GPCR-I-TASSER results for P59533

[Click on P59533_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>P59533
MLTLTRIRTVSYEVRSTFLFISVLEFAVGFLTNAFVFLVNFWDVVKRQALSNSDCVLLCL
SISRLFLHGLLFLSAIQLTHFQKLSEPLNHSYQAIIMLWMIANQANLWLAACLSLLYCSK
LIRFSHTFLICLASWVSRKISQMLLGIILCSCICTVLCVWCFFSRPHFTVTTVLFMNNNT
RLNWQIKDLNLFYSFLFCYLWSVPPFLLFLVSSGMLTVSLGRHMRTMKVYTRNSRDPSLE
AHIKALKSLVSFFCFFVISSCAAFISVPLLILWRDKIGVMVCVGIMAACPSGHAAILISG
NAKLRRAVMTILLWAQSSLKVRADHKADSRTLC

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |             
MLTLTRIRTVSYEVRSTFLFISVLEFAVGFLTNAFVFLVNFWDVVKRQALSNSDCVLLCLSISRLFLHGLLFLSAIQLTHFQKLSEPLNHSYQAIIMLWMIANQANLWLAACLSLLYCSKLIRFSHTFLICLASWVSRKISQMLLGIILCSCICTVLCVWCFFSRPHFTVTTVLFMNNNTRLNWQIKDLNLFYSFLFCYLWSVPPFLLFLVSSGMLTVSLGRHMRTMKVYTRNSRDPSLEAHIKALKSLVSFFCFFVISSCAAFISVPLLILWRDKIGVMVCVGIMAACPSGHAAILISGNAKLRRAVMTILLWAQSSLKVRADHKADSRTLC
PredictionCCCCCCCCHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHSSCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSSCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCSSSSSCCCCSSSSSSSCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
Conf.Score998886101069999999999999999999999999999999999369898788999999999888365089979999967352555443579999999999399999999999998456368896699999987448276999999999999999999984146551035553169659998741168999999999999999999999999999999999999861878999999809999999999999999999999999999998713566999999999999789867998608739999999999860411468999999877789

