Count | |
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GPCRs | 44 |
Structures | 194 |
Species | 7 |
General | Batch PDB Files |
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GPCR-EXP Data | Original PDB |
Detailed Statistics | Single chain, no fusion protein |
GPCR fragments |
W Chan, H Zhang, J Yang, J Brender, J Hur, A Ozgur, Y Zhang. GLASS: a comprehensive database for experimentally-validated GPCR-ligand associations. Bioinformatics, 31: 3035-3042 (2015). [PDF] [Support Information] [Database]
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Homo sapiens (Human) (P28222) | Crystal structure of the chimeric protein of 5-ht1b-bril in complex with dihydroergotamine (psi community target) | X-Ray Diffraction | 2.8 | 2013-03-13 | Wang, C.; Jiang, Y.; Ma, J.; Wu, H.; Wacker, D.; Katritch, V.; Han, G.W.; Liu, W.; Huang, X.P.; Vardy, E.; Mccorvy, J.D.; Gao, X.; Zhou, X.E.; Melcher, K.; Zhang, C.; Bai, F.; Yang, H.; Yang, L.; Jiang, H.; Roth, B.L.; Cherezov, V.; Stevens, R.C.; Xu, H.E. Science 2013, 340, 610 (PMID: 23519210) | |
![]() | Homo sapiens (Human) (P28222) | Crystal structure of the chimeric protein of 5-ht1b-bril in complex with ergotamine (psi community target) | X-Ray Diffraction | 2.7 | 2013-03-13 | Wang, C.; Jiang, Y.; Ma, J.; Wu, H.; Wacker, D.; Katritch, V.; Han, G.W.; Liu, W.; Huang, X.P.; Vardy, E.; Mccorvy, J.D.; Gao, X.; Zhou, X.E.; Melcher, K.; Zhang, C.; Bai, F.; Yang, H.; Yang, L.; Jiang, H.; Roth, B.L.; Cherezov, V.; Stevens, R.C.; Xu, H.E. Science 2013, 340, 610 (PMID: 23519210) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Homo sapiens (Human) (P41595) | Crystal structure of the lsd-bound 5-ht2b receptor | X-Ray Diffraction | 2.9 | 2017-02-01 | Wacker, D.; Wang, S.; Mccorvy, J.D.; Betz, R.M.; Venkatakrishnan, A.J.; Levit, A.; Lansu, K.; Schools, Z.L.; Che, T.; Nichols, D.E.; Shoichet, B.K.; Dror, R.O.; Roth, B.L. Cell 2017, 168, 377 (PMID: 28129538) | |
![]() | Homo sapiens (Human) (P41595) | Crystal structure of the 5-ht2b receptor solved using serial femtosecond crystallography in lipidic cubic phase. | X-Ray Diffraction | 2.8 | 2013-12-18 | Liu, W.; Wacker, D.; Gati, C.; Han, G.W.; James, D.; Wang, D.; Nelson, G.; Weierstall, U.; Katritch, V.; Barty, A.; Zatsepin, N.A.; Li, D.; Messerschmidt, M.; Boutet, S.; Williams, G.J.; Koglin, J.E.; Seibert, M.M.; Wang, C.; Shah, S.T.; Basu, S.; Fromme, R.; Kupitz, C.; Rendek, K.N.; Grotjohann, I.; Fromme, P.; Kirian, R.A.; Beyerlein, K.R.; White, T.A.; Chapman, H.N.; Caffrey, M.; Spence, J.C.; Stevens, R.C.; Cherezov, V. Science 2013, 342, 1521 (PMID: 24357322) | |
![]() | Homo sapiens (Human) (P41595) | Crystal structure of the chimeric protein of 5-ht2b-bril in complex with ergotamine | X-Ray Diffraction | 2.7 | 2013-03-13 | Wacker, D.; Wang, C.; Katritch, V.; Han, G.W.; Huang, X.P.; Vardy, E.; Mccorvy, J.D.; Jiang, Y.; Chu, M.; Siu, F.Y.; Liu, W.; Xu, H.E.; Cherezov, V.; Roth, B.L.; Stevens, R.C. Science 2013, 340, 615 (PMID: 23519215) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
---|---|---|---|---|---|---|---|
![]() | Homo sapiens (Human) (P30542) | Crystal structure of the human adenosine a1 receptor a1ar-bril in complex with the covalent antagonist du172 at 3.2a resolution | X-Ray Diffraction | 3.2 | 2017-03-01 | Glukhova, A.; Thal, D.M.; Nguyen, A.T.; Vecchio, E.A.; Jorg, M.; Scammells, P.J.; May, L.T.; Sexton, P.M.; Christopoulos, A. Cell 2017, 168, 867 (PMID: 28235198) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
---|---|---|---|---|---|---|---|
![]() | Homo sapiens (Human) (P29274) | Thermostabilised adenosine a2a receptor in complex with 4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol | X-Ray Diffraction | 3.34 | 2012-03-21 | Congreve, M.; Andrews, S.P.; Dore, A.S.; Hollenstein, K.; Hurrell, E.; Langmead, C.J.; Mason, J.S.; Ng, I.W.; Tehan, B.; Zhukov, A.; Weir, M.; Marshall, F.H. J Med Chem 2012, 55, 1898 (PMID: 22220592) | |
![]() | Homo sapiens (Human) (P29274) | Thermostabilised adenosine a2a receptor | X-Ray Diffraction | 3.3 | 2011-09-07 | Dore, A.S.; Robertson, N.; Errey, J.C.; Ng, I.; Hollenstein, K.; Tehan, B.; Hurrell, E.; Bennett, K.; Congreve, M.; Magnani, F.; Tate, C.G.; Weir, M.; Marshall, F.H. Structure 2011, 19, 1283 (PMID: 21885291) | |
![]() | Homo sapiens (Human) (P29274) | Crystal structure of the chimeric protein of a2aar-bril in complex with zm241385 at 1.8a resolution | X-Ray Diffraction | 1.8 | 2012-07-25 | Liu, W.; Chun, E.; Thompson, A.A.; Chubukov, P.; Xu, F.; Katritch, V.; Han, G.W.; Roth, C.B.; Heitman, L.H.; Ijzerman, A.P.; Cherezov, V.; Stevens, R.C. Science 2012, 337, 232 (PMID: 22798613) | |
![]() | Homo sapiens (Human) (P29274) | Agonist bound structure of the human adenosine a2a receptor | X-Ray Diffraction | 2.71 | 2011-03-09 | Xu, F.; Wu, H.; Katritch, V.; Han, G.W.; Jacobson, K.A.; Gao, Z.G.; Cherezov, V.; Stevens, R.C. Science 2011, 332, 322 (PMID: 21393508) | |
![]() | Homo sapiens (Human) (P29274) | Crystal structure of stabilized a2a adenosine receptor a2ar-star2-bril in complex with zm241385 at 1.7a resolution | X-Ray Diffraction | 1.72 | 2016-06-29 | Segala, E.; Guo, D.; Cheng, R.K.; Bortolato, A.; Deflorian, F.; Dore, A.S.; Errey, J.C.; Heitman, L.H.; Ijzerman, A.P.; Marshall, F.H.; Cooke, R.M. J Med Chem 2016, 59, 6470 (PMID: 27312113) | |
![]() | Homo sapiens (Human) (P29274) | Thermostabilised adenosine a2a receptor in complex with caffeine | X-Ray Diffraction | 3.6 | 2011-09-07 | Dore, A.S.; Robertson, N.; Errey, J.C.; Ng, I.; Hollenstein, K.; Tehan, B.; Hurrell, E.; Bennett, K.; Congreve, M.; Magnani, F.; Tate, C.G.; Weir, M.; Marshall, F.H. Structure 2011, 19, 1283 (PMID: 21885291) | |
![]() | Homo sapiens (Human) (P29274) | The 2.6 a crystal structure of a human a2a adenosine receptor bound to zm241385. | X-Ray Diffraction | 2.6 | 2008-10-14 | Jaakola, V.P.; Griffith, M.T.; Hanson, M.A.; Cherezov, V.; Chien, E.Y.; Lane, J.R.; Ijzerman, A.P.; Stevens, R.C. Science 2008, 322, 1211 (PMID: 18832607) | |
![]() | Homo sapiens (Human) (P29274) | 1.9a angstrom a2a adenosine receptor structure with mr phasing using xfel data | X-Ray Diffraction | 1.9 | 2016-09-21 | Batyuk, A.; Galli, L.; Ishchenko, A.; Han, G.W.; Gati, C.; Popov, P.A.; Lee, M.Y.; Stauch, B.; White, T.A.; Barty, A.; Aquila, A.; Hunter, M.S.; Liang, M.; Boutet, S.; Pu, M.; Liu, Z.J.; Nelson, G.; James, D.; Li, C.; Zhao, Y.; Spence, J.C.; Liu, W.; Fromme, P.; Katritch, V.; Weierstall, U.; Stevens, R.C.; Cherezov, V. Sci Adv 2016, 2, 00292 (PMID: 27679816) | |
![]() | Homo sapiens (Human) (P29274) | Crystal structure of stabilized a2a adenosine receptor a2ar-star2-bril in complex with compound 12c at 1.9a resolution | X-Ray Diffraction | 1.9 | 2016-06-29 | Segala, E.; Guo, D.; Cheng, R.K.; Bortolato, A.; Deflorian, F.; Dore, A.S.; Errey, J.C.; Heitman, L.H.; Ijzerman, A.P.; Marshall, F.H.; Cooke, R.M. J Med Chem 2016, 59, 6470 (PMID: 27312113) | |
![]() | Homo sapiens (Human) (P29274) | Thermostabilised human a2a receptor with neca bound | X-Ray Diffraction | 2.6 | 2011-05-18 | Lebon, G.; Warne, T.; Edwards, P.C.; Bennett, K.; Langmead, C.J.; Leslie, A.G.W.; Tate, C.G. Nature 2011, 474, 521 (PMID: 21593763) | |
![]() | Homo sapiens (Human) (P29274) | Thermostabilised human a2a receptor with cgs21680 bound | X-Ray Diffraction | 2.6 | 2015-04-08 | Lebon, G.; Edwards, P.C.; Leslie, A.G.W.; Tate, C.G. Mol Pharmacol 2015, 87, 907 (PMID: 25762024) | |
![]() | Homo sapiens (Human) (P29274) | 2.5 angstrom a2a adenosine receptor structure with sulfur sad phasing using xfel data | X-Ray Diffraction | 2.5 | 2016-09-21 | Batyuk, A.; Galli, L.; Ishchenko, A.; Han, G.W.; Gati, C.; Popov, P.A.; Lee, M.Y.; Stauch, B.; White, T.A.; Barty, A.; Aquila, A.; Hunter, M.S.; Liang, M.; Boutet, S.; Pu, M.; Liu, Z.J.; Nelson, G.; James, D.; Li, C.; Zhao, Y.; Spence, J.C.; Liu, W.; Fromme, P.; Katritch, V.; Weierstall, U.; Stevens, R.C.; Cherezov, V. Sci Adv 2016, 2, 00292 (PMID: 27679816) | |
![]() | Homo sapiens (Human) (P29274) | Crystal structure of human adenosine a2a receptor with an allosteric inverse-agonist antibody at 2.7 a resolution | X-Ray Diffraction | 2.7 | 2012-02-01 | Hino, T.; Arakawa, T.; Iwanari, H.; Yurugi-Kobayashi, T.; Ikeda-Suno, C.; Nakada-Nakura, Y.; Kusano-Arai, O.; Weyand, S.; Shimamura, T.; Nomura, N.; Cameron, A.D.; Kobayashi, T.; Hamakubo, T.; Iwata, S.; Murata, T. Nature 2012, 482, 237 (PMID: 22286059) | |
![]() | Homo sapiens (Human) (P29274) | Thermostabilised adenosine a2a receptor in complex with 6-(2,6-dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine | X-Ray Diffraction | 3.27 | 2012-03-21 | Congreve, M.; Andrews, S.P.; Dore, A.S.; Hollenstein, K.; Hurrell, E.; Langmead, C.J.; Mason, J.S.; Ng, I.W.; Tehan, B.; Zhukov, A.; Weir, M.; Marshall, F.H. J Med Chem 2012, 55, 1898 (PMID: 22220592) | |
![]() | Homo sapiens (Human) (P29274) | Crystal structure of stabilized a2a adenosine receptor a2ar-star2-bril in complex with compound 12f at 2.0a resolution | X-Ray Diffraction | 2.0 | 2016-06-29 | Segala, E.; Guo, D.; Cheng, R.K.; Bortolato, A.; Deflorian, F.; Dore, A.S.; Errey, J.C.; Heitman, L.H.; Ijzerman, A.P.; Marshall, F.H.; Cooke, R.M. J Med Chem 2016, 59, 6470 (PMID: 27312113) | |
![]() | Homo sapiens (Human) (P29274) | Thermostabilised human a2a receptor with adenosine bound | X-Ray Diffraction | 3.0 | 2011-05-18 | Lebon, G.; Warne, T.; Edwards, P.C.; Bennett, K.; Langmead, C.J.; Leslie, A.G.W.; Tate, C.G. Nature 2011, 474, 521 (PMID: 21593763) | |
