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All Structures Class A Class B Class C Class F

	Count
GPCRs	44
Structures	194
Species	7

General	Batch PDB Files
GPCR-EXP Data	Original PDB
Detailed Statistics	Single chain, no fusion protein
	GPCR fragments

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[About GPCR-EXP] [GLASS] [GPCR-I-TASSER] [GPCR-HGmod] [GPCR-RD]

References

W Chan, H Zhang, J Yang, J Brender, J Hur, A Ozgur, Y Zhang. GLASS: a comprehensive database for experimentally-validated GPCR-ligand associations. Bioinformatics, 31: 3035-3042 (2015). [PDF] [Support Information] [Database]

Class A

1.) 5-hydroxytryptamine receptor 1B (n = 2)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
4IAQ	Homo sapiens (Human) (P28222)	Crystal structure of the chimeric protein of 5-ht1b-bril in complex with dihydroergotamine (psi community target)	X-Ray Diffraction	2.8	2013-03-13	Wang, C.; Jiang, Y.; Ma, J.; Wu, H.; Wacker, D.; Katritch, V.; Han, G.W.; Liu, W.; Huang, X.P.; Vardy, E.; Mccorvy, J.D.; Gao, X.; Zhou, X.E.; Melcher, K.; Zhang, C.; Bai, F.; Yang, H.; Yang, L.; Jiang, H.; Roth, B.L.; Cherezov, V.; Stevens, R.C.; Xu, H.E. Science 2013, 340, 610 (PMID: 23519210)
4IAR	Homo sapiens (Human) (P28222)	Crystal structure of the chimeric protein of 5-ht1b-bril in complex with ergotamine (psi community target)	X-Ray Diffraction	2.7	2013-03-13	Wang, C.; Jiang, Y.; Ma, J.; Wu, H.; Wacker, D.; Katritch, V.; Han, G.W.; Liu, W.; Huang, X.P.; Vardy, E.; Mccorvy, J.D.; Gao, X.; Zhou, X.E.; Melcher, K.; Zhang, C.; Bai, F.; Yang, H.; Yang, L.; Jiang, H.; Roth, B.L.; Cherezov, V.; Stevens, R.C.; Xu, H.E. Science 2013, 340, 610 (PMID: 23519210)

2.) 5-hydroxytryptamine receptor 2B (n = 3)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
5TVN	Homo sapiens (Human) (P41595)	Crystal structure of the lsd-bound 5-ht2b receptor	X-Ray Diffraction	2.9	2017-02-01	Wacker, D.; Wang, S.; Mccorvy, J.D.; Betz, R.M.; Venkatakrishnan, A.J.; Levit, A.; Lansu, K.; Schools, Z.L.; Che, T.; Nichols, D.E.; Shoichet, B.K.; Dror, R.O.; Roth, B.L. Cell 2017, 168, 377 (PMID: 28129538)
4NC3	Homo sapiens (Human) (P41595)	Crystal structure of the 5-ht2b receptor solved using serial femtosecond crystallography in lipidic cubic phase.	X-Ray Diffraction	2.8	2013-12-18	Liu, W.; Wacker, D.; Gati, C.; Han, G.W.; James, D.; Wang, D.; Nelson, G.; Weierstall, U.; Katritch, V.; Barty, A.; Zatsepin, N.A.; Li, D.; Messerschmidt, M.; Boutet, S.; Williams, G.J.; Koglin, J.E.; Seibert, M.M.; Wang, C.; Shah, S.T.; Basu, S.; Fromme, R.; Kupitz, C.; Rendek, K.N.; Grotjohann, I.; Fromme, P.; Kirian, R.A.; Beyerlein, K.R.; White, T.A.; Chapman, H.N.; Caffrey, M.; Spence, J.C.; Stevens, R.C.; Cherezov, V. Science 2013, 342, 1521 (PMID: 24357322)
4IB4	Homo sapiens (Human) (P41595)	Crystal structure of the chimeric protein of 5-ht2b-bril in complex with ergotamine	X-Ray Diffraction	2.7	2013-03-13	Wacker, D.; Wang, C.; Katritch, V.; Han, G.W.; Huang, X.P.; Vardy, E.; Mccorvy, J.D.; Jiang, Y.; Chu, M.; Siu, F.Y.; Liu, W.; Xu, H.E.; Cherezov, V.; Roth, B.L.; Stevens, R.C. Science 2013, 340, 615 (PMID: 23519215)

3.) Adenosine receptor A1 (n = 1)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
5UEN	Homo sapiens (Human) (P30542)	Crystal structure of the human adenosine a1 receptor a1ar-bril in complex with the covalent antagonist du172 at 3.2a resolution	X-Ray Diffraction	3.2	2017-03-01	Glukhova, A.; Thal, D.M.; Nguyen, A.T.; Vecchio, E.A.; Jorg, M.; Scammells, P.J.; May, L.T.; Sexton, P.M.; Christopoulos, A. Cell 2017, 168, 867 (PMID: 28235198)

4.) Adenosine receptor A2a (n = 25)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
3UZC	Homo sapiens (Human) (P29274)	Thermostabilised adenosine a2a receptor in complex with 4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol	X-Ray Diffraction	3.34	2012-03-21	Congreve, M.; Andrews, S.P.; Dore, A.S.; Hollenstein, K.; Hurrell, E.; Langmead, C.J.; Mason, J.S.; Ng, I.W.; Tehan, B.; Zhukov, A.; Weir, M.; Marshall, F.H. J Med Chem 2012, 55, 1898 (PMID: 22220592)
3PWH	Homo sapiens (Human) (P29274)	Thermostabilised adenosine a2a receptor	X-Ray Diffraction	3.3	2011-09-07	Dore, A.S.; Robertson, N.; Errey, J.C.; Ng, I.; Hollenstein, K.; Tehan, B.; Hurrell, E.; Bennett, K.; Congreve, M.; Magnani, F.; Tate, C.G.; Weir, M.; Marshall, F.H. Structure 2011, 19, 1283 (PMID: 21885291)
4EIY	Homo sapiens (Human) (P29274)	Crystal structure of the chimeric protein of a2aar-bril in complex with zm241385 at 1.8a resolution	X-Ray Diffraction	1.8	2012-07-25	Liu, W.; Chun, E.; Thompson, A.A.; Chubukov, P.; Xu, F.; Katritch, V.; Han, G.W.; Roth, C.B.; Heitman, L.H.; Ijzerman, A.P.; Cherezov, V.; Stevens, R.C. Science 2012, 337, 232 (PMID: 22798613)
3QAK	Homo sapiens (Human) (P29274)	Agonist bound structure of the human adenosine a2a receptor	X-Ray Diffraction	2.71	2011-03-09	Xu, F.; Wu, H.; Katritch, V.; Han, G.W.; Jacobson, K.A.; Gao, Z.G.; Cherezov, V.; Stevens, R.C. Science 2011, 332, 322 (PMID: 21393508)
5IU4	Homo sapiens (Human) (P29274)	Crystal structure of stabilized a2a adenosine receptor a2ar-star2-bril in complex with zm241385 at 1.7a resolution	X-Ray Diffraction	1.72	2016-06-29	Segala, E.; Guo, D.; Cheng, R.K.; Bortolato, A.; Deflorian, F.; Dore, A.S.; Errey, J.C.; Heitman, L.H.; Ijzerman, A.P.; Marshall, F.H.; Cooke, R.M. J Med Chem 2016, 59, 6470 (PMID: 27312113)
3RFM	Homo sapiens (Human) (P29274)	Thermostabilised adenosine a2a receptor in complex with caffeine	X-Ray Diffraction	3.6	2011-09-07	Dore, A.S.; Robertson, N.; Errey, J.C.; Ng, I.; Hollenstein, K.; Tehan, B.; Hurrell, E.; Bennett, K.; Congreve, M.; Magnani, F.; Tate, C.G.; Weir, M.; Marshall, F.H. Structure 2011, 19, 1283 (PMID: 21885291)
3EML	Homo sapiens (Human) (P29274)	The 2.6 a crystal structure of a human a2a adenosine receptor bound to zm241385.	X-Ray Diffraction	2.6	2008-10-14	Jaakola, V.P.; Griffith, M.T.; Hanson, M.A.; Cherezov, V.; Chien, E.Y.; Lane, J.R.; Ijzerman, A.P.; Stevens, R.C. Science 2008, 322, 1211 (PMID: 18832607)
5K2D	Homo sapiens (Human) (P29274)	1.9a angstrom a2a adenosine receptor structure with mr phasing using xfel data	X-Ray Diffraction	1.9	2016-09-21	Batyuk, A.; Galli, L.; Ishchenko, A.; Han, G.W.; Gati, C.; Popov, P.A.; Lee, M.Y.; Stauch, B.; White, T.A.; Barty, A.; Aquila, A.; Hunter, M.S.; Liang, M.; Boutet, S.; Pu, M.; Liu, Z.J.; Nelson, G.; James, D.; Li, C.; Zhao, Y.; Spence, J.C.; Liu, W.; Fromme, P.; Katritch, V.; Weierstall, U.; Stevens, R.C.; Cherezov, V. Sci Adv 2016, 2, 00292 (PMID: 27679816)
5IU7	Homo sapiens (Human) (P29274)	Crystal structure of stabilized a2a adenosine receptor a2ar-star2-bril in complex with compound 12c at 1.9a resolution	X-Ray Diffraction	1.9	2016-06-29	Segala, E.; Guo, D.; Cheng, R.K.; Bortolato, A.; Deflorian, F.; Dore, A.S.; Errey, J.C.; Heitman, L.H.; Ijzerman, A.P.; Marshall, F.H.; Cooke, R.M. J Med Chem 2016, 59, 6470 (PMID: 27312113)
2YDV	Homo sapiens (Human) (P29274)	Thermostabilised human a2a receptor with neca bound	X-Ray Diffraction	2.6	2011-05-18	Lebon, G.; Warne, T.; Edwards, P.C.; Bennett, K.; Langmead, C.J.; Leslie, A.G.W.; Tate, C.G. Nature 2011, 474, 521 (PMID: 21593763)
4UHR	Homo sapiens (Human) (P29274)	Thermostabilised human a2a receptor with cgs21680 bound	X-Ray Diffraction	2.6	2015-04-08	Lebon, G.; Edwards, P.C.; Leslie, A.G.W.; Tate, C.G. Mol Pharmacol 2015, 87, 907 (PMID: 25762024)
5K2A	Homo sapiens (Human) (P29274)	2.5 angstrom a2a adenosine receptor structure with sulfur sad phasing using xfel data	X-Ray Diffraction	2.5	2016-09-21	Batyuk, A.; Galli, L.; Ishchenko, A.; Han, G.W.; Gati, C.; Popov, P.A.; Lee, M.Y.; Stauch, B.; White, T.A.; Barty, A.; Aquila, A.; Hunter, M.S.; Liang, M.; Boutet, S.; Pu, M.; Liu, Z.J.; Nelson, G.; James, D.; Li, C.; Zhao, Y.; Spence, J.C.; Liu, W.; Fromme, P.; Katritch, V.; Weierstall, U.; Stevens, R.C.; Cherezov, V. Sci Adv 2016, 2, 00292 (PMID: 27679816)
3VG9	Homo sapiens (Human) (P29274)	Crystal structure of human adenosine a2a receptor with an allosteric inverse-agonist antibody at 2.7 a resolution	X-Ray Diffraction	2.7	2012-02-01	Hino, T.; Arakawa, T.; Iwanari, H.; Yurugi-Kobayashi, T.; Ikeda-Suno, C.; Nakada-Nakura, Y.; Kusano-Arai, O.; Weyand, S.; Shimamura, T.; Nomura, N.; Cameron, A.D.; Kobayashi, T.; Hamakubo, T.; Iwata, S.; Murata, T. Nature 2012, 482, 237 (PMID: 22286059)
3UZA	Homo sapiens (Human) (P29274)	Thermostabilised adenosine a2a receptor in complex with 6-(2,6-dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine	X-Ray Diffraction	3.27	2012-03-21	Congreve, M.; Andrews, S.P.; Dore, A.S.; Hollenstein, K.; Hurrell, E.; Langmead, C.J.; Mason, J.S.; Ng, I.W.; Tehan, B.; Zhukov, A.; Weir, M.; Marshall, F.H. J Med Chem 2012, 55, 1898 (PMID: 22220592)
5IU8	Homo sapiens (Human) (P29274)	Crystal structure of stabilized a2a adenosine receptor a2ar-star2-bril in complex with compound 12f at 2.0a resolution	X-Ray Diffraction	2.0	2016-06-29	Segala, E.; Guo, D.; Cheng, R.K.; Bortolato, A.; Deflorian, F.; Dore, A.S.; Errey, J.C.; Heitman, L.H.; Ijzerman, A.P.; Marshall, F.H.; Cooke, R.M. J Med Chem 2016, 59, 6470 (PMID: 27312113)
2YDO	Homo sapiens (Human) (P29274)	Thermostabilised human a2a receptor with adenosine bound	X-Ray Diffraction	3.0	2011-05-18	Lebon, G.; Warne, T.; Edwards, P.C.; Bennett, K.; Langmead, C.J.; Leslie, A.G.W.; Tate, C.G. Nature 2011, 474, 521 (PMID: 21593763)
3VGA	Homo sapiens (Human) (P29274)	Crystal structure of human adenosine a2a receptor with an allosteric inverse-agonist antibody at 3.1 a resolution	X-Ray Diffraction	3.1	2012-02-01	Hino, T.; Arakawa, T.; Iwanari, H.; Yurugi-Kobayashi, T.; Ikeda-Suno, C.; Nakada-Nakura, Y.; Kusano-Arai, O.; Weyand, S.; Shimamura, T.; Nomura, N.; Cameron, A.D.; Kobayashi, T.; Hamakubo, T.; Iwata, S.; Murata, T. Nature 2012, 482, 237 (PMID: 22286059)
4UG2	Homo sapiens (Human) (P29274)	Thermostabilised human a2a receptor with cgs21680 bound	X-Ray Diffraction	2.6	2015-04-08	Lebon, G.; Edwards, P.C.; Leslie, A.G.W.; Tate, C.G. Mol Pharmacol 2015, 87, 907 (PMID: 25762024)
5IUB	Homo sapiens (Human) (P29274)	Crystal structure of stabilized a2a adenosine receptor a2ar-star2-bril in complex with compound 12x at 2.1a resolution	X-Ray Diffraction	2.1	2016-06-29	Segala, E.; Guo, D.; Cheng, R.K.; Bortolato, A.; Deflorian, F.; Dore, A.S.; Errey, J.C.; Heitman, L.H.; Ijzerman, A.P.; Marshall, F.H.; Cooke, R.M. J Med Chem 2016, 59, 6470 (PMID: 27312113)
5K2C	Homo sapiens (Human) (P29274)	1.9 angstrom a2a adenosine receptor structure with sulfur sad phasing and phase extension using xfel data	X-Ray Diffraction	1.9	2016-09-21	Batyuk, A.; Galli, L.; Ishchenko, A.; Han, G.W.; Gati, C.; Popov, P.A.; Lee, M.Y.; Stauch, B.; White, T.A.; Barty, A.; Aquila, A.; Hunter, M.S.; Liang, M.; Boutet, S.; Pu, M.; Liu, Z.J.; Nelson, G.; James, D.; Li, C.; Zhao, Y.; Spence, J.C.; Liu, W.; Fromme, P.; Katritch, V.; Weierstall, U.; Stevens, R.C.; Cherezov, V. Sci Adv 2016, 2, 00292 (PMID: 27679816)
5UIG	Homo sapiens (Human) (P29274)	Crystal structure of adenosine a2a receptor bound to a novel triazole-carboximidamide antagonist	X-Ray Diffraction	3.5	2017-02-08	Sun, B.; Bachhawat, P.; Chu, M.L.; Wood, M.; Ceska, T.; Sands, Z.A.; Mercier, J.; Lebon, F.; Kobilka, T.S.; Kobilka, B.K. Proc Natl Acad Sci U S A 2017, 114, 2066 (PMID: 28167788)
3REY	Homo sapiens (Human) (P29274)	Thermostabilised adenosine a2a receptor in complex with xac	X-Ray Diffraction	3.31	2011-09-07	Dore, A.S.; Robertson, N.; Errey, J.C.; Ng, I.; Hollenstein, K.; Tehan, B.; Hurrell, E.; Bennett, K.; Congreve, M.; Magnani, F.; Tate, C.G.; Weir, M.; Marshall, F.H. Structure 2011, 19, 1283 (PMID: 21885291)
5K2B	Homo sapiens (Human) (P29274)	2.5 angstrom a2a adenosine receptor structure with mr phasing using xfel data	X-Ray Diffraction	2.5	2016-09-21	Batyuk, A.; Galli, L.; Ishchenko, A.; Han, G.W.; Gati, C.; Popov, P.A.; Lee, M.Y.; Stauch, B.; White, T.A.; Barty, A.; Aquila, A.; Hunter, M.S.; Liang, M.; Boutet, S.; Pu, M.; Liu, Z.J.; Nelson, G.; James, D.; Li, C.; Zhao, Y.; Spence, J.C.; Liu, W.; Fromme, P.; Katritch, V.; Weierstall, U.; Stevens, R.C.; Cherezov, V. Sci Adv 2016, 2, 00292 (PMID: 27679816)
5G53	Homo sapiens (Human) (P29274)	Structure of the adenosine a2a receptor bound to an engineered g protein	X-Ray Diffraction	3.4	2016-08-03	Carpenter, B.; Nehme, R.; Warne, T.; Leslie, A.G.W.; Tate, C.G. Nature 2016, 536, 104 (PMID: 27462812)
5IUA	Homo sapiens (Human) (P29274)	Crystal structure of stabilized a2a adenosine receptor a2ar-star2-bril in complex with compound 12b at 2.2a resolution	X-Ray Diffraction	2.2	2016-06-29	Segala, E.; Guo, D.; Cheng, R.K.; Bortolato, A.; Deflorian, F.; Dore, A.S.; Errey, J.C.; Heitman, L.H.; Ijzerman, A.P.; Marshall, F.H.; Cooke, R.M. J Med Chem 2016, 59, 6470 (PMID: 27312113)

