GPCR-I-TASSER results for Q9ULW2

[Click on Q9ULW2_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q9ULW2
MQRPGPRLWLVLQVMGSCAAISSMDMERPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHEN
QREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPI
MEQFNFKWPDSLDCRKLPNKNDPNYLCMEAPNNGSDEPTRGSGLFPPLFRPQRPHSAQEH
PLKDGGPGRGGCDNPGKFHHVEKSASCAPLCTPGVDVYWSREDKRFAVVWLAIWAVLCFF
SSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACDRDSGQLYVI
QEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWA
IPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVAL
FHIRRVMKTGGENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHK
CKMNNQTKTLDCLMAASIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQVCSRRLK
KKSRRKPASVITSGGIYKKAQHPQKTHHGKYEIPAQSPTCV

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   | 
MQRPGPRLWLVLQVMGSCAAISSMDMERPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPNYLCMEAPNNGSDEPTRGSGLFPPLFRPQRPHSAQEHPLKDGGPGRGGCDNPGKFHHVEKSASCAPLCTPGVDVYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACDRDSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHKCKMNNQTKTLDCLMAASIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQVCSRRLKKKSRRKPASVITSGGIYKKAQHPQKTHHGKYEIPAQSPTCV
PredictionCCCCCCSSSSCHHHHHCCCCCCCCCCCCCCCCSSSSCCHHCCCCCCCCCSSCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCSSCCCCHHHHHHHHCHCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHSSSSSSSHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCSSSSSCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCSSSSCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score99875775230685416666544567899998646278120089998705787757886999999998889998752687768899885347756699982679758999999701202388548999987835578723477655568887676788888887898654444444544566766765311224676312156677355346631234320245545411135589999998978789897254454862159999999999999999988622320012357770589824778625999999999999999999999999999885113452145554578999999999999999986404556776744344068567899999999999999999999999999987677642564036789999998679999999999999999999985289999888861020578999864325788870799999999999999986875157899999999985325787768862375446743458998767778878999899879

