagonist mk-0893 X-Ray Diffraction2.52016-04-20Jazayeri, A.; Dore, A.S.; Lamb, D.; Krishnamurthy, H.; Southall, S.M.; Baig, A.H.; Bortolato, A.; Koglin, M.; Robertson, N.J.; Errey, J.C.; Andrews, S.P.; Teobald, I.; Brown, A.J.; Cooke, R.M.; Weir, M.; Marshall, F.H. Nature 2016, 533, 274 (PMID: 27111510)
4L6R
Homo sapiens (Human) (P47871)Structure of the class b human glucagon g protein coupled receptor X-Ray Diffraction3.32013-07-24Siu, F.Y.; He, M.; Degraaf, C.; Han, G.W.; Yang, D.; Zhang, Z.; Zhou, C.; Xu, Q.; Wacker, D.; Joseph, J.S.; Liu, W.; Lau, J.; Cherezov, V.; Katritch, V.; Wang, M.W.; Stevens, R.C. Nature 2013, 499, 444 (PMID: 23863937)
41.) Glucagon-like peptide 1 receptor (n = 1)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
5VEX
Homo sapiens (Human) (P43220)Structure of the human glp-1 receptor complex with nnc0640 X-Ray Diffraction3.02017-05-17Song, G.; Yang, D.; Wang, Y.; Degraaf, C.; Zhou, Q.; Jiang, S.; Liu, K.; Cai, X.; Dai, A.; Lin, G.; Liu, D.; Wu, F.; Wu, Y.; Zhao, S.; Ye, L.; Han, G.W.; Lau, J.; Wu, B.; Hanson, M.A.; Liu, Z.-J.; Wang, M.-W.; Stevens, R.C. Nature 2017 (PMID: N/A)

Class C

42.) Metabotropic glutamate receptor 1 (n = 1)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
4OR2
Homo sapiens (Human) (Q13255)Human class c g protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator X-Ray Diffraction2.82014-03-19Wu, H.; Wang, C.; Gregory, K.J.; Han, G.W.; Cho, H.P.; Xia, Y.; Niswender, C.M.; Katritch, V.; Meiler, J.; Cherezov, V.; Conn, P.J.; Stevens, R.C. Science 2014, 344, 58 (PMID: 24603153)
43.) Metabotropic glutamate receptor 5 (n = 3)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
5CGD
Homo sapiens (Human) (P41594)Structure of the human class c gpcr metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile -(htl14242) X-Ray Diffraction2.62015-08-12Christopher, J.A.; Aves, S.J.; Bennett, K.A.; Dore, A.S.; Errey, J.C.; Jazayeri, A.; Marshall, F.H.; Okrasa, K.; Serrano-Vega, M.J.; Tehan, B.G.; Wiggin, G.R.; Congreve, M. J Med Chem 2015, 58, 6653 (PMID: 26225459)
4OO9
Homo sapiens (Human) (P41594)Structure of the human class c gpcr metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator mavoglurant X-Ray Diffraction2.62014-07-02Dore, A.S.; Okrasa, K.; Patel, J.C.; Serrano-Vega, M.; Bennett, K.; Cooke, R.M.; Errey, J.C.; Jazayeri, A.; Khan, S.; Tehan, B.; Weir, M.; Wiggin, G.R.; Marshall, F.H. Nature 2014, 511, 557 (PMID: 25042998)
5CGC
Homo sapiens (Human) (P41594)Structure of the human class c gpcr metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-4-fluoro-5-[6-(1h-pyrazol-1-yl)pyrimidin-4-yl]benzonitrile X-Ray Diffraction3.12015-08-12Christopher, J.A.; Aves, S.J.; Bennett, K.A.; Dore, A.S.; Errey, J.C.; Jazayeri, A.; Marshall, F.H.; Okrasa, K.; Serrano-Vega, M.J.; Tehan, B.G.; Wiggin, G.R.; Congreve, M. J Med Chem 2015, 58, 6653 (PMID: 26225459)