5.) Beta-1 adrenergic receptor (n = 18)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
4AMI	Meleagris gallopavo (Common turkey) (P07700)	Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist bucindolol	X-Ray Diffraction	3.2	2012-05-23	Warne, T.; Edwards, P.C.; Leslie, A.G.; Tate, C.G. Structure 2012, 20, 841 (PMID: 22579251)
2YCZ	Meleagris gallopavo (Common turkey) (P07700)	Turkey beta1 adrenergic receptor with stabilising mutations and bound antagonist iodocyanopindolol	X-Ray Diffraction	3.65	2011-06-01	Moukhametzianov, R.; Warne, T.; Edwards, P.C.; Serrano-Vega, M.J.; Leslie, A.G.; Tate, C.G.; Schertler, G.F. Proc Natl Acad Sci USA 2011, 108, 8228 (PMID: 21540331)
3ZPR	Meleagris gallopavo (Common turkey) (P07700)	Thermostabilised turkey beta1 adrenergic receptor with 4-methyl-2-(piperazin-1-yl) quinoline bound	X-Ray Diffraction	2.7	2013-04-03	Christopher, J.; Brown, J.; Dore, A.; Errey, J.; Koglin, M.; Marshall, F.H.; Myszka, D.; Rich, R.L.; Tate, C.G.; Tehan, B.; Warne, T.; Congreve, M. J Med Chem 2013, 56, 3446 (PMID: 23517028)
5F8U	Meleagris gallopavo (Common turkey) (P07700)	Ligand occupancy in crystal structure of beta1-adrenergic receptor previously submitted by huang et al	X-Ray Diffraction	3.35	2015-12-23	Leslie, A.G.W.; Warne, T.; Tate, C.G. Nat Struct Mol Biol 2015, 22, 941 (PMID: 26643842)
4GPO	Meleagris gallopavo (Common turkey) (P07700)	Oligomeic turkey beta1-adrenergic g protein-coupled receptor	X-Ray Diffraction	3.5	2013-02-27	Huang, J.; Chen, S.; Zhang, J.J.; Huang, X.Y. Nat Struct Mol Biol 2013, 20, 419 (PMID: 23435379)
2Y03	Meleagris gallopavo (Common turkey) (P07700)	Turkey beta1 adrenergic receptor with stabilising mutations and bound agonist isoprenaline	X-Ray Diffraction	2.85	2011-01-12	Warne, A.; Moukhametzianov, R.; Baker, J.G.; Nehme, R.; Edwards, P.C.; Leslie, A.G.W.; Schertler, G.F.X.; Tate, C.G. Nature 2011, 469, 241 (PMID: 21228877)
4BVN	Meleagris gallopavo (Common turkey) (P07700)	Ultra-thermostable beta1-adrenoceptor with cyanopindolol bound	X-Ray Diffraction	2.1	2014-04-02	Miller-Gallacher, J.L.; Nehme, R.; Warne, T.; Edwards, P.C.; Schertler, G.F.X.; Leslie, A.G.W.; Tate, C.G. PLoS One 2014, 9, 92727 (PMID: 24663151)
2YCX	Meleagris gallopavo (Common turkey) (P07700)	Turkey beta1 adrenergic receptor with stabilising mutations and bound antagonist cyanopindolol	X-Ray Diffraction	3.25	2011-06-01	Moukhametzianov, R.; Warne, T.; Edwards, P.C.; Serrano-Vega, M.J.; Leslie, A.G.; Tate, C.G.; Schertler, G.F. Proc Natl Acad Sci USA 2011, 108, 8228 (PMID: 21540331)
3ZPQ	Meleagris gallopavo (Common turkey) (P07700)	Thermostabilised turkey beta1 adrenergic receptor with 4-( piperazin-1-yl)-1h-indole bound (compound 19)	X-Ray Diffraction	2.8	2013-04-03	Christopher, J.; Brown, J.; Dore, A.; Errey, J.; Koglin, M.; Marshall, F.H.; Myszka, D.; Rich, R.L.; Tate, C.G.; Tehan, B.; Warne, T.; Congreve, M. J Med Chem 2013, 56, 3446 (PMID: 23517028)
2VT4	Meleagris gallopavo (Common turkey) (P07700)	Turkey beta1 adrenergic receptor with stabilising mutations and bound cyanopindolol	X-Ray Diffraction	2.7	2008-06-24	Warne, A.; Serrano-Vega, M.J.; Baker, J.G.; Moukhametzianov, R.; Edwards, P.C.; Henderson, R.; Leslie, A.G.W.; Tate, C.G.; Schertler, G.F.X. Nature 2008, 454, 486 (PMID: 18594507)
2Y04	Meleagris gallopavo (Common turkey) (P07700)	Turkey beta1 adrenergic receptor with stabilising mutations and bound partial agonist salbutamol	X-Ray Diffraction	3.05	2011-01-12	Warne, A.; Moukhametzianov, R.; Baker, J.G.; Nehme, R.; Edwards, P.C.; Leslie, A.G.W.; Schertler, G.F.X.; Tate, C.G. Nature 2011, 469, 241 (PMID: 21228877)
2Y01	Meleagris gallopavo (Common turkey) (P07700)	Turkey beta1 adrenergic receptor with stabilising mutations and bound partial agonist dobutamine (crystal dob102)	X-Ray Diffraction	2.6	2011-03-30	Warne, A.; Moukhametzianov, R.; Baker, J.G.; Nehme, R.; Edwards, P.C.; Leslie, A.G.W.; Schertler, G.F.X.; Tate, C.G. Nature 2011, 469, 241 (PMID: 21228877)
5A8E	Meleagris gallopavo (Common turkey) (P07700)	Thermostabilised beta1-adrenoceptor with rationally designed inverse agonist 7-methylcyanopindolol bound	X-Ray Diffraction	2.4	2015-09-30	Sato, T.; Baker, J.; Warne, T.; Brown, G.; Leslie, A.; Congreve, M.; Tate, C. Mol Pharmacol 2015, 88, 1024 (PMID: 26385885)
4AMJ	Meleagris gallopavo (Common turkey) (P07700)	Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist carvedilol	X-Ray Diffraction	2.3	2012-05-23	Warne, T.; Edwards, P.C.; Leslie, A.G.; Tate, C.G. Structure 2012, 20, 841 (PMID: 22579251)
2YCW	Meleagris gallopavo (Common turkey) (P07700)	Turkey beta1 adrenergic receptor with stabilising mutations and bound antagonist carazolol	X-Ray Diffraction	3.0	2011-06-01	Moukhametzianov, R.; Warne, T.; Edwards, P.C.; Serrano-Vega, M.J.; Leslie, A.G.; Tate, C.G.; Schertler, G.F. Proc Natl Acad Sci USA 2011, 108, 8228 (PMID: 21540331)
2Y02	Meleagris gallopavo (Common turkey) (P07700)	Turkey beta1 adrenergic receptor with stabilising mutations and bound agonist carmoterol	X-Ray Diffraction	2.6	2011-01-12	Warne, A.; Moukhametzianov, R.; Baker, J.G.; Nehme, R.; Edwards, P.C.; Leslie, A.G.W.; Schertler, G.F.X.; Tate, C.G. Nature 2011, 469, 241 (PMID: 21228877)
2YCY	Meleagris gallopavo (Common turkey) (P07700)	Turkey beta1 adrenergic receptor with stabilising mutations and bound antagonist cyanopindolol	X-Ray Diffraction	3.15	2011-06-08	Moukhametzianov, R.; Warne, T.; Edwards, P.C.; Serrano-Vega, M.J.; Leslie, A.G.W.; Tate, C.G.; Schertler, G.F.X. Proc Natl Acad Sci USA 2011, 108, 8228 (PMID: 21540331)
2Y00	Meleagris gallopavo (Common turkey) (P07700)	Turkey beta1 adrenergic receptor with stabilising mutations and bound partial agonist dobutamine (crystal dob92)	X-Ray Diffraction	2.5	2011-01-12	Warne, A.; Moukhametzianov, R.; Baker, J.G.; Nehme, R.; Edwards, P.C.; Leslie, A.G.W.; Schertler, G.F.X.; Tate, C.G. Nature 2011, 469, 241 (PMID: 21228877)