![]() | Homo sapiens (Human) (P29274) | Crystal structure of human adenosine a2a receptor with an allosteric inverse-agonist antibody at 3.1 a resolution | X-Ray Diffraction | 3.1 | 2012-02-01 | Hino, T.; Arakawa, T.; Iwanari, H.; Yurugi-Kobayashi, T.; Ikeda-Suno, C.; Nakada-Nakura, Y.; Kusano-Arai, O.; Weyand, S.; Shimamura, T.; Nomura, N.; Cameron, A.D.; Kobayashi, T.; Hamakubo, T.; Iwata, S.; Murata, T. Nature 2012, 482, 237 (PMID: 22286059) | |
![]() | Homo sapiens (Human) (P29274) | Thermostabilised human a2a receptor with cgs21680 bound | X-Ray Diffraction | 2.6 | 2015-04-08 | Lebon, G.; Edwards, P.C.; Leslie, A.G.W.; Tate, C.G. Mol Pharmacol 2015, 87, 907 (PMID: 25762024) | |
![]() | Homo sapiens (Human) (P29274) | Crystal structure of stabilized a2a adenosine receptor a2ar-star2-bril in complex with compound 12x at 2.1a resolution | X-Ray Diffraction | 2.1 | 2016-06-29 | Segala, E.; Guo, D.; Cheng, R.K.; Bortolato, A.; Deflorian, F.; Dore, A.S.; Errey, J.C.; Heitman, L.H.; Ijzerman, A.P.; Marshall, F.H.; Cooke, R.M. J Med Chem 2016, 59, 6470 (PMID: 27312113) | |
![]() | Homo sapiens (Human) (P29274) | 1.9 angstrom a2a adenosine receptor structure with sulfur sad phasing and phase extension using xfel data | X-Ray Diffraction | 1.9 | 2016-09-21 | Batyuk, A.; Galli, L.; Ishchenko, A.; Han, G.W.; Gati, C.; Popov, P.A.; Lee, M.Y.; Stauch, B.; White, T.A.; Barty, A.; Aquila, A.; Hunter, M.S.; Liang, M.; Boutet, S.; Pu, M.; Liu, Z.J.; Nelson, G.; James, D.; Li, C.; Zhao, Y.; Spence, J.C.; Liu, W.; Fromme, P.; Katritch, V.; Weierstall, U.; Stevens, R.C.; Cherezov, V. Sci Adv 2016, 2, 00292 (PMID: 27679816) | |
![]() | Homo sapiens (Human) (P29274) | Crystal structure of adenosine a2a receptor bound to a novel triazole-carboximidamide antagonist | X-Ray Diffraction | 3.5 | 2017-02-08 | Sun, B.; Bachhawat, P.; Chu, M.L.; Wood, M.; Ceska, T.; Sands, Z.A.; Mercier, J.; Lebon, F.; Kobilka, T.S.; Kobilka, B.K. Proc Natl Acad Sci U S A 2017, 114, 2066 (PMID: 28167788) | |
![]() | Homo sapiens (Human) (P29274) | Thermostabilised adenosine a2a receptor in complex with xac | X-Ray Diffraction | 3.31 | 2011-09-07 | Dore, A.S.; Robertson, N.; Errey, J.C.; Ng, I.; Hollenstein, K.; Tehan, B.; Hurrell, E.; Bennett, K.; Congreve, M.; Magnani, F.; Tate, C.G.; Weir, M.; Marshall, F.H. Structure 2011, 19, 1283 (PMID: 21885291) | |
![]() | Homo sapiens (Human) (P29274) | 2.5 angstrom a2a adenosine receptor structure with mr phasing using xfel data | X-Ray Diffraction | 2.5 | 2016-09-21 | Batyuk, A.; Galli, L.; Ishchenko, A.; Han, G.W.; Gati, C.; Popov, P.A.; Lee, M.Y.; Stauch, B.; White, T.A.; Barty, A.; Aquila, A.; Hunter, M.S.; Liang, M.; Boutet, S.; Pu, M.; Liu, Z.J.; Nelson, G.; James, D.; Li, C.; Zhao, Y.; Spence, J.C.; Liu, W.; Fromme, P.; Katritch, V.; Weierstall, U.; Stevens, R.C.; Cherezov, V. Sci Adv 2016, 2, 00292 (PMID: 27679816) | |
![]() | Homo sapiens (Human) (P29274) | Structure of the adenosine a2a receptor bound to an engineered g protein | X-Ray Diffraction | 3.4 | 2016-08-03 | Carpenter, B.; Nehme, R.; Warne, T.; Leslie, A.G.W.; Tate, C.G. Nature 2016, 536, 104 (PMID: 27462812) | |
![]() | Homo sapiens (Human) (P29274) | Crystal structure of stabilized a2a adenosine receptor a2ar-star2-bril in complex with compound 12b at 2.2a resolution | X-Ray Diffraction | 2.2 | 2016-06-29 | Segala, E.; Guo, D.; Cheng, R.K.; Bortolato, A.; Deflorian, F.; Dore, A.S.; Errey, J.C.; Heitman, L.H.; Ijzerman, A.P.; Marshall, F.H.; Cooke, R.M. J Med Chem 2016, 59, 6470 (PMID: 27312113) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Meleagris gallopavo (Common turkey) (P07700) | Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist bucindolol | X-Ray Diffraction | 3.2 | 2012-05-23 | Warne, T.; Edwards, P.C.; Leslie, A.G.; Tate, C.G. Structure 2012, 20, 841 (PMID: 22579251) | |
![]() | Meleagris gallopavo (Common turkey) (P07700) | Turkey beta1 adrenergic receptor with stabilising mutations and bound antagonist iodocyanopindolol | X-Ray Diffraction | 3.65 | 2011-06-01 | Moukhametzianov, R.; Warne, T.; Edwards, P.C.; Serrano-Vega, M.J.; Leslie, A.G.; Tate, C.G.; Schertler, G.F. Proc Natl Acad Sci USA 2011, 108, 8228 (PMID: 21540331) | |
![]() | Meleagris gallopavo (Common turkey) (P07700) | Thermostabilised turkey beta1 adrenergic receptor with 4-methyl-2-(piperazin-1-yl) quinoline bound | X-Ray Diffraction | 2.7 | 2013-04-03 | Christopher, J.; Brown, J.; Dore, A.; Errey, J.; Koglin, M.; Marshall, F.H.; Myszka, D.; Rich, R.L.; Tate, C.G.; Tehan, B.; Warne, T.; Congreve, M. J Med Chem 2013, 56, 3446 (PMID: 23517028) | |
![]() | Meleagris gallopavo (Common turkey) (P07700) | Ligand occupancy in crystal structure of beta1-adrenergic receptor previously submitted by huang et al | X-Ray Diffraction | 3.35 | 2015-12-23 | Leslie, A.G.W.; Warne, T.; Tate, C.G. Nat Struct Mol Biol 2015, 22, 941 (PMID: 26643842) | |
![]() | Meleagris gallopavo (Common turkey) (P07700) | Oligomeic turkey beta1-adrenergic g protein-coupled receptor | X-Ray Diffraction | 3.5 | 2013-02-27 | Huang, J.; Chen, S.; Zhang, J.J.; Huang, X.Y. Nat Struct Mol Biol 2013, 20, 419 (PMID: 23435379) | |
![]() | Meleagris gallopavo (Common turkey) (P07700) | Turkey beta1 adrenergic receptor with stabilising mutations and bound agonist isoprenaline | X-Ray Diffraction | 2.85 | 2011-01-12 | Warne, A.; Moukhametzianov, R.; Baker, J.G.; Nehme, R.; Edwards, P.C.; Leslie, A.G.W.; Schertler, G.F.X.; Tate, C.G. Nature 2011, 469, 241 (PMID: 21228877) | |
![]() | Meleagris gallopavo (Common turkey) (P07700) | Ultra-thermostable beta1-adrenoceptor with cyanopindolol bound | X-Ray Diffraction | 2.1 | 2014-04-02 | Miller-Gallacher, J.L.; Nehme, R.; Warne, T.; Edwards, P.C.; Schertler, G.F.X.; Leslie, A.G.W.; Tate, C.G. PLoS One 2014, 9, 92727 (PMID: 24663151) | |
![]() | Meleagris gallopavo (Common turkey) (P07700) | Turkey beta1 adrenergic receptor with stabilising mutations and bound antagonist cyanopindolol | X-Ray Diffraction | 3.25 | 2011-06-01 | Moukhametzianov, R.; Warne, T.; Edwards, P.C.; Serrano-Vega, M.J.; Leslie, A.G.; Tate, C.G.; Schertler, G.F. Proc Natl Acad Sci USA 2011, 108, 8228 (PMID: 21540331) | |
![]() | Meleagris gallopavo (Common turkey) (P07700) | Thermostabilised turkey beta1 adrenergic receptor with 4-( piperazin-1-yl)-1h-indole bound (compound 19) | X-Ray Diffraction | 2.8 | 2013-04-03 | Christopher, J.; Brown, J.; Dore, A.; Errey, J.; Koglin, M.; Marshall, F.H.; Myszka, D.; Rich, R.L.; Tate, C.G.; Tehan, B.; Warne, T.; Congreve, M. J Med Chem 2013, 56, 3446 (PMID: 23517028) | |
![]() | Meleagris gallopavo (Common turkey) (P07700) | Turkey beta1 adrenergic receptor with stabilising mutations and bound cyanopindolol | X-Ray Diffraction | 2.7 | 2008-06-24 | Warne, A.; Serrano-Vega, M.J.; Baker, J.G.; Moukhametzianov, R.; Edwards, P.C.; Henderson, R.; Leslie, A.G.W.; Tate, C.G.; Schertler, G.F.X. Nature 2008, 454, 486 (PMID: 18594507) | |
![]() | Meleagris gallopavo (Common turkey) (P07700) | Turkey beta1 adrenergic receptor with stabilising mutations and bound partial agonist salbutamol | X-Ray Diffraction | 3.05 | 2011-01-12 | Warne, A.; Moukhametzianov, R.; Baker, J.G.; Nehme, R.; Edwards, P.C.; Leslie, A.G.W.; Schertler, G.F.X.; Tate, C.G. Nature 2011, 469, 241 (PMID: 21228877) | |
![]() | Meleagris gallopavo (Common turkey) (P07700) | Turkey beta1 adrenergic receptor with stabilising mutations and bound partial agonist dobutamine (crystal dob102) | X-Ray Diffraction | 2.6 | 2011-03-30 | Warne, A.; Moukhametzianov, R.; Baker, J.G.; Nehme, R.; Edwards, P.C.; Leslie, A.G.W.; Schertler, G.F.X.; Tate, C.G. Nature 2011, 469, 241 (PMID: 21228877) | |
![]() | Meleagris gallopavo (Common turkey) (P07700) | Thermostabilised beta1-adrenoceptor with rationally designed inverse agonist 7-methylcyanopindolol bound | X-Ray Diffraction | 2.4 | 2015-09-30 | Sato, T.; Baker, J.; Warne, T.; Brown, G.; Leslie, A.; Congreve, M.; Tate, C. Mol Pharmacol 2015, 88, 1024 (PMID: 26385885) | |
![]() | Meleagris gallopavo (Common turkey) (P07700) | Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist carvedilol | X-Ray Diffraction | 2.3 | 2012-05-23 | Warne, T.; Edwards, P.C.; Leslie, A.G.; Tate, C.G. Structure 2012, 20, 841 (PMID: 22579251) | |
![]() | Meleagris gallopavo (Common turkey) (P07700) | Turkey beta1 adrenergic receptor with stabilising mutations and bound antagonist carazolol | X-Ray Diffraction | 3.0 | 2011-06-01 | Moukhametzianov, R.; Warne, T.; Edwards, P.C.; Serrano-Vega, M.J.; Leslie, A.G.; Tate, C.G.; Schertler, G.F. Proc Natl Acad Sci USA 2011, 108, 8228 (PMID: 21540331) | |
![]() | Meleagris gallopavo (Common turkey) (P07700) | Turkey beta1 adrenergic receptor with stabilising mutations and bound agonist carmoterol | X-Ray Diffraction | 2.6 | 2011-01-12 | Warne, A.; Moukhametzianov, R.; Baker, J.G.; Nehme, R.; Edwards, P.C.; Leslie, A.G.W.; Schertler, G.F.X.; Tate, C.G. Nature 2011, 469, 241 (PMID: 21228877) | |
![]() | Meleagris gallopavo (Common turkey) (P07700) | Turkey beta1 adrenergic receptor with stabilising mutations and bound antagonist cyanopindolol | X-Ray Diffraction | 3.15 | 2011-06-08 | Moukhametzianov, R.; Warne, T.; Edwards, P.C.; Serrano-Vega, M.J.; Leslie, A.G.W.; Tate, C.G.; Schertler, G.F.X. Proc Natl Acad Sci USA 2011, 108, 8228 (PMID: 21540331) | |
