GPCR-I-TASSER results for Q8NFJ5

[Click on Q8NFJ5_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q8NFJ5
MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATAGVVTSVAFMLTLPILVCKVQDSN
RRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICFSCLLAHAVSLT
KLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTNVNVFSELSAPRRNEDFVLL
LTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLMLPDFDRRW
DDTILSSALAANGWVFLLAYVSPEFWLLTKQRNPMDYPVEDAFCKPQLVKKSYGVENRAY
SQEEITQGFEETGDTLYAPYSTHFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEGS

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                 
MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATAGVVTSVAFMLTLPILVCKVQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICFSCLLAHAVSLTKLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTNVNVFSELSAPRRNEDFVLLLTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLMLPDFDRRWDDTILSSALAANGWVFLLAYVSPEFWLLTKQRNPMDYPVEDAFCKPQLVKKSYGVENRAYSQEEITQGFEETGDTLYAPYSTHFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEGS
PredictionCCCCCCCCCCCCCCCCCSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHSSSSSSSSCCHHHHCCCHHHHHHHHHHHHHHHHHHHHSSCCCCCHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCSSSSSSSSHHHHHHHHCSSSSSCCCCCCCCCCCCSSCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCSSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score998899876789983102114653318999999999999999999841378963213634311402899999999999998885154787421066899999999999999999999999997268799752426874231254562401145503677777752021356562678799999999999999999999616476544322416999999999999999999456888661358899999999999998751857999745666444664121025765666531245334633444322467884068765651555789998753778999999854566788899