6.) Beta-2 adrenergic receptor (n = 20)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
2R4R	Homo sapiens (Human) (P07550)	Crystal structure of the human beta2 adrenoceptor	X-Ray Diffraction	3.4	2007-11-06	Rasmussen, S.G.F.; Choi, H.J.; Rosenbaum, D.M.; Kobilka, T.S.; Thian, F.S.; Edwards, P.C.; Burghammer, M.; Ratnala, V.R.; Sanishvili, R.; Fischetti, R.F.; Schertler, G.F.; Weis, W.I.; Kobilka, B.K. Nature 2007, 450, 383 (PMID: 17952055)
4QKX	Homo sapiens (Human) (P07550)	Structure of beta2 adrenoceptor bound to a covalent agonist and an engineered nanobody	X-Ray Diffraction	3.3	2014-07-23	Weichert, D.; Kruse, A.C.; Manglik, A.; Hiller, C.; Zhang, C.; Hubner, H.; Kobilka, B.K.; Gmeiner, P. Proc Natl Acad Sci USA 2014, 111, 10744 (PMID: 25006259)
5D5B	Homo sapiens (Human) (P07550)	In meso x-ray crystallography structure of the beta2-adrenergic receptor at 100 k	X-Ray Diffraction	3.8	2016-01-13	Huang, C.Y.; Olieric, V.; Ma, P.; Howe, N.; Vogeley, L.; Liu, X.; Warshamanage, R.; Weinert, T.; Panepucci, E.; Kobilka, B.; Diederichs, K.; Wang, M.; Caffrey, M. Acta Crystallogr D Struct Biol 2016, 72, 93 (PMID: 26894538)
4GBR	Homo sapiens (Human) (P07550)	N-terminal t4 lysozyme fusion facilitates crystallization of a g protein coupled receptor	X-Ray Diffraction	3.99	2012-10-24	Zou, Y.; Weis, W.I.; Kobilka, B.K. PLoS One 2012, 7, 46039 (PMID: 23056231)
2R4S	Homo sapiens (Human) (P07550)	Crystal structure of the human beta2 adrenoceptor	X-Ray Diffraction	3.4	2007-11-06	Rasmussen, S.G.F.; Choi, H.J.; Rosenbaum, D.M.; Kobilka, T.S.; Thian, F.S.; Edwards, P.C.; Burghammer, M.; Ratnala, V.R.; Sanishvili, R.; Fischetti, R.F.; Schertler, G.F.; Weis, W.I.; Kobilka, B.K. Nature 2007, 450, 383 (PMID: 17952055)
3KJ6	Homo sapiens (Human) (P07550)	Crystal structure of a methylated beta2 adrenergic receptor-fab complex	X-Ray Diffraction	3.4	2010-02-16	Bokoch, M.P.; Zou, Y.; Rasmussen, S.G.; Liu, C.W.; Nygaard, R.; Rosenbaum, D.M.; Fung, J.J.; Choi, H.J.; Thian, F.S.; Kobilka, T.S.; Puglisi, J.D.; Weis, W.I.; Pardo, L.; Prosser, R.S.; Mueller, L.; Kobilka, B.K. Nature 2010, 463, 108 (PMID: 20054398)
2RH1	Homo sapiens (Human) (P07550)	High resolution crystal structure of human b2-adrenergic g protein-coupled receptor.	X-Ray Diffraction	2.4	2007-10-30	Cherezov, V.; Rosenbaum, D.M.; Hanson, M.A.; Rasmussen, S.G.; Thian, F.S.; Kobilka, T.S.; Choi, H.J.; Kuhn, P.; Weis, W.I.; Kobilka, B.K.; Stevens, R.C. Science 2007, 318, 1258 (PMID: 17962520)
3NY8	Homo sapiens (Human) (P07550)	Crystal structure of the human beta2 adrenergic receptor in complex with the inverse agonist ici 118,551	X-Ray Diffraction	2.84	2010-08-11	Wacker, D.; Fenalti, G.; Brown, M.A.; Katritch, V.; Abagyan, R.; Cherezov, V.; Stevens, R.C. J Am Chem Soc 2010, 132, 11443 (PMID: 20669948)
3PDS	Homo sapiens (Human) (P07550)	Irreversible agonist-beta2 adrenoceptor complex	X-Ray Diffraction	3.5	2011-01-12	Rosenbaum, D.M.; Zhang, C.; Lyons, J.A.; Holl, R.; Aragao, D.; Arlow, D.H.; Rasmussen, S.G.F.; Choi, H.J.; Devree, B.T.; Sunahara, R.K.; Chae, P.S.; Gellman, S.H.; Dror, R.O.; Shaw, D.E.; Weis, W.I.; Caffrey, M.; Gmeiner, P.; Kobilka, B.K. Nature 2011, 469, 236 (PMID: 21228876)
5D6L	Homo sapiens (Human) (P07550)	Beta2ar-t4l -cim	X-Ray Diffraction	3.2	2016-08-17	Ma, P.; Caffrey, M. To Be Published (PMID: N/A)
5D5A	Homo sapiens (Human) (P07550)	In meso in situ serial x-ray crystallography structure of the beta2-adrenergic receptor at 100 k	X-Ray Diffraction	2.48	2016-01-13	Huang, C.Y.; Olieric, V.; Ma, P.; Howe, N.; Vogeley, L.; Liu, X.; Warshamanage, R.; Weinert, T.; Panepucci, E.; Kobilka, B.; Diederichs, K.; Wang, M.; Caffrey, M. Acta Crystallogr D Struct Biol 2016, 72, 93 (PMID: 26894538)
4LDE	Homo sapiens (Human) (P07550)	Structure of beta2 adrenoceptor bound to bi167107 and an engineered nanobody	X-Ray Diffraction	2.79	2013-09-25	Ring, A.M.; Manglik, A.; Kruse, A.C.; Enos, M.D.; Weis, W.I.; Garcia, K.C.; Kobilka, B.K. Nature 2013, 502, 575 (PMID: 24056936)
3P0G	Homo sapiens (Human) (P07550)	Structure of a nanobody-stabilized active state of the beta2 adrenoceptor	X-Ray Diffraction	3.5	2011-01-19	Rasmussen, S.G.; Choi, H.J.; Fung, J.J.; Pardon, E.; Casarosa, P.; Chae, P.S.; Devree, B.T.; Rosenbaum, D.M.; Thian, F.S.; Kobilka, T.S.; Schnapp, A.; Konetzki, I.; Sunahara, R.K.; Gellman, S.H.; Pautsch, A.; Steyaert, J.; Weis, W.I.; Kobilka, B.K. Nature 2011, 469, 175 (PMID: 21228869)
5JQH	Homo sapiens (Human) (P07550)	Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, nb60	X-Ray Diffraction	3.2	2016-07-13	Staus, D.P.; Strachan, R.T.; Manglik, A.; Pani, B.; Kahsai, A.W.; Kim, T.H.; Wingler, L.M.; Ahn, S.; Chatterjee, A.; Masoudi, A.; Kruse, A.C.; Pardon, E.; Steyaert, J.; Weis, W.I.; Prosser, R.S.; Kobilka, B.K.; Costa, T.; Lefkowitz, R.J. Nature 2016, 535, 448 (PMID: 27409812)
4LDO	Homo sapiens (Human) (P07550)	Structure of beta2 adrenoceptor bound to adrenaline and an engineered nanobody	X-Ray Diffraction	3.2	2013-09-25	Ring, A.M.; Manglik, A.; Kruse, A.C.; Enos, M.D.; Weis, W.I.; Garcia, K.C.; Kobilka, B.K. Nature 2013, 502, 575 (PMID: 24056936)
3SN6	Homo sapiens (Human) (P07550)	Crystal structure of the beta2 adrenergic receptor-gs protein complex	X-Ray Diffraction	3.2	2011-07-20	Rasmussen, S.G.; Devree, B.T.; Zou, Y.; Kruse, A.C.; Chung, K.Y.; Kobilka, T.S.; Thian, F.S.; Chae, P.S.; Pardon, E.; Calinski, D.; Mathiesen, J.M.; Shah, S.T.; Lyons, J.A.; Caffrey, M.; Gellman, S.H.; Steyaert, J.; Skiniotis, G.; Weis, W.I.; Sunahara, R.K.; Kobilka, B.K. Nature 2011, 477, 549 (PMID: 21772288)
3D4S	Homo sapiens (Human) (P07550)	Cholesterol bound form of human beta2 adrenergic receptor.	X-Ray Diffraction	2.8	2008-06-17	Hanson, M.A.; Cherezov, V.; Griffith, M.T.; Roth, C.B.; Jaakola, V.P.; Chien, E.Y.; Velasquez, J.; Kuhn, P.; Stevens, R.C. Structure 2008, 16, 897 (PMID: 18547522)
3NY9	Homo sapiens (Human) (P07550)	Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist	X-Ray Diffraction	2.84	2010-08-11	Wacker, D.; Fenalti, G.; Brown, M.A.; Katritch, V.; Abagyan, R.; Cherezov, V.; Stevens, R.C. J Am Chem Soc 2010, 132, 11443 (PMID: 20669948)
4LDL	Homo sapiens (Human) (P07550)	Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody	X-Ray Diffraction	3.1	2013-09-25	Ring, A.M.; Manglik, A.; Kruse, A.C.; Enos, M.D.; Weis, W.I.; Garcia, K.C.; Kobilka, B.K. Nature 2013, 502, 575 (PMID: 24056936)
3NYA	Homo sapiens (Human) (P07550)	Crystal structure of the human beta2 adrenergic receptor in complex with the neutral antagonist alprenolol	X-Ray Diffraction	3.16	2010-08-11	Wacker, D.; Fenalti, G.; Brown, M.A.; Katritch, V.; Abagyan, R.; Cherezov, V.; Stevens, R.C. J Am Chem Soc 2010, 132, 11443 (PMID: 20669948)

7.) C-C chemokine receptor type 2 (n = 1)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
5T1A	Homo sapiens (Human) (P41597)	Structure of cc chemokine receptor 2 with orthosteric and allosteric antagonists	X-Ray Diffraction	2.81	2016-12-14	Zheng, Y.; Qin, L.; Zacarias, N.V.; Devries, H.; Han, G.W.; Gustavsson, M.; Dabros, M.; Zhao, C.; Cherney, R.J.; Carter, P.; Stamos, D.; Abagyan, R.; Cherezov, V.; Stevens, R.C.; Ijzerman, A.P.; Heitman, L.H.; Tebben, A.; Kufareva, I.; Handel, T.M. Nature 2016, 540, 458 (PMID: 27926736)

8.) C-C chemokine receptor type 5 (n = 1)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
4MBS	Homo sapiens (Human) (P51681)	Crystal structure of the ccr5 chemokine receptor	X-Ray Diffraction	2.71	2013-09-11	Tan, Q.; Zhu, Y.; Li, J.; Chen, Z.; Han, G.W.; Kufareva, I.; Li, T.; Ma, L.; Fenalti, G.; Li, J.; Zhang, W.; Xie, X.; Yang, H.; Jiang, H.; Cherezov, V.; Liu, H.; Stevens, R.C.; Zhao, Q.; Wu, B. Science 2013, 341, 1387 (PMID: 24030490)

9.) C-C chemokine receptor type 9 (n = 1)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
5LWE	Homo sapiens (Human) (P51686)	Crystal structure of the human cc chemokine receptor type 9 (ccr9) in complex with vercirnon	X-Ray Diffraction	2.8	2016-12-07	Oswald, C.; Rappas, M.; Kean, J.; Dore, A.S.; Errey, J.C.; Bennett, K.; Deflorian, F.; Christopher, J.A.; Jazayeri, A.; Mason, J.S.; Congreve, M.; Cooke, R.M.; Marshall, F.H. Nature 2016, 540, 462 (PMID: 27926729)

10.) C-X-C chemokine receptor type 1 (n = 1)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
2LNL	Homo sapiens (Human) (P25024)	Structure of human cxcr1 in phospholipid bilayers	Solid-State NMR	N/A	2012-10-17	Park, S.H.; Das, B.B.; Casagrande, F.; Tian, Y.; Nothnagel, H.J.; Chu, M.; Kiefer, H.; Maier, K.; Deangelis, A.A.; Marassi, F.M.; Opella, S.J. Nature 2012, 491, 779 (PMID: 23086146)