![]() | Meleagris gallopavo (Common turkey) (P07700) | Turkey beta1 adrenergic receptor with stabilising mutations and bound partial agonist dobutamine (crystal dob92) | X-Ray Diffraction | 2.5 | 2011-01-12 | Warne, A.; Moukhametzianov, R.; Baker, J.G.; Nehme, R.; Edwards, P.C.; Leslie, A.G.W.; Schertler, G.F.X.; Tate, C.G. Nature 2011, 469, 241 (PMID: 21228877) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
---|---|---|---|---|---|---|---|
![]() | Homo sapiens (Human) (P07550) | Crystal structure of the human beta2 adrenoceptor | X-Ray Diffraction | 3.4 | 2007-11-06 | Rasmussen, S.G.F.; Choi, H.J.; Rosenbaum, D.M.; Kobilka, T.S.; Thian, F.S.; Edwards, P.C.; Burghammer, M.; Ratnala, V.R.; Sanishvili, R.; Fischetti, R.F.; Schertler, G.F.; Weis, W.I.; Kobilka, B.K. Nature 2007, 450, 383 (PMID: 17952055) | |
![]() | Homo sapiens (Human) (P07550) | Structure of beta2 adrenoceptor bound to a covalent agonist and an engineered nanobody | X-Ray Diffraction | 3.3 | 2014-07-23 | Weichert, D.; Kruse, A.C.; Manglik, A.; Hiller, C.; Zhang, C.; Hubner, H.; Kobilka, B.K.; Gmeiner, P. Proc Natl Acad Sci USA 2014, 111, 10744 (PMID: 25006259) | |
![]() | Homo sapiens (Human) (P07550) | In meso x-ray crystallography structure of the beta2-adrenergic receptor at 100 k | X-Ray Diffraction | 3.8 | 2016-01-13 | Huang, C.Y.; Olieric, V.; Ma, P.; Howe, N.; Vogeley, L.; Liu, X.; Warshamanage, R.; Weinert, T.; Panepucci, E.; Kobilka, B.; Diederichs, K.; Wang, M.; Caffrey, M. Acta Crystallogr D Struct Biol 2016, 72, 93 (PMID: 26894538) | |
![]() | Homo sapiens (Human) (P07550) | N-terminal t4 lysozyme fusion facilitates crystallization of a g protein coupled receptor | X-Ray Diffraction | 3.99 | 2012-10-24 | Zou, Y.; Weis, W.I.; Kobilka, B.K. PLoS One 2012, 7, 46039 (PMID: 23056231) | |
![]() | Homo sapiens (Human) (P07550) | Crystal structure of the human beta2 adrenoceptor | X-Ray Diffraction | 3.4 | 2007-11-06 | Rasmussen, S.G.F.; Choi, H.J.; Rosenbaum, D.M.; Kobilka, T.S.; Thian, F.S.; Edwards, P.C.; Burghammer, M.; Ratnala, V.R.; Sanishvili, R.; Fischetti, R.F.; Schertler, G.F.; Weis, W.I.; Kobilka, B.K. Nature 2007, 450, 383 (PMID: 17952055) | |
![]() | Homo sapiens (Human) (P07550) | Crystal structure of a methylated beta2 adrenergic receptor-fab complex | X-Ray Diffraction | 3.4 | 2010-02-16 | Bokoch, M.P.; Zou, Y.; Rasmussen, S.G.; Liu, C.W.; Nygaard, R.; Rosenbaum, D.M.; Fung, J.J.; Choi, H.J.; Thian, F.S.; Kobilka, T.S.; Puglisi, J.D.; Weis, W.I.; Pardo, L.; Prosser, R.S.; Mueller, L.; Kobilka, B.K. Nature 2010, 463, 108 (PMID: 20054398) | |
![]() | Homo sapiens (Human) (P07550) | High resolution crystal structure of human b2-adrenergic g protein-coupled receptor. | X-Ray Diffraction | 2.4 | 2007-10-30 | Cherezov, V.; Rosenbaum, D.M.; Hanson, M.A.; Rasmussen, S.G.; Thian, F.S.; Kobilka, T.S.; Choi, H.J.; Kuhn, P.; Weis, W.I.; Kobilka, B.K.; Stevens, R.C. Science 2007, 318, 1258 (PMID: 17962520) | |
![]() | Homo sapiens (Human) (P07550) | Crystal structure of the human beta2 adrenergic receptor in complex with the inverse agonist ici 118,551 | X-Ray Diffraction | 2.84 | 2010-08-11 | Wacker, D.; Fenalti, G.; Brown, M.A.; Katritch, V.; Abagyan, R.; Cherezov, V.; Stevens, R.C. J Am Chem Soc 2010, 132, 11443 (PMID: 20669948) | |
![]() | Homo sapiens (Human) (P07550) | Irreversible agonist-beta2 adrenoceptor complex | X-Ray Diffraction | 3.5 | 2011-01-12 | Rosenbaum, D.M.; Zhang, C.; Lyons, J.A.; Holl, R.; Aragao, D.; Arlow, D.H.; Rasmussen, S.G.F.; Choi, H.J.; Devree, B.T.; Sunahara, R.K.; Chae, P.S.; Gellman, S.H.; Dror, R.O.; Shaw, D.E.; Weis, W.I.; Caffrey, M.; Gmeiner, P.; Kobilka, B.K. Nature 2011, 469, 236 (PMID: 21228876) | |
![]() | Homo sapiens (Human) (P07550) | Beta2ar-t4l -cim | X-Ray Diffraction | 3.2 | 2016-08-17 | Ma, P.; Caffrey, M. To Be Published (PMID: N/A) | |
![]() | Homo sapiens (Human) (P07550) | In meso in situ serial x-ray crystallography structure of the beta2-adrenergic receptor at 100 k | X-Ray Diffraction | 2.48 | 2016-01-13 | Huang, C.Y.; Olieric, V.; Ma, P.; Howe, N.; Vogeley, L.; Liu, X.; Warshamanage, R.; Weinert, T.; Panepucci, E.; Kobilka, B.; Diederichs, K.; Wang, M.; Caffrey, M. Acta Crystallogr D Struct Biol 2016, 72, 93 (PMID: 26894538) | |
![]() | Homo sapiens (Human) (P07550) | Structure of beta2 adrenoceptor bound to bi167107 and an engineered nanobody | X-Ray Diffraction | 2.79 | 2013-09-25 | Ring, A.M.; Manglik, A.; Kruse, A.C.; Enos, M.D.; Weis, W.I.; Garcia, K.C.; Kobilka, B.K. Nature 2013, 502, 575 (PMID: 24056936) | |
![]() | Homo sapiens (Human) (P07550) | Structure of a nanobody-stabilized active state of the beta2 adrenoceptor | X-Ray Diffraction | 3.5 | 2011-01-19 | Rasmussen, S.G.; Choi, H.J.; Fung, J.J.; Pardon, E.; Casarosa, P.; Chae, P.S.; Devree, B.T.; Rosenbaum, D.M.; Thian, F.S.; Kobilka, T.S.; Schnapp, A.; Konetzki, I.; Sunahara, R.K.; Gellman, S.H.; Pautsch, A.; Steyaert, J.; Weis, W.I.; Kobilka, B.K. Nature 2011, 469, 175 (PMID: 21228869) | |
![]() | Homo sapiens (Human) (P07550) | Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, nb60 | X-Ray Diffraction | 3.2 | 2016-07-13 | Staus, D.P.; Strachan, R.T.; Manglik, A.; Pani, B.; Kahsai, A.W.; Kim, T.H.; Wingler, L.M.; Ahn, S.; Chatterjee, A.; Masoudi, A.; Kruse, A.C.; Pardon, E.; Steyaert, J.; Weis, W.I.; Prosser, R.S.; Kobilka, B.K.; Costa, T.; Lefkowitz, R.J. Nature 2016, 535, 448 (PMID: 27409812) | |
![]() | Homo sapiens (Human) (P07550) | Structure of beta2 adrenoceptor bound to adrenaline and an engineered nanobody | X-Ray Diffraction | 3.2 | 2013-09-25 | Ring, A.M.; Manglik, A.; Kruse, A.C.; Enos, M.D.; Weis, W.I.; Garcia, K.C.; Kobilka, B.K. Nature 2013, 502, 575 (PMID: 24056936) | |
![]() | Homo sapiens (Human) (P07550) | Crystal structure of the beta2 adrenergic receptor-gs protein complex | X-Ray Diffraction | 3.2 | 2011-07-20 | Rasmussen, S.G.; Devree, B.T.; Zou, Y.; Kruse, A.C.; Chung, K.Y.; Kobilka, T.S.; Thian, F.S.; Chae, P.S.; Pardon, E.; Calinski, D.; Mathiesen, J.M.; Shah, S.T.; Lyons, J.A.; Caffrey, M.; Gellman, S.H.; Steyaert, J.; Skiniotis, G.; Weis, W.I.; Sunahara, R.K.; Kobilka, B.K. Nature 2011, 477, 549 (PMID: 21772288) | |
![]() | Homo sapiens (Human) (P07550) | Cholesterol bound form of human beta2 adrenergic receptor. | X-Ray Diffraction | 2.8 | 2008-06-17 | Hanson, M.A.; Cherezov, V.; Griffith, M.T.; Roth, C.B.; Jaakola, V.P.; Chien, E.Y.; Velasquez, J.; Kuhn, P.; Stevens, R.C. Structure 2008, 16, 897 (PMID: 18547522) | |
![]() | Homo sapiens (Human) (P07550) | Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist | X-Ray Diffraction | 2.84 | 2010-08-11 | Wacker, D.; Fenalti, G.; Brown, M.A.; Katritch, V.; Abagyan, R.; Cherezov, V.; Stevens, R.C. J Am Chem Soc 2010, 132, 11443 (PMID: 20669948) | |
![]() | Homo sapiens (Human) (P07550) | Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody | X-Ray Diffraction | 3.1 | 2013-09-25 | Ring, A.M.; Manglik, A.; Kruse, A.C.; Enos, M.D.; Weis, W.I.; Garcia, K.C.; Kobilka, B.K. Nature 2013, 502, 575 (PMID: 24056936) | |
![]() | Homo sapiens (Human) (P07550) | Crystal structure of the human beta2 adrenergic receptor in complex with the neutral antagonist alprenolol | X-Ray Diffraction | 3.16 | 2010-08-11 | Wacker, D.; Fenalti, G.; Brown, M.A.; Katritch, V.; Abagyan, R.; Cherezov, V.; Stevens, R.C. J Am Chem Soc 2010, 132, 11443 (PMID: 20669948) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Homo sapiens (Human) (P41597) | Structure of cc chemokine receptor 2 with orthosteric and allosteric antagonists | X-Ray Diffraction | 2.81 | 2016-12-14 | Zheng, Y.; Qin, L.; Zacarias, N.V.; Devries, H.; Han, G.W.; Gustavsson, M.; Dabros, M.; Zhao, C.; Cherney, R.J.; Carter, P.; Stamos, D.; Abagyan, R.; Cherezov, V.; Stevens, R.C.; Ijzerman, A.P.; Heitman, L.H.; Tebben, A.; Kufareva, I.; Handel, T.M. Nature 2016, 540, 458 (PMID: 27926736) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Homo sapiens (Human) (P51681) | Crystal structure of the ccr5 chemokine receptor | X-Ray Diffraction | 2.71 | 2013-09-11 | Tan, Q.; Zhu, Y.; Li, J.; Chen, Z.; Han, G.W.; Kufareva, I.; Li, T.; Ma, L.; Fenalti, G.; Li, J.; Zhang, W.; Xie, X.; Yang, H.; Jiang, H.; Cherezov, V.; Liu, H.; Stevens, R.C.; Zhao, Q.; Wu, B. Science 2013, 341, 1387 (PMID: 24030490) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Homo sapiens (Human) (P51686) | Crystal structure of the human cc chemokine receptor type 9 (ccr9) in complex with vercirnon | X-Ray Diffraction | 2.8 | 2016-12-07 | Oswald, C.; Rappas, M.; Kean, J.; Dore, A.S.; Errey, J.C.; Bennett, K.; Deflorian, F.; Christopher, J.A.; Jazayeri, A.; Mason, J.S.; Congreve, M.; Cooke, R.M.; Marshall, F.H. Nature 2016, 540, 462 (PMID: 27926729) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Homo sapiens (Human) (P25024) | Structure of human cxcr1 in phospholipid bilayers | Solid-State NMR | N/A | 2012-10-17 | Park, S.H.; Das, B.B.; Casagrande, F.; Tian, Y.; Nothnagel, H.J.; Chu, M.; Kiefer, H.; Maier, K.; Deangelis, A.A.; Marassi, F.M.; Opella, S.J. Nature 2012, 491, 779 (PMID: 23086146) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Homo sapiens (Human) (P61073) | Crystal structure of the cxcr4 chemokine receptor in complex with a small molecule antagonist it1t in p1 spacegroup | X-Ray Diffraction | 3.1 | 2010-10-27 | Wu, B.; Chien, E.Y.; Mol, C.D.; Fenalti, G.; Liu, W.; Katritch, V.; Abagyan, R.; Brooun, A.; Wells, P.; Bi, F.C.; Hamel, D.J.; Kuhn, P.; Handel, T.M.; Cherezov, V.; Stevens, R.C. Science 2010, 330, 1066 (PMID: 20929726) | |
