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GPCR-I-TASSER results for job id Q86SQ3

[Click on Q86SQ3_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q86SQ3
MGSRFLLVLLSGASCPPCPKYASCHNSTHCTCEDGFRARSGRTYFHDSSEKCEDINECET
GLAKCKYKAYCRNKVGGYICSCLVKYTLFNFLAGIIDYDHPDCYENNSQGTTQSNVDIWV
SGVKPGFGKQLPGDKRTKHICVYWEGSEGGWSTEGCSHVHSNGSYTKCKCFHLSSFAVLV
ALAPKEDPVLTVITQVGLTISLLCLFLAILTFLLCRPIQNTSTSLHLELSLCLFLAHLLF
LTGINRTEPEVLCSIIAGLLHFLYLACFTWMLLEGLHLFLTVRNLKVANYTSTGRFKKRF
MYPVGYGIPAVIIAVSAIVGPQNYGTFTCWLKLDKGFIWSFMGPVAVIILINLVFYFQVL
WILRSKLSSLNKEVSTIQDTRVMTFKAISQLFILGCSWGLGFFMVEEVGKTIGSIIAYSF
TIINTLQGVLLFVVHCLLNRQVRLIILSVISLVPKSN

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                 
MGSRFLLVLLSGASCPPCPKYASCHNSTHCTCEDGFRARSGRTYFHDSSEKCEDINECETGLAKCKYKAYCRNKVGGYICSCLVKYTLFNFLAGIIDYDHPDCYENNSQGTTQSNVDIWVSGVKPGFGKQLPGDKRTKHICVYWEGSEGGWSTEGCSHVHSNGSYTKCKCFHLSSFAVLVALAPKEDPVLTVITQVGLTISLLCLFLAILTFLLCRPIQNTSTSLHLELSLCLFLAHLLFLTGINRTEPEVLCSIIAGLLHFLYLACFTWMLLEGLHLFLTVRNLKVANYTSTGRFKKRFMYPVGYGIPAVIIAVSAIVGPQNYGTFTCWLKLDKGFIWSFMGPVAVIILINLVFYFQVLWILRSKLSSLNKEVSTIQDTRVMTFKAISQLFILGCSWGLGFFMVEEVGKTIGSIIAYSFTIINTLQGVLLFVVHCLLNRQVRLIILSVISLVPKSN
PredictionCCCSSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHSSSSCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSSCCCCCCCCCCHHHHSSSSSHHHHHHHHHSSSSSSSCCCCCCCCSSSCCCCCSSSSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHSSSSCCCCCCHHHHHHHHHHHHHHHHHHHHHHSSSSCCHHHHHHHHHHCCCCCCCC
Conf.Score9856999766899899999999388997433887673777873314999986640342479999999973122477377882687715897555677566654577755443446886433445443333345554433443333222223344432234444334434343355543234466544300000011256888999999999987514311443058999999999888632441124555430137889999999999999999999987310210234444531234167643243332233137999526677754586688746899963389999998999999999998764321123462999999999999999999999986054400377609999999999999999988402244508999999999803787899

