GPCR-I-TASSER results for Q8NFZ6

[Click on Q8NFZ6_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q8NFZ6
MTHTLYPTPFALYPINISAAWHLGPLPVSCFVSNKYQCSLAFGATTGLRVLVVVVPQTQL
SFLSSLCLVSLFLHSLVSAHGEKPTKPVGLDPTLFQVVVGILGNFSLLYYYMFLYFRGYK
PRSTDLILRHLTVADSLVILSKRIPETMATFGLKHFDNYFGCKFLLYAHRVGRGVSIGST
CLLSVFQVITINPRNSRWAEMKVKAPTYIGLSNILCWAFHMLVNAIFPIYTTGKWSNNNI
TKKGDLGYCSAPLSDEVTKSVYAALTSFHDVLCLGLMLWASSSIVLVLYRHKQQVQHICR
NNLYPNSSPGNRAIQSILALVSTFALCYALSFITYVYLALFDNSSWWLVNTAALIIACFP
TISPFVLMCRDPSRSRLCSICCRRNRRFFHDFRKM

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |               
MTHTLYPTPFALYPINISAAWHLGPLPVSCFVSNKYQCSLAFGATTGLRVLVVVVPQTQLSFLSSLCLVSLFLHSLVSAHGEKPTKPVGLDPTLFQVVVGILGNFSLLYYYMFLYFRGYKPRSTDLILRHLTVADSLVILSKRIPETMATFGLKHFDNYFGCKFLLYAHRVGRGVSIGSTCLLSVFQVITINPRNSRWAEMKVKAPTYIGLSNILCWAFHMLVNAIFPIYTTGKWSNNNITKKGDLGYCSAPLSDEVTKSVYAALTSFHDVLCLGLMLWASSSIVLVLYRHKQQVQHICRNNLYPNSSPGNRAIQSILALVSTFALCYALSFITYVYLALFDNSSWWLVNTAALIIACFPTISPFVLMCRDPSRSRLCSICCRRNRRFFHDFRKM
PredictionCCCCCCCCCCSSSSCCHHHHHCCCCCCCSSSSCCCHHHCSSCCCCCCCSSSSSSSCCSSSSHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCSSSSSSSHHHHCHHHHHHHHHHHHHHSSSSCCCCHHHHHHHHHCCCSSHHHHHHHHHHHHHHHHCSSSSSSCCCCCCCCCCSSSCCSSSCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCSSSSHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHCC
Conf.Score98634688732541011244215886404675250442023055457379999850043313468899999999863430135066899998599998899999999999999998388889689999999999999999974899999965540589872389998858756266889999998751998079727653114158677688999999999986146799986875730250665408866676248999999999999999999999888878887643568876113889999988799999999999999999998899999999991789931357999996253674846632379746889999866157631765269

