GPCR-I-TASSER results for Q15760

[Click on Q15760_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q15760
MVFAHRMDNSKPHLIIPTLLVPLQNRSCTETATPLPSQYLMELSEEHSWMSNQTDLHYVL
KPGEVATASIFFGILWLFSIFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLISVASTP
FVLLQFTTGRWTLGSATCKVVRYFQYLTPGVQIYVLLSICIDRFYTIVYPLSFKVSREKA
KKMIAASWIFDAGFVTPVLFFYGSNWDSHCNYFLPSSWEGTAYTVIHFLVGFVIPSVLII
LFYQKVIKYIWRIGTDGRTVRRTMNIVPRTKVKTIKMFLILNLLFLLSWLPFHVAQLWHP
HEQDYKKSSLVFTAITWISFSSSASKPTLYSIYNANFRRGMKETFCMSSMKCYRSNAYTI
TTSSRMAKKNYVGISEIPSMAKTITKDSIYDSFDREAKEKKLAWPINSNPPNTFV

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |               
MVFAHRMDNSKPHLIIPTLLVPLQNRSCTETATPLPSQYLMELSEEHSWMSNQTDLHYVLKPGEVATASIFFGILWLFSIFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLISVASTPFVLLQFTTGRWTLGSATCKVVRYFQYLTPGVQIYVLLSICIDRFYTIVYPLSFKVSREKAKKMIAASWIFDAGFVTPVLFFYGSNWDSHCNYFLPSSWEGTAYTVIHFLVGFVIPSVLIILFYQKVIKYIWRIGTDGRTVRRTMNIVPRTKVKTIKMFLILNLLFLLSWLPFHVAQLWHPHEQDYKKSSLVFTAITWISFSSSASKPTLYSIYNANFRRGMKETFCMSSMKCYRSNAYTITTSSRMAKKNYVGISEIPSMAKTITKDSIYDSFDREAKEKKLAWPINSNPPNTFV
PredictionCCCCHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHSCCSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCSSCSSCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score9520100246787787733265668888987888985311356766566678876555788589999999999999999986887530046068888533789999999999999998899999998173007468998799999999999999999999872542105766632366688843799999999999999834340054110225870042999999999999999999999999999998013799886403566888998999999999999999998999999999996337775389999999999999999999999729999999999848777787777876768776202578775425899876755787676777610014657889999998879

