GPCR-I-TASSER results for Q4KKW2

[Click on Q4KKW2_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q4KKW2
MNTSHLLALLLPKSPQGENRSKPLGTPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNL
CLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFI
QCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVLIWVIACVLSLPFLANSIL
ENVFHKNHSKALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRR
LQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAMLWLPLHVFNSLEDWHHEAIPICHG
NLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEESEHLPLSTVHTE
VSKGSLRLSGRSNPI

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |               
MNTSHLLALLLPKSPQGENRSKPLGTPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNLCLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFIQCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVLIWVIACVLSLPFLANSILENVFHKNHSKALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRRLQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAMLWLPLHVFNSLEDWHHEAIPICHGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEESEHLPLSTVHTEVSKGSLRLSGRSNPI
PredictionCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHSSSCCCCCCCCCCCCCCCCCSSCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score987754101488999988878888999886655577616898999999999999988899986988618988848899999999999999999899999999839677956889889999999999999999999998486731658632116468885359999999999999999641210246765433357986355067894689999999999999999999999999999999810478887514589988535599999999999999968999999999964344425699999999999999999999999997499999999999510046887777888788887757889988889898999

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |               
MNTSHLLALLLPKSPQGENRSKPLGTPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNLCLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFIQCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVLIWVIACVLSLPFLANSILENVFHKNHSKALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRRLQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAMLWLPLHVFNSLEDWHHEAIPICHGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEESEHLPLSTVHTEVSKGSLRLSGRSNPI
Prediction422332332022313433232333333232343242020010000210010022023232100000011241211110210010001000020113010000014201012010001000010000000101000000001000000223223320000000000000000110000120232333433321413442010102013630220000011331331100000101110012013334434444444434432100000000010000002120000001001332232200100101011001200011000000015410410140021024334456454343333334324334434446337
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |               
Sec.Str
Seq		CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHSSSCCCCCCCCCCCCCCCCCSSCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MNTSHLLALLLPKSPQGENRSKPLGTPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNLCLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFIQCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVLIWVIACVLSLPFLANSILENVFHKNHSKALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRRLQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAMLWLPLHVFNSLEDWHHEAIPICHGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEESEHLPLSTVHTEVSKGSLRLSGRSNPI
14n6hA 0.26 0.23 0.77 3.97Download ------------------------------------SLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALRTPAKAKLINICIWVLASGVGVPIMVMAVTRPR------------DGAVVCMLQFPSPSWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGS---KEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKP-----------------------------------
24n6hA 0.26 0.23 0.79 3.81Download ----------------------------SPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATST-LPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRD------------GAVVCMLQFPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSG---SKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG---------------------------------
34n6hA 0.26 0.23 0.79 3.27Download ----------------------------SPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLM--TWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRD------------GAVVCMLQFPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGS---KEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG---------------------------------
42rh1A 0.20 0.23 0.77 2.56Download ------------------------------------DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQLTKNKARVIILMVWIVSGLTSFLPIQMHWYRAT-HQ----------EAINCYAEETDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNIFEMLRAYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLI----RKEVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQELL-CL-----------------------------------
54buoA 0.22 0.20 0.78 1.94Download ------------------NSD----------LDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARKKS---TVDYYLGSLALSDLLILLLAMPVELYNFIHHPWAFGDAGCRGYYFLRDACTYATALNVVSLSVELYLAICHPFKAKMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLSGDGT------HPGGLVCTP-IVDTATLKVVIQVNTFMSFLFPMLVASILNTVIANKLTVMQ--------PGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFYHYFYMLTNALVYVSAAINPILYNLVSANFRQVFLSTL--------------------------------------
64n6hA 0.26 0.23 0.79 3.70Download ------------------------------GARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRD------------GAVVCMLQFPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSG---SKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG---------------------------------
71u19A 0.20 0.22 0.91 2.90Download MNGTEGPNFYVPFSNKTG----VVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGM-Q----------CSCGIDYHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQE--SATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSD---FGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEAS-T--TVSKTET--------SQVAP-
84ea3A 0.26 0.22 0.74 4.75Download ------------------------------------PLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLL-TLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPT-----SSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEI----------ECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGS---REKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQP-SSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFR-----------------------------------------
94n6hA 0.26 0.23 0.79 3.40Download ----------------------------SPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLM--TWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALRTPAKAKLINICIWVLASGVGVPIMVMAVTRPR------------DGAVVCMLQFPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGS---KEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG---------------------------------
104n6hA 0.26 0.23 0.79 4.32Download ----------------------------SPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDTPAKAKLINICIWVLASGVGVPIMVMAVTRPR------------DGAVVCMLQFPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGS---KEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG---------------------------------
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: FFAS-3D   2: SPARKS-X   3: MUSTER   4: HHSEARCH2   5: HHSEARCH I   6: Neff-PPAS   7: HHSEARCH   8: pGenTHREADER   9: wdPPAS   10: PROSPECT2   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=-0.03 (Read more about C-score)
  • Estimated TM-score = 0.71±0.12
  • Estimated RMSD = 6.7±4.0Å

  • Download Model 2
  • C-score = -1.85

  • Download Model 3
  • C-score = -2.07

  • Download Model 4
  • C-score = -1.22

  • Download Model 5
  • C-score = -4.47




    •  Please cite following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted (2015).