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |             
MLTLTRIRTVSYEVRSTFLFISVLEFAVGFLTNAFVFLVNFWDVVKRQALSNSDCVLLCLSISRLFLHGLLFLSAIQLTHFQKLSEPLNHSYQAIIMLWMIANQANLWLAACLSLLYCSKLIRFSHTFLICLASWVSRKISQMLLGIILCSCICTVLCVWCFFSRPHFTVTTVLFMNNNTRLNWQIKDLNLFYSFLFCYLWSVPPFLLFLVSSGMLTVSLGRHMRTMKVYTRNSRDPSLEAHIKALKSLVSFFCFFVISSCAAFISVPLLILWRDKIGVMVCVGIMAACPSGHAAILISGNAKLRRAVMTILLWAQSSLKVRADHKADSRTLC
Prediction735434344032102120232133123313311220021001000453403101100000011102001113332210000031323321000000000122112001000000000000002231100000132033200110121223233122110110233331323333334210213132332220312223333333333213313310110022023203432534411314002200100020222133333212310012233443001010112002100100101013143013001300220202032457463445443
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit
Iden1Iden2Cov.Norm.
Z-score
Download
Align.
                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |             
Sec.Str
Seq
CCCCCCCCHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHSSCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSSCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCSSSSSCCCCSSSSSSSCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
MLTLTRIRTVSYEVRSTFLFISVLEFAVGFLTNAFVFLVNFWDVVKRQALSNSDCVLLCLSISRLFLHGLLFLSAIQLTHFQKLSEPLNHSYQAIIMLWMIANQANLWLAACLSLLYCSKLIRFSHTFLICLASWVSRKISQMLLGIILCSCICTVLCVWCFFSRPHFTVTTVLFMNNNTRLNWQIKDLNLFYSFLFCYLWSVPPFLLFLVSSGMLTVSLGRHMRTMKVYTRNSRDPSLEAHIKALKSLVSFFCFFVISSCAAFISVPLLILWRDKIGVMVCVGIMAACPSGHAAILISGNAKLRRAVMTILLWAQSSLKVRADHKADSRTLC
14bwbA 0.11 0.20 0.88 2.71Download --NSDLDVNTDIYSKVLVTAIYLALFVVGTVGNGVTLFT-----LAQSLQSRVDYYLGSLALSDLLILLFALVDLYNFIWVHHPWAFGDAGCKGYYFLREACTYATALNVVSLSVELYLAICHPFKA----KTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLS--GDGTHPGGLVCTPIVDTATLRVVIQLNTFMSFLFPMLVASILNTVAARRLTVM----------VEPGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFVYISDHYFYMLSNALVYVSAAINPILYNLVSANFRQVFLSTLAC-----------------LC
24n6hA 0.11 0.22 0.88 2.41Download --SPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRY--TKMK-TATNIYIFNLALADALATST--LPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKA----LDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDG-AVVCMLQ------FPSPSWYWDTVTKICVFLFVVPILIITVCYGLMLLRLRSV------RLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDPLVVAALHLCIALGYSSLNPVLYAFLDENFKRCFRQLCRKPCG----------------
34grvA 0.11 0.16 0.86 1.39Download --NSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLA----RKSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAGDAGCRGYYFLRDACTYATALNVASLSVARYLAIC---HPFKAK--LMSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSADGT--HPGGLVCTPIVDTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVM--------SGSVQALRHGVLVARAVVIAFVVCWLPYHVRRLMFCYISDEQWTHYFYMLTNALAYASSAINPILYNLVSANFRQV--------------------------
44bvnA 0.11 0.19 0.84 2.51Download ---------LSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGS---TQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWG-SFLCELWTSLDVLCVTASVETLCVIAIDRYLAITSPFRYQSL----MTRARAKVIICTVWAISALVSFLPIMMHWW----RD----EDPQALKCYPGDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKEQIRK------RTSRVMLMREHKALKTLGVFTLCWLPFFLVNIVNVFNRD-LVPKWLFVAFNWLGYANSAMNPIILC-RSPDFRKAFKRLLA--------------------
52z73A 0.12 0.18 0.95 2.01Download ----REFDQVPDAVYYSLGIFIGICGIIGCGGNGIVIYLFTK---TKSLQTPANMFIINLAFSDFTFSLVNGFPLMTISCFLKKWIFGFAACKVYGFIGGIFGFMSIMTMAMISIDRYNVIGR---PMAA-SKKMSHRRAFIMIIFVWLWSVLWAIGPIFGWG------AYTLEGVLCNCSFDYIRDSTTRSNILCMFILGFFGPILIIFFCYFNIVMSVSNHEKEMAAMAKRLNAKELNAEMRLAKISIVIVSQFLLSWSPYAVVALLAQFGVTPYAAQLPVMFAKASAIHNPMIYSVSHPKFREAISQTFPWVLTCCQFDDKETEIPAGE-
64djhA 0.09 0.20 0.84 1.61Download -----------PAIPVIITAVYSVVFVVGLVGNSLVMFVIIRY---TKMKTATNIYIFNLALADALVTTTMPFQSTVYLM--NSWPFGDVLCKIVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDD------DYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSD-----------RNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFP-------------------
74iarA 0.13 0.17 0.86 2.82Download ---YIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYR---TRKLHTPANYLIASLAVTDLLVSILVMPISTMYTV-TGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISIS----LPPFF-WRQA------SECVVN------TD----HILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIADLEDLPDSPQKYLAARERKATKTLGIILGAFIVCWLPFFIISLVMPIWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK------------------
84n6hA 0.11 0.22 0.88 2.81Download -GSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRY---TKMKTATNIYIFNLALADALA--TSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVK----ALDFRTPAKAKLINICIWVLASGVGVPIMVM--------AVTRPRDGAVVCMLQPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSV------RLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRK---PCG-------------
94djhA 0.11 0.20 0.83 1.58Download ----------SPAIPVIITAVYSVVFVVGLVGNSLVMFVIIR----TKMKTATNIYIFNLALADALV--TTTMPFQSTVYLMNSWPFGDVLCKIVLSIDYYNMFTSIFTLTMMSVDRYIAVC---HPVKA-LDFRTPLKAKIINICIWLLSSSVGISAIVLKVREDVDVIECSLQFPDD-----DYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLL------------DRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFP-------------------
103a6pA 0.09 0.16 0.99 1.66Download --AMDQVNALCEQLVKAVTVMMICVPCGLRLAEKHFGLQILEHVVKFRKVYLKNSVMELIANNHIKDALSRIVVEMIKREWPQ--HWPDMLIELDTLSKQGETQTELVMFILLRLAEDVVTFQTLPPQRRDIQQTLTQNMERIFSFLLNTLQENVNKYQQVKTDTSQESKAAGYIDWVSMSHITAENCKLLEILCLLLNEQELQLGAAECLLIAVLMVLFGDVAYILSAAQTADGGGLVEKHYVFLKRLCQVLCALGNQLCALLGADSDVETPSNFGKYLESFLAFTTHPSQFLRSSTQRDPLLLAIIPKYLRASMTNLVKMGFPSKTDSPSC
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: FFAS-3D   2: SPARKS-X   3: MUSTER   4: HHSEARCH2   5: HHSEARCH I   6: Neff-PPAS   7: HHSEARCH   8: pGenTHREADER   9: wdPPAS   10: PROSPECT2   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=-0.94 (Read more about C-score)
  • Estimated TM-score = 0.60±0.14
  • Estimated RMSD = 8.5±4.5Å

  • Download Model 2
  • C-score = -1.52

  • Download Model 3
  • C-score = -0.74

  • Download Model 4
  • C-score = -3.96

  • Download Model 5
  • C-score = -3.30





  •  Please cite following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted (2015).