11.) C-X-C chemokine receptor type 4 (n = 6)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
3OE8	Homo sapiens (Human) (P61073)	Crystal structure of the cxcr4 chemokine receptor in complex with a small molecule antagonist it1t in p1 spacegroup	X-Ray Diffraction	3.1	2010-10-27	Wu, B.; Chien, E.Y.; Mol, C.D.; Fenalti, G.; Liu, W.; Katritch, V.; Abagyan, R.; Brooun, A.; Wells, P.; Bi, F.C.; Hamel, D.J.; Kuhn, P.; Handel, T.M.; Cherezov, V.; Stevens, R.C. Science 2010, 330, 1066 (PMID: 20929726)
3OE6	Homo sapiens (Human) (P61073)	Crystal structure of the cxcr4 chemokine receptor in complex with a small molecule antagonist it1t in i222 spacegroup	X-Ray Diffraction	3.2	2010-10-27	Wu, B.; Chien, E.Y.; Mol, C.D.; Fenalti, G.; Liu, W.; Katritch, V.; Abagyan, R.; Brooun, A.; Wells, P.; Bi, F.C.; Hamel, D.J.; Kuhn, P.; Handel, T.M.; Cherezov, V.; Stevens, R.C. Science 2010, 330, 1066 (PMID: 20929726)
4RWS	Homo sapiens (Human) (P61073)	Crystal structure of cxcr4 and viral chemokine antagonist vmip-ii complex (psi community target)	X-Ray Diffraction	3.1	2015-02-11	Qin, L.; Kufareva, I.; Holden, L.G.; Wang, C.; Zheng, Y.; Zhao, C.; Fenalti, G.; Wu, H.; Han, G.W.; Cherezov, V.; Abagyan, R.; Stevens, R.C.; Handel, T.M. Science 2015, 347, 1117 (PMID: 25612609)
3OE9	Homo sapiens (Human) (P61073)	Crystal structure of the chemokine cxcr4 receptor in complex with a small molecule antagonist it1t in p1 spacegroup	X-Ray Diffraction	3.1	2010-10-27	Wu, B.; Chien, E.Y.; Mol, C.D.; Fenalti, G.; Liu, W.; Katritch, V.; Abagyan, R.; Brooun, A.; Wells, P.; Bi, F.C.; Hamel, D.J.; Kuhn, P.; Handel, T.M.; Cherezov, V.; Stevens, R.C. Science 2010, 330, 1066 (PMID: 20929726)
3ODU	Homo sapiens (Human) (P61073)	The 2.5 a structure of the cxcr4 chemokine receptor in complex with small molecule antagonist it1t	X-Ray Diffraction	2.5	2010-10-27	Wu, B.; Chien, E.Y.; Mol, C.D.; Fenalti, G.; Liu, W.; Katritch, V.; Abagyan, R.; Brooun, A.; Wells, P.; Bi, F.C.; Hamel, D.J.; Kuhn, P.; Handel, T.M.; Cherezov, V.; Stevens, R.C. Science 2010, 330, 1066 (PMID: 20929726)
3OE0	Homo sapiens (Human) (P61073)	Crystal structure of the cxcr4 chemokine receptor in complex with a cyclic peptide antagonist cvx15	X-Ray Diffraction	2.9	2010-10-27	Wu, B.; Chien, E.Y.; Mol, C.D.; Fenalti, G.; Liu, W.; Katritch, V.; Abagyan, R.; Brooun, A.; Wells, P.; Bi, F.C.; Hamel, D.J.; Kuhn, P.; Handel, T.M.; Cherezov, V.; Stevens, R.C. Science 2010, 330, 1066 (PMID: 20929726)

12.) Cannabinoid receptor 1 (n = 2)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
5U09	Homo sapiens (Human) (P21554)	High-resolution crystal structure of the human cb1 cannabinoid receptor	X-Ray Diffraction	2.6	2016-12-07	Shao, Z.; Yin, J.; Chapman, K.; Grzemska, M.; Clark, L.; Wang, J.; Rosenbaum, D.M. Nature 2016 (PMID: 27851727)
5TGZ	Homo sapiens (Human) (P21554)	Crystal structure of the human cannabinoid receptor cb1	X-Ray Diffraction	2.8	2016-11-02	Hua, T.; Vemuri, K.; Pu, M.; Qu, L.; Han, G.W.; Wu, Y.; Zhao, S.; Shui, W.; Li, S.; Korde, A.; Laprairie, R.B.; Stahl, E.L.; Ho, J.H.; Zvonok, N.; Zhou, H.; Kufareva, I.; Wu, B.; Zhao, Q.; Hanson, M.A.; Bohn, L.M.; Makriyannis, A.; Stevens, R.C.; Liu, Z.J. Cell 2016, 167, 750 (PMID: 27768894)

13.) D(3) dopamine receptor (n = 1)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
3PBL	Homo sapiens (Human) (P35462)	Structure of the human dopamine d3 receptor in complex with eticlopride	X-Ray Diffraction	2.89	2010-11-03	Chien, E.Y.; Liu, W.; Zhao, Q.; Katritch, V.; Han, G.W.; Hanson, M.A.; Shi, L.; Newman, A.H.; Javitch, J.A.; Cherezov, V.; Stevens, R.C. Science 2010, 330, 1091 (PMID: 21097933)

14.) Delta-type opioid receptor (n = 4)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
4EJ4	Mus musculus (Mouse) (P32300)	Structure of the delta opioid receptor bound to naltrindole	X-Ray Diffraction	3.4	2012-05-16	Granier, S.; Manglik, A.; Kruse, A.C.; Kobilka, T.S.; Thian, F.S.; Weis, W.I.; Kobilka, B.K. Nature 2012, 485, 400 (PMID: 22596164)
4RWD	Homo sapiens (Human) (P41143)	Xfel structure of the human delta opioid receptor in complex with a bifunctional peptide	X-Ray Diffraction	2.7	2015-01-14	Fenalti, G.; Zatsepin, N.A.; Betti, C.; Giguere, P.; Han, G.W.; Ishchenko, A.; Liu, W.; Guillemyn, K.; Zhang, H.; James, D.; Wang, D.; Weierstall, U.; Spence, J.C.; Boutet, S.; Messerschmidt, M.; Williams, G.J.; Gati, C.; Yefanov, O.M.; White, T.A.; Oberthuer, D.; Metz, M.; Yoon, C.H.; Barty, A.; Chapman, H.N.; Basu, S.; Coe, J.; Conrad, C.E.; Fromme, R.; Fromme, P.; Tourwe, D.; Schiller, P.W.; Roth, B.L.; Ballet, S.; Katritch, V.; Stevens, R.C.; Cherezov, V. Nat Struct Mol Biol 2015, 22, 265 (PMID: 25686086)
4N6H	Homo sapiens (Human) (P41143)	1.8 a structure of the human delta opioid 7tm receptor (psi community target)	X-Ray Diffraction	1.8	2013-12-25	Fenalti, G.; Giguere, P.M.; Katritch, V.; Huang, X.P.; Thompson, A.A.; Cherezov, V.; Roth, B.L.; Stevens, R.C. Nature 2014, 506, 191 (PMID: 24413399)
4RWA	Homo sapiens (Human) (P41143)	Synchrotron structure of the human delta opioid receptor in complex with a bifunctional peptide (psi community target)	X-Ray Diffraction	3.28	2015-01-14	Fenalti, G.; Zatsepin, N.A.; Betti, C.; Giguere, P.; Han, G.W.; Ishchenko, A.; Liu, W.; Guillemyn, K.; Zhang, H.; James, D.; Wang, D.; Weierstall, U.; Spence, J.C.; Boutet, S.; Messerschmidt, M.; Williams, G.J.; Gati, C.; Yefanov, O.M.; White, T.A.; Oberthuer, D.; Metz, M.; Yoon, C.H.; Barty, A.; Chapman, H.N.; Basu, S.; Coe, J.; Conrad, C.E.; Fromme, R.; Fromme, P.; Tourwe, D.; Schiller, P.W.; Roth, B.L.; Ballet, S.; Katritch, V.; Stevens, R.C.; Cherezov, V. Nat Struct Mol Biol 2015, 22, 265 (PMID: 25686086)

15.) Free fatty acid receptor 1 (n = 1)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
4PHU	Homo sapiens (Human) (O14842)	Crystal structure of human gpr40 bound to allosteric agonist tak-875	X-Ray Diffraction	2.33	2014-07-16	Srivastava, A.; Yano, J.; Hirozane, Y.; Kefala, G.; Gruswitz, F.; Snell, G.; Lane, W.; Ivetac, A.; Aertgeerts, K.; Nguyen, J.; Jennings, A.; Okada, K. Nature 2014, 513, 124 (PMID: 25043059)

16.) G-protein coupled receptor homolog US28 (n = 2)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
4XT3	Human cytomegalovirus (strain AD169) (HHV-5) (P69332)	Structure of a viral gpcr bound to human chemokine cx3cl1	X-Ray Diffraction	3.8	2015-03-04	Burg, J.S.; Ingram, J.R.; Venkatakrishnan, A.J.; Jude, K.M.; Dukkipati, A.; Feinberg, E.N.; Angelini, A.; Waghray, D.; Dror, R.O.; Ploegh, H.L.; Garcia, K.C. Science 2015, 347, 1113 (PMID: 25745166)
4XT1	Human cytomegalovirus (strain AD169) (HHV-5) (P69332)	Structure of a nanobody-bound viral gpcr bound to human chemokine cx3cl1	X-Ray Diffraction	2.89	2015-03-04	Burg, J.S.; Ingram, J.R.; Venkatakrishnan, A.J.; Jude, K.M.; Dukkipati, A.; Feinberg, E.N.; Angelini, A.; Waghray, D.; Dror, R.O.; Ploegh, H.L.; Garcia, K.C. Science 2015, 347, 1113 (PMID: 25745166)

17.) Histamine H1 receptor (n = 1)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
3RZE	Homo sapiens (Human) (P35367)	Structure of the human histamine h1 receptor in complex with doxepin	X-Ray Diffraction	3.1	2011-06-15	Shimamura, T.; Shiroishi, M.; Weyand, S.; Tsujimoto, H.; Winter, G.; Katritch, V.; Abagyan, R.; Cherezov, V.; Liu, W.; Han, G.W.; Kobayashi, T.; Stevens, R.C.; Iwata, S. Nature 2011, 475, 65 (PMID: 21697825)

18.) Kappa-type opioid receptor (n = 1)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
4DJH	Homo sapiens (Human) (P41145)	Structure of the human kappa opioid receptor in complex with jdtic	X-Ray Diffraction	2.9	2012-03-21	Wu, H.; Wacker, D.; Mileni, M.; Katritch, V.; Han, G.W.; Vardy, E.; Liu, W.; Thompson, A.A.; Huang, X.P.; Carroll, F.I.; Mascarella, S.W.; Westkaemper, R.B.; Mosier, P.D.; Roth, B.L.; Cherezov, V.; Stevens, R.C. Nature 2012, 485, 327 (PMID: 22437504)

19.) Lysophosphatidic acid receptor 1 (n = 3)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
4Z35	Homo sapiens (Human) (Q92633)	Crystal structure of human lysophosphatidic acid receptor 1 in complex with ono-9910539	X-Ray Diffraction	2.9	2015-06-03	Chrencik, J.E.; Roth, C.B.; Terakado, M.; Kurata, H.; Omi, R.; Kihara, Y.; Warshaviak, D.; Nakade, S.; Asmar-Rovira, G.; Mileni, M.; Mizuno, H.; Griffith, M.T.; Rodgers, C.; Han, G.W.; Velasquez, J.; Chun, J.; Stevens, R.C.; Hanson, M.A. Cell 2015, 161, 1633 (PMID: 26091040)
4Z36	Homo sapiens (Human) (Q92633)	Crystal structure of human lysophosphatidic acid receptor 1 in complex with ono-3080573	X-Ray Diffraction	2.9	2015-06-03	Chrencik, J.E.; Roth, C.B.; Terakado, M.; Kurata, H.; Omi, R.; Kihara, Y.; Warshaviak, D.; Nakade, S.; Asmar-Rovira, G.; Mileni, M.; Mizuno, H.; Griffith, M.T.; Rodgers, C.; Han, G.W.; Velasquez, J.; Chun, J.; Stevens, R.C.; Hanson, M.A. Cell 2015, 161, 1633 (PMID: 26091040)
4Z34	Homo sapiens (Human) (Q92633)	Crystal structure of human lysophosphatidic acid receptor 1 in complex with ono9780307	X-Ray Diffraction	3.0	2015-06-03	Chrencik, J.E.; Roth, C.B.; Terakado, M.; Kurata, H.; Omi, R.; Kihara, Y.; Warshaviak, D.; Nakade, S.; Asmar-Rovira, G.; Mileni, M.; Mizuno, H.; Griffith, M.T.; Rodgers, C.; Han, G.W.; Velasquez, J.; Chun, J.; Stevens, R.C.; Hanson, M.A. Cell 2015, 161, 1633 (PMID: 26091040)

20.) Mu-type opioid receptor (n = 2)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
4DKL	Mus musculus (Mouse) (P42866)	Crystal structure of the mu-opioid receptor bound to a morphinan antagonist	X-Ray Diffraction	2.8	2012-03-21	Manglik, A.; Kruse, A.C.; Kobilka, T.S.; Thian, F.S.; Mathiesen, J.M.; Sunahara, R.K.; Pardo, L.; Weis, W.I.; Kobilka, B.K.; Granier, S. Nature 2012, 485, 321 (PMID: 22437502)
5C1M	Mus musculus (Mouse) (P42866)	Crystal structure of active mu-opioid receptor bound to the agonist bu72	X-Ray Diffraction	2.1	2015-08-05	Huang, W.; Manglik, A.; Venkatakrishnan, A.J.; Laeremans, T.; Feinberg, E.N.; Sanborn, A.L.; Kato, H.E.; Livingston, K.E.; Thorsen, T.S.; Kling, R.C.; Granier, S.; Gmeiner, P.; Husbands, S.M.; Traynor, J.R.; Weis, W.I.; Steyaert, J.; Dror, R.O.; Kobilka, B.K. Nature 2015, 524, 315 (PMID: 26245379)