![]() | Homo sapiens (Human) (P61073) | Crystal structure of the cxcr4 chemokine receptor in complex with a small molecule antagonist it1t in i222 spacegroup | X-Ray Diffraction | 3.2 | 2010-10-27 | Wu, B.; Chien, E.Y.; Mol, C.D.; Fenalti, G.; Liu, W.; Katritch, V.; Abagyan, R.; Brooun, A.; Wells, P.; Bi, F.C.; Hamel, D.J.; Kuhn, P.; Handel, T.M.; Cherezov, V.; Stevens, R.C. Science 2010, 330, 1066 (PMID: 20929726) | |
![]() | Homo sapiens (Human) (P61073) | Crystal structure of cxcr4 and viral chemokine antagonist vmip-ii complex (psi community target) | X-Ray Diffraction | 3.1 | 2015-02-11 | Qin, L.; Kufareva, I.; Holden, L.G.; Wang, C.; Zheng, Y.; Zhao, C.; Fenalti, G.; Wu, H.; Han, G.W.; Cherezov, V.; Abagyan, R.; Stevens, R.C.; Handel, T.M. Science 2015, 347, 1117 (PMID: 25612609) | |
![]() | Homo sapiens (Human) (P61073) | Crystal structure of the chemokine cxcr4 receptor in complex with a small molecule antagonist it1t in p1 spacegroup | X-Ray Diffraction | 3.1 | 2010-10-27 | Wu, B.; Chien, E.Y.; Mol, C.D.; Fenalti, G.; Liu, W.; Katritch, V.; Abagyan, R.; Brooun, A.; Wells, P.; Bi, F.C.; Hamel, D.J.; Kuhn, P.; Handel, T.M.; Cherezov, V.; Stevens, R.C. Science 2010, 330, 1066 (PMID: 20929726) | |
![]() | Homo sapiens (Human) (P61073) | The 2.5 a structure of the cxcr4 chemokine receptor in complex with small molecule antagonist it1t | X-Ray Diffraction | 2.5 | 2010-10-27 | Wu, B.; Chien, E.Y.; Mol, C.D.; Fenalti, G.; Liu, W.; Katritch, V.; Abagyan, R.; Brooun, A.; Wells, P.; Bi, F.C.; Hamel, D.J.; Kuhn, P.; Handel, T.M.; Cherezov, V.; Stevens, R.C. Science 2010, 330, 1066 (PMID: 20929726) | |
![]() | Homo sapiens (Human) (P61073) | Crystal structure of the cxcr4 chemokine receptor in complex with a cyclic peptide antagonist cvx15 | X-Ray Diffraction | 2.9 | 2010-10-27 | Wu, B.; Chien, E.Y.; Mol, C.D.; Fenalti, G.; Liu, W.; Katritch, V.; Abagyan, R.; Brooun, A.; Wells, P.; Bi, F.C.; Hamel, D.J.; Kuhn, P.; Handel, T.M.; Cherezov, V.; Stevens, R.C. Science 2010, 330, 1066 (PMID: 20929726) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
---|---|---|---|---|---|---|---|
![]() | Homo sapiens (Human) (P21554) | High-resolution crystal structure of the human cb1 cannabinoid receptor | X-Ray Diffraction | 2.6 | 2016-12-07 | Shao, Z.; Yin, J.; Chapman, K.; Grzemska, M.; Clark, L.; Wang, J.; Rosenbaum, D.M. Nature 2016 (PMID: 27851727) | |
![]() | Homo sapiens (Human) (P21554) | Crystal structure of the human cannabinoid receptor cb1 | X-Ray Diffraction | 2.8 | 2016-11-02 | Hua, T.; Vemuri, K.; Pu, M.; Qu, L.; Han, G.W.; Wu, Y.; Zhao, S.; Shui, W.; Li, S.; Korde, A.; Laprairie, R.B.; Stahl, E.L.; Ho, J.H.; Zvonok, N.; Zhou, H.; Kufareva, I.; Wu, B.; Zhao, Q.; Hanson, M.A.; Bohn, L.M.; Makriyannis, A.; Stevens, R.C.; Liu, Z.J. Cell 2016, 167, 750 (PMID: 27768894) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Homo sapiens (Human) (P35462) | Structure of the human dopamine d3 receptor in complex with eticlopride | X-Ray Diffraction | 2.89 | 2010-11-03 | Chien, E.Y.; Liu, W.; Zhao, Q.; Katritch, V.; Han, G.W.; Hanson, M.A.; Shi, L.; Newman, A.H.; Javitch, J.A.; Cherezov, V.; Stevens, R.C. Science 2010, 330, 1091 (PMID: 21097933) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Mus musculus (Mouse) (P32300) | Structure of the delta opioid receptor bound to naltrindole | X-Ray Diffraction | 3.4 | 2012-05-16 | Granier, S.; Manglik, A.; Kruse, A.C.; Kobilka, T.S.; Thian, F.S.; Weis, W.I.; Kobilka, B.K. Nature 2012, 485, 400 (PMID: 22596164) | |
![]() | Homo sapiens (Human) (P41143) | Xfel structure of the human delta opioid receptor in complex with a bifunctional peptide | X-Ray Diffraction | 2.7 | 2015-01-14 | Fenalti, G.; Zatsepin, N.A.; Betti, C.; Giguere, P.; Han, G.W.; Ishchenko, A.; Liu, W.; Guillemyn, K.; Zhang, H.; James, D.; Wang, D.; Weierstall, U.; Spence, J.C.; Boutet, S.; Messerschmidt, M.; Williams, G.J.; Gati, C.; Yefanov, O.M.; White, T.A.; Oberthuer, D.; Metz, M.; Yoon, C.H.; Barty, A.; Chapman, H.N.; Basu, S.; Coe, J.; Conrad, C.E.; Fromme, R.; Fromme, P.; Tourwe, D.; Schiller, P.W.; Roth, B.L.; Ballet, S.; Katritch, V.; Stevens, R.C.; Cherezov, V. Nat Struct Mol Biol 2015, 22, 265 (PMID: 25686086) | |
![]() | Homo sapiens (Human) (P41143) | 1.8 a structure of the human delta opioid 7tm receptor (psi community target) | X-Ray Diffraction | 1.8 | 2013-12-25 | Fenalti, G.; Giguere, P.M.; Katritch, V.; Huang, X.P.; Thompson, A.A.; Cherezov, V.; Roth, B.L.; Stevens, R.C. Nature 2014, 506, 191 (PMID: 24413399) | |
![]() | Homo sapiens (Human) (P41143) | Synchrotron structure of the human delta opioid receptor in complex with a bifunctional peptide (psi community target) | X-Ray Diffraction | 3.28 | 2015-01-14 | Fenalti, G.; Zatsepin, N.A.; Betti, C.; Giguere, P.; Han, G.W.; Ishchenko, A.; Liu, W.; Guillemyn, K.; Zhang, H.; James, D.; Wang, D.; Weierstall, U.; Spence, J.C.; Boutet, S.; Messerschmidt, M.; Williams, G.J.; Gati, C.; Yefanov, O.M.; White, T.A.; Oberthuer, D.; Metz, M.; Yoon, C.H.; Barty, A.; Chapman, H.N.; Basu, S.; Coe, J.; Conrad, C.E.; Fromme, R.; Fromme, P.; Tourwe, D.; Schiller, P.W.; Roth, B.L.; Ballet, S.; Katritch, V.; Stevens, R.C.; Cherezov, V. Nat Struct Mol Biol 2015, 22, 265 (PMID: 25686086) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Homo sapiens (Human) (O14842) | Crystal structure of human gpr40 bound to allosteric agonist tak-875 | X-Ray Diffraction | 2.33 | 2014-07-16 | Srivastava, A.; Yano, J.; Hirozane, Y.; Kefala, G.; Gruswitz, F.; Snell, G.; Lane, W.; Ivetac, A.; Aertgeerts, K.; Nguyen, J.; Jennings, A.; Okada, K. Nature 2014, 513, 124 (PMID: 25043059) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Human cytomegalovirus (strain AD169) (HHV-5) (P69332) | Structure of a viral gpcr bound to human chemokine cx3cl1 | X-Ray Diffraction | 3.8 | 2015-03-04 | Burg, J.S.; Ingram, J.R.; Venkatakrishnan, A.J.; Jude, K.M.; Dukkipati, A.; Feinberg, E.N.; Angelini, A.; Waghray, D.; Dror, R.O.; Ploegh, H.L.; Garcia, K.C. Science 2015, 347, 1113 (PMID: 25745166) | |
![]() | Human cytomegalovirus (strain AD169) (HHV-5) (P69332) | Structure of a nanobody-bound viral gpcr bound to human chemokine cx3cl1 | X-Ray Diffraction | 2.89 | 2015-03-04 | Burg, J.S.; Ingram, J.R.; Venkatakrishnan, A.J.; Jude, K.M.; Dukkipati, A.; Feinberg, E.N.; Angelini, A.; Waghray, D.; Dror, R.O.; Ploegh, H.L.; Garcia, K.C. Science 2015, 347, 1113 (PMID: 25745166) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Homo sapiens (Human) (P35367) | Structure of the human histamine h1 receptor in complex with doxepin | X-Ray Diffraction | 3.1 | 2011-06-15 | Shimamura, T.; Shiroishi, M.; Weyand, S.; Tsujimoto, H.; Winter, G.; Katritch, V.; Abagyan, R.; Cherezov, V.; Liu, W.; Han, G.W.; Kobayashi, T.; Stevens, R.C.; Iwata, S. Nature 2011, 475, 65 (PMID: 21697825) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Homo sapiens (Human) (P41145) | Structure of the human kappa opioid receptor in complex with jdtic | X-Ray Diffraction | 2.9 | 2012-03-21 | Wu, H.; Wacker, D.; Mileni, M.; Katritch, V.; Han, G.W.; Vardy, E.; Liu, W.; Thompson, A.A.; Huang, X.P.; Carroll, F.I.; Mascarella, S.W.; Westkaemper, R.B.; Mosier, P.D.; Roth, B.L.; Cherezov, V.; Stevens, R.C. Nature 2012, 485, 327 (PMID: 22437504) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
---|---|---|---|---|---|---|---|
![]() | Homo sapiens (Human) (Q92633) | Crystal structure of human lysophosphatidic acid receptor 1 in complex with ono-9910539 | X-Ray Diffraction | 2.9 | 2015-06-03 | Chrencik, J.E.; Roth, C.B.; Terakado, M.; Kurata, H.; Omi, R.; Kihara, Y.; Warshaviak, D.; Nakade, S.; Asmar-Rovira, G.; Mileni, M.; Mizuno, H.; Griffith, M.T.; Rodgers, C.; Han, G.W.; Velasquez, J.; Chun, J.; Stevens, R.C.; Hanson, M.A. Cell 2015, 161, 1633 (PMID: 26091040) | |
![]() | Homo sapiens (Human) (Q92633) | Crystal structure of human lysophosphatidic acid receptor 1 in complex with ono-3080573 | X-Ray Diffraction | 2.9 | 2015-06-03 | Chrencik, J.E.; Roth, C.B.; Terakado, M.; Kurata, H.; Omi, R.; Kihara, Y.; Warshaviak, D.; Nakade, S.; Asmar-Rovira, G.; Mileni, M.; Mizuno, H.; Griffith, M.T.; Rodgers, C.; Han, G.W.; Velasquez, J.; Chun, J.; Stevens, R.C.; Hanson, M.A. Cell 2015, 161, 1633 (PMID: 26091040) | |
![]() | Homo sapiens (Human) (Q92633) | Crystal structure of human lysophosphatidic acid receptor 1 in complex with ono9780307 | X-Ray Diffraction | 3.0 | 2015-06-03 | Chrencik, J.E.; Roth, C.B.; Terakado, M.; Kurata, H.; Omi, R.; Kihara, Y.; Warshaviak, D.; Nakade, S.; Asmar-Rovira, G.; Mileni, M.; Mizuno, H.; Griffith, M.T.; Rodgers, C.; Han, G.W.; Velasquez, J.; Chun, J.; Stevens, R.C.; Hanson, M.A. Cell 2015, 161, 1633 (PMID: 26091040) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
---|---|---|---|---|---|---|---|
![]() | Mus musculus (Mouse) (P42866) | Crystal structure of the mu-opioid receptor bound to a morphinan antagonist | X-Ray Diffraction | 2.8 | 2012-03-21 | Manglik, A.; Kruse, A.C.; Kobilka, T.S.; Thian, F.S.; Mathiesen, J.M.; Sunahara, R.K.; Pardo, L.; Weis, W.I.; Kobilka, B.K.; Granier, S. Nature 2012, 485, 321 (PMID: 22437502) | |
![]() | Mus musculus (Mouse) (P42866) | Crystal structure of active mu-opioid receptor bound to the agonist bu72 | X-Ray Diffraction | 2.1 | 2015-08-05 | Huang, W.; Manglik, A.; Venkatakrishnan, A.J.; Laeremans, T.; Feinberg, E.N.; Sanborn, A.L.; Kato, H.E.; Livingston, K.E.; Thorsen, T.S.; Kling, R.C.; Granier, S.; Gmeiner, P.; Husbands, S.M.; Traynor, J.R.; Weis, W.I.; Steyaert, J.; Dror, R.O.; Kobilka, B.K. Nature 2015, 524, 315 (PMID: 26245379) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