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                 
MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATAGVVTSVAFMLTLPILVCKVQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICFSCLLAHAVSLTKLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTNVNVFSELSAPRRNEDFVLLLTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLMLPDFDRRWDDTILSSALAANGWVFLLAYVSPEFWLLTKQRNPMDYPVEDAFCKPQLVKKSYGVENRAYSQEEITQGFEETGDTLYAPYSTHFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEGS
Prediction862433630365034302300324300000000100211211231221010202213333443310000000111231110000000213310000011010201000000000000100100234323322210000001131013100010000022334423231314132100000121221122201100000002414623210000001031121012111000010345341300000000012010000001201000013344455243652344444344213141331134334643564443333223230334536473423013143344335424336668
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                 
Sec.Str
Seq		CCCCCCCCCCCCCCCCCSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHSSSSSSSSCCHHHHCCCHHHHHHHHHHHHHHHHHHHHSSCCCCCHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCSSSSSSSSHHHHHHHHCSSSSSCCCCCCCCCCCCSSCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCSSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATAGVVTSVAFMLTLPILVCKVQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICFSCLLAHAVSLTKLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTNVNVFSELSAPRRNEDFVLLLTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLMLPDFDRRWDDTILSSALAANGWVFLLAYVSPEFWLLTKQRNPMDYPVEDAFCKPQLVKKSYGVENRAYSQEEITQGFEETGDTLYAPYSTHFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEGS
14or2A 0.14 0.14 0.70 3.18Download -----------------VRYLEWSNIESIIAIAFSCLGILVTLFVTLIFV--LYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKT--RNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNY----KIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERN----------------------------------------------------------------------------------
23orgA 0.12 0.21 0.89 1.10Download IAHQFYR------LGVFKELCTDRALRLQTLAAACAVGLASSFGIETIASFYLVQ--------------AFWKGVLSALSGAIVY--ELDVSRTQTLLYAILGALMGVLGALFIRCVRSIYELRMRHYPGTNR--------YFLVGVVALFASALQYPFPRATINDLFKAVTELIKFILVALSIFLIGAGFGRLYGELMRVVFGNAIVPGSYAVVGAAAFTAGVTAVIIFEVTGQIRHLVPVLISVLLAVIVGNAFNVLMKHLPYMPILRRDRSPEMTAREIMHPIEGEPHLF-----------PDSEPQHIKGILEKFPNRLFPVIDANGYLLGAISRKEIVDRLQHVVVPCDVSP
34or2A 0.13 0.13 0.69 4.24Download -----------------VRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLY--RDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSEVYLICNTSN-LGVVAPLGYNGLLIMSCTYYAFKT--RNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYK--IITTCFAVSLSVTVALGCMFTPKMYIIIAKPE--------------------------------------------------------------------------------------
43wajA 0.07 0.22 0.96 1.60Download PFTYYPYGSYTHFGPIAGIIFSATSGESLRAVLAFIPAIGGVVIAAFLIAIVPGQFLQRSILGFNDHHIWEAFWQVSALGTFLLAYNRWKGHDAGITIGLYVLSWGAGFIIAPIILAFMFFAFVLAGFVNADRKNLSLVAVVTFAVSALIYLPFAFNYPGFST-------IFYSPFQLLVLLGSAVIAAAFYQIEKWNDVGFFERVGLGRKGMPLAVIVLTALILIWAIAMFIALWGQNRFAYYFAAVSAVYSALALSVVF--------DKLHFRVAFALLIALAAIYPTYILADAQSSYAGGPNKQWYDALTWMRENTPDGEKYDEYYLQLYPTPQSNKEPFSYPFETYGANPFQA
54or2A 0.15 0.13 0.69 1.82Download -----------------VRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRD--TPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTR--NVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNY----KIITTCFAVSLSVTVALGCMFTPKMYIIIAKPE------------------------------------------------------------------------------------
63wb8A 0.07 0.18 0.88 1.56Download FQGMLEYKLELKPRGVAVNLIPGLPAYILFMCVRHADYLNDDQKVRSLLTSTINSIKKVLKKRGDDFETVSFWLSNTCRFLHCLKQYSGNFDLAEYRQVLSDLAYQQLVRVLENILQPMIVSGEHETIQTYTLDSILRQLNSFHSVMCQ--------------------HGMDPELIKQVVKQMFYIVGAITLNNLLL----------RKDMCSWSKGMQIRYNVSQLEEWLRDKNLMNSGAKETLEPLIQAAQLLQ-----------VKKKTDDDAEAICSMCNALTTATPVNEFEERVSIRTIQMRLRDRKDSPQLLMDAKHIFPVTFPFNPSSLALETIQIPASLGLGFIAR-V
74or2A 0.16 0.16 0.71 8.46Download QLKTTRNAYIQKIPVRYLEW---SNIESIIAIAFSCLGILVTLFVTL--IFVLYRVKSSS-RE---LCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILA----MSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEYLICNTGVVAPLGYNGLLIMSCTYYAFKTRNVPAN--FNEAKYIAFTMYTTCIIWLAFVPIYFGSNY----KIITTCFAVSLSVTVALGCMFTPKMYIIAKPE-------------------------------------------------------------------------------------
84or2A 0.13 0.16 0.73 6.15Download LK-TTRNAYI-QKYLIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFV--LYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILA--RFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYVYLICNT-SNLGVVAPLGYNGLLIMSCTYYAFKT--RNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKI--ITTCFAVSLSVTVALGCMFTPKMYIIIAKPE--------------------------------------------------------------------------------------
94or2A 0.15 0.13 0.69 2.91Download -----------------VRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLY--RDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKT--RNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGS----NYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPE------------------------------------------------------------------------------------
104or2A 0.15 0.16 0.73 8.68Download QLKTTRNAYIQKYLIPVRYL-EWSNIESIIAIAFSCLGILVTLFVTLIFVLYTPVVKSSSRE----LCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILA--RFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKT--RNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSN----YKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPE------------------------------------------------------------------------------------
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: FFAS-3D   2: pGenTHREADER   3: SPARKS-X   4: PROSPECT2   5: MUSTER   6: PROSPECT2   7: HHSEARCH2   8: HHSEARCH I   9: Neff-PPAS   10: HHSEARCH   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=-2.32 (Read more about C-score)
  • Estimated TM-score = 0.44±0.14
  • Estimated RMSD = 12.1±4.4Å

  • Download Model 2
  • C-score = -2.65

  • Download Model 3
  • C-score = -2.81

  • Download Model 4
  • C-score = -2.62

  • Download Model 5
  • C-score = -2.74




    •  Please cite following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted (2015).