GPCR-I-TASSER results for Q52R92

[Click on Q52R92_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q52R92
MKKVTAEAISWNESTSETNNSMVTEFIFLGLSDSQELQTFLFMLFFVFYGGIVFGNLLIV
ITVVSDSHLHSPMYFLLANLSLIDLSLSSVTAPKMITDFFSQRKVISFKGCLVQIFLLHF
FGGSEMVILIAMGFDRYIAICKPLHYTTIMCGNACVGIMAVAWGIGFLHSVSQLAFAVHL
PFCGPNEVDSFYCDLPRVIKLACTDTYRLDIMVIANSGVLTVCSFVLLIISYTIILMTIQ
HRPLDKSSKALSTLTAHITVVLLFFGP

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |       
MKKVTAEAISWNESTSETNNSMVTEFIFLGLSDSQELQTFLFMLFFVFYGGIVFGNLLIVITVVSDSHLHSPMYFLLANLSLIDLSLSSVTAPKMITDFFSQRKVISFKGCLVQIFLLHFFGGSEMVILIAMGFDRYIAICKPLHYTTIMCGNACVGIMAVAWGIGFLHSVSQLAFAVHLPFCGPNEVDSFYCDLPRVIKLACTDTYRLDIMVIANSGVLTVCSFVLLIISYTIILMTIQHRPLDKSSKALSTLTAHITVVLLFFGP
PredictionCCCCCHCCCCCCCCCCCCCCCSSCSSCSCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHSSCSSCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCSSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCSSCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHSSSSSSCC
Conf.Score963111004463310055587110310207998832699999999999999999888842201327999997899988599987875423629999998549975738999999999999999999999999976188857431362316875899999999999999999999997048999988476861381888888203324667678766889999999999999999999984627240519988888698878988587

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |       
MKKVTAEAISWNESTSETNNSMVTEFIFLGLSDSQELQTFLFMLFFVFYGGIVFGNLLIVITVVSDSHLHSPMYFLLANLSLIDLSLSSVTAPKMITDFFSQRKVISFKGCLVQIFLLHFFGGSEMVILIAMGFDRYIAICKPLHYTTIMCGNACVGIMAVAWGIGFLHSVSQLAFAVHLPFCGPNEVDSFYCDLPRVIKLACTDTYRLDIMVIANSGVLTVCSFVLLIISYTIILMTIQHRPLDKSSKALSTLTAHITVVLLFFGP
Prediction744333741433550366030300000000004346112100131133133233333300200100430100001002300020111000100200100125431010400000011111102300200110030000000211202000033100000220132023003201310230300241411000002320030001103311230233023303331320331123002001322461232001001002100201337
Values range from 0 (buried residue) to 9 (highly exposed residue)

  Top 5 Models predicted by GPCR-I-TASSER

Download Model 1 Download Model 2 Download Model 3 Download Model 4 Download Model 5
C-score=-0.50
 C-score=-2.09
 C-score=-2.29
 C-score=-3.89
 C-score=-1.12
 
Estimated accuracy of Model1: 0.65±0.13 (TM-score)    7.0±4.1Å (RMSD)    (Read more about C-score of generated models)
Estimated local accuracy of Model1: The estiamted distances (between model and native structure, shown in 1st figure) for residues are more reliable for aligned (i.e., residues with high alignment coverage shown in 2nd figure) α-helix and β-strand regions.
Download estimated local accuracy of Model2, Model3, Model4, Model5

  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |       
Sec.Str
Seq		CCCCCHCCCCCCCCCCCCCCCSSCSSCSCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHSSCSSCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCSSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCSSCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHSSSSSSCC
MKKVTAEAISWNESTSETNNSMVTEFIFLGLSDSQELQTFLFMLFFVFYGGIVFGNLLIVITVVSDSHLHSPMYFLLANLSLIDLSLSSVTAPKMITDFFSQRKVISFKGCLVQIFLLHFFGGSEMVILIAMGFDRYIAICKPLHYTTIMCGNACVGIMAVAWGIGFLHSVSQLAFAVHLPFCGPNEVDSFYCDLPRVIKLACTDTYRLDIMVIANSGVLTVCSFVLLIISYTIILMTIQHRPLDKSSKALSTLTAHITVVLLFFGP
14iaqA 0.22 0.21 0.74 1.61Download --------------------------YIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGR----WVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISILYTVYSTVGAF---------------------------------------YFPTLLLIALYGRIYVEARSRIIQKERKATKTLGIILGAFIVCWLP
23oduA 0.19 0.19 0.85 2.90Download ---------------------------PCFRENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVI-TLPFWAVDAVA-NWYFGNFLCKAVHVIYTVNLYSSVWILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSE-----ADDRYICDRFYP------NDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSGGHQKRKALKTTVILILAFFACWLP
33emlA 0.21 0.24 0.82 2.88Download ----------------------------------IMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIS---GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGGCGEGQVACLFEDVVPMNYMVYF-----------NFFACVLVPLLLMLGVYLRIFLAARRQVHAAKSLAIIVGLFALCWLPLHFCP
41l9hA 0.15 0.24 0.93 4.03Download YVPFSNKTGVVRSPFEAPQYYLA----------EPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFR-FGENHAIMGVAFTWVMALACAA--PPLVGWSRYIPEGMQCSCGIDYYT-----PHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAATTQKAEKEVTRMVIIMVIAFLP
53emlA 0.19 0.24 0.82 3.87Download I----------------------------------MGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI--TISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLNCGQSQGCGEGQVACLFEDVVPMNYMVYFNFFACV-----------LVPLLLMLGVYLRIFLAARQLVHAAKSLAIIVGLFALCWLPLHLRQ
64iaqA 0.20 0.21 0.77 1.71Download -------------------------------------KVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFW-------------------------ECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRMAARERKATKTLGIILGAFIVCWLP
74grvA 0.17 0.21 0.83 3.56Download -------------------------NSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARK----STVHYHLGSLALSDLLILLLAMPVELYNFIWVHWAFGDAGCRGYYFLRDACTYATALNVASLSVARYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQ---------NRSADGTHPGGLVCTDTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVMVNGLRLKIYKDTEG-------YYT-
83emlA 0.20 0.24 0.82 2.49Download -----------------------------------MGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIS--TGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQSQGCGEGQVACLFEDV--------VPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQ----LVHAAKSLAIIVGLFALCWLP
93emlA 0.21 0.24 0.82 6.76Download ----------------------------------IMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIST--GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLNCGQSQGCGEGQVACLFE-----------DVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLVAAKSLAIIVGLFALCW-LPLHII
103emlA 0.21 0.24 0.82 3.34Download -----------------------------------MGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGGCGEGQVACLFEDVVP-----------MNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQVHAAKSLAIIVGLFALCWLPLHIIN
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: SPARKS-X   2: HHSEARCH2   3: MUSTER   4: SP3   5: PROSPECT2   6: FFAS03   7: HHSEARCH   8: PRC   9: dPPAS   10: Neff-PPAS   


[Click on Q52R92_results.tar.bz2 to download the tarball file including all modeling results listed on this page]


 Please cite following article when you use the GPCR-I-TASSER server:
J Zhang, J Yang, R Jang, Y Zhang. GPCR-I-TASSER: A new hybrid approach to G protein-coupled receptor structure modeling with application to the human genome, submitted, 2014.