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |               
MVFAHRMDNSKPHLIIPTLLVPLQNRSCTETATPLPSQYLMELSEEHSWMSNQTDLHYVLKPGEVATASIFFGILWLFSIFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLISVASTPFVLLQFTTGRWTLGSATCKVVRYFQYLTPGVQIYVLLSICIDRFYTIVYPLSFKVSREKAKKMIAASWIFDAGFVTPVLFFYGSNWDSHCNYFLPSSWEGTAYTVIHFLVGFVIPSVLIILFYQKVIKYIWRIGTDGRTVRRTMNIVPRTKVKTIKMFLILNLLFLLSWLPFHVAQLWHPHEQDYKKSSLVFTAITWISFSSSASKPTLYSIYNANFRRGMKETFCMSSMKCYRSNAYTITTSSRMAKKNYVGISEIPSMAKTITKDSIYDSFDREAKEKKLAWPINSNPPNTFV
Prediction6424331343644312120021133431341212133321232344332332333342322200100000001200220130120000000103412000000000001000000000010100000232001010000000000100000000000000000010001002232133100000000000000000100000103331201000024112200000001310321020102000100010133235354454444433331100000000000000001000000000001134231010000001110110000000100000640040011002023232444544434343333443333344444444333443334344364544523243465344334
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |               
Sec.Str
Seq		CCCCHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHSCCSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCSSCSSCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MVFAHRMDNSKPHLIIPTLLVPLQNRSCTETATPLPSQYLMELSEEHSWMSNQTDLHYVLKPGEVATASIFFGILWLFSIFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLISVASTPFVLLQFTTGRWTLGSATCKVVRYFQYLTPGVQIYVLLSICIDRFYTIVYPLSFKVSREKAKKMIAASWIFDAGFVTPVLFFYGSNWDSHCNYFLPSSWEGTAYTVIHFLVGFVIPSVLIILFYQKVIKYIWRIGTDGRTVRRTMNIVPRTKVKTIKMFLILNLLFLLSWLPFHVAQLWHPHEQDYKKSSLVFTAITWISFSSSASKPTLYSIYNANFRRGMKETFCMSSMKCYRSNAYTITTSSRMAKKNYVGISEIPSMAKTITKDSIYDSFDREAKEKKLAWPINSNPPNTFV
14n6hA 0.19 0.21 0.70 3.58Download ---------------------------------------------------GSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRVVCMLQFPSPYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGS-----KEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKP-------------------------------------------------------------------
24n6hA 0.19 0.19 0.70 3.61Download ----------------------------------------------------SPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATST-LPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALRTPAKAKLINICIWVLASGVGVPIMVMAVTDGAVVCMLQFPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSK-----EKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG-----------------------------------------------------------------
34n6hA 0.18 0.19 0.70 2.72Download ----------------------------------------------------SPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLM--TWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRAVVCMLFPSPYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGS-----KEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG-----------------------------------------------------------------
42rh1A 0.25 0.21 0.69 2.56Download ------------------------------------------------------------DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQLTKNKARVIILMVWIVSGLTSFLPIQMWYRAEAINCYAEETDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNIFEMLDWDAYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDN-LIRKEVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQELLCL--------------------------------------------------------------------
54iarA 0.23 0.20 0.68 1.98Download ----------------------------------------------------YIY-QDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYKRTPKRAAVMIALVWVFSISISLPPFFWRQA---SECVVNT----DHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIADLDSPGYIQKYLAARERKATKTLGIILGAFIVCWLPFFIISLVMPI----WFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK-------------------------------------------------------------------
64n6hA 0.17 0.21 0.83 3.42Download PEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRVVCMLQFPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGS-----KEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG-----------------------------------------------------------------
71u19A 0.18 0.17 0.82 2.81Download -----------------------MNGTGPNFYVPFSN--KTGVVRSPF----EAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPCSCGIDYYTETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQ----QESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEASTTVS-----KTET---SQVAPA-----------------------------------
84ea3A 0.22 0.17 0.65 4.17Download ------------------------------------------------------------PLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLT-LPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPT-----SSKAQAVNVAIWALASVVGVPVAIMQVEDEEIECLVEIPTPYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGS-----REKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSAVAILRFCTALGYVNSCLNPILYAFLDENFKACFR-------------------------------------------------------------------------
94iaqA 0.23 0.17 0.67 3.09Download -----------------------------------------------------YIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYKRTPKRAAVMIALVWVFSISISLPPFFWRQASE---CVVNTDH----ILYTVYSTVGAFYFPTLLLIALYGRIYVEARSR------IIQKYLLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPIH------LAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK-------------------------------------------------------------------
101l9hA 0.20 0.17 0.80 4.08Download M----------NGTEGPNFYVPFSNKTGVVRSPFEAPQ------------------YYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSFRFGENHAIMGVAFTWVMALACAAPPLVGWSRGMQCSCGIDYYTPHEEESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAATT---------QKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDSTTVSKTETS-------------------------------------------QVAPA---
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: FFAS-3D   2: SPARKS-X   3: MUSTER   4: HHSEARCH2   5: HHSEARCH I   6: Neff-PPAS   7: HHSEARCH   8: pGenTHREADER   9: wdPPAS   10: PROSPECT2   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=-1.89 (Read more about C-score)
  • Estimated TM-score = 0.49±0.15
  • Estimated RMSD = 11.4±4.5Å

  • Download Model 2
  • C-score = -2.28

  • Download Model 3
  • C-score = -2.52

  • Download Model 4
  • C-score = -3.03

  • Download Model 5
  • C-score = -2.55




    •  Please cite following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted (2015).