GPCR-I-TASSER results for Q5VX04

[Click on Q5VX04_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q5VX04
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW
DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI
VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR
YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT
IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE
ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC
IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK
LAERPERPEFVLITRTSGVHQALENFPWGNEVNRWRKSCEYFCTDKMLTTVEKKVMIHD

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLITRTSGVHQALENFPWGNEVNRWRKSCEYFCTDKMLTTVEKKVMIHD
PredictionCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHSSSSSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCSSSCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCSSSSSSCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHCCCCC
Conf.Score97778888831210556756789998999999998888877777753223577898877678987556777788888899999999999999999995887178777557777557899999999999999998409999999749654778899999999999999999999999986455055410488646489999979999999999999999748864789984797126566676788999999999999999999998887766522332222333322112443333444221234433333311002232001013535589999999977999999999982863346660799999999999998270697860889999999998386467888787756565556556568888753413677653787778999988765641231200466775312115779

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLITRTSGVHQALENFPWGNEVNRWRKSCEYFCTDKMLTTVEKKVMIHD
Prediction72416433322022302121224233211323333321112332232112333333333331133121332342412200000000000210220232020000000103300000000000001000100000002000000022101001000000000001000000200000010000000200313331221000000000001000001000000032233421000001320000000100220001002000000000120021021122221222221222233222222221211021210222212222332220200000000000000000000000000132212200100000001000200000000000004400300130020212336343443343333433444434333333333334443543234443443353143214543144245413468
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   
Sec.Str
Seq		CCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHSSSSSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCSSSCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCSSSSSSCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHCCCCC
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLITRTSGVHQALENFPWGNEVNRWRKSCEYFCTDKMLTTVEKKVMIHD
14ib4A 0.26 0.23 0.67 3.76Download --------------------------------------------------------------------------------LHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIWHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETNPNNITLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAADLEDNWETLNDNLKVIEKADNAAQEAQAAAEQLKTTRNAYIQKYLQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQT-TLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNY----------------------------------------------------------------------------
24ib4A 0.25 0.23 0.69 3.30Download --------------------------------------------------------------------------EEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIWHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETNPNNITCVLTRFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAADLEADNAATKMRAAALDAQKKILVGQIDDALKLANEGKVKEAQAAAEISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCN-QTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYR---------------------------------------------------------------------------
33sn6R 0.36 0.22 0.58 2.19Download -----------------------------------------------------------------------------EVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILTK-TWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGR---------------------------------------CLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD----NLIRKEVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQELLC-------------------------------------------------------------------------------
44iarA 0.38 0.29 0.67 2.58Download ------------------------------------------------------------------Y---IYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTV-TGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFF-WRQA----SECVVNTDILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIADLEDNWEEAADLATPPKLEDKSPDSPDHGEAQAAAEQTRNAYIQKYLAARERKATKTLGIILGAFIVCWLPFFIISLVMPI-------WFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK-----------------------------------------------------------------------------
54iarA 0.38 0.29 0.67 2.07Download ---------------------------------------------------------------------YIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTV-TGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFF-WRQA----SECVVNTDILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIADLEDNWETLNDNLAADALAQKATPPKLEDKSPDSPKDTRNAYIQKYLAARERKATKTLGIILGAFIVCWLPFFIISLVMPI-------WFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK-----------------------------------------------------------------------------
64ib4A 0.26 0.23 0.68 2.95Download -----------------------------------------------------------------------------GNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIWHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETNPNNITCVLTKFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRATTRNAYIQKYLQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCN-QTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYR---------------------------------------------------------------------------
74iarA 0.37 0.29 0.67 2.99Download ---------------------------------------------------------------------YIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTV-TGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFF-WRQA----SECVVNTDILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIADLEDNWETLNDDLQKATPPKLEDKSPDSPDHGKVAKTTRNAYIQKYLAARERKATKTLGIILGAFIVCWLPFFIISLVMPI-------WFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK-----------------------------------------------------------------------------
82rh1A 0.31 0.25 0.67 4.21Download ----------------------------------------------------------------------------DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKM-WTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD----NLIRKEVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQELLCL------------------------------------------------------------------------------
94ib4A 0.26 0.23 0.69 2.72Download --------------------------------------------------------------------------EEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIWHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETNPNNITLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKQKYLQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCN-QTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYR---------------------------------------------------------------------------
104ib4A 0.26 0.23 0.69 3.89Download EEQGNK--------------------------------------------------------------------------LHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIWHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETNPNNITCVLTKEGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAADLEDNWETLNDNLKVIEKADGKVKEAQAAAEQLKTTRNAYIQKYLQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQT-TLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYR---------------------------------------------------------------------------
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: FFAS-3D   2: SPARKS-X   3: MUSTER   4: HHSEARCH2   5: HHSEARCH I   6: Neff-PPAS   7: HHSEARCH   8: pGenTHREADER   9: wdPPAS   10: PROSPECT2   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=-3.09 (Read more about C-score)
  • Estimated TM-score = 0.37±0.12
  • Estimated RMSD = 14.9±3.6Å

  • Download Model 2
  • C-score = -3.22

  • Download Model 3
  • C-score = -3.52

  • Download Model 4
  • C-score = -3.56

  • Download Model 5
  • C-score = -3.36




    •  Please cite following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted (2015).