GPCR-I-TASSER results for Q8TDT9

[Click on Q8TDT9_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>tr|Q8TDT9|Q8TDT9_HUMAN
MYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLM
YFIGFLLGDSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTITW
FLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDAS
RYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYLVP
LVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQVKAITWIMSLFTFNVENVSWKYT
CHGCKS

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |      
MYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMYFIGFLLGDSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQVKAITWIMSLFTFNVENVSWKYTCHGCKS
PredictionCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCSSSSSCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHSSSSSSSCCCCCC
Conf.Score988888999999999999999999999999999836510368357999999999999999999980798776676544334333024678898558999999999999999999999899987631566135888889999999998899999999500001687787569843767889999999899999999999999999981027753476003678999999999999999999999999999888526679998764524457899971789999999999876714578885463579

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |      
MYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMYFIGFLLGDSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQVKAITWIMSLFTFNVENVSWKYTCHGCKS
Prediction631377124002100021012002102301000102353142131000000001210010100100233413034344434334233433442200010122110110020000000110110013324343044212100000023023300000012313444221100002233300110133232111331220231000000302531466643352034002210120112323332110000001223630341135440663434112203013201211011230010000233168
Values range from 0 (buried residue) to 9 (highly exposed residue)

  Top 5 Models predicted by GPCR-I-TASSER

Download Model 1
C-score=1.61
 
Estimated accuracy of Model1: 0.94±0.05 (TM-score)    3.0±2.2Å (RMSD)    (Read more about C-score of generated models)
Estimated local accuracy of Model1: The estiamted distances (between model and native structure, shown in 1st figure) for residues are more reliable for aligned (i.e., residues with high alignment coverage shown in 2nd figure) α-helix and β-strand regions.

  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |      
Sec.Str
Seq		CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCSSSSSCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHSSSSSSSCCCCCC
MYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMYFIGFLLGDSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQVKAITWIMSLFTFNVENVSWKYTCHGCKS
14jkvA 0.25 0.29 0.98 2.22Download PLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSRYPAVILFYVNACFFVGSIGWLAQFMARREIVCRADG---TMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTYQPGKTS--YFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYQANCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLI
24jkvA 0.27 0.29 0.97 8.54Download PLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRSNRYPAVILFYVNACFFVGSIGWLAQFMDGREIVCRADGTM-RLGEP--TSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKAGTTYQP--GKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYLCQAN---CEIKSEKINLFAMFG-TGIAMSTWVWTKATLLI
34jkvA 0.25 0.29 0.99 2.31Download PLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIV-CRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKA-LGTTYQPGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLNCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLI
44jkvA 0.25 0.29 0.99 5.74Download PLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIV-CRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFK-ALGTTYQPGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLNCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLI
54jkvA 0.25 0.29 0.99 3.56Download PLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRLG-EPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFK-ALGTTYQPGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLNCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLI
64jkvA 0.25 0.29 0.99 4.83Download -LFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSRYPAVILFYVNACFFVGSIGWLAQFMDGARREIV-CRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKAL-GTTYQPGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFVLCQANCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLI
74jkvA 0.27 0.29 0.98 9.06Download PLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRSNRYPAVILFYVNACFFVGSIGWLAQFMDGAREIVCRADGTMRLGE--PTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKAGTTYQP--GKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYLC--CEINRPSLLVEKINLFAMFGTGIAMSTWVWTKATLL-
84jkvA 0.24 0.29 0.98 7.56Download -LFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWNSNRYPAVILFYVNACFFVGSIGWLAQFMDGREIVCRADGTMRLGE---PTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTS-FKALGTTYQPGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANCEIKEKINLFAMFGTGIAMSTWVWTKATLLIWRR-
94jkvA 0.25 0.29 0.99 1.95Download PLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIV-CRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTT-YQPGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLNCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLI
104jkvA 0.25 0.29 0.99 3.52Download PLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR-ADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGT-TYQPGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYQANCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLI
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: SPARKS-X   2: HHSEARCH2   3: MUSTER   4: SP3   5: PROSPECT2   6: FFAS03   7: HHSEARCH   8: PRC   9: dPPAS   10: Neff-PPAS   


[Click on Q8TDT9_results.tar.bz2 to download the tarball file including all modeling results listed on this page]


 Please cite following article when you use the GPCR-I-TASSER server:
J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted, 2015.