---|---|---|---|---|---|---|---|
![]() | Homo sapiens (Human) (P11229) | Structure of the human m1 muscarinic acetylcholine receptor bound to antagonist tiotropium | X-Ray Diffraction | 2.7 | 2016-03-09 | Thal, D.M.; Sun, B.; Feng, D.; Nawaratne, V.; Leach, K.; Felder, C.C.; Bures, M.G.; Evans, D.A.; Weis, W.I.; Bachhawat, P.; Kobilka, T.S.; Sexton, P.M.; Kobilka, B.K.; Christopoulos, A. Nature 2016, 531, 335 (PMID: 26958838) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Homo sapiens (Human) (P08172) | Structure of active human m2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator ly2119620 | X-Ray Diffraction | 3.7 | 2013-11-27 | Kruse, A.C.; Ring, A.M.; Manglik, A.; Hu, J.; Hu, K.; Eitel, K.; Hubner, H.; Pardon, E.; Valant, C.; Sexton, P.M.; Christopoulos, A.; Felder, C.C.; Gmeiner, P.; Steyaert, J.; Weis, W.I.; Garcia, K.C.; Wess, J.; Kobilka, B.K. Nature 2013, 504, 101 (PMID: 24256733) | |
![]() | Homo sapiens (Human) (P08172) | Structure of the human m2 muscarinic acetylcholine receptor bound to an antagonist | X-Ray Diffraction | 3.0 | 2012-02-01 | Haga, K.; Kruse, A.C.; Asada, H.; Yurugi-Kobayashi, T.; Shiroishi, M.; Zhang, C.; Weis, W.I.; Okada, T.; Kobilka, B.K.; Haga, T.; Kobayashi, T. Nature 2012, 482, 547 (PMID: 22278061) | |
![]() | Homo sapiens (Human) (P08172) | Structure of active human m2 muscarinic acetylcholine receptor bound to the agonist iperoxo | X-Ray Diffraction | 3.5 | 2013-11-27 | Kruse, A.C.; Ring, A.M.; Manglik, A.; Hu, J.; Hu, K.; Eitel, K.; Hubner, H.; Pardon, E.; Valant, C.; Sexton, P.M.; Christopoulos, A.; Felder, C.C.; Gmeiner, P.; Steyaert, J.; Weis, W.I.; Garcia, K.C.; Wess, J.; Kobilka, B.K. Nature 2013, 504, 101 (PMID: 24256733) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Rattus norvegicus (Rat) (P08483) | Structure of the m3 muscarinic acetylcholine receptor bound to the antagonist tiotropium crystallized with disulfide-stabilized t4 lysozyme (dst4l) | X-Ray Diffraction | 3.57 | 2014-11-26 | Thorsen, T.S.; Matt, R.; Weis, W.I.; Kobilka, B.K. Structure 2014, 22, 1657 (PMID: 25450769) | |
![]() | Rattus norvegicus (Rat) (P08483) | M3-mt4l receptor bound to nms | X-Ray Diffraction | 3.7 | 2014-11-26 | Thorsen, T.S.; Matt, R.; Weis, W.I.; Kobilka, B.K. Structure 2014, 22, 1657 (PMID: 25450769) | |
![]() | Rattus norvegicus (Rat) (P08483) | Structure of the m3 muscarinic acetylcholine receptor | X-Ray Diffraction | 3.4 | 2012-02-22 | Kruse, A.C.; Hu, J.; Pan, A.C.; Arlow, D.H.; Rosenbaum, D.M.; Rosemond, E.; Green, H.F.; Liu, T.; Chae, P.S.; Dror, R.O.; Shaw, D.E.; Weis, W.I.; Wess, J.; Kobilka, B.K. Nature 2012, 482, 552 (PMID: 22358844) | |
![]() | Rattus norvegicus (Rat) (P08483) | M3-mt4l receptor bound to tiotropium | X-Ray Diffraction | 2.8 | 2014-11-26 | Thorsen, T.S.; Matt, R.; Weis, W.I.; Kobilka, B.K. Structure 2014, 22, 1657 (PMID: 25450769) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Homo sapiens (Human) (P08173) | Structure of the m4 muscarinic acetylcholine receptor (m4-mt4l) bound to tiotropium | X-Ray Diffraction | 2.6 | 2016-03-16 | Thal, D.M.; Sun, B.; Feng, D.; Nawaratne, V.; Leach, K.; Felder, C.C.; Bures, M.G.; Evans, D.A.; Weis, W.I.; Bachhawat, P.; Kobilka, T.S.; Sexton, P.M.; Kobilka, B.K.; Christopoulos, A. Nature 2016, 531, 335 (PMID: 26958838) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Rattus norvegicus (Rat) (P20789) | High resolution structure of evolved agonist-bound neurotensin receptor 1 mutant without lysozyme fusion | X-Ray Diffraction | 3.1 | 2014-01-29 | Egloff, P.; Hillenbrand, M.; Klenk, C.; Batyuk, A.; Heine, P.; Balada, S.; Schlinkmann, K.M.; Scott, D.J.; Schuetz, M.; Plueckthun, A. Proc Natl Acad Sci USA 2014, 111, E655 (PMID: 24453215) | |
![]() | Rattus norvegicus (Rat) (P20789) | The crystal structure of the neurotensin receptor nts1 in complex with neurotensin (8-13) | X-Ray Diffraction | 2.8 | 2012-10-17 | White, J.F.; Noinaj, N.; Shibata, Y.; Love, J.; Kloss, B.; Xu, F.; Gvozdenovic-Jeremic, J.; Shah, P.; Shiloach, J.; Tate, C.G.; Grisshammer, R. Nature 2012, 490, 508 (PMID: 23051748) | |
![]() | Rattus norvegicus (Rat) (P20789) | Structure of constitutively active neurotensin receptor | X-Ray Diffraction | 3.3 | 2016-12-21 | Krumm, B.E.; Lee, S.; Bhattacharya, S.; Botos, I.; White, C.F.; Du, H.; Vaidehi, N.; Grisshammer, R. Sci Rep 2016, 6, 38564 (PMID: 27924846) | |
![]() | Rattus norvegicus (Rat) (P20789) | High resolution structure of thermostable agonist-bound neurotensin receptor 1 mutant without lysozyme fusion | X-Ray Diffraction | 2.75 | 2014-01-29 | Egloff, P.; Hillenbrand, M.; Klenk, C.; Batyuk, A.; Heine, P.; Balada, S.; Schlinkmann, K.M.; Scott, D.J.; Schuetz, M.; Plueckthun, A. Proc Natl Acad Sci USA 2014, 111, E655 (PMID: 24453215) | |
![]() | Rattus norvegicus (Rat) (P20789) | Structure of evolved agonist-bound neurotensin receptor 1 mutant without lysozyme fusion | X-Ray Diffraction | 3.57 | 2014-01-29 | Egloff, P.; Hillenbrand, M.; Klenk, C.; Batyuk, A.; Heine, P.; Balada, S.; Schlinkmann, K.M.; Scott, D.J.; Schuetz, M.; Plueckthun, A. Proc Natl Acad Sci USA 2014, 111, E655 (PMID: 24453215) | |
![]() | Rattus norvegicus (Rat) (P20789) | Structure of thermostable agonist-bound neurotensin receptor 1 mutant without lysozyme fusion | X-Ray Diffraction | 3.0 | 2014-01-29 | Egloff, P.; Hillenbrand, M.; Klenk, C.; Batyuk, A.; Heine, P.; Balada, S.; Schlinkmann, K.M.; Scott, D.J.; Schuetz, M.; Plueckthun, A. Proc Natl Acad Sci USA 2014, 111, E655 (PMID: 24453215) | |
![]() | Rattus norvegicus (Rat) (P20789) | Structure of active-like neurotensin receptor | X-Ray Diffraction | 2.9 | 2015-07-29 | Krumm, B.E.; White, J.F.; Shah, P.; Grisshammer, R. Nat Commun 2015, 6, 7895 (PMID: 26205105) | |
![]() | Rattus norvegicus (Rat) (P20789) | Structure of active-like neurotensin receptor | X-Ray Diffraction | 2.6 | 2015-07-29 | Krumm, B.E.; White, J.F.; Shah, P.; Grisshammer, R. Nat Commun 2015, 6, 7895 (PMID: 26205105) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Homo sapiens (Human) (P41146) | The crystal structure of nociceptin/orphanin fq peptide receptor (nop) in complex with sb-612111 (psi community target) | X-Ray Diffraction | 3.0 | 2015-10-21 | Miller, R.L.; Thompson, A.A.; Trapella, C.; Guerrini, R.; Malfacini, D.; Patel, N.; Han, G.W.; Cherezov, V.; Calo, G.; Katritch, V.; Stevens, R.C. Structure 2015, 23, 2291 (PMID: 26526853) | |
![]() | Homo sapiens (Human) (P41146) | The crystal structure of nociceptin/orphanin fq peptide receptor (nop) in complex with c-35 (psi community target) | X-Ray Diffraction | 3.0 | 2015-10-21 | Miller, R.L.; Thompson, A.A.; Trapella, C.; Guerrini, R.; Malfacini, D.; Patel, N.; Han, G.W.; Cherezov, V.; Calo, G.; Katritch, V.; Stevens, R.C. Structure 2015, 23, 2291 (PMID: 26526853) | |
![]() | Homo sapiens (Human) (P41146) | Structure of the n/ofq opioid receptor in complex with a peptide mimetic | X-Ray Diffraction | 3.01 | 2012-04-25 | Thompson, A.A.; Liu, W.; Chun, E.; Katritch, V.; Wu, H.; Vardy, E.; Huang, X.P.; Trapella, C.; Guerrini, R.; Calo, G.; Roth, B.L.; Cherezov, V.; Stevens, R.C. Nature 2012, 485, 395 (PMID: 22596163) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Homo sapiens (Human) (O43613) | Structures of the human ox1 orexin receptor bound to selective and dual antagonists | X-Ray Diffraction | 2.75 | 2016-03-09 | Yin, J.; Babaoglu, K.; Brautigam, C.A.; Clark, L.; Shao, Z.; Scheuermann, T.H.; Harrell, C.M.; Gotter, A.L.; Roecker, A.J.; Winrow, C.J.; Renger, J.J.; Coleman, P.J.; Rosenbaum, D.M. Nat Struct Mol Biol 2016, 23, 293 (PMID: 26950369) | |
![]() | Homo sapiens (Human) (O43613) | Structures of the human ox1 orexin receptor bound to selective and dual antagonists | X-Ray Diffraction | 2.83 | 2016-03-09 | Yin, J.; Babaoglu, K.; Brautigam, C.A.; Clark, L.; Shao, Z.; Scheuermann, T.H.; Harrell, C.M.; Gotter, A.L.; Roecker, A.J.; Winrow, C.J.; Renger, J.J.; Coleman, P.J.; Rosenbaum, D.M. Nat Struct Mol Biol 2016, 23, 293 (PMID: 26950369) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Homo sapiens (Human) (O43614) | Crystal structure of the human ox2 orexin receptor bound to the insomnia drug suvorexant | X-Ray Diffraction | 2.5 | 2015-01-14 | Yin, J.; Mobarec, J.C.; Kolb, P.; Rosenbaum, D.M. Nature 2015, 519, 247 (PMID: 25533960) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Homo sapiens (Human) (P47900) | The human p2y1 receptor in complex with mrs2500 | X-Ray Diffraction | 2.7 | 2015-04-01 | Zhang, D.; Gao, Z.G.; Zhang, K.; Kiselev, E.; Crane, S.; Wang, J.; Paoletta, S.; Yi, C.; Ma, L.; Zhang, W.; Han, G.W.; Liu, H.; Cherezov, V.; Katritch, V.; Jiang, H.; Stevens, R.C.; Jacobson, K.A.; Zhao, Q.; Wu, B. Nature 2015, 520, 317 (PMID: 25822790) | |
![]() | Homo sapiens (Human) (P47900) | The human p2y1 receptor in complex with bptu | X-Ray Diffraction | 2.2 | 2015-04-01 | Zhang, D.; Gao, Z.G.; Zhang, K.; Kiselev, E.; Crane, S.; Wang, J.; Paoletta, S.; Yi, C.; Ma, L.; Zhang, W.; Han, G.W.; Liu, H.; Cherezov, V.; Katritch, V.; Jiang, H.; Stevens, R.C.; Jacobson, K.A.; Zhao, Q.; Wu, B. Nature 2015, 520, 317 (PMID: 25822790) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Homo sapiens (Human) (Q9H244) | Crystal structure of p2y12 receptor in complex with 2mesatp | X-Ray Diffraction | 3.1 | 2014-04-30 | Zhang, J.; Zhang, K.; Gao, Z.G.; Paoletta, S.; Zhang, D.; Han, G.W.; Li, T.; Ma, L.; Zhang, W.; Muller, C.E.; Yang, H.; Jiang, H.; Cherezov, V.; Katritch, V.; Jacobson, K.A.; Stevens, R.C.; Wu, B.; Zhao, Q. Nature 2014, 509, 119 (PMID: 24784220) | |
