GPCR-I-TASSER