21.) Muscarinic acetylcholine receptor M1 (n = 1)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
5CXV	Homo sapiens (Human) (P11229)	Structure of the human m1 muscarinic acetylcholine receptor bound to antagonist tiotropium	X-Ray Diffraction	2.7	2016-03-09	Thal, D.M.; Sun, B.; Feng, D.; Nawaratne, V.; Leach, K.; Felder, C.C.; Bures, M.G.; Evans, D.A.; Weis, W.I.; Bachhawat, P.; Kobilka, T.S.; Sexton, P.M.; Kobilka, B.K.; Christopoulos, A. Nature 2016, 531, 335 (PMID: 26958838)

22.) Muscarinic acetylcholine receptor M2 (n = 3)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
4MQT	Homo sapiens (Human) (P08172)	Structure of active human m2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator ly2119620	X-Ray Diffraction	3.7	2013-11-27	Kruse, A.C.; Ring, A.M.; Manglik, A.; Hu, J.; Hu, K.; Eitel, K.; Hubner, H.; Pardon, E.; Valant, C.; Sexton, P.M.; Christopoulos, A.; Felder, C.C.; Gmeiner, P.; Steyaert, J.; Weis, W.I.; Garcia, K.C.; Wess, J.; Kobilka, B.K. Nature 2013, 504, 101 (PMID: 24256733)
3UON	Homo sapiens (Human) (P08172)	Structure of the human m2 muscarinic acetylcholine receptor bound to an antagonist	X-Ray Diffraction	3.0	2012-02-01	Haga, K.; Kruse, A.C.; Asada, H.; Yurugi-Kobayashi, T.; Shiroishi, M.; Zhang, C.; Weis, W.I.; Okada, T.; Kobilka, B.K.; Haga, T.; Kobayashi, T. Nature 2012, 482, 547 (PMID: 22278061)
4MQS	Homo sapiens (Human) (P08172)	Structure of active human m2 muscarinic acetylcholine receptor bound to the agonist iperoxo	X-Ray Diffraction	3.5	2013-11-27	Kruse, A.C.; Ring, A.M.; Manglik, A.; Hu, J.; Hu, K.; Eitel, K.; Hubner, H.; Pardon, E.; Valant, C.; Sexton, P.M.; Christopoulos, A.; Felder, C.C.; Gmeiner, P.; Steyaert, J.; Weis, W.I.; Garcia, K.C.; Wess, J.; Kobilka, B.K. Nature 2013, 504, 101 (PMID: 24256733)

23.) Muscarinic acetylcholine receptor M3 (n = 4)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
4U14	Rattus norvegicus (Rat) (P08483)	Structure of the m3 muscarinic acetylcholine receptor bound to the antagonist tiotropium crystallized with disulfide-stabilized t4 lysozyme (dst4l)	X-Ray Diffraction	3.57	2014-11-26	Thorsen, T.S.; Matt, R.; Weis, W.I.; Kobilka, B.K. Structure 2014, 22, 1657 (PMID: 25450769)
4U16	Rattus norvegicus (Rat) (P08483)	M3-mt4l receptor bound to nms	X-Ray Diffraction	3.7	2014-11-26	Thorsen, T.S.; Matt, R.; Weis, W.I.; Kobilka, B.K. Structure 2014, 22, 1657 (PMID: 25450769)
4DAJ	Rattus norvegicus (Rat) (P08483)	Structure of the m3 muscarinic acetylcholine receptor	X-Ray Diffraction	3.4	2012-02-22	Kruse, A.C.; Hu, J.; Pan, A.C.; Arlow, D.H.; Rosenbaum, D.M.; Rosemond, E.; Green, H.F.; Liu, T.; Chae, P.S.; Dror, R.O.; Shaw, D.E.; Weis, W.I.; Wess, J.; Kobilka, B.K. Nature 2012, 482, 552 (PMID: 22358844)
4U15	Rattus norvegicus (Rat) (P08483)	M3-mt4l receptor bound to tiotropium	X-Ray Diffraction	2.8	2014-11-26	Thorsen, T.S.; Matt, R.; Weis, W.I.; Kobilka, B.K. Structure 2014, 22, 1657 (PMID: 25450769)

24.) Muscarinic acetylcholine receptor M4 (n = 1)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
5DSG	Homo sapiens (Human) (P08173)	Structure of the m4 muscarinic acetylcholine receptor (m4-mt4l) bound to tiotropium	X-Ray Diffraction	2.6	2016-03-16	Thal, D.M.; Sun, B.; Feng, D.; Nawaratne, V.; Leach, K.; Felder, C.C.; Bures, M.G.; Evans, D.A.; Weis, W.I.; Bachhawat, P.; Kobilka, T.S.; Sexton, P.M.; Kobilka, B.K.; Christopoulos, A. Nature 2016, 531, 335 (PMID: 26958838)

25.) Neurotensin receptor type 1 (n = 8)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
4BV0	Rattus norvegicus (Rat) (P20789)	High resolution structure of evolved agonist-bound neurotensin receptor 1 mutant without lysozyme fusion	X-Ray Diffraction	3.1	2014-01-29	Egloff, P.; Hillenbrand, M.; Klenk, C.; Batyuk, A.; Heine, P.; Balada, S.; Schlinkmann, K.M.; Scott, D.J.; Schuetz, M.; Plueckthun, A. Proc Natl Acad Sci USA 2014, 111, E655 (PMID: 24453215)
4GRV	Rattus norvegicus (Rat) (P20789)	The crystal structure of the neurotensin receptor nts1 in complex with neurotensin (8-13)	X-Ray Diffraction	2.8	2012-10-17	White, J.F.; Noinaj, N.; Shibata, Y.; Love, J.; Kloss, B.; Xu, F.; Gvozdenovic-Jeremic, J.; Shah, P.; Shiloach, J.; Tate, C.G.; Grisshammer, R. Nature 2012, 490, 508 (PMID: 23051748)
5T04	Rattus norvegicus (Rat) (P20789)	Structure of constitutively active neurotensin receptor	X-Ray Diffraction	3.3	2016-12-21	Krumm, B.E.; Lee, S.; Bhattacharya, S.; Botos, I.; White, C.F.; Du, H.; Vaidehi, N.; Grisshammer, R. Sci Rep 2016, 6, 38564 (PMID: 27924846)
4BUO	Rattus norvegicus (Rat) (P20789)	High resolution structure of thermostable agonist-bound neurotensin receptor 1 mutant without lysozyme fusion	X-Ray Diffraction	2.75	2014-01-29	Egloff, P.; Hillenbrand, M.; Klenk, C.; Batyuk, A.; Heine, P.; Balada, S.; Schlinkmann, K.M.; Scott, D.J.; Schuetz, M.; Plueckthun, A. Proc Natl Acad Sci USA 2014, 111, E655 (PMID: 24453215)
4BWB	Rattus norvegicus (Rat) (P20789)	Structure of evolved agonist-bound neurotensin receptor 1 mutant without lysozyme fusion	X-Ray Diffraction	3.57	2014-01-29	Egloff, P.; Hillenbrand, M.; Klenk, C.; Batyuk, A.; Heine, P.; Balada, S.; Schlinkmann, K.M.; Scott, D.J.; Schuetz, M.; Plueckthun, A. Proc Natl Acad Sci USA 2014, 111, E655 (PMID: 24453215)
3ZEV	Rattus norvegicus (Rat) (P20789)	Structure of thermostable agonist-bound neurotensin receptor 1 mutant without lysozyme fusion	X-Ray Diffraction	3.0	2014-01-29	Egloff, P.; Hillenbrand, M.; Klenk, C.; Batyuk, A.; Heine, P.; Balada, S.; Schlinkmann, K.M.; Scott, D.J.; Schuetz, M.; Plueckthun, A. Proc Natl Acad Sci USA 2014, 111, E655 (PMID: 24453215)
4XEE	Rattus norvegicus (Rat) (P20789)	Structure of active-like neurotensin receptor	X-Ray Diffraction	2.9	2015-07-29	Krumm, B.E.; White, J.F.; Shah, P.; Grisshammer, R. Nat Commun 2015, 6, 7895 (PMID: 26205105)
4XES	Rattus norvegicus (Rat) (P20789)	Structure of active-like neurotensin receptor	X-Ray Diffraction	2.6	2015-07-29	Krumm, B.E.; White, J.F.; Shah, P.; Grisshammer, R. Nat Commun 2015, 6, 7895 (PMID: 26205105)

26.) Nociceptin receptor (n = 3)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
5DHH	Homo sapiens (Human) (P41146)	The crystal structure of nociceptin/orphanin fq peptide receptor (nop) in complex with sb-612111 (psi community target)	X-Ray Diffraction	3.0	2015-10-21	Miller, R.L.; Thompson, A.A.; Trapella, C.; Guerrini, R.; Malfacini, D.; Patel, N.; Han, G.W.; Cherezov, V.; Calo, G.; Katritch, V.; Stevens, R.C. Structure 2015, 23, 2291 (PMID: 26526853)
5DHG	Homo sapiens (Human) (P41146)	The crystal structure of nociceptin/orphanin fq peptide receptor (nop) in complex with c-35 (psi community target)	X-Ray Diffraction	3.0	2015-10-21	Miller, R.L.; Thompson, A.A.; Trapella, C.; Guerrini, R.; Malfacini, D.; Patel, N.; Han, G.W.; Cherezov, V.; Calo, G.; Katritch, V.; Stevens, R.C. Structure 2015, 23, 2291 (PMID: 26526853)
4EA3	Homo sapiens (Human) (P41146)	Structure of the n/ofq opioid receptor in complex with a peptide mimetic	X-Ray Diffraction	3.01	2012-04-25	Thompson, A.A.; Liu, W.; Chun, E.; Katritch, V.; Wu, H.; Vardy, E.; Huang, X.P.; Trapella, C.; Guerrini, R.; Calo, G.; Roth, B.L.; Cherezov, V.; Stevens, R.C. Nature 2012, 485, 395 (PMID: 22596163)

27.) Orexin receptor type 1 (n = 2)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
4ZJ8	Homo sapiens (Human) (O43613)	Structures of the human ox1 orexin receptor bound to selective and dual antagonists	X-Ray Diffraction	2.75	2016-03-09	Yin, J.; Babaoglu, K.; Brautigam, C.A.; Clark, L.; Shao, Z.; Scheuermann, T.H.; Harrell, C.M.; Gotter, A.L.; Roecker, A.J.; Winrow, C.J.; Renger, J.J.; Coleman, P.J.; Rosenbaum, D.M. Nat Struct Mol Biol 2016, 23, 293 (PMID: 26950369)
4ZJC	Homo sapiens (Human) (O43613)	Structures of the human ox1 orexin receptor bound to selective and dual antagonists	X-Ray Diffraction	2.83	2016-03-09	Yin, J.; Babaoglu, K.; Brautigam, C.A.; Clark, L.; Shao, Z.; Scheuermann, T.H.; Harrell, C.M.; Gotter, A.L.; Roecker, A.J.; Winrow, C.J.; Renger, J.J.; Coleman, P.J.; Rosenbaum, D.M. Nat Struct Mol Biol 2016, 23, 293 (PMID: 26950369)

28.) Orexin receptor type 2 (n = 1)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
4S0V	Homo sapiens (Human) (O43614)	Crystal structure of the human ox2 orexin receptor bound to the insomnia drug suvorexant	X-Ray Diffraction	2.5	2015-01-14	Yin, J.; Mobarec, J.C.; Kolb, P.; Rosenbaum, D.M. Nature 2015, 519, 247 (PMID: 25533960)

29.) P2Y purinoceptor 1 (n = 2)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
4XNW	Homo sapiens (Human) (P47900)	The human p2y1 receptor in complex with mrs2500	X-Ray Diffraction	2.7	2015-04-01	Zhang, D.; Gao, Z.G.; Zhang, K.; Kiselev, E.; Crane, S.; Wang, J.; Paoletta, S.; Yi, C.; Ma, L.; Zhang, W.; Han, G.W.; Liu, H.; Cherezov, V.; Katritch, V.; Jiang, H.; Stevens, R.C.; Jacobson, K.A.; Zhao, Q.; Wu, B. Nature 2015, 520, 317 (PMID: 25822790)
4XNV	Homo sapiens (Human) (P47900)	The human p2y1 receptor in complex with bptu	X-Ray Diffraction	2.2	2015-04-01	Zhang, D.; Gao, Z.G.; Zhang, K.; Kiselev, E.; Crane, S.; Wang, J.; Paoletta, S.; Yi, C.; Ma, L.; Zhang, W.; Han, G.W.; Liu, H.; Cherezov, V.; Katritch, V.; Jiang, H.; Stevens, R.C.; Jacobson, K.A.; Zhao, Q.; Wu, B. Nature 2015, 520, 317 (PMID: 25822790)