![]() | Homo sapiens (Human) (Q9H244) | Crystal structure of p2y12 receptor in complex with 2mesadp | X-Ray Diffraction | 2.5 | 2014-04-30 | Zhang, J.; Zhang, K.; Gao, Z.G.; Paoletta, S.; Zhang, D.; Han, G.W.; Li, T.; Ma, L.; Zhang, W.; Muller, C.E.; Yang, H.; Jiang, H.; Cherezov, V.; Katritch, V.; Jacobson, K.A.; Stevens, R.C.; Wu, B.; Zhao, Q. Nature 2014, 509, 119 (PMID: 24784220) | |
![]() | Homo sapiens (Human) (Q9H244) | Structure of the human p2y12 receptor in complex with an antithrombotic drug | X-Ray Diffraction | 2.62 | 2014-03-26 | Zhang, K.; Zhang, J.; Gao, Z.-G.; Zhang, D.; Zhu, L.; Han, G.W.; Moss, S.M.; Paoletta, S.; Kiselev, E.; Lu, W.; Fenalti, G.; Zhang, W.; Muller, C.E.; Yang, H.; Jiang, H.; Cherezov, V.; Katritch, V.; Jacobson, K.A.; Stevens, R.C.; Wu, B.; Zhao, Q. Nature 2014, 509, 115 (PMID: 24670650) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Homo sapiens (Human) (P25116) | Crystal structure of human protease-activated receptor 1 (par1) bound with antagonist vorapaxar at 2.2 angstrom | X-Ray Diffraction | 2.2 | 2012-12-12 | Zhang, C.; Srinivasan, Y.; Arlow, D.H.; Fung, J.J.; Palmer, D.; Zheng, Y.; Green, H.F.; Pandey, A.; Dror, R.O.; Shaw, D.E.; Weis, W.I.; Coughlin, S.R.; Kobilka, B.K. Nature 2012, 492, 387 (PMID: 23222541) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Homo sapiens (Human) (P55085) | Crystal structure of a thermostabilised human protease-activated receptor-2 (par2) in ternary complex with fab3949 and az7188 at 4.0 angstrom resolution | X-Ray Diffraction | 4.0 | 2017-05-03 | Cheng, R.K.Y.; Fiez-Vandal, C.; Schlenker, O.; Edman, K.; Aggeler, B.; Brown, D.G.; Brown, G.A.; Cooke, R.M.; Dumelin, C.E.; Dore, A.S.; Geschwindner, S.; Grebner, C.; Hermansson, N.O.; Jazayeri, A.; Johansson, P.; Leong, L.; Prihandoko, R.; Rappas, M.; Soutter, H.; Snijder, A.; Sundstrom, L.; Tehan, B.; Thornton, P.; Troast, D.; Wiggin, G.; Zhukov, A.; Marshall, F.H.; Dekker, N. Nature 2017, 545, 112 (PMID: 28445455) | |
![]() | Homo sapiens (Human) (P55085) | Crystal structure of a thermostabilised human protease-activated receptor-2 (par2) in complex with az8838 at 2.8 angstrom resolution | X-Ray Diffraction | 2.8 | 2017-05-03 | Cheng, R.K.Y.; Fiez-Vandal, C.; Schlenker, O.; Edman, K.; Aggeler, B.; Brown, D.G.; Brown, G.A.; Cooke, R.M.; Dumelin, C.E.; Dore, A.S.; Geschwindner, S.; Grebner, C.; Hermansson, N.O.; Jazayeri, A.; Johansson, P.; Leong, L.; Prihandoko, R.; Rappas, M.; Soutter, H.; Snijder, A.; Sundstrom, L.; Tehan, B.; Thornton, P.; Troast, D.; Wiggin, G.; Zhukov, A.; Marshall, F.H.; Dekker, N. Nature 2017, 545, 112 (PMID: 28445455) | |
![]() | Homo sapiens (Human) (P55085) | Crystal structure of a thermostabilised human protease-activated receptor-2 (par2) in complex with az3451 at 3.6 angstrom resolution | X-Ray Diffraction | 3.6 | 2017-05-03 | Cheng, R.K.Y.; Fiez-Vandal, C.; Schlenker, O.; Edman, K.; Aggeler, B.; Brown, D.G.; Brown, G.A.; Cooke, R.M.; Dumelin, C.E.; Dore, A.S.; Geschwindner, S.; Grebner, C.; Hermansson, N.O.; Jazayeri, A.; Johansson, P.; Leong, L.; Prihandoko, R.; Rappas, M.; Soutter, H.; Snijder, A.; Sundstrom, L.; Tehan, B.; Thornton, P.; Troast, D.; Wiggin, G.; Zhukov, A.; Marshall, F.H.; Dekker, N. Nature 2017, 545, 112 (PMID: 28445455) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Bos taurus (Bovine) (P02699) | Crystal structure of the active g-protein-coupled receptor opsin in complex with the finger-loop peptide derived from the full-length arrestin-1 | X-Ray Diffraction | 2.75 | 2014-09-17 | Szczepek, M.; Beyriere, F.; Hofmann, K.P.; Elgeti, M.; Kazmin, R.; Rose, A.; Bartl, F.J.; Vonstetten, D.; Heck, M.; Sommer, M.E.; Hildebrand, P.W.; Scheerer, P. Nat Commun 2014, 5, 4801 (PMID: 25205354) | |
![]() | Bos taurus (Bovine) (P02699) | Crystal structure of bovine rhodopsin at 2.2 angstroms resolution | X-Ray Diffraction | 2.2 | 2004-10-12 | Okada, T.; Sugihara, M.; Bondar, A.N.; Elstner, M.; Entel, P.; Buss, V. J Mol Biol 2004, 342, 571 (PMID: 15327956) | |
![]() | Bos taurus (Bovine) (P02699) | Crystal structure of bovine rhodopsin | X-Ray Diffraction | 2.8 | 2001-07-04 | Teller, D.C.; Okada, T.; Behnke, C.A.; Palczewski, K.; Stenkamp, R.E. Biochemistry 2001, 40, 7761 (PMID: 11425302) | |
![]() | Bos taurus (Bovine) (P02699) | Crystal structure of metarhodopsin ii in complex with a c-terminal peptide derived from the galpha subunit of transducin | X-Ray Diffraction | 2.85 | 2011-03-09 | Choe, H.W.; Kim, Y.J.; Park, J.H.; Morizumi, T.; Pai, E.F.; Krauss, N.; Hofmann, K.P.; Scheerer, P.; Ernst, O.P. Nature 2011, 471, 651 (PMID: 21389988) | |
![]() | Bos taurus (Bovine) (P02699) | Structure of ground-state bovine rhodospin in a hexagonal crystal form | X-Ray Diffraction | 2.65 | 2008-08-05 | Stenkamp, R.E. Acta Crystallogr, Sect D 2008, 64, 902 (PMID: 18645239) | |
![]() | Bos taurus (Bovine) (P02699) | Crystallographic model of 9-cis-rhodopsin | X-Ray Diffraction | 2.95 | 2007-10-30 | Nakamichi, H.; Buss, V.; Okada, T. Biophys J 2007, 92, L106 (PMID: 17449675) | |
![]() | Bos taurus (Bovine) (P02699) | Structure of bovine rhodopsin (dark adapted) | Solution NMR | N/A | 2001-10-05 | Yeagle, P.L.; Choi, G.; Albert, A.D. Biochemistry 2001, 40, 11932 (PMID: 11570894) | |
![]() | Bos taurus (Bovine) (P02699) | Crystal structure of bovine rhodopsin at 2.6 angstroms resolution | X-Ray Diffraction | 2.6 | 2002-05-15 | Okada, T.; Fujiyoshi, Y.; Silow, M.; Navarro, J.; Landau, E.M.; Shichida, Y. Proc Natl Acad Sci USA 2002, 99, 5982 (PMID: 11972040) | |
![]() | Bos taurus (Bovine) (P02699) | Crystal structure of trigonal crystal form of ground-state rhodopsin | X-Ray Diffraction | 4.1 | 2006-10-17 | Salom, D.; Lodowski, D.T.; Stenkamp, R.E.; Trong, I.L.; Golczak, M.; Jastrzebska, B.; Harris, T.; Ballesteros, J.A.; Palczewski, K. Proc Natl Acad Sci USA 2006, 103, 16123 (PMID: 17060607) | |
![]() | Bos taurus (Bovine) (P02699) | Crystal structure of bos taurus opsin at 2.7 angstrom | X-Ray Diffraction | 2.7 | 2017-03-15 | Gulati, S.; Jastrzebska, B.; Banerjee, S.; Placeres, A.L.; Miszta, P.; Gao, S.; Gunderson, K.; Tochtrop, G.P.; Filipek, S.; Katayama, K.; Kiser, P.D.; Mogi, M.; Stewart, P.L.; Palczewski, K. Proc Natl Acad Sci U S A 2017, 114, E2608 (PMID: 28289214) | |
![]() | Bos taurus (Bovine) (P02699) | Crystal structure of the constitutively active e113q,n2c, d282c rhodopsin mutant with bound galphact peptide. | X-Ray Diffraction | 3.0 | 2011-03-16 | Standfuss, J.; Edwards, P.C.; Dantona, A.; Fransen, M.; Xie, G.; Oprian, D.D.; Schertler, G.F.X. Nature 2011, 471, 656 (PMID: 21389983) | |
![]() | Bos taurus (Bovine) (P02699) | Structure of bovine rhodopsin in a trigonal crystal form | X-Ray Diffraction | 2.65 | 2003-11-20 | Li, J.; Edwards, P.; Burghammer, M.; Villa, C.; Schertler, G.F.X. J Mol Biol 2004, 343, 1409 (PMID: 15491621) | |
![]() | Bos taurus (Bovine) (P02699) | Crystallographic model of lumirhodopsin | X-Ray Diffraction | 2.8 | 2006-08-22 | Nakamichi, H.; Okada, T. Proc Natl Acad Sci USA 2006, 103, 12729 (PMID: 16908857) | |
![]() | Bos taurus (Bovine) (P02699) | Crystal structure of native opsin: the g protein-coupled receptor rhodopsin in its ligand-free state | X-Ray Diffraction | 2.9 | 2008-06-24 | Park, J.H.; Scheerer, P.; Hofmann, K.P.; Choe, H.-W.; Ernst, O.P. Nature 2008, 454, 183 (PMID: 18563085) | |
![]() | Bos taurus (Bovine) (P02699) | Crystal structure of bovine rhodopsin with beta-ionone | X-Ray Diffraction | 2.6 | 2011-01-19 | Makino, C.L.; Riley, C.K.; Looney, J.; Crouch, R.K.; Okada, T. Biophys J 2010, 99, 2366 (PMID: 20923672) | |
![]() | Bos taurus (Bovine) (P02699) | Crystal structure of bos taurus opsin regenerated with 6-carbon ring retinal chromophore | X-Ray Diffraction | 4.01 | 2017-03-15 | Gulati, S.; Jastrzebska, B.; Banerjee, S.; Placeres, A.L.; Miszta, P.; Gao, S.; Gunderson, K.; Tochtrop, G.P.; Filipek, S.; Katayama, K.; Kiser, P.D.; Mogi, M.; Stewart, P.L.; Palczewski, K. Proc Natl Acad Sci U S A 2017, 114, E2608 (PMID: 28289214) | |
![]() | Bos taurus (Bovine) (P02699) | Crystal structure of a rhodopsin stabilizing mutant expressed in mammalian cells | X-Ray Diffraction | 3.4 | 2007-09-25 | Standfuss, J.; Xie, G.; Edwards, P.C.; Burghammer, M.; Oprian, D.D.; Schertler, G.F.X. J Mol Biol 2007, 372, 1179 (PMID: 17825322) | |
![]() | Bos taurus (Bovine) (P02699) | Crystal structure of the active g-protein-coupled receptor opsin in complex with a c-terminal peptide derived from the galpha subunit of transducin | X-Ray Diffraction | 3.2 | 2008-09-23 | Scheerer, P.; Park, J.H.; Hildebrand, P.W.; Kim, Y.J.; Krauss, N.; Choe, H.-W.; Hofmann, K.P.; Ernst, O.P. Nature 2008, 455, 497 (PMID: 18818650) | |
![]() | Bos taurus (Bovine) (P02699) | Night blindness causing g90d rhodopsin in complex with gact2 peptide | X-Ray Diffraction | 2.9 | 2013-05-08 | Singhal, A.; Ostermaier, M.K.; Vishnivetskiy, S.A.; Panneels, V.; Homan, K.T.; Tesmer, J.J.; Veprintsev, D.; Deupi, X.; Gurevich, V.V.; Schertler, G.F.; Standfuss, J. EMBO Rep 2013, 14, 520 (PMID: 23579341) | |