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                 
MGSRFLLVLLSGASCPPCPKYASCHNSTHCTCEDGFRARSGRTYFHDSSEKCEDINECETGLAKCKYKAYCRNKVGGYICSCLVKYTLFNFLAGIIDYDHPDCYENNSQGTTQSNVDIWVSGVKPGFGKQLPGDKRTKHICVYWEGSEGGWSTEGCSHVHSNGSYTKCKCFHLSSFAVLVALAPKEDPVLTVITQVGLTISLLCLFLAILTFLLCRPIQNTSTSLHLELSLCLFLAHLLFLTGINRTEPEVLCSIIAGLLHFLYLACFTWMLLEGLHLFLTVRNLKVANYTSTGRFKKRFMYPVGYGIPAVIIAVSAIVGPQNYGTFTCWLKLDKGFIWSFMGPVAVIILINLVFYFQVLWILRSKLSSLNKEVSTIQDTRVMTFKAISQLFILGCSWGLGFFMVEEVGKTIGSIIAYSFTIINTLQGVLLFVVHCLLNRQVRLIILSVISLVPKSN
Prediction7312000001142413311620514111202033103243233303323330430340334344134313033232001010233332344443334333241233313123324243233222232333244433332000002134230133203233344220202321000000000134444200200010000000000110010000002243320100000000002111000000213313000000000001000000000000020002001101212323342000000000001100000000000226212210000024200000000110000110321121000000231343446344243002000000000000230100000001334320100000000000030001000000011540041013103426578
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                 
Sec.Str
Seq		CCCSSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHSSSSCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSSCCCCCCCCCCHHHHSSSSSHHHHHHHHHSSSSSSSCCCCCCCCSSSCCCCCSSSSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHSSSSCCCCCCHHHHHHHHHHHHHHHHHHHHHHSSSSCCHHHHHHHHHHCCCCCCCC
MGSRFLLVLLSGASCPPCPKYASCHNSTHCTCEDGFRARSGRTYFHDSSEKCEDINECETGLAKCKYKAYCRNKVGGYICSCLVKYTLFNFLAGIIDYDHPDCYENNSQGTTQSNVDIWVSGVKPGFGKQLPGDKRTKHICVYWEGSEGGWSTEGCSHVHSNGSYTKCKCFHLSSFAVLVALAPKEDPVLTVITQVGLTISLLCLFLAILTFLLCRPIQNTSTSLHLELSLCLFLAHLLFLTGINRTEPEVLCSIIAGLLHFLYLACFTWMLLEGLHLFLTVRNLKVANYTSTGRFKKRFMYPVGYGIPAVIIAVSAIVGPQNYGTFTCWLKLDKGFIWSFMGPVAVIILINLVFYFQVLWILRSKLSSLNKEVSTIQDTRVMTFKAISQLFILGCSWGLGFFMVEEVGKTIGSIIAYSFTIINTLQGVLLFVVHCLLNRQVRLIILSVISLVPKSN
14l6rA 0.17 0.20 0.83 1.69Download ------------------------------------------ADLEDNWETLNDNKVIEKADNA--KDALTKMRAAALDAQ------KATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKL---------------------ANEGKVKEAQAAAEQLKTTRNAYIQKYLMDGEEIEVEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLL-----GLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTD--YKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGK
24l6rA 0.19 0.20 0.67 2.84Download --------------------------------------------------------------------------------------------------------------------------------------------------NEGKVKEAQAAAEQLKTTRNAYIQKYLMDGEEIEKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLAT-----LPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTD--YKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGK
34l6rA 0.16 0.20 0.82 2.91Download ----------------------------------------------------DNWETLNDNLKVIEKDALTKMRAAALDAQ-------------------------KATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLG-----LATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRAR--QMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGK
45ee7A 0.23 0.14 0.54 2.36Download ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YSSFQVMYTVGYSLSLAALLLALAILGGLSKLHCTANAIHANLFLSFVLKASAVLFIDGLLRAVAACRVAAVFMQYGIVANYCWLLVEGLYLHNLLG----------LRSFFSLYLGIGWGAPALFVVPWAVVKCLFE-NVQCW--TNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRA--RQMHHTDYAFRLAKSTLTLIPLLGVHFVVFAFVTDEHRS----AKLFFDLALSSFQGLLVAVLYCFLNKEVQSELRRRWHRA----
54l6rA 0.16 0.20 0.80 2.20Download -----------------------------------------------------------------------------------ADLEEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQILKLANEGKVKEAQAAAEQLKTTRNAYIQKYLMDGEEIEKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTLAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATL-----PERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTD--YKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGK
65vaiA 0.19 0.14 0.58 2.50Download ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSPEERLLSLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDATYQDSLGCRLVFLLMQYCVAANYYWLLVEGAYLYTLLAFAVF-----SEQRIFKLYLSIGWGVPLLFVIPWGIVKY-LYEDEGCWTRNSNNYWLIIRLPILFAIGVNFLIFIRVICIVVSKLKANLMCKTDI--KCRLAKSTLTLIPLLGTHEVIFAFVMDEHRGTLRFVKLFTELSFTSFQGLMVAILYCFVNNEVQMEFRKSWERWR---
75nx2A 0.17 0.19 0.81 1.33Download ------------------------------------------------------------TVSLWET----VQKWREYRRQCQRSLTEDPPPATDLF---CNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTA--------EGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSCRLVFLFMQYCVAANYYWLLVEGVYLYTLL-----AFSVFSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEACWARNSNMNYWLIIRLPILFAIGVNFLIFVRVIAIVVSKLK--ANLMCKTDIKCRLAKSTLTLIALLATVEVIFAFVMDEHAGTLRFIKLFTELSFTSFQGLMVAILYCFANNEVQLEFRKSW-------
85vaiA 0.19 0.14 0.58 2.14Download ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSPEERLLSLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDATYQDSLGCRLVFLLMQYCVAANYYWLLVEGAYLYTLLAFAVF-----SEQRIFKLYLSIGWGVPLLFVIPWGIVKY-LYEDEGCWTRNSMNYWLIIRLPILFAIGVNFLIFIRVICIVVSKLKANLMCKTDI--KCRLAKSTLTLIPLLGTHEVFAFVMDEHARGTLRFVKLFTELSFTSFQGLMVAILYCFVNNEVQMEFRKSWERWR---
95l7dA 0.10 0.17 0.88 2.33Download -----------PPPLSHCGRAAPCLRYNVCLG----SVLPYGATSTLLAGDSDSQEECENDRVELPSRTLCQATRGP----CAIVERERGWPDFLRCTPDRFPEGCTNEVQNIKFNSS--------------------------------GQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLGEPTSNETLSCVIIFVIVYYALMAGFVWFVVLTYAWHTSFKALQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDG----DSVSGICFVGYKNYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSARRQLADLEDNWETLNDNLKVIEKAQVKDALTKMRAAALDAQKATPPSPEMKDFRHGFDILVGQIDDALKLANERSFRDYVLCQANVTIGLP
104k5yA 0.25 0.15 0.53 2.97Download ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YHVAAIINYLGHCISLVALLVAFVLFLRARSIRCLRNIIHANLIAAFILRNATWFVVQLTQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLWDA-----YDRLRAWMFICIGWGVPFPIIVAWAIG-KLYYDNEKCWAGKRPGVYYIYQGPMALVLLINFIFLFNIVRILMTKLRAST--TSETIQARKAVKATLVLLPLLGITYMLAFVN-----EVSRVVFIYFNAFLESFQGFFVSVFACFLNS-----------------
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: MUSTER   2: FFAS-3D   3: Neff-PPAS   4: SPARKS-X   5: wdPPAS   6: HHSEARCH2   7: cdPPAS   8: HHSEARCH I   9: PROSPECT2   10: HHSEARCH   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=-2.53 (Read more about C-score)
  • Estimated TM-score = 0.42±0.14
  • Estimated RMSD = 13.3±4.1Å

  • Download Model 2
  • C-score = -3.00

  • Download Model 3
  • C-score = -3.31

  • Download Model 4
  • C-score = -2.90

  • Download Model 5
  • C-score = -3.71



    • [Click on Q86SQ3_results.tar.bz2 to download the tarball file including all modeling results listed on this page]


     Please cite the following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. GPCR-I-TASSER: A hybrid approach to G protein-coupled receptor structure modeling and the application to the human genome, Structure, 23: 1538-1549, 2015.