Detailed GPCR-I-TASSER Statistics for P33032

Submitted Sequence

>sp|P33032|MC5R_HUMAN
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGA
IVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDS
MICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILY
SESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTV
TMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQ
EMRKTFKEIICCRGFRIACSFPRRD

Predicted Secondary Structure

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |     
Sequence MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
Prediction CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHSSSSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCSSCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHSSSSSSSHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCC
Conf.Score 9876555566876788888767643368999824889999999999999999899840225657988869999999999999999999999999999953886220340999999999999999999999999999997078603546687464689999999999999999999999936762244210788999999999999999999999977997324654224577789999988537776213079999999999869866641089999999999898887809999808999999999994755789998999998

Predicted Solvent Accessibility

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |     
Sequence MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
Prediction 6223233411314232443423253264642332200001111220022033233000000010340100000000000100000012123300000034332011010002100300000001001002300000011000000100203331323000000000011001001000023331000000233133122101203220010013103303435646444333121000000000000110113010100000003331313002010110001013211220002001164003001100002002462544368

Predicted Normalized B-Factor


Read more about predicted normalized B-factor

  Top 10 Templates Used by GPCR-I-TASSER


Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |     
Sec.Str
Seq		CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHSSSSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCSSCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHSSSSSSSHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCC
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
15tjvA 0.25 0.23 0.85 2.75Download ---------------ENFMDIECFMVLN----PSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCPSYHFIGSLAVADLLGSVIFVYSFIDFHVFH-------RKDSRNVFLFKLGGVTASFTASVGSLFLAAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAGKRAMSF-----SDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGK---MNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMF---------------
22rh1A 0.25 0.24 0.78 3.88Download ----------------------------------WVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKM------WTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQ--------------LLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIR----KEVYILLNWIGYVNSGFNPLIYCR-SPDFRIAFQELLC--------------
35tgzA 0.25 0.24 0.85 3.24Download --------------GGRGENFMDIECFMVLNP-SQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDS-------RNVFLFKLGGVTASFTASVGSLFLAAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEDKTYLMFWIGVVSVLLLFIVYAYMYILWKAHSHA--------PDQARMDIELAKTLVLILVVLIICWGPLLAIMVYDVFGKMN---KLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMF---------------
44ib4 0.19 0.26 0.85 1.56Download -----------------------------EEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFE--------AMWPLPLVLCPAWLFLDVLASIWHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIEDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAADLEDNWQKYLQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCN-QTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYR----------
53uon 0.21 0.24 0.83 1.19Download --------------------------------TFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIG------YWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRINIFEMLTWDAYPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAP----CIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLM--------------
65tjvA 0.25 0.23 0.85 2.92Download ----------------NFMDIECFMV----LNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCPSYHFIGSLAVADLLGSVIFVYSFIDFHVFH-------RKDSRNVFLFKLGGVTASFTASVGSLFLAAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAG-----KRAMSFSDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNK---LIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMF---------------
74ib4 0.19 0.26 0.84 1.75Download ----------------------------------KLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFE-AM----WPLPLVLCPAWLFLDVLFSTASIWHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAADLEDNWQKYLQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCN-QTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNY-----------
82z73A 0.19 0.21 0.93 2.56Download -ETWWY----------NPSIVVHPHWREFDQVPDAVYYSLGIFIGIGIIGCGGNGIVIYLFTKTKSLQTPANMFIINLAFSDFTFSLVNGFPLMTISCFLKKWI-----FGFAACKVYGFIGGIFGFMSIMTMAMISIDRYNVIGRPMAASKKMSHRRAFIMIIFVWLWSVLWAIGPIFGWGA-YTLEMFILGFFGPILIIFFCYFNIVMSVSNHEKEMAAMAKRLNAGANAEMRLAKISIVIVSQFLLSWSPYAVVALLAQFGPLEWVT---PYAAQLPVMFAKASAIHNPMIYSVSHPKFREAISQTFPWVLTC--CQFDDKE
94iaqA 0.24 0.23 0.82 3.02Download ------------------------YIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTG------RWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIIQKYL------LMAARERKATKTLGIILGAFIVCWLPFFIISLVMPIH---------LAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK------------
105g53A 0.29 0.27 0.82 3.66Download -----------------------------------SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITI--------STGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMT---------LQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDC--SHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLENLY------
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: MUSTER   2: FFAS-3D   3: SPARKS-X   4: HHSEARCH2   5: HHSEARCH I   6: Neff-PPAS   7: HHSEARCH   8: pGenTHREADER   9: wdPPAS   10: cdPPAS   

  Top 5 Models Predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=-0.42 (Read more about C-score)
  • Estimated TM-score = 0.66±0.13
  • Estimated RMSD = 7.3±4.2Å

  • Download Model 2
  • C-score = -1.16

  • Download Model 3
  • C-score = -1.02

  • Download Model 4
  • C-score = -2.96

  • Download Model 5
  • C-score = -1.38


    • [Click on P33032_results.tar.bz2 to download the tarball file including all modeling results listed on this page]