30.) P2Y purinoceptor 12 (n = 3)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
4PY0	Homo sapiens (Human) (Q9H244)	Crystal structure of p2y12 receptor in complex with 2mesatp	X-Ray Diffraction	3.1	2014-04-30	Zhang, J.; Zhang, K.; Gao, Z.G.; Paoletta, S.; Zhang, D.; Han, G.W.; Li, T.; Ma, L.; Zhang, W.; Muller, C.E.; Yang, H.; Jiang, H.; Cherezov, V.; Katritch, V.; Jacobson, K.A.; Stevens, R.C.; Wu, B.; Zhao, Q. Nature 2014, 509, 119 (PMID: 24784220)
4PXZ	Homo sapiens (Human) (Q9H244)	Crystal structure of p2y12 receptor in complex with 2mesadp	X-Ray Diffraction	2.5	2014-04-30	Zhang, J.; Zhang, K.; Gao, Z.G.; Paoletta, S.; Zhang, D.; Han, G.W.; Li, T.; Ma, L.; Zhang, W.; Muller, C.E.; Yang, H.; Jiang, H.; Cherezov, V.; Katritch, V.; Jacobson, K.A.; Stevens, R.C.; Wu, B.; Zhao, Q. Nature 2014, 509, 119 (PMID: 24784220)
4NTJ	Homo sapiens (Human) (Q9H244)	Structure of the human p2y12 receptor in complex with an antithrombotic drug	X-Ray Diffraction	2.62	2014-03-26	Zhang, K.; Zhang, J.; Gao, Z.-G.; Zhang, D.; Zhu, L.; Han, G.W.; Moss, S.M.; Paoletta, S.; Kiselev, E.; Lu, W.; Fenalti, G.; Zhang, W.; Muller, C.E.; Yang, H.; Jiang, H.; Cherezov, V.; Katritch, V.; Jacobson, K.A.; Stevens, R.C.; Wu, B.; Zhao, Q. Nature 2014, 509, 115 (PMID: 24670650)

31.) Proteinase-activated receptor 1 (n = 1)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
3VW7	Homo sapiens (Human) (P25116)	Crystal structure of human protease-activated receptor 1 (par1) bound with antagonist vorapaxar at 2.2 angstrom	X-Ray Diffraction	2.2	2012-12-12	Zhang, C.; Srinivasan, Y.; Arlow, D.H.; Fung, J.J.; Palmer, D.; Zheng, Y.; Green, H.F.; Pandey, A.; Dror, R.O.; Shaw, D.E.; Weis, W.I.; Coughlin, S.R.; Kobilka, B.K. Nature 2012, 492, 387 (PMID: 23222541)

32.) Proteinase-activated receptor 2 (n = 3)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
5NJ6	Homo sapiens (Human) (P55085)	Crystal structure of a thermostabilised human protease-activated receptor-2 (par2) in ternary complex with fab3949 and az7188 at 4.0 angstrom resolution	X-Ray Diffraction	4.0	2017-05-03	Cheng, R.K.Y.; Fiez-Vandal, C.; Schlenker, O.; Edman, K.; Aggeler, B.; Brown, D.G.; Brown, G.A.; Cooke, R.M.; Dumelin, C.E.; Dore, A.S.; Geschwindner, S.; Grebner, C.; Hermansson, N.O.; Jazayeri, A.; Johansson, P.; Leong, L.; Prihandoko, R.; Rappas, M.; Soutter, H.; Snijder, A.; Sundstrom, L.; Tehan, B.; Thornton, P.; Troast, D.; Wiggin, G.; Zhukov, A.; Marshall, F.H.; Dekker, N. Nature 2017, 545, 112 (PMID: 28445455)
5NDD	Homo sapiens (Human) (P55085)	Crystal structure of a thermostabilised human protease-activated receptor-2 (par2) in complex with az8838 at 2.8 angstrom resolution	X-Ray Diffraction	2.8	2017-05-03	Cheng, R.K.Y.; Fiez-Vandal, C.; Schlenker, O.; Edman, K.; Aggeler, B.; Brown, D.G.; Brown, G.A.; Cooke, R.M.; Dumelin, C.E.; Dore, A.S.; Geschwindner, S.; Grebner, C.; Hermansson, N.O.; Jazayeri, A.; Johansson, P.; Leong, L.; Prihandoko, R.; Rappas, M.; Soutter, H.; Snijder, A.; Sundstrom, L.; Tehan, B.; Thornton, P.; Troast, D.; Wiggin, G.; Zhukov, A.; Marshall, F.H.; Dekker, N. Nature 2017, 545, 112 (PMID: 28445455)
5NDZ	Homo sapiens (Human) (P55085)	Crystal structure of a thermostabilised human protease-activated receptor-2 (par2) in complex with az3451 at 3.6 angstrom resolution	X-Ray Diffraction	3.6	2017-05-03	Cheng, R.K.Y.; Fiez-Vandal, C.; Schlenker, O.; Edman, K.; Aggeler, B.; Brown, D.G.; Brown, G.A.; Cooke, R.M.; Dumelin, C.E.; Dore, A.S.; Geschwindner, S.; Grebner, C.; Hermansson, N.O.; Jazayeri, A.; Johansson, P.; Leong, L.; Prihandoko, R.; Rappas, M.; Soutter, H.; Snijder, A.; Sundstrom, L.; Tehan, B.; Thornton, P.; Troast, D.; Wiggin, G.; Zhukov, A.; Marshall, F.H.; Dekker, N. Nature 2017, 545, 112 (PMID: 28445455)

