GPCR-I-TASSER results for P59540

[Click on P59540_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>P59540
MITFLPIIFSILIVVTFVIGNFANGFIALVNSIEWFKRQKISFADQILTALAVSRVGLLW
VLVLNWYATELNPAFNSIEVRITAYNVWAVINHFSNWLATSLSIFYLLKIANFSNLIFLH
LKRRVKSVVLVILLGPLLFLVCHLFVINMNQIIWTKEYEGNMTWKIKLRSAMYLSNTTVT
ILANLVPFTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSMKVHIKALQTVTSFLLLCAI
YFLSIIMSVWSFESLENKPVFMFCEAIAFSYPSTHPFILIWGNKKLKQTFLSVLWHVRYW
VKGEKPSSS

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |         
MITFLPIIFSILIVVTFVIGNFANGFIALVNSIEWFKRQKISFADQILTALAVSRVGLLWVLVLNWYATELNPAFNSIEVRITAYNVWAVINHFSNWLATSLSIFYLLKIANFSNLIFLHLKRRVKSVVLVILLGPLLFLVCHLFVINMNQIIWTKEYEGNMTWKIKLRSAMYLSNTTVTILANLVPFTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSMKVHIKALQTVTSFLLLCAIYFLSIIMSVWSFESLENKPVFMFCEAIAFSYPSTHPFILIWGNKKLKQTFLSVLWHVRYWVKGEKPSSS
PredictionCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCSSSCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCSCCCCCCCSSSSSSCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
Conf.Score976899999999999999999999999999999998679887777999999999999999999969987736412363058889989999818999999999999706761899679999999835049999999999999999999542120237888823688750044889999999999999999999999999999999999974879999999808999999999999999999999999999988503764999999999998378878989419639999999999846470379898999