![]() | Bos taurus (Bovine) (P02699) | Crystal structure of t94i rhodopsin mutant | X-Ray Diffraction | 2.3 | 2016-08-10 | Singhal, A.; Guo, Y.; Matkovic, M.; Schertler, G.; Deupi, X.; Yan, E.C.; Standfuss, J. EMBO Rep 2016, 17, 1431 (PMID: 27458239) | |
![]() | Bos taurus (Bovine) (P02699) | Crystal structure of t94i rhodopsin mutant | X-Ray Diffraction | 2.81 | 2016-08-10 | Singhal, A.; Guo, Y.; Matkovic, M.; Schertler, G.; Deupi, X.; Yan, E.C.; Standfuss, J. EMBO Rep 2016, 17, 1431 (PMID: 27458239) | |
![]() | Bos taurus (Bovine) (P02699) | Crystal structure of rhombohedral crystal form of ground-state rhodopsin | X-Ray Diffraction | 3.8 | 2006-10-17 | Salom, D.; Lodowski, D.T.; Stenkamp, R.E.; Trong, I.L.; Golczak, M.; Jastrzebska, B.; Harris, T.; Ballesteros, J.A.; Palczewski, K. Proc Natl Acad Sci USA 2006, 103, 16123 (PMID: 17060607) | |
![]() | Bos taurus (Bovine) (P02699) | Structure of a mutant bovine rhodopsin in hexagonal crystal form | X-Ray Diffraction | 3.4 | 2008-08-05 | Stenkamp, R.E. Acta Crystallogr, Sect D 2008, 64, 902 (PMID: 18645239) | |
![]() | Bos taurus (Bovine) (P02699) | Crystal structure of active conformation of gpcr opsin stabilized by octylglucoside | X-Ray Diffraction | 2.65 | 2013-10-30 | Park, J.H.; Morizumi, T.; Li, Y.; Hong, J.E.; Pai, E.F.; Hofmann, K.P.; Choe, H.W.; Ernst, O.P. Angew Chem Int Ed Engl 2013, 52, 11021 (PMID: 24038729) | |
![]() | Bos taurus (Bovine) (P02699) | Structure of bovine rhodopsin (metarhodopsin ii) | Solution NMR | N/A | 2002-07-10 | Choi, G.; Landin, J.; Galan, J.F.; Birge, R.R.; Albert, A.D.; Yeagle, P.L. Biochemistry 2002, 41, 7318 (PMID: 12044163) | |
![]() | Bos taurus (Bovine) (P02699) | Crystal structure of bovine rhodopsin | X-Ray Diffraction | 2.8 | 2000-08-04 | Palczewski, K.; Kumasaka, T.; Hori, T.; Behnke, C.A.; Motoshima, H.; Fox, B.A.; Letrong, I.; Teller, D.C.; Okada, T.; Stenkamp, R.E.; Yamamoto, M.; Miyano, M. Science 2000, 289, 739 (PMID: 10926528) | |
![]() | Bos taurus (Bovine) (P02699) | Night blindness causing g90d rhodopsin in the active conformation | X-Ray Diffraction | 3.3 | 2013-04-24 | Singhal, A.; Ostermaier, M.K.; Vishnivetskiy, S.A.; Panneels, V.; Homan, K.T.; Tesmer, J.J.; Veprintsev, D.; Deupi, X.; Gurevich, V.V.; Schertler, G.F.; Standfuss, J. EMBO Rep 2013, 14, 520 (PMID: 23579341) | |
![]() | Bos taurus (Bovine) (P02699) | Crystal structure of a photoactivated rhodopsin | X-Ray Diffraction | 4.15 | 2006-10-17 | Salom, D.; Lodowski, D.T.; Stenkamp, R.E.; Trong, I.L.; Golczak, M.; Jastrzebska, B.; Harris, T.; Ballesteros, J.A.; Palczewski, K. Proc Natl Acad Sci USA 2006, 103, 16123 (PMID: 17060607) | |
![]() | Bos taurus (Bovine) (P02699) | Crystallographic model of bathorhodopsin | X-Ray Diffraction | 2.6 | 2006-09-02 | Nakamichi, H.; Okada, T. Angew Chem Int Ed Engl 2006, 45, 4270 (PMID: 16586416) | |
![]() | Bos taurus (Bovine) (P02699) | Crystal structure of the light-activated constitutively active n2c,m257y,d282c rhodopsin mutant in complex with a peptide resembling the c-terminus of the galpha-protein subunit (gact) | X-Ray Diffraction | 3.3 | 2012-01-25 | Deupi, X.; Edwards, P.; Singhal, A.; Nickle, B.; Oprian, D.; Schertler, G.; Standfuss, J. Proc Natl Acad Sci USA 2012, 109, 119 (PMID: 22198838) | |
![]() | Bos taurus (Bovine) (P02699) | Opsin/g(alpha) peptide complex stabilized by nonyl-glucoside | X-Ray Diffraction | 2.29 | 2015-11-04 | Blankenship, E.; Vahedi-Faridi, A.; Lodowski, D.T. Structure 2015, 23, 2358 (PMID: 26526852) | |
![]() | Bos taurus (Bovine) (P02699) | Crystal structure of metarhodopsin ii | X-Ray Diffraction | 3.0 | 2011-03-09 | Choe, H.W.; Kim, Y.J.; Park, J.H.; Morizumi, T.; Pai, E.F.; Krauss, N.; Hofmann, K.P.; Scheerer, P.; Ernst, O.P. Nature 2011, 471, 651 (PMID: 21389988) | |
![]() | Todarodes pacificus (Japanese flying squid) (P31356) | Crystal structure of the batho intermediate of squid rhodopsin | X-Ray Diffraction | 2.8 | 2011-08-17 | Murakami, M.; Kouyama, T. J Mol Biol 2011, 413, 615 (PMID: 21906602) | |
![]() | Todarodes pacificus (Japanese flying squid) (P31356) | Crystal structure of squid rhodopsin | X-Ray Diffraction | 3.7 | 2008-05-06 | Shimamura, T.; Hiraki, K.; Takahashi, N.; Hori, T.; Ago, H.; Masuda, K.; Takio, K.; Ishiguro, M.; Miyano, M. J Biol Chem 2008, 283, 17753 (PMID: 18463093) | |
![]() | Todarodes pacificus (Japanese flying squid) (P31356) | Crystal structure of the lumi intermediate of squid rhodopsin | X-Ray Diffraction | 2.8 | 2015-06-17 | Murakami, M.; Kouyama, T. PLoS One 2015, 10, 26970 (PMID: 26024518) | |
![]() | Todarodes pacificus (Japanese flying squid) (P31356) | Crystal structure of squid rhodopsin | X-Ray Diffraction | 2.5 | 2008-05-13 | Murakami, M.; Kouyama, T. Nature 2008, 453, 363 (PMID: 18480818) | |
![]() | Todarodes pacificus (Japanese flying squid) (P31356) | Crystal structure of squid isorhodopsin | X-Ray Diffraction | 2.7 | 2011-08-17 | Murakami, M.; Kouyama, T. J Mol Biol 2011, 413, 615 (PMID: 21906602) | |
![]() | Homo sapiens (Human) (P08100) | Crystal structure of rhodopsin bound to visual arrestin | X-Ray Diffraction | 7.7 | 2016-03-23 | Zhou, X.E.; Gao, X.; Barty, A.; Kang, Y.; He, Y.; Liu, W.; Ishchenko, A.; White, T.A.; Yefanov, O.; Han, G.W.; Xu, Q.; Dewaal, P.W.; Suino-Powell, K.M.; Boutet, S.; Williams, G.J.; Wang, M.; Li, D.; Caffrey, M.; Chapman, H.N.; Spence, J.C.; Fromme, P.; Weierstall, U.; Stevens, R.C.; Cherezov, V.; Melcher, K.; Xu, H.E. Sci Data 2016, 3, 60021 (PMID: 27070998) | |
![]() | Homo sapiens (Human) (P08100) | Crystal structure of rhodopsin bound to arrestin by femtosecond x-ray laser | X-Ray Diffraction | 3.3 | 2015-07-29 | Kang, Y.; Zhou, X.E.; Gao, X.; He, Y.; Liu, W.; Ishchenko, A.; Barty, A.; White, T.A.; Yefanov, O.; Han, G.W.; Xu, Q.; Dewaal, P.W.; Ke, J.; Tan, M.H.; Zhang, C.; Moeller, A.; West, G.M.; Pascal, B.D.; Vaneps, N.; Caro, L.N.; Vishnivetskiy, S.A.; Lee, R.J.; Suino-Powell, K.M.; Gu, X.; Pal, K.; Ma, J.; Zhi, X.; Boutet, S.; Williams, G.J.; Messerschmidt, M.; Gati, C.; Zatsepin, N.A.; Wang, D.; James, D.; Basu, S.; Roy-Chowdhury, S.; Conrad, C.E.; Coe, J.; Liu, H.; Lisova, S.; Kupitz, C.; Grotjohann, I.; Fromme, R.; Jiang, Y.; Tan, M.; Yang, H.; Li, J.; Wang, M.; Zheng, Z.; Li, D.; Howe, N.; Zhao, Y.; Standfuss, J.; Diederichs, K.; Dong, Y.; Potter, C.S.; Carragher, B.; Caffrey, M.; Jiang, H.; Chapman, H.N.; Spence, J.C.; Fromme, P.; Weierstall, U.; Ernst, O.P.; Katritch, V.; Gurevich, V.V.; Griffin, P.R.; Hubbell, W.L.; Stevens, R.C.; Cherezov, V.; Melcher, K.; Xu, H.E. Nature 2015, 523, 561 (PMID: 26200343) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
---|---|---|---|---|---|---|---|
![]() | Homo sapiens (Human) (P21453) | Crystal structure of a lipid g protein-coupled receptor at 3.35a | X-Ray Diffraction | 3.35 | 2012-02-15 | Hanson, M.A.; Roth, C.B.; Jo, E.; Griffith, M.T.; Scott, F.L.; Reinhart, G.; Desale, H.; Clemons, B.; Cahalan, S.M.; Schuerer, S.C.; Sanna, M.G.; Han, G.W.; Kuhn, P.; Rosen, H.; Stevens, R.C. Science 2012, 335, 851 (PMID: 22344443) | |
![]() | Homo sapiens (Human) (P21453) | Crystal structure of a lipid g protein-coupled receptor at 2.80a | X-Ray Diffraction | 2.8 | 2012-02-15 | Hanson, M.A.; Roth, C.B.; Jo, E.; Griffith, M.T.; Scott, F.L.; Reinhart, G.; Desale, H.; Clemons, B.; Cahalan, S.M.; Schuerer, S.C.; Sanna, M.G.; Han, G.W.; Kuhn, P.; Rosen, H.; Stevens, R.C. Science 2012, 335, 851 (PMID: 22344443) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
---|---|---|---|---|---|---|---|
![]() | Homo sapiens (Human) (P25103) | Solution conformation of substance p in water complexed with nk1r | Solution NMR | N/A | 2010-11-03 | Gayen, A.; Goswami, S.K.; Mukhopadhyay, C. Biochim Biophys Acta 2010 (PMID: 20937248) | |
![]() | Homo sapiens (Human) (P25103) | Substance p in dmpc/chaps isotropic q=0.25 bicelles as a ligand for nk1r | Solution NMR | N/A | 2010-11-03 | Gayen, A.; Goswami, S.K.; Mukhopadhyay, C. Biochim Biophys Acta 2010 (PMID: 20937248) | |
![]() | Homo sapiens (Human) (P25103) | Substance p in isotropic q=0.25 dmpc/chaps/gm1 bicelles as a ligand for nk1r | Solution NMR | N/A | 2010-11-03 | Gayen, A.; Goswami, S.K.; Mukhopadhyay, C. Biochim Biophys Acta 2010 (PMID: 20937248) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
---|---|---|---|---|---|---|---|
![]() | Homo sapiens (Human) (P30556) | Crystal structure of human angiotensin receptor in complex with inverse agonist olmesartan at 2.8a resolution. | X-Ray Diffraction | 2.8 | 2015-10-07 | Zhang, H.; Unal, H.; Desnoyer, R.; Han, G.W.; Patel, N.; Katritch, V.; Karnik, S.S.; Cherezov, V.; Stevens, R.C. J Biol Chem 2015, 290, 29127 (PMID: 26420482) | |
![]() | Homo sapiens (Human) (P30556) | Xfel structure of human angiotensin receptor | X-Ray Diffraction | 2.9 | 2015-04-22 | Zhang, H.; Unal, H.; Gati, C.; Han, G.W.; Liu, W.; Zatsepin, N.A.; James, D.; Wang, D.; Nelson, G.; Weierstall, U.; Sawaya, M.R.; Xu, Q.; Messerschmidt, M.; Williams, G.J.; Boutet, S.; Yefanov, O.M.; White, T.A.; Wang, C.; Ishchenko, A.; Tirupula, K.C.; Desnoyer, R.; Coe, J.; Conrad, C.E.; Fromme, P.; Stevens, R.C.; Katritch, V.; Karnik, S.S.; Cherezov, V. Cell 2015, 161, 833 (PMID: 25913193) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