33.) Rhodopsin (n = 39)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
4PXF	Bos taurus (Bovine) (P02699)	Crystal structure of the active g-protein-coupled receptor opsin in complex with the finger-loop peptide derived from the full-length arrestin-1	X-Ray Diffraction	2.75	2014-09-17	Szczepek, M.; Beyriere, F.; Hofmann, K.P.; Elgeti, M.; Kazmin, R.; Rose, A.; Bartl, F.J.; Vonstetten, D.; Heck, M.; Sommer, M.E.; Hildebrand, P.W.; Scheerer, P. Nat Commun 2014, 5, 4801 (PMID: 25205354)
1U19	Bos taurus (Bovine) (P02699)	Crystal structure of bovine rhodopsin at 2.2 angstroms resolution	X-Ray Diffraction	2.2	2004-10-12	Okada, T.; Sugihara, M.; Bondar, A.N.; Elstner, M.; Entel, P.; Buss, V. J Mol Biol 2004, 342, 571 (PMID: 15327956)
1HZX	Bos taurus (Bovine) (P02699)	Crystal structure of bovine rhodopsin	X-Ray Diffraction	2.8	2001-07-04	Teller, D.C.; Okada, T.; Behnke, C.A.; Palczewski, K.; Stenkamp, R.E. Biochemistry 2001, 40, 7761 (PMID: 11425302)
3PQR	Bos taurus (Bovine) (P02699)	Crystal structure of metarhodopsin ii in complex with a c-terminal peptide derived from the galpha subunit of transducin	X-Ray Diffraction	2.85	2011-03-09	Choe, H.W.; Kim, Y.J.; Park, J.H.; Morizumi, T.; Pai, E.F.; Krauss, N.; Hofmann, K.P.; Scheerer, P.; Ernst, O.P. Nature 2011, 471, 651 (PMID: 21389988)
3C9L	Bos taurus (Bovine) (P02699)	Structure of ground-state bovine rhodospin in a hexagonal crystal form	X-Ray Diffraction	2.65	2008-08-05	Stenkamp, R.E. Acta Crystallogr, Sect D 2008, 64, 902 (PMID: 18645239)
2PED	Bos taurus (Bovine) (P02699)	Crystallographic model of 9-cis-rhodopsin	X-Ray Diffraction	2.95	2007-10-30	Nakamichi, H.; Buss, V.; Okada, T. Biophys J 2007, 92, L106 (PMID: 17449675)
1JFP	Bos taurus (Bovine) (P02699)	Structure of bovine rhodopsin (dark adapted)	Solution NMR	N/A	2001-10-05	Yeagle, P.L.; Choi, G.; Albert, A.D. Biochemistry 2001, 40, 11932 (PMID: 11570894)
1L9H	Bos taurus (Bovine) (P02699)	Crystal structure of bovine rhodopsin at 2.6 angstroms resolution	X-Ray Diffraction	2.6	2002-05-15	Okada, T.; Fujiyoshi, Y.; Silow, M.; Navarro, J.; Landau, E.M.; Shichida, Y. Proc Natl Acad Sci USA 2002, 99, 5982 (PMID: 11972040)
2I36	Bos taurus (Bovine) (P02699)	Crystal structure of trigonal crystal form of ground-state rhodopsin	X-Ray Diffraction	4.1	2006-10-17	Salom, D.; Lodowski, D.T.; Stenkamp, R.E.; Trong, I.L.; Golczak, M.; Jastrzebska, B.; Harris, T.; Ballesteros, J.A.; Palczewski, K. Proc Natl Acad Sci USA 2006, 103, 16123 (PMID: 17060607)
5TE3	Bos taurus (Bovine) (P02699)	Crystal structure of bos taurus opsin at 2.7 angstrom	X-Ray Diffraction	2.7	2017-03-15	Gulati, S.; Jastrzebska, B.; Banerjee, S.; Placeres, A.L.; Miszta, P.; Gao, S.; Gunderson, K.; Tochtrop, G.P.; Filipek, S.; Katayama, K.; Kiser, P.D.; Mogi, M.; Stewart, P.L.; Palczewski, K. Proc Natl Acad Sci U S A 2017, 114, E2608 (PMID: 28289214)
2X72	Bos taurus (Bovine) (P02699)	Crystal structure of the constitutively active e113q,n2c, d282c rhodopsin mutant with bound galphact peptide.	X-Ray Diffraction	3.0	2011-03-16	Standfuss, J.; Edwards, P.C.; Dantona, A.; Fransen, M.; Xie, G.; Oprian, D.D.; Schertler, G.F.X. Nature 2011, 471, 656 (PMID: 21389983)
1GZM	Bos taurus (Bovine) (P02699)	Structure of bovine rhodopsin in a trigonal crystal form	X-Ray Diffraction	2.65	2003-11-20	Li, J.; Edwards, P.; Burghammer, M.; Villa, C.; Schertler, G.F.X. J Mol Biol 2004, 343, 1409 (PMID: 15491621)
2HPY	Bos taurus (Bovine) (P02699)	Crystallographic model of lumirhodopsin	X-Ray Diffraction	2.8	2006-08-22	Nakamichi, H.; Okada, T. Proc Natl Acad Sci USA 2006, 103, 12729 (PMID: 16908857)
3CAP	Bos taurus (Bovine) (P02699)	Crystal structure of native opsin: the g protein-coupled receptor rhodopsin in its ligand-free state	X-Ray Diffraction	2.9	2008-06-24	Park, J.H.; Scheerer, P.; Hofmann, K.P.; Choe, H.-W.; Ernst, O.P. Nature 2008, 454, 183 (PMID: 18563085)
3OAX	Bos taurus (Bovine) (P02699)	Crystal structure of bovine rhodopsin with beta-ionone	X-Ray Diffraction	2.6	2011-01-19	Makino, C.L.; Riley, C.K.; Looney, J.; Crouch, R.K.; Okada, T. Biophys J 2010, 99, 2366 (PMID: 20923672)
5TE5	Bos taurus (Bovine) (P02699)	Crystal structure of bos taurus opsin regenerated with 6-carbon ring retinal chromophore	X-Ray Diffraction	4.01	2017-03-15	Gulati, S.; Jastrzebska, B.; Banerjee, S.; Placeres, A.L.; Miszta, P.; Gao, S.; Gunderson, K.; Tochtrop, G.P.; Filipek, S.; Katayama, K.; Kiser, P.D.; Mogi, M.; Stewart, P.L.; Palczewski, K. Proc Natl Acad Sci U S A 2017, 114, E2608 (PMID: 28289214)
2J4Y	Bos taurus (Bovine) (P02699)	Crystal structure of a rhodopsin stabilizing mutant expressed in mammalian cells	X-Ray Diffraction	3.4	2007-09-25	Standfuss, J.; Xie, G.; Edwards, P.C.; Burghammer, M.; Oprian, D.D.; Schertler, G.F.X. J Mol Biol 2007, 372, 1179 (PMID: 17825322)
3DQB	Bos taurus (Bovine) (P02699)	Crystal structure of the active g-protein-coupled receptor opsin in complex with a c-terminal peptide derived from the galpha subunit of transducin	X-Ray Diffraction	3.2	2008-09-23	Scheerer, P.; Park, J.H.; Hildebrand, P.W.; Kim, Y.J.; Krauss, N.; Choe, H.-W.; Hofmann, K.P.; Ernst, O.P. Nature 2008, 455, 497 (PMID: 18818650)
4BEY	Bos taurus (Bovine) (P02699)	Night blindness causing g90d rhodopsin in complex with gact2 peptide	X-Ray Diffraction	2.9	2013-05-08	Singhal, A.; Ostermaier, M.K.; Vishnivetskiy, S.A.; Panneels, V.; Homan, K.T.; Tesmer, J.J.; Veprintsev, D.; Deupi, X.; Gurevich, V.V.; Schertler, G.F.; Standfuss, J. EMBO Rep 2013, 14, 520 (PMID: 23579341)
5DYS	Bos taurus (Bovine) (P02699)	Crystal structure of t94i rhodopsin mutant	X-Ray Diffraction	2.3	2016-08-10	Singhal, A.; Guo, Y.; Matkovic, M.; Schertler, G.; Deupi, X.; Yan, E.C.; Standfuss, J. EMBO Rep 2016, 17, 1431 (PMID: 27458239)
5EN0	Bos taurus (Bovine) (P02699)	Crystal structure of t94i rhodopsin mutant	X-Ray Diffraction	2.81	2016-08-10	Singhal, A.; Guo, Y.; Matkovic, M.; Schertler, G.; Deupi, X.; Yan, E.C.; Standfuss, J. EMBO Rep 2016, 17, 1431 (PMID: 27458239)
2I35	Bos taurus (Bovine) (P02699)	Crystal structure of rhombohedral crystal form of ground-state rhodopsin	X-Ray Diffraction	3.8	2006-10-17	Salom, D.; Lodowski, D.T.; Stenkamp, R.E.; Trong, I.L.; Golczak, M.; Jastrzebska, B.; Harris, T.; Ballesteros, J.A.; Palczewski, K. Proc Natl Acad Sci USA 2006, 103, 16123 (PMID: 17060607)
3C9M	Bos taurus (Bovine) (P02699)	Structure of a mutant bovine rhodopsin in hexagonal crystal form	X-Ray Diffraction	3.4	2008-08-05	Stenkamp, R.E. Acta Crystallogr, Sect D 2008, 64, 902 (PMID: 18645239)
4J4Q	Bos taurus (Bovine) (P02699)	Crystal structure of active conformation of gpcr opsin stabilized by octylglucoside	X-Ray Diffraction	2.65	2013-10-30	Park, J.H.; Morizumi, T.; Li, Y.; Hong, J.E.; Pai, E.F.; Hofmann, K.P.; Choe, H.W.; Ernst, O.P. Angew Chem Int Ed Engl 2013, 52, 11021 (PMID: 24038729)
1LN6	Bos taurus (Bovine) (P02699)	Structure of bovine rhodopsin (metarhodopsin ii)	Solution NMR	N/A	2002-07-10	Choi, G.; Landin, J.; Galan, J.F.; Birge, R.R.; Albert, A.D.; Yeagle, P.L. Biochemistry 2002, 41, 7318 (PMID: 12044163)
1F88	Bos taurus (Bovine) (P02699)	Crystal structure of bovine rhodopsin	X-Ray Diffraction	2.8	2000-08-04	Palczewski, K.; Kumasaka, T.; Hori, T.; Behnke, C.A.; Motoshima, H.; Fox, B.A.; Letrong, I.; Teller, D.C.; Okada, T.; Stenkamp, R.E.; Yamamoto, M.; Miyano, M. Science 2000, 289, 739 (PMID: 10926528)
4BEZ	Bos taurus (Bovine) (P02699)	Night blindness causing g90d rhodopsin in the active conformation	X-Ray Diffraction	3.3	2013-04-24	Singhal, A.; Ostermaier, M.K.; Vishnivetskiy, S.A.; Panneels, V.; Homan, K.T.; Tesmer, J.J.; Veprintsev, D.; Deupi, X.; Gurevich, V.V.; Schertler, G.F.; Standfuss, J. EMBO Rep 2013, 14, 520 (PMID: 23579341)
2I37	Bos taurus (Bovine) (P02699)	Crystal structure of a photoactivated rhodopsin	X-Ray Diffraction	4.15	2006-10-17	Salom, D.; Lodowski, D.T.; Stenkamp, R.E.; Trong, I.L.; Golczak, M.; Jastrzebska, B.; Harris, T.; Ballesteros, J.A.; Palczewski, K. Proc Natl Acad Sci USA 2006, 103, 16123 (PMID: 17060607)
2G87	Bos taurus (Bovine) (P02699)	Crystallographic model of bathorhodopsin	X-Ray Diffraction	2.6	2006-09-02	Nakamichi, H.; Okada, T. Angew Chem Int Ed Engl 2006, 45, 4270 (PMID: 16586416)
4A4M	Bos taurus (Bovine) (P02699)	Crystal structure of the light-activated constitutively active n2c,m257y,d282c rhodopsin mutant in complex with a peptide resembling the c-terminus of the galpha-protein subunit (gact)	X-Ray Diffraction	3.3	2012-01-25	Deupi, X.; Edwards, P.; Singhal, A.; Nickle, B.; Oprian, D.; Schertler, G.; Standfuss, J. Proc Natl Acad Sci USA 2012, 109, 119 (PMID: 22198838)
4X1H	Bos taurus (Bovine) (P02699)	Opsin/g(alpha) peptide complex stabilized by nonyl-glucoside	X-Ray Diffraction	2.29	2015-11-04	Blankenship, E.; Vahedi-Faridi, A.; Lodowski, D.T. Structure 2015, 23, 2358 (PMID: 26526852)
3PXO	Bos taurus (Bovine) (P02699)	Crystal structure of metarhodopsin ii	X-Ray Diffraction	3.0	2011-03-09	Choe, H.W.; Kim, Y.J.; Park, J.H.; Morizumi, T.; Pai, E.F.; Krauss, N.; Hofmann, K.P.; Scheerer, P.; Ernst, O.P. Nature 2011, 471, 651 (PMID: 21389988)
3AYM	Todarodes pacificus (Japanese flying squid) (P31356)	Crystal structure of the batho intermediate of squid rhodopsin	X-Ray Diffraction	2.8	2011-08-17	Murakami, M.; Kouyama, T. J Mol Biol 2011, 413, 615 (PMID: 21906602)
2ZIY	Todarodes pacificus (Japanese flying squid) (P31356)	Crystal structure of squid rhodopsin	X-Ray Diffraction	3.7	2008-05-06	Shimamura, T.; Hiraki, K.; Takahashi, N.; Hori, T.; Ago, H.; Masuda, K.; Takio, K.; Ishiguro, M.; Miyano, M. J Biol Chem 2008, 283, 17753 (PMID: 18463093)
4WW3	Todarodes pacificus (Japanese flying squid) (P31356)	Crystal structure of the lumi intermediate of squid rhodopsin	X-Ray Diffraction	2.8	2015-06-17	Murakami, M.; Kouyama, T. PLoS One 2015, 10, 26970 (PMID: 26024518)
2Z73	Todarodes pacificus (Japanese flying squid) (P31356)	Crystal structure of squid rhodopsin	X-Ray Diffraction	2.5	2008-05-13	Murakami, M.; Kouyama, T. Nature 2008, 453, 363 (PMID: 18480818)
3AYN	Todarodes pacificus (Japanese flying squid) (P31356)	Crystal structure of squid isorhodopsin	X-Ray Diffraction	2.7	2011-08-17	Murakami, M.; Kouyama, T. J Mol Biol 2011, 413, 615 (PMID: 21906602)
5DGY	Homo sapiens (Human) (P08100)	Crystal structure of rhodopsin bound to visual arrestin	X-Ray Diffraction	7.7	2016-03-23	Zhou, X.E.; Gao, X.; Barty, A.; Kang, Y.; He, Y.; Liu, W.; Ishchenko, A.; White, T.A.; Yefanov, O.; Han, G.W.; Xu, Q.; Dewaal, P.W.; Suino-Powell, K.M.; Boutet, S.; Williams, G.J.; Wang, M.; Li, D.; Caffrey, M.; Chapman, H.N.; Spence, J.C.; Fromme, P.; Weierstall, U.; Stevens, R.C.; Cherezov, V.; Melcher, K.; Xu, H.E. Sci Data 2016, 3, 60021 (PMID: 27070998)
4ZWJ	Homo sapiens (Human) (P08100)	Crystal structure of rhodopsin bound to arrestin by femtosecond x-ray laser	X-Ray Diffraction	3.3	2015-07-29	Kang, Y.; Zhou, X.E.; Gao, X.; He, Y.; Liu, W.; Ishchenko, A.; Barty, A.; White, T.A.; Yefanov, O.; Han, G.W.; Xu, Q.; Dewaal, P.W.; Ke, J.; Tan, M.H.; Zhang, C.; Moeller, A.; West, G.M.; Pascal, B.D.; Vaneps, N.; Caro, L.N.; Vishnivetskiy, S.A.; Lee, R.J.; Suino-Powell, K.M.; Gu, X.; Pal, K.; Ma, J.; Zhi, X.; Boutet, S.; Williams, G.J.; Messerschmidt, M.; Gati, C.; Zatsepin, N.A.; Wang, D.; James, D.; Basu, S.; Roy-Chowdhury, S.; Conrad, C.E.; Coe, J.; Liu, H.; Lisova, S.; Kupitz, C.; Grotjohann, I.; Fromme, R.; Jiang, Y.; Tan, M.; Yang, H.; Li, J.; Wang, M.; Zheng, Z.; Li, D.; Howe, N.; Zhao, Y.; Standfuss, J.; Diederichs, K.; Dong, Y.; Potter, C.S.; Carragher, B.; Caffrey, M.; Jiang, H.; Chapman, H.N.; Spence, J.C.; Fromme, P.; Weierstall, U.; Ernst, O.P.; Katritch, V.; Gurevich, V.V.; Griffin, P.R.; Hubbell, W.L.; Stevens, R.C.; Cherezov, V.; Melcher, K.; Xu, H.E. Nature 2015, 523, 561 (PMID: 26200343)

34.) Sphingosine 1-phosphate receptor 1 (n = 2)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
3V2W	Homo sapiens (Human) (P21453)	Crystal structure of a lipid g protein-coupled receptor at 3.35a	X-Ray Diffraction	3.35	2012-02-15	Hanson, M.A.; Roth, C.B.; Jo, E.; Griffith, M.T.; Scott, F.L.; Reinhart, G.; Desale, H.; Clemons, B.; Cahalan, S.M.; Schuerer, S.C.; Sanna, M.G.; Han, G.W.; Kuhn, P.; Rosen, H.; Stevens, R.C. Science 2012, 335, 851 (PMID: 22344443)
3V2Y	Homo sapiens (Human) (P21453)	Crystal structure of a lipid g protein-coupled receptor at 2.80a	X-Ray Diffraction	2.8	2012-02-15	Hanson, M.A.; Roth, C.B.; Jo, E.; Griffith, M.T.; Scott, F.L.; Reinhart, G.; Desale, H.; Clemons, B.; Cahalan, S.M.; Schuerer, S.C.; Sanna, M.G.; Han, G.W.; Kuhn, P.; Rosen, H.; Stevens, R.C. Science 2012, 335, 851 (PMID: 22344443)

35.) Substance-P receptor (n = 3)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
2KS9	Homo sapiens (Human) (P25103)	Solution conformation of substance p in water complexed with nk1r	Solution NMR	N/A	2010-11-03	Gayen, A.; Goswami, S.K.; Mukhopadhyay, C. Biochim Biophys Acta 2010 (PMID: 20937248)
2KSA	Homo sapiens (Human) (P25103)	Substance p in dmpc/chaps isotropic q=0.25 bicelles as a ligand for nk1r	Solution NMR	N/A	2010-11-03	Gayen, A.; Goswami, S.K.; Mukhopadhyay, C. Biochim Biophys Acta 2010 (PMID: 20937248)
2KSB	Homo sapiens (Human) (P25103)	Substance p in isotropic q=0.25 dmpc/chaps/gm1 bicelles as a ligand for nk1r	Solution NMR	N/A	2010-11-03	Gayen, A.; Goswami, S.K.; Mukhopadhyay, C. Biochim Biophys Acta 2010 (PMID: 20937248)

36.) Type-1 angiotensin II receptor (n = 2)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
4ZUD	Homo sapiens (Human) (P30556)	Crystal structure of human angiotensin receptor in complex with inverse agonist olmesartan at 2.8a resolution.	X-Ray Diffraction	2.8	2015-10-07	Zhang, H.; Unal, H.; Desnoyer, R.; Han, G.W.; Patel, N.; Katritch, V.; Karnik, S.S.; Cherezov, V.; Stevens, R.C. J Biol Chem 2015, 290, 29127 (PMID: 26420482)
4YAY	Homo sapiens (Human) (P30556)	Xfel structure of human angiotensin receptor	X-Ray Diffraction	2.9	2015-04-22	Zhang, H.; Unal, H.; Gati, C.; Han, G.W.; Liu, W.; Zatsepin, N.A.; James, D.; Wang, D.; Nelson, G.; Weierstall, U.; Sawaya, M.R.; Xu, Q.; Messerschmidt, M.; Williams, G.J.; Boutet, S.; Yefanov, O.M.; White, T.A.; Wang, C.; Ishchenko, A.; Tirupula, K.C.; Desnoyer, R.; Coe, J.; Conrad, C.E.; Fromme, P.; Stevens, R.C.; Katritch, V.; Karnik, S.S.; Cherezov, V. Cell 2015, 161, 833 (PMID: 25913193)