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |               
MTHTLYPTPFALYPINISAAWHLGPLPVSCFVSNKYQCSLAFGATTGLRVLVVVVPQTQLSFLSSLCLVSLFLHSLVSAHGEKPTKPVGLDPTLFQVVVGILGNFSLLYYYMFLYFRGYKPRSTDLILRHLTVADSLVILSKRIPETMATFGLKHFDNYFGCKFLLYAHRVGRGVSIGSTCLLSVFQVITINPRNSRWAEMKVKAPTYIGLSNILCWAFHMLVNAIFPIYTTGKWSNNNITKKGDLGYCSAPLSDEVTKSVYAALTSFHDVLCLGLMLWASSSIVLVLYRHKQQVQHICRNNLYPNSSPGNRAIQSILALVSTFALCYALSFITYVYLALFDNSSWWLVNTAALIIACFPTISPFVLMCRDPSRSRLCSICCRRNRRFFHDFRKM
Prediction74220100000010030300010110100000234142100110213020000013303021013110011024212443443222100011033033333312220021000000353331100000100130011001011211000000221111021000010000001000000000000100000003212003011200100011000100100211230001020333231323332111000023332210000001023112010000000000000011333202201324224333112100000000001002103300000000010333200000000020010010000000011320120020013233402431474
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |               
Sec.Str
Seq		CCCCCCCCCCSSSSCCHHHHHCCCCCCCSSSSCCCHHHCSSCCCCCCCSSSSSSSCCSSSSHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCSSSSSSSHHHHCHHHHHHHHHHHHHHSSSSCCCCHHHHHHHHHCCCSSHHHHHHHHHHHHHHHHCSSSSSSCCCCCCCCCCSSSCCSSSCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCSSSSHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHCC
MTHTLYPTPFALYPINISAAWHLGPLPVSCFVSNKYQCSLAFGATTGLRVLVVVVPQTQLSFLSSLCLVSLFLHSLVSAHGEKPTKPVGLDPTLFQVVVGILGNFSLLYYYMFLYFRGYKPRSTDLILRHLTVADSLVILSKRIPETMATFGLKHFDNYFGCKFLLYAHRVGRGVSIGSTCLLSVFQVITINPRNSRWAEMKVKAPTYIGLSNILCWAFHMLVNAIFPIYTTGKWSNNNITKKGDLGYCSAPLSDEVTKSVYAALTSFHDVLCLGLMLWASSSIVLVLYRHKQQVQHICRNNLYPNSSPGNRAIQSILALVSTFALCYALSFITYVYLALFDNSSWWLVNTAALIIACFPTISPFVLMCRDPSRSRLCSICCRRNRRFFHDFRKM
11gzmA 0.13 0.14 0.69 1.65Download ------------------------------------------------------------------------------------QFSMLAAYMFLLIMLGFPINFLTL----YVTVQHKKLRPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHA----IMGVAFTWVMALACAAPPLYIPEG-----------MQCSCGTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAA-----QQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTL-------------
24n6hA 0.14 0.21 0.89 1.24Download --EDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGK------------VKEAQAAAEQLKTTRNAYIQKYLGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRY---TKMKTATNIYIFNLALADALATSTLPFQSAKYLMET-WPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCPVKALDFR----TPAKAKLINICIWVLASGVGVPIMVM-------AVTRPRDGAVVCMLQPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLL------SGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG--------
34n6hA 0.17 0.19 0.73 1.32Download -------------------------------------------------------------------------SPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRY---TKMKTATNIYIFNLALADALATST--LPFQSAKYLMETWFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVHPVKA----LDFRTPAKAKLINICIWVLASGVGVPIMVMA-------VTRPRDGAVVCMLQPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSV--------RLLSGSKEKSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG--------
44grvA 0.15 0.17 0.73 1.05Download -------------------------------------------------------------------------NSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLAR-----KSLQTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHAFGDAGCRGYYFLRDACTYATALNVASLSVARYLAIHPFKAKT----LMSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSADGTHPGGL-VCTPIVDTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVM-------------GSVQALRHGVLVARAVVIAFVVCWLPYHVRRLMFCYISDEQW--TFLFDFYHYFYMLTNALAYASS--AINPILYNLVSAN------FRQV
53a6pA 0.09 0.19 0.89 1.59Download AMDQVDPNSLQILEHVVKFRWNGMSRLEKVYLKNSVMELIANGTLNILEE----------ENHIKDALSRIVVEMIKREWPQHWPDMLIELDTLSKQGETQTELVMFILLRLAEDVVTFQTLPPQRIQQTLTMERIFSFLLNTLQENVNKYQQVKTDTSQ-----------ESKAQANCRVGVAALNTLAGYIDWVSMSHITAENCKLLEILCLLLGAAECLLIAVS----------------------RKGKLEDRKPLMVLFGDVAMHYILSAAYVFLKRLCQVLCALGNQLCALLGADSDVETPSNFGKYLESFLAFTTQFLRSSTQMTWGALFRHEILSRDPLLLAIPKYLRASMTNLVMGFPSKTDSPSCEYSRFDFDSDEDFNAFFNTF
63uonA 0.12 0.20 0.72 2.58Download ---------------------------------------------------------------------------------TFEVVFIVL-VAGSLSLVTIIGNILVM--VSI-KVNRHLQTVNNYFLFSLACADLIIGVFS-MNLYTLYTIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTPLT----YPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV----EDGECYIQFFSNA--AVTFGTAIAAFYLPVIIMTVLYWHISRASKSRINIFEMLEGTDAYPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPIPNTVWTIGYWLCYINSTINPACYALCNATFKK-TFHM--------------
74n6hA 0.14 0.21 0.87 2.02Download -AALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRY---TKMKTATNIYIFNLALADALATSTLPFQSAKYLME-TWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPV---KALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRD-------GAVVCMLQFPSPWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLL------SGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRDPLVVAALHLCIALGSLNPVL-----------------------------
82rh1A 0.14 0.19 0.73 2.75Download -------------------------------------------------------------------------------------DEVGMGIMSLIVLAIVFGNVLVITAI---AKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLL---TKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEETCCDFFTN---QAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNIFEMLRTWDAYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNIRKEVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQLLCL------------
94n6hA 0.15 0.21 0.92 1.30Download LTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLGSPGALALAIAITALYSAVCAVGLLGNVLVMFGIVRY---TKMKTATNIYIFNLALADALATST--LPFQSAKYLMETWFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVHPVKA----LDFRTPAKAKLINICIWVLASGVGVPIMVMA-------VTRPRDGAVVCMLQPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSV--------RLLSGSKEKSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLIDRRDVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG--------
104n6hA 0.15 0.19 0.72 1.94Download ---------------------------------------------------------------------------------GSPLAIAITALYSAVCAVGLLGNVLVMF----GIVRYTKMKTTNIYIFNLALADALATST-LPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVK---ALDFRTPAKAKLINICIWVLASGVGVPAVTRPRDG--------AVV--CMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVR---LLSGS-KEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG--------
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: FFAS-3D   2: Neff-PPAS   3: SPARKS-X   4: MUSTER   5: PROSPECT2   6: HHSEARCH2   7: PRC   8: HHSEARCH   9: SPARKS-X   10: pGenTHREADER   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=-1.39 (Read more about C-score)
  • Estimated TM-score = 0.54±0.15
  • Estimated RMSD = 10.0±4.6Å

  • Download Model 2
  • C-score = -3.08

  • Download Model 3
  • C-score = -1.69

  • Download Model 4
  • C-score = -4.46

  • Download Model 5
  • C-score = -2.54




    •  Please cite following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted (2015).