GPCR-I-TASSER results for Q9NZH0

[Click on Q9NZH0_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q9NZH0
MFVASERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVE
AVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDET
ICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLMLVQVIIAVEW
LVLTVLRDTRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLITA
FLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLPAL
QENTPNYFDTSQPRMRETAFEEDVQLPRAYMENKAFSMDEHNAALRTAGFPNGSLGKRPS
GSLGKRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHTGRHLW

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |   
MFVASERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLMLVQVIIAVEWLVLTVLRDTRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLPALQENTPNYFDTSQPRMRETAFEEDVQLPRAYMENKAFSMDEHNAALRTAGFPNGSLGKRPSGSLGKRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHTGRHLW
PredictionCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHCSCSSSSSCCCCCCSSCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCSSSSSSSCHHHCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSCCCCCCCCCCCHCCCCCC
Conf.Score9769888667999977108899987878898889999988896414531624159999999999999999999999987600012245445257899999999999999999854765144628899999999999999999887577440657695122005547777753531050278962675431204679678979999999999999999998743667323410999999999999999999988620133200103688899999999999999998750158999835242471444047888665643467765675400488878677643557887766676667764467888876778888986168851698779999751022469

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |   
MFVASERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLMLVQVIIAVEWLVLTVLRDTRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLPALQENTPNYFDTSQPRMRETAFEEDVQLPRAYMENKAFSMDEHNAALRTAGFPNGSLGKRPSGSLGKRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHTGRHLW
Prediction7230364404435204100400413243444430450445222410300324200000000201210220211111001202213234331010000000200220120000000112200000000010101010000000000000102222332222100000000001101000000000023302220323010000001110102220110000020341451220000000001100000000000000023322212302000000000310232020112110000003065423652346443333543354546344333424233354444444543332334443444543543445345433332112213445313533123103237
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit
Iden1Iden2Cov.Norm.
Z-score
Download
Align.
                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |   
Sec.Str
Seq
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHCSCSSSSSCCCCCCSSCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCSSSSSSSCHHHCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSCCCCCCCCCCCHCCCCCC
MFVASERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLMLVQVIIAVEWLVLTVLRDTRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLPALQENTPNYFDTSQPRMRETAFEEDVQLPRAYMENKAFSMDEHNAALRTAGFPNGSLGKRPSGSLGKRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHTGRHLW
14or2A 0.22 0.15 0.60 3.60Download ---------------------------------------------VRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYTPVVKSSSR----ELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKT--RNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYK--------IITTCFAVSLSVTVALGCMFTPKMYIIIAKPE-------------------------------------------------------------------------------------------------------
23wajA 0.09 0.21 0.93 1.81Download SILNPWNSVFTWTVRLGGNHNFPHRIWFDPFTYYPYGSYTHFGIIFSATSGESLRAVLAFIPAIGGVLAILPVYLLTREVFDKQRSILGFNDHHIWEAFWQVSALGTFLLAYNRWKGHDLTARQMAYPVIAGITIGLYVLIILAFMFFAFVLAGFVNADRKNLSLVAVVTFAVSALIYLPFAFNYPGFST---IFYSPFQLLVLLGSAVIAAAFYQIEKWNDVGFFERVGLGRKGMPLAVIVLTALFFFGMAGILYSAYRFLKRRSFPEMALLIWAIAMVSAVYSALALSVVF------------DKLHFRVAFALLIALAAIYPTYILADAQSSYAGGPNKQWYDALTWMRENTPDGEKYDEYYLQLYPTPQSNKEPF------------SYPFETYGVISW
