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GPCR-I-TASSER results for job id Q99463

[Click on Q99463_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q99463
MEVSLNHPASNTTSTKNNNSAFFYFESCQPPSPALLLLCIAYTVVLIVGLFGNLSLIIII
FKKQRKAQNFTSILIANLSLSDTLVCVMCIHFTIIYTLMDHWIFGDTMCRLTSYVQSVSI
SVSIFSLVFTAVERYQLIVNPRGWKPSVTHAYWGITLIWLFSLLLSIPFFLSYHLTDEPF
RNLSLPTDLYTHQVACVENWPSKKDRLLFTTSLFLLQYFVPLGFILICYLKIVICLRRRN
AKVDKKKENEGRLNENKRINTMLISIVVTFGACWLPRISSMSSLTGIMRC

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |          
MEVSLNHPASNTTSTKNNNSAFFYFESCQPPSPALLLLCIAYTVVLIVGLFGNLSLIIIIFKKQRKAQNFTSILIANLSLSDTLVCVMCIHFTIIYTLMDHWIFGDTMCRLTSYVQSVSISVSIFSLVFTAVERYQLIVNPRGWKPSVTHAYWGITLIWLFSLLLSIPFFLSYHLTDEPFRNLSLPTDLYTHQVACVENWPSKKDRLLFTTSLFLLQYFVPLGFILICYLKIVICLRRRNAKVDKKKENEGRLNENKRINTMLISIVVTFGACWLPRISSMSSLTGIMRC
PredictionCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHSSSSSSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCSSCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSSSCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHSSSSSCCCCCCCCCCCCCCCCCSSSCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
Conf.Score99756799888778878888765554556762999999999998788850167870887777588878599999999999999999994699999998276036436898799999999999999999999982503421687633264688715599999999999999887799604777544445578873560469977899999999999999999999999999999998053666662166999999875899999999999999999999999999656669

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |          
MEVSLNHPASNTTSTKNNNSAFFYFESCQPPSPALLLLCIAYTVVLIVGLFGNLSLIIIIFKKQRKAQNFTSILIANLSLSDTLVCVMCIHFTIIYTLMDHWIFGDTMCRLTSYVQSVSISVSIFSLVFTAVERYQLIVNPRGWKPSVTHAYWGITLIWLFSLLLSIPFFLSYHLTDEPFRNLSLPTDLYTHQVACVENWPSKKDRLLFTTSLFLLQYFVPLGFILICYLKIVICLRRRNAKVDKKKENEGRLNENKRINTMLISIVVTFGACWLPRISSMSSLTGIMRC
Prediction55432333342323333443323324424233001000021113002202321320010000123402100010020003002110200010101110253011130022001101110000002000000100020001002433333200000000111010001010001203434345342333334320101030127403200000103321331010002000100110233434354454344234432100000000000100033313011001132357
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |          
Sec.Str
Seq		CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHSSSSSSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCSSCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSSSCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHSSSSSCCCCCCCCCCCCCCCCCSSSCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
MEVSLNHPASNTTSTKNNNSAFFYFESCQPPSPALLLLCIAYTVVLIVGLFGNLSLIIIIFKKQRKAQNFTSILIANLSLSDTLVCVMCIHFTIIYTLMDHWIFGDTMCRLTSYVQSVSISVSIFSLVFTAVERYQLIVNPRGWKPSVTHAYWGITLIWLFSLLLSIPFFLSYHLTDEPFRNLSLPTDLYTHQVACVENWPSKKDRLLFTTSLFLLQYFVPLGFILICYLKIVICLRRRNAKVDKKKENEGRLNENKRINTMLISIVVTFGACWLPRISSMSSLTGIMRC
14n6hA 0.22 0.26 0.86 2.33Download ----------------------SPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRY-TKMKTATNIYIFNLALADALATSTLPFQSAKYLM--TWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDG------------AVVCMLQFPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGS----KEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDID
21gzmA 0.20 0.22 0.94 3.61Download MNGTEGPPFSNKTGVVRSPFEAPQ--YYLAEPWQFSMLAAYMFLLIMLGFPINF-LTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEG-----------MQCSCGIDYYTETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQESA---TTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGS
34n6hA 0.23 0.26 0.86 3.61Download ----------------------SPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRY-TKMKTATNIYIFNLALADALATST-LPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRD------------GAVVCMLQFPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGS----KEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDID
44djh 0.23 0.28 0.86 1.51Download ------------------------------SPAIPVIITAVYSVVFVVGLVGNSLVMF-VIIRYTKMKTATNIYIFNLALADALVTT-TMPFQSTVYLMNSWPFGDVLCKIVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDTPLKAKIINICIWLLSSSVGISAIVLGGTKVRE----------DVDVIECSLQFPDDDYDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGNIPAYREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSAA
54djh 0.23 0.28 0.86 1.13Download ------------------------------SPAIPVIITAVYSVVFVVGLVGNS-LVMFVIIRYTKMKTATNIYIFNLALADALVT-TTMPFQSTVYLMNSWPFGDVLCKIVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALRTPLKAKIINICIWLLSSSVGISAIVLGGTKVRED----------VDVIECSLQFPDDDWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGNTPNRREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSAA
64n6hA 0.23 0.26 0.86 2.81Download ------------------------GARSASSLALAIAITALYSAVCAVGLLGNVLV-MFGIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRD------------GAVVCMLQFPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSG----SKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDID
73uon 0.18 0.24 0.67 1.68Download ----------------------------------VVFIVLVAGSLSLVTIIGNILVMVSIK-VNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRT---------VEDGECYIQFFSN---AAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRINI------------------------------------------------
81u19A 0.21 0.22 0.95 3.54Download MNGNFYVPFSNKTGV--VRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPIN-FLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPH----EETN----NESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQESA---TTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGS
94n6hA 0.22 0.26 0.86 2.60Download ----------------------SPGARSASSLALAIAITALYSAVCAVGLLGNVL-VMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLM--TWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRD------------GAVVCMLQFPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGS----KEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDID
105c1mA 0.22 0.24 0.87 3.44Download -------------------GSHSLPQTGSPSMVTAITIMALYSIVCVVGLFGNFL-VMYVIVRYTKMKTATNIYIFNLALADALAT-STLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQ------------GSIDCTLTFPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGS----KEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIP
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: MUSTER   2: FFAS-3D   3: SPARKS-X   4: HHSEARCH2   5: HHSEARCH I   6: Neff-PPAS   7: HHSEARCH   8: pGenTHREADER   9: wdPPAS   10: cdPPAS   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=0.09 (Read more about C-score)
  • Estimated TM-score = 0.73±0.11
  • Estimated RMSD = 5.9±3.7Å

  • Download Model 2
  • C-score = -1.69

  • Download Model 3
  • C-score = -2.63

  • Download Model 4
  • C-score = -2.57

  • Download Model 5
  • C-score = -3.12



    • [Click on Q99463_results.tar.bz2 to download the tarball file including all modeling results listed on this page]


     Please cite the following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. GPCR-I-TASSER: A hybrid approach to G protein-coupled receptor structure modeling and the application to the human genome, Structure, 23: 1538-1549, 2015.