Class F

44.) Smoothened homolog (n = 7)
PDB IDSpecies (UniProt ID)DescriptionMethodResolution (Å)ReleasedReference
4QIN
Homo sapiens (Human) (Q99835)Structure of the human smoothened receptor in complex with sag1.5 X-Ray Diffraction2.62014-07-23Wang, C.; Wu, H.; Evron, T.; Vardy, E.; Han, G.W.; Huang, X.P.; Hufeisen, S.J.; Mangano, T.J.; Urban, D.J.; Katritch, V.; Cherezov, V.; Caron, M.G.; Roth, B.L.; Stevens, R.C. Nat Commun 2014, 5, 4355 (PMID: 25008467)
4O9R
Homo sapiens (Human) (Q99835)Human smoothened receptor structure in complex with cyclopamine X-Ray Diffraction3.22014-03-05Weierstall, U.; James, D.; Wang, C.; White, T.A.; Wang, D.; Liu, W.; Spence, J.C.; Brucedoak, R.; Nelson, G.; Fromme, P.; Fromme, R.; Grotjohann, I.; Kupitz, C.; Zatsepin, N.A.; Liu, H.; Basu, S.; Wacker, D.; Han, G.W.; Katritch, V.; Boutet, S.; Messerschmidt, M.; Williams, G.J.; Koglin, J.E.; Marvinseibert, M.; Klinker, M.; Gati, C.; Shoeman, R.L.; Barty, A.; Chapman, H.N.; Kirian, R.A.; Beyerlein, K.R.; Stevens, R.C.; Li, D.; Shah, S.T.; Howe, N.; Caffrey, M.; Cherezov, V. Nat Commun 2014, 5, 3309 (PMID: 24525480)
4N4W
Homo sapiens (Human) (Q99835)Structure of the human smoothened receptor in complex with sant-1. X-Ray Diffraction2.82014-01-22Wang, C.; Wu, H.; Evron, T.; Vardy, E.; Han, G.W.; Huang, X.P.; Hufeisen, S.J.; Mangano, T.J.; Urban, D.J.; Katritch, V.; Cherezov, V.; Caron, M.G.; Roth, B.L.; Stevens, R.C. Nat Commun 2014, 5, 4355 (PMID: 25008467)
5L7I
Homo sapiens (Human) (Q99835)Structure of human smoothened in complex with vismodegib X-Ray Diffraction3.32016-07-20Byrne, E.F.; Sircar, R.; Miller, P.S.; Hedger, G.; Luchetti, G.; Nachtergaele, S.; Tully, M.D.; Mydock-Mcgrane, L.; Covey, D.F.; Rambo, R.P.; Sansom, M.S.; Newstead, S.; Rohatgi, R.; Siebold, C. Nature 2016, 535, 517 (PMID: 27437577)
4JKV
Homo sapiens (Human) (Q99835)Structure of the human smoothened 7tm receptor in complex with an antitumor agent X-Ray Diffraction2.452013-04-24Wang, C.; Wu, H.; Katritch, V.; Han, G.W.; Huang, X.P.; Liu, W.; Siu, F.Y.; Roth, B.L.; Cherezov, V.; Stevens, R.C. Nature 2013, 497, 338 (PMID: 23636324)
5L7D
Homo sapiens (Human) (Q99835)Structure of human smoothened in complex with cholesterol X-Ray Diffraction3.22016-07-20Byrne, E.F.; Sircar, R.; Miller, P.S.; Hedger, G.; Luchetti, G.; Nachtergaele, S.; Tully, M.D.; Mydock-Mcgrane, L.; Covey, D.F.; Rambo, R.P.; Sansom, M.S.; Newstead, S.; Rohatgi, R.; Siebold, C. Nature 2016, 535, 517 (PMID: 27437577)
4QIM
Homo sapiens (Human) (Q99835)Structure of the human smoothened receptor in complex with anta xv X-Ray Diffraction2.612014-07-23Wang, C.; Wu, H.; Evron, T.; Vardy, E.; Han, G.W.; Huang, X.P.; Hufeisen, S.J.; Mangano, T.J.; Urban, D.J.; Katritch, V.; Cherezov, V.; Caron, M.G.; Roth, B.L.; Stevens, R.C. Nat Commun 2014, 5, 4355 (PMID: 25008467)

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