34or2A 0.22 0.15 0.60 1.76Download ---------------------------------------------VRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYTPVVKSSS----RELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTR--NVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSN--------YKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPE-------------------------------------------------------------------------------------------------------
43orgA 0.08 0.19 0.89 1.29Download ICAIGGGLPVGWEGPNVHIACIIAHQFYRLGVFKELCTD------------RALRLQTLAAACAVGLASSFGVLYSIETIASFYLVQ------------AFWKGVLSALSGAIVYELDVRTQTLLYAILGALMGVLGALFIRCVRSIYELRMRHYPGTNRYFLVGVVALFASALQYP------FPRATINDLFKAVTIKFILVALSISFLIGAGFGRLYGELMRVVFGNAIVGSYAVVGAAAFTAGVTSCAVIIFEVTGQIRHLVPVLISVLLAVIVGNAFNTLVLMKHLPYMPILRR----------DRSPEMTAREIMHPIEGEPHLFPDSEPQHIKGILEKFPNRLPVIDANGYLLGKEIVDRLQHVVVPCDVSPI---VVTSYSLVRQLHFLFVMLMPS
54or2A 0.20 0.17 0.69 8.31Download DFHGFDILVGQIDDAL---KLA-NEGKVKEKTTRNAYIQKYLIPVRYL-EWSNIESIIAIAFSCLGILVTLFVTLIFVLDTPVVKS----SSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILA----MSAWAQVIIASILISVQLTLVVTLIIMEPPMSVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTR--NVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNY--------KIITTCFAVSLSVTVALGCMFTPKMYIIIAKPE-------------------------------------------------------------------------------------------------------
64j5mA 0.10 0.16 0.81 1.68Download V----QRKEKDFQGMLEYIRNLVTDLKPQMLSGTVPC---------------LPAYILYMCIRHADYKVHSLLTSTINGIKKVLKKHNDDFEMTSFWLSNTCRLLHCLKKQNEHCLKNFDLTEYRQVLSDLSYQQLIKIAEGVLQPMIVSAMLESYCLEAIIRQMNAFHTVMCD------------------QGLDPEIILQVFKQLFYMINAVTLNNLLL----------RKDVCSWSTGMQLRYNISQLEEWLRGRNLHQSGAVQTMEPLIQAAQL---------------LQLKKKTQEDAEAICSLCTSLSTQQIVKILNLYTPLNEFEERVTVATIQAQLQERNDPQQLLLDAKHMFPVLFPFNPSSLTMDS-------------IHIPACLNLEFLV
74or2A 0.20 0.17 0.67 6.23Download LKLANEGKVK------EAQAAAE--QLKTTRNAYIQ----KYLIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFYRDTPVVKSSSRE----LCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILA---FMSAWAQVIIASILISVQLTLVVTLIIMEPPMPVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKT--RNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKII--TT------CFAVSLSVTVALGCMFTPKMYIIIAKPE-------------------------------------------------------------------------------------------------------
84or2A 0.22 0.15 0.60 2.66Download ---------------------------------------------VRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYTPVVKSSS----RELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKT--RNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSN--------YKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPE-------------------------------------------------------------------------------------------------------
94or2A 0.19 0.17 0.70 8.85Download DFRHGFDILVGQ-I---DDALKLANGKVKLKTTRNAYIQKYLIPV-RYLEWSNIESIIAIAFSCLGILVTLFVTLIFVL--YRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILA--RFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKT--RNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNY--------KIITTCFAVSLSVTVALGCMFTPKMYIIIAKPE-------------------------------------------------------------------------------------------------------
104or2A 0.23 0.15 0.60 2.81Download -----------------------------------------IP--VRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYTPVVKS----SSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKT--RNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNY--------KIITTCFAVSLSVTVALGCMFTPKMYIIIAKPE-------------------------------------------------------------------------------------------------------
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: SPARKS-X   2: PROSPECT2   3: MUSTER   4: pGenTHREADER   5: HHSEARCH2   6: PROSPECT2   7: HHSEARCH I   8: Neff-PPAS   9: HHSEARCH   10: pGenTHREADER   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=-2.42 (Read more about C-score)
  • Estimated TM-score = 0.43±0.14
  • Estimated RMSD = 12.6±4.3Å





  •  Please cite following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted (2015).