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   | 
MQRPGPRLWLVLQVMGSCAAISSMDMERPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPNYLCMEAPNNGSDEPTRGSGLFPPLFRPQRPHSAQEHPLKDGGPGRGGCDNPGKFHHVEKSASCAPLCTPGVDVYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACDRDSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHKCKMNNQTKTLDCLMAASIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQVCSRRLKKKSRRKPASVITSGGIYKKAQHPQKTHHGKYEIPAQSPTCV
Prediction73430000000000000011122132632540303304142036020120100020314215202321312220142211330110000000010245253202002300330243033214314230132030330354333322014222333432242232201112122012022111201000100111222011012223011002022212222332211220100000000000000000000023224121000000000000000000000012222001232221010122024100000000010000000000000000000000012133430431000000000010112000000022223331110010023210000001211211012002201100000001013314465433430330102000000013332221000000011122102301311202134444334113333201000001102011211320010000330040013002321445434433411333333444433543344434434634416
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   | 
Sec.Str
Seq		CCCCCCSSSSCHHHHHCCCCCCCCCCCCCCCCSSSSCCHHCCCCCCCCCSSCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCSSCCCCHHHHHHHHCHCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHSSSSSSSHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCSSSSSCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCSSSSCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MQRPGPRLWLVLQVMGSCAAISSMDMERPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPNYLCMEAPNNGSDEPTRGSGLFPPLFRPQRPHSAQEHPLKDGGPGRGGCDNPGKFHHVEKSASCAPLCTPGVDVYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACDRDSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHKCKMNNQTKTLDCLMAASIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQVCSRRLKKKSRRKPASVITSGGIYKKAQHPQKTHHGKYEIPAQSPTCV
14jkvA 0.21 0.21 0.76 1.84Download -------------------------------------------------------GTADLEDNWETLNDNLKVIEKADN----------------AAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDALKLANEGK--------VKEAQAAAEQLKTTRNAYIQKYLSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRLGEPSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALKTSY--------FHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANCEIKNR-------PSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWC---------------------------------------------
24jkvA 0.23 0.21 0.77 2.18Download --------------------------------------------------------GTADLEDNWETLNDNLKVIEKA---------------DNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDIVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLS-----GQCEVPLVRTDNPKSWYEDVEGCGIQCQN---PLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRSNRYPAVILFYVNACFFVGSIGWLAQFMDGARRIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFK-ALGTTYQPGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANCE-------IKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWC---------------------------------------------
34o9rA 0.28 0.17 0.57 5.74Download ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QCEVPLVRTDN---PKSW--YEDVEGCGIQCQ---NPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRSNRYPAVILFYVNACFFVGSIGWLAQFMDGRREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSF----------GKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHADDGLAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRYVLCQANV---P-DCEI-KNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCR--------------------------------------------
44o9rA 0.27 0.17 0.58 4.59Download -------------------------------------------------------------------------------------------------------------------------------------------------QCEVPLV-----------------RT----------------DN------PKS-WYEDVEGCGIQCQ---NPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRSNRYPAVILFYVNACFFVGSIGWLAQFMDGRREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSF----------GKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHADDGLAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFDYVLCQANVT----PDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCR--------------------------------------------
54jkvA 0.22 0.21 0.77 4.03Download --------------------------------------------------------GTADLEDNWETLNDNLKVIEKA---------------DNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLSGQ-----CEVPLVRTDNPKSWYEDVEGCGIQCQN---PLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADRNSNRYPAVILFYVNACFFVGSIGWLAQFMGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKA-LGTTYQPGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANCE-------IKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWC---------------------------------------------
64o9rA 0.27 0.17 0.57 8.14Download ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QCEVPLVRTDNPK-SWYEDVEGCGIQCQN---PLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRSNRYPAVILFYVNACFFVGSIGWLAQFMDGRREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSF----------GKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHADEGLAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYLCQANV-----PDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCR--------------------------------------------
74o9rA 0.28 0.17 0.56 4.75Download ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QCEVPNPKSWYEDVEGCGIQCQ---NPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSRYPAVILFYVNACFFVGSIGWLAQFMDGRREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKGKTS---------YFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHAAS-----KINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIP-DC-EIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCR--------------------------------------------
84jkvA 0.22 0.21 0.77 2.63Download --------------------------------------------------------GTADLEDNWETLNDNLKVIEKA---------------DNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLSG----QCEVPLVRTDNPKSWYEDVEGCGIQCQ---NPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGRREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKA-LGTTYQPGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVCQAN--------CEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWC---------------------------------------------
94jkvA 0.23 0.21 0.77 3.58Download --------------------------------------------------------GTADLEDNW---------------ETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDAL----KLANEGKVKEAQAAAEQLKTTRNAYIQKYLSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNP---LFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSF-KALGTTYQPGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANCEIK-------NRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTW---------------------------------------------C
104jkvA 0.24 0.21 0.7611.66Download -------------------------------------------------------------------------TADLDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILV---GQIDD------ALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLSGQCEVPLVRTDNEDVEGCGIQCQNP---LFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWNSNRYPAVILFYVNACFFVGSIGWLAQFMDGAREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTS-FKALGTTYQPGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRYVLCQ-ANCEIKN-------RPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRR------------------------------------------------
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: SPARKS-X   2: MUSTER   3: HHSEARCH2   4: HHSEARCH I   5: Neff-PPAS   6: HHSEARCH   7: pGenTHREADER   8: wdPPAS   9: PROSPECT2   10: PRC   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1

    Estimated acuracy of domain 1 (1-215)
  • C-score=-2.48 (Read more about C-score)
  • Estimated TM-score = 0.43±0.14
  • Estimated RMSD = 11.2±4.6Å

    Estimated acuracy of domain 2 (216-542)
  • C-score=-0.42 (Read more about C-score)
  • Estimated TM-score = 0.66±0.13
  • Estimated RMSD = 7.5±4.3Å




    •  Please cite following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted (2015).