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![]() | Homo sapiens (Human) (P50052) | Synchrotron structure of human angiotensin ii type 2 receptor in complex with compound 2 (n-[(furan-2-yl)methyl]-n-(4-oxo-2-propyl-3-{[2'-(2h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-3,4-dihydroquinazolin-6-yl)benzamide) | X-Ray Diffraction | 2.9 | 2017-04-05 | Zhang, H.; Han, G.W.; Batyuk, A.; Ishchenko, A.; White, K.L.; Patel, N.; Sadybekov, A.; Zamlynny, B.; Rudd, M.T.; Hollenstein, K.; Tolstikova, A.; White, T.A.; Hunter, M.S.; Weierstall, U.; Liu, W.; Babaoglu, K.; Moore, E.L.; Katz, R.D.; Shipman, J.M.; Garcia-Calvo, M.; Sharma, S.; Sheth, P.; Soisson, S.M.; Stevens, R.C.; Katritch, V.; Cherezov, V. Nature 2017, 544, 327 (PMID: 28379944) | |
![]() | Homo sapiens (Human) (P50052) | Xfel structure of human angiotensin ii type 2 receptor (monoclinic form) in complex with compound 1 (n-benzyl-n-(2-ethyl-4-oxo-3-{[2'-(2h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]) | X-Ray Diffraction | 2.8 | 2017-04-05 | Zhang, H.; Han, G.W.; Batyuk, A.; Ishchenko, A.; White, K.L.; Patel, N.; Sadybekov, A.; Zamlynny, B.; Rudd, M.T.; Hollenstein, K.; Tolstikova, A.; White, T.A.; Hunter, M.S.; Weierstall, U.; Liu, W.; Babaoglu, K.; Moore, E.L.; Katz, R.D.; Shipman, J.M.; Garcia-Calvo, M.; Sharma, S.; Sheth, P.; Soisson, S.M.; Stevens, R.C.; Katritch, V.; Cherezov, V. Nature 2017, 544, 327 (PMID: 28379944) | |
![]() | Homo sapiens (Human) (P50052) | Xfel structure of human angiotensin ii type 2 receptor (orthorhombic form) in complex with compound 1 (n-benzyl-n-(2-ethyl-4-oxo-3-{[2'-(2h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl] methyl}-3,4-dihydroquinazolin-6-yl)thiophene-2-carboxamide) | X-Ray Diffraction | 2.8 | 2017-04-05 | Zhang, H.; Han, G.W.; Batyuk, A.; Ishchenko, A.; White, K.L.; Patel, N.; Sadybekov, A.; Zamlynny, B.; Rudd, M.T.; Hollenstein, K.; Tolstikova, A.; White, T.A.; Hunter, M.S.; Weierstall, U.; Liu, W.; Babaoglu, K.; Moore, E.L.; Katz, R.D.; Shipman, J.M.; Garcia-Calvo, M.; Sharma, S.; Sheth, P.; Soisson, S.M.; Stevens, R.C.; Katritch, V.; Cherezov, V. Nature 2017, 544, 327 (PMID: 28379944) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
---|---|---|---|---|---|---|---|
![]() | Homo sapiens (Human) (P30988) | Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric gs protein complex | Electron Microscopy | 4.1 | 2017-05-03 | Liang, Y.L.; Khoshouei, M.; Radjainia, M.; Zhang, Y.; Glukhova, A.; Tarrasch, J.; Thal, D.M.; Furness, S.G.B.; Christopoulos, G.; Coudrat, T.; Danev, R.; Baumeister, W.; Miller, L.J.; Christopoulos, A.; Kobilka, B.K.; Wootten, D.; Skiniotis, G.; Sexton, P.M. Nature 2017 (PMID: 28437792) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
---|---|---|---|---|---|---|---|
![]() | Homo sapiens (Human) (P34998) | Crystal structure of human corticotropin-releasing factor receptor 1 (crf1r) in complex with the antagonist cp-376395 | X-Ray Diffraction | 2.98 | 2013-07-17 | Hollenstein, K.; Kean, J.; Bortolato, A.; Cheng, R.K.; Dore, A.S.; Jazayeri, A.; Cooke, R.M.; Weir, M.; Marshall, F.H. Nature 2013, 499, 438 (PMID: 23863939) | |
![]() | Homo sapiens (Human) (P34998) | Crystal structure of human corticotropin-releasing factor receptor 1 (crf1r) in complex with the antagonist cp-376395 in a hexagonal setting with translational non-crystallographic symmetry | X-Ray Diffraction | 3.18 | 2016-06-29 | Dore, A.S.; Bortolato, A.; Hollenstein, K.; Cheng, R.K.Y.; Read, R.J.; Marshall, F.H. To Be Published (PMID: N/A) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
---|---|---|---|---|---|---|---|
![]() | Homo sapiens (Human) (P47871) | Crystal structure of the human glucagon receptor (gcgr) in complex with the antagonist mk-0893 | X-Ray Diffraction | 2.5 | 2016-04-20 | Jazayeri, A.; Dore, A.S.; Lamb, D.; Krishnamurthy, H.; Southall, S.M.; Baig, A.H.; Bortolato, A.; Koglin, M.; Robertson, N.J.; Errey, J.C.; Andrews, S.P.; Teobald, I.; Brown, A.J.; Cooke, R.M.; Weir, M.; Marshall, F.H. Nature 2016, 533, 274 (PMID: 27111510) | |
![]() | Homo sapiens (Human) (P47871) | Structure of the class b human glucagon g protein coupled receptor | X-Ray Diffraction | 3.3 | 2013-07-24 | Siu, F.Y.; He, M.; Degraaf, C.; Han, G.W.; Yang, D.; Zhang, Z.; Zhou, C.; Xu, Q.; Wacker, D.; Joseph, J.S.; Liu, W.; Lau, J.; Cherezov, V.; Katritch, V.; Wang, M.W.; Stevens, R.C. Nature 2013, 499, 444 (PMID: 23863937) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
---|---|---|---|---|---|---|---|
![]() | Homo sapiens (Human) (P43220) | Structure of the human glp-1 receptor complex with nnc0640 | X-Ray Diffraction | 3.0 | 2017-05-17 | Song, G.; Yang, D.; Wang, Y.; Degraaf, C.; Zhou, Q.; Jiang, S.; Liu, K.; Cai, X.; Dai, A.; Lin, G.; Liu, D.; Wu, F.; Wu, Y.; Zhao, S.; Ye, L.; Han, G.W.; Lau, J.; Wu, B.; Hanson, M.A.; Liu, Z.-J.; Wang, M.-W.; Stevens, R.C. Nature 2017 (PMID: N/A) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
---|---|---|---|---|---|---|---|
![]() | Homo sapiens (Human) (Q13255) | Human class c g protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator | X-Ray Diffraction | 2.8 | 2014-03-19 | Wu, H.; Wang, C.; Gregory, K.J.; Han, G.W.; Cho, H.P.; Xia, Y.; Niswender, C.M.; Katritch, V.; Meiler, J.; Cherezov, V.; Conn, P.J.; Stevens, R.C. Science 2014, 344, 58 (PMID: 24603153) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
---|---|---|---|---|---|---|---|
![]() | Homo sapiens (Human) (P41594) | Structure of the human class c gpcr metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile -(htl14242) | X-Ray Diffraction | 2.6 | 2015-08-12 | Christopher, J.A.; Aves, S.J.; Bennett, K.A.; Dore, A.S.; Errey, J.C.; Jazayeri, A.; Marshall, F.H.; Okrasa, K.; Serrano-Vega, M.J.; Tehan, B.G.; Wiggin, G.R.; Congreve, M. J Med Chem 2015, 58, 6653 (PMID: 26225459) | |
![]() | Homo sapiens (Human) (P41594) | Structure of the human class c gpcr metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator mavoglurant | X-Ray Diffraction | 2.6 | 2014-07-02 | Dore, A.S.; Okrasa, K.; Patel, J.C.; Serrano-Vega, M.; Bennett, K.; Cooke, R.M.; Errey, J.C.; Jazayeri, A.; Khan, S.; Tehan, B.; Weir, M.; Wiggin, G.R.; Marshall, F.H. Nature 2014, 511, 557 (PMID: 25042998) | |
![]() | Homo sapiens (Human) (P41594) | Structure of the human class c gpcr metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-4-fluoro-5-[6-(1h-pyrazol-1-yl)pyrimidin-4-yl]benzonitrile | X-Ray Diffraction | 3.1 | 2015-08-12 | Christopher, J.A.; Aves, S.J.; Bennett, K.A.; Dore, A.S.; Errey, J.C.; Jazayeri, A.; Marshall, F.H.; Okrasa, K.; Serrano-Vega, M.J.; Tehan, B.G.; Wiggin, G.R.; Congreve, M. J Med Chem 2015, 58, 6653 (PMID: 26225459) |
PDB ID | Species (UniProt ID) | Description | Method | Resolution (Å) | Released | Reference | |
---|---|---|---|---|---|---|---|
![]() | Homo sapiens (Human) (Q99835) | Structure of the human smoothened receptor in complex with sag1.5 | X-Ray Diffraction | 2.6 | 2014-07-23 | Wang, C.; Wu, H.; Evron, T.; Vardy, E.; Han, G.W.; Huang, X.P.; Hufeisen, S.J.; Mangano, T.J.; Urban, D.J.; Katritch, V.; Cherezov, V.; Caron, M.G.; Roth, B.L.; Stevens, R.C. Nat Commun 2014, 5, 4355 (PMID: 25008467) | |
![]() | Homo sapiens (Human) (Q99835) | Human smoothened receptor structure in complex with cyclopamine | X-Ray Diffraction | 3.2 | 2014-03-05 | Weierstall, U.; James, D.; Wang, C.; White, T.A.; Wang, D.; Liu, W.; Spence, J.C.; Brucedoak, R.; Nelson, G.; Fromme, P.; Fromme, R.; Grotjohann, I.; Kupitz, C.; Zatsepin, N.A.; Liu, H.; Basu, S.; Wacker, D.; Han, G.W.; Katritch, V.; Boutet, S.; Messerschmidt, M.; Williams, G.J.; Koglin, J.E.; Marvinseibert, M.; Klinker, M.; Gati, C.; Shoeman, R.L.; Barty, A.; Chapman, H.N.; Kirian, R.A.; Beyerlein, K.R.; Stevens, R.C.; Li, D.; Shah, S.T.; Howe, N.; Caffrey, M.; Cherezov, V. Nat Commun 2014, 5, 3309 (PMID: 24525480) | |
![]() | Homo sapiens (Human) (Q99835) | Structure of the human smoothened receptor in complex with sant-1. | X-Ray Diffraction | 2.8 | 2014-01-22 | Wang, C.; Wu, H.; Evron, T.; Vardy, E.; Han, G.W.; Huang, X.P.; Hufeisen, S.J.; Mangano, T.J.; Urban, D.J.; Katritch, V.; Cherezov, V.; Caron, M.G.; Roth, B.L.; Stevens, R.C. Nat Commun 2014, 5, 4355 (PMID: 25008467) | |
![]() | Homo sapiens (Human) (Q99835) | Structure of human smoothened in complex with vismodegib | X-Ray Diffraction | 3.3 | 2016-07-20 | Byrne, E.F.; Sircar, R.; Miller, P.S.; Hedger, G.; Luchetti, G.; Nachtergaele, S.; Tully, M.D.; Mydock-Mcgrane, L.; Covey, D.F.; Rambo, R.P.; Sansom, M.S.; Newstead, S.; Rohatgi, R.; Siebold, C. Nature 2016, 535, 517 (PMID: 27437577) | |
![]() | Homo sapiens (Human) (Q99835) | Structure of the human smoothened 7tm receptor in complex with an antitumor agent | X-Ray Diffraction | 2.45 | 2013-04-24 | Wang, C.; Wu, H.; Katritch, V.; Han, G.W.; Huang, X.P.; Liu, W.; Siu, F.Y.; Roth, B.L.; Cherezov, V.; Stevens, R.C. Nature 2013, 497, 338 (PMID: 23636324) | |
![]() | Homo sapiens (Human) (Q99835) | Structure of human smoothened in complex with cholesterol | X-Ray Diffraction | 3.2 | 2016-07-20 | Byrne, E.F.; Sircar, R.; Miller, P.S.; Hedger, G.; Luchetti, G.; Nachtergaele, S.; Tully, M.D.; Mydock-Mcgrane, L.; Covey, D.F.; Rambo, R.P.; Sansom, M.S.; Newstead, S.; Rohatgi, R.; Siebold, C. Nature 2016, 535, 517 (PMID: 27437577) | |
![]() | Homo sapiens (Human) (Q99835) | Structure of the human smoothened receptor in complex with anta xv | X-Ray Diffraction | 2.61 | 2014-07-23 | Wang, C.; Wu, H.; Evron, T.; Vardy, E.; Han, G.W.; Huang, X.P.; Hufeisen, S.J.; Mangano, T.J.; Urban, D.J.; Katritch, V.; Cherezov, V.; Caron, M.G.; Roth, B.L.; Stevens, R.C. Nat Commun 2014, 5, 4355 (PMID: 25008467) |
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