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |         
MITFLPIIFSILIVVTFVIGNFANGFIALVNSIEWFKRQKISFADQILTALAVSRVGLLWVLVLNWYATELNPAFNSIEVRITAYNVWAVINHFSNWLATSLSIFYLLKIANFSNLIFLHLKRRVKSVVLVILLGPLLFLVCHLFVINMNQIIWTKEYEGNMTWKIKLRSAMYLSNTTVTILANLVPFTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSMKVHIKALQTVTSFLLLCAIYFLSIIMSVWSFESLENKPVFMFCEAIAFSYPSTHPFILIWGNKKLKQTFLSVLWHVRYWVKGEKPSSS
Prediction733323321132133123313311220021001100443403201100000021100000113320000000121233300000001012112200000000000000000123110000012203310011012122332322231313331324434211113131332220211123333333233213313210210032024203423434411314002200100120221133113100100012233433011110122002101210101013143003002300220102046562578
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit
Iden1Iden2Cov.Norm.
Z-score
Download
Align.
                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |         
Sec.Str
Seq
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCSSSCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCSCCCCCCCSSSSSSCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
MITFLPIIFSILIVVTFVIGNFANGFIALVNSIEWFKRQKISFADQILTALAVSRVGLLWVLVLNWYATELNPAFNSIEVRITAYNVWAVINHFSNWLATSLSIFYLLKIANFSNLIFLHLKRRVKSVVLVILLGPLLFLVCHLFVINMNQIIWTKEYEGNMTWKIKLRSAMYLSNTTVTILANLVPFTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSMKVHIKALQTVTSFLLLCAIYFLSIIMSVWSFESLENKPVFMFCEAIAFSYPSTHPFILIWGNKKLKQTFLSVLWHVRYWVKGEKPSSS
14djhA 0.13 0.16 0.89 2.37Download -SPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRY--TKMK-TATNIYIFNLALADALVTTT-MPFQSTVYLMNSWFGDVLCKIVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKAL----DFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLL-------------RNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFP-------------
24djhA 0.13 0.16 0.89 1.48Download -SPAIPVIITAVYSVVFVVGLVGNSLVMFVIIR----TKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKA----LDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLL-------------RNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFP-------------
34bvnA 0.14 0.18 0.90 2.51Download LSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGS---TQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVR-GTWLWGSLELWTSLDVLCVTASVETLCVIAIDRYLAIT---SPFRYQSLMT-RARAKVIICTVWAISALVSFLIMMHWWRDEDPQALKCYQDPGDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKEQIRK------RKSRVMLMREHKALKTLGVFTLCWLPFFLVNIVNVFNRD-LVPKWLFVAFNWLGYANSAMNPIILC-RSPDFRKAFKRLLA--------------
42z73A 0.12 0.21 0.98 1.92Download VPDAVYYSLGIFIGICGIIGCGGNGIVIYLFTK---TKSLQTPANMFIINLAFSDFTFSLVNFPLMTISCFLKKIFGFAACKVYGFIGGIFGFMSIMTMAMISIDRYNVIGRPMAA----SKKMSHRRAFIMIIFVWLWSVLWAIGPIFGWGAYTLEGVLCNCSFYSRDSTTRSNILCMFILGFFGPILIIFFCYFNIVMSVSNHEKEMAAMAKRLNAKELNAEMRLAKISIVIVSQFLLSWSPYAVVALLAFGPVTPYAAQLPVMFAKASAIHNPMIYSVSHPKFREAISQTFPWVLTCQFDDKETED
54djhA 0.13 0.16 0.90 1.68Download -SPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRY---TKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKA----LDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSD-----------RNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFP-------------
64iarA 0.11 0.23 0.89 2.81Download ISLPWKVLLVMLLALITLATTLSNAFVIATVYR---TRKLHTPANYLIASLAVTDLLVSILMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFF----WRQA------SECVVN-T---DHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIADLEDDSPYLAARERKATKTLGIILGAFIVCWLPFFIISLVMPI----WFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK------------
74buoA 0.15 0.18 0.91 2.38Download TDIYSKVLVTAIYLALFVVGTVGNSVTLFTLAR---KKSLQSTVDYYLGSLALSDLLILLLAMPVELYNFIWPWAFGDAGCRGYYFLRDACTYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLSGDGTHPGGLVCTPIVTATLKVVIQVNTFMSFLFPMLVASILNTVIANKLTVMVHQ---------PGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDHYFYMLTNALVYVSAAINPILYNLVSANFRQVFLSTL---------------
84djhA 0.13 0.16 0.89 1.66Download -SPAIPVIITAVYSVVFVVGLVGNSLVMFVIIR----TKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKA----LDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLL------------DRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFP-------------
93rzeA 0.13 0.18 0.84 1.62Download M------PLVVVLSTICLVTVGLNLLVLYAVRS---ERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHRREDKCETDFYDV-----------TWFKVMTAIINFYLPTLLMLWFYAKIYKAV----------------RHMNRERKAAKQLGFIMAAFILCYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL-------------HI
103vw7A 0.11 0.17 0.91 1.56Download --SWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKM---KVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMRTLGRA--SF-----C---LAIWALAIAGVVPLLLKEQTIGITTCHDVLSETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSANEMLRIDEGLRLKIYKNTEGYYTIGIGHLLTKSPSLNAAKSELDKATKDEAEKLFNQDVDAAVRGILRNAKLYDSLDAVRRAALINMVFQ-------------
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: SPARKS-X   2: MUSTER   3: HHSEARCH2   4: HHSEARCH I   5: Neff-PPAS   6: HHSEARCH   7: pGenTHREADER   8: wdPPAS   9: PROSPECT2   10: PRC   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=0.16 (Read more about C-score)
  • Estimated TM-score = 0.73±0.11
  • Estimated RMSD = 5.9±3.7Å

  • Download Model 2
  • C-score = -3.92

  • Download Model 3
  • C-score = -3.95

  • Download Model 4
  • C-score = -5

  • Download Model 5
  • C-score = -4.00





  •  Please cite following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted (2015).