37.) Type-2 angiotensin II receptor (n = 3)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
5UNH	Homo sapiens (Human) (P50052)	Synchrotron structure of human angiotensin ii type 2 receptor in complex with compound 2 (n-[(furan-2-yl)methyl]-n-(4-oxo-2-propyl-3-{[2'-(2h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-3,4-dihydroquinazolin-6-yl)benzamide)	X-Ray Diffraction	2.9	2017-04-05	Zhang, H.; Han, G.W.; Batyuk, A.; Ishchenko, A.; White, K.L.; Patel, N.; Sadybekov, A.; Zamlynny, B.; Rudd, M.T.; Hollenstein, K.; Tolstikova, A.; White, T.A.; Hunter, M.S.; Weierstall, U.; Liu, W.; Babaoglu, K.; Moore, E.L.; Katz, R.D.; Shipman, J.M.; Garcia-Calvo, M.; Sharma, S.; Sheth, P.; Soisson, S.M.; Stevens, R.C.; Katritch, V.; Cherezov, V. Nature 2017, 544, 327 (PMID: 28379944)
5UNF	Homo sapiens (Human) (P50052)	Xfel structure of human angiotensin ii type 2 receptor (monoclinic form) in complex with compound 1 (n-benzyl-n-(2-ethyl-4-oxo-3-{[2'-(2h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl])	X-Ray Diffraction	2.8	2017-04-05	Zhang, H.; Han, G.W.; Batyuk, A.; Ishchenko, A.; White, K.L.; Patel, N.; Sadybekov, A.; Zamlynny, B.; Rudd, M.T.; Hollenstein, K.; Tolstikova, A.; White, T.A.; Hunter, M.S.; Weierstall, U.; Liu, W.; Babaoglu, K.; Moore, E.L.; Katz, R.D.; Shipman, J.M.; Garcia-Calvo, M.; Sharma, S.; Sheth, P.; Soisson, S.M.; Stevens, R.C.; Katritch, V.; Cherezov, V. Nature 2017, 544, 327 (PMID: 28379944)
5UNG	Homo sapiens (Human) (P50052)	Xfel structure of human angiotensin ii type 2 receptor (orthorhombic form) in complex with compound 1 (n-benzyl-n-(2-ethyl-4-oxo-3-{[2'-(2h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl] methyl}-3,4-dihydroquinazolin-6-yl)thiophene-2-carboxamide)	X-Ray Diffraction	2.8	2017-04-05	Zhang, H.; Han, G.W.; Batyuk, A.; Ishchenko, A.; White, K.L.; Patel, N.; Sadybekov, A.; Zamlynny, B.; Rudd, M.T.; Hollenstein, K.; Tolstikova, A.; White, T.A.; Hunter, M.S.; Weierstall, U.; Liu, W.; Babaoglu, K.; Moore, E.L.; Katz, R.D.; Shipman, J.M.; Garcia-Calvo, M.; Sharma, S.; Sheth, P.; Soisson, S.M.; Stevens, R.C.; Katritch, V.; Cherezov, V. Nature 2017, 544, 327 (PMID: 28379944)

Class B

38.) Calcitonin receptor (n = 1)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
5UZ7	Homo sapiens (Human) (P30988)	Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric gs protein complex	Electron Microscopy	4.1	2017-05-03	Liang, Y.L.; Khoshouei, M.; Radjainia, M.; Zhang, Y.; Glukhova, A.; Tarrasch, J.; Thal, D.M.; Furness, S.G.B.; Christopoulos, G.; Coudrat, T.; Danev, R.; Baumeister, W.; Miller, L.J.; Christopoulos, A.; Kobilka, B.K.; Wootten, D.; Skiniotis, G.; Sexton, P.M. Nature 2017 (PMID: 28437792)

39.) Corticotropin-releasing factor receptor 1 (n = 2)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
4K5Y	Homo sapiens (Human) (P34998)	Crystal structure of human corticotropin-releasing factor receptor 1 (crf1r) in complex with the antagonist cp-376395	X-Ray Diffraction	2.98	2013-07-17	Hollenstein, K.; Kean, J.; Bortolato, A.; Cheng, R.K.; Dore, A.S.; Jazayeri, A.; Cooke, R.M.; Weir, M.; Marshall, F.H. Nature 2013, 499, 438 (PMID: 23863939)
4Z9G	Homo sapiens (Human) (P34998)	Crystal structure of human corticotropin-releasing factor receptor 1 (crf1r) in complex with the antagonist cp-376395 in a hexagonal setting with translational non-crystallographic symmetry	X-Ray Diffraction	3.18	2016-06-29	Dore, A.S.; Bortolato, A.; Hollenstein, K.; Cheng, R.K.Y.; Read, R.J.; Marshall, F.H. To Be Published (PMID: N/A)

40.) Glucagon receptor (n = 2)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
5EE7	Homo sapiens (Human) (P47871)	Crystal structure of the human glucagon receptor (gcgr) in complex with the antagonist mk-0893	X-Ray Diffraction	2.5	2016-04-20	Jazayeri, A.; Dore, A.S.; Lamb, D.; Krishnamurthy, H.; Southall, S.M.; Baig, A.H.; Bortolato, A.; Koglin, M.; Robertson, N.J.; Errey, J.C.; Andrews, S.P.; Teobald, I.; Brown, A.J.; Cooke, R.M.; Weir, M.; Marshall, F.H. Nature 2016, 533, 274 (PMID: 27111510)
4L6R	Homo sapiens (Human) (P47871)	Structure of the class b human glucagon g protein coupled receptor	X-Ray Diffraction	3.3	2013-07-24	Siu, F.Y.; He, M.; Degraaf, C.; Han, G.W.; Yang, D.; Zhang, Z.; Zhou, C.; Xu, Q.; Wacker, D.; Joseph, J.S.; Liu, W.; Lau, J.; Cherezov, V.; Katritch, V.; Wang, M.W.; Stevens, R.C. Nature 2013, 499, 444 (PMID: 23863937)

41.) Glucagon-like peptide 1 receptor (n = 1)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
5VEX	Homo sapiens (Human) (P43220)	Structure of the human glp-1 receptor complex with nnc0640	X-Ray Diffraction	3.0	2017-05-17	Song, G.; Yang, D.; Wang, Y.; Degraaf, C.; Zhou, Q.; Jiang, S.; Liu, K.; Cai, X.; Dai, A.; Lin, G.; Liu, D.; Wu, F.; Wu, Y.; Zhao, S.; Ye, L.; Han, G.W.; Lau, J.; Wu, B.; Hanson, M.A.; Liu, Z.-J.; Wang, M.-W.; Stevens, R.C. Nature 2017 (PMID: N/A)

Class C

42.) Metabotropic glutamate receptor 1 (n = 1)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
4OR2	Homo sapiens (Human) (Q13255)	Human class c g protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator	X-Ray Diffraction	2.8	2014-03-19	Wu, H.; Wang, C.; Gregory, K.J.; Han, G.W.; Cho, H.P.; Xia, Y.; Niswender, C.M.; Katritch, V.; Meiler, J.; Cherezov, V.; Conn, P.J.; Stevens, R.C. Science 2014, 344, 58 (PMID: 24603153)

43.) Metabotropic glutamate receptor 5 (n = 3)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
5CGD	Homo sapiens (Human) (P41594)	Structure of the human class c gpcr metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile -(htl14242)	X-Ray Diffraction	2.6	2015-08-12	Christopher, J.A.; Aves, S.J.; Bennett, K.A.; Dore, A.S.; Errey, J.C.; Jazayeri, A.; Marshall, F.H.; Okrasa, K.; Serrano-Vega, M.J.; Tehan, B.G.; Wiggin, G.R.; Congreve, M. J Med Chem 2015, 58, 6653 (PMID: 26225459)
4OO9	Homo sapiens (Human) (P41594)	Structure of the human class c gpcr metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator mavoglurant	X-Ray Diffraction	2.6	2014-07-02	Dore, A.S.; Okrasa, K.; Patel, J.C.; Serrano-Vega, M.; Bennett, K.; Cooke, R.M.; Errey, J.C.; Jazayeri, A.; Khan, S.; Tehan, B.; Weir, M.; Wiggin, G.R.; Marshall, F.H. Nature 2014, 511, 557 (PMID: 25042998)
5CGC	Homo sapiens (Human) (P41594)	Structure of the human class c gpcr metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-4-fluoro-5-[6-(1h-pyrazol-1-yl)pyrimidin-4-yl]benzonitrile	X-Ray Diffraction	3.1	2015-08-12	Christopher, J.A.; Aves, S.J.; Bennett, K.A.; Dore, A.S.; Errey, J.C.; Jazayeri, A.; Marshall, F.H.; Okrasa, K.; Serrano-Vega, M.J.; Tehan, B.G.; Wiggin, G.R.; Congreve, M. J Med Chem 2015, 58, 6653 (PMID: 26225459)

Class F

44.) Smoothened homolog (n = 7)

PDB ID	Species (UniProt ID)	Description	Method	Resolution (Å)	Released	Reference
4QIN	Homo sapiens (Human) (Q99835)	Structure of the human smoothened receptor in complex with sag1.5	X-Ray Diffraction	2.6	2014-07-23	Wang, C.; Wu, H.; Evron, T.; Vardy, E.; Han, G.W.; Huang, X.P.; Hufeisen, S.J.; Mangano, T.J.; Urban, D.J.; Katritch, V.; Cherezov, V.; Caron, M.G.; Roth, B.L.; Stevens, R.C. Nat Commun 2014, 5, 4355 (PMID: 25008467)
4O9R	Homo sapiens (Human) (Q99835)	Human smoothened receptor structure in complex with cyclopamine	X-Ray Diffraction	3.2	2014-03-05	Weierstall, U.; James, D.; Wang, C.; White, T.A.; Wang, D.; Liu, W.; Spence, J.C.; Brucedoak, R.; Nelson, G.; Fromme, P.; Fromme, R.; Grotjohann, I.; Kupitz, C.; Zatsepin, N.A.; Liu, H.; Basu, S.; Wacker, D.; Han, G.W.; Katritch, V.; Boutet, S.; Messerschmidt, M.; Williams, G.J.; Koglin, J.E.; Marvinseibert, M.; Klinker, M.; Gati, C.; Shoeman, R.L.; Barty, A.; Chapman, H.N.; Kirian, R.A.; Beyerlein, K.R.; Stevens, R.C.; Li, D.; Shah, S.T.; Howe, N.; Caffrey, M.; Cherezov, V. Nat Commun 2014, 5, 3309 (PMID: 24525480)
4N4W	Homo sapiens (Human) (Q99835)	Structure of the human smoothened receptor in complex with sant-1.	X-Ray Diffraction	2.8	2014-01-22	Wang, C.; Wu, H.; Evron, T.; Vardy, E.; Han, G.W.; Huang, X.P.; Hufeisen, S.J.; Mangano, T.J.; Urban, D.J.; Katritch, V.; Cherezov, V.; Caron, M.G.; Roth, B.L.; Stevens, R.C. Nat Commun 2014, 5, 4355 (PMID: 25008467)
5L7I	Homo sapiens (Human) (Q99835)	Structure of human smoothened in complex with vismodegib	X-Ray Diffraction	3.3	2016-07-20	Byrne, E.F.; Sircar, R.; Miller, P.S.; Hedger, G.; Luchetti, G.; Nachtergaele, S.; Tully, M.D.; Mydock-Mcgrane, L.; Covey, D.F.; Rambo, R.P.; Sansom, M.S.; Newstead, S.; Rohatgi, R.; Siebold, C. Nature 2016, 535, 517 (PMID: 27437577)
4JKV	Homo sapiens (Human) (Q99835)	Structure of the human smoothened 7tm receptor in complex with an antitumor agent	X-Ray Diffraction	2.45	2013-04-24	Wang, C.; Wu, H.; Katritch, V.; Han, G.W.; Huang, X.P.; Liu, W.; Siu, F.Y.; Roth, B.L.; Cherezov, V.; Stevens, R.C. Nature 2013, 497, 338 (PMID: 23636324)
5L7D	Homo sapiens (Human) (Q99835)	Structure of human smoothened in complex with cholesterol	X-Ray Diffraction	3.2	2016-07-20	Byrne, E.F.; Sircar, R.; Miller, P.S.; Hedger, G.; Luchetti, G.; Nachtergaele, S.; Tully, M.D.; Mydock-Mcgrane, L.; Covey, D.F.; Rambo, R.P.; Sansom, M.S.; Newstead, S.; Rohatgi, R.; Siebold, C. Nature 2016, 535, 517 (PMID: 27437577)
4QIM	Homo sapiens (Human) (Q99835)	Structure of the human smoothened receptor in complex with anta xv	X-Ray Diffraction	2.61	2014-07-23	Wang, C.; Wu, H.; Evron, T.; Vardy, E.; Han, G.W.; Huang, X.P.; Hufeisen, S.J.; Mangano, T.J.; Urban, D.J.; Katritch, V.; Cherezov, V.; Caron, M.G.; Roth, B.L.; Stevens, R.C. Nat Commun 2014, 5, 4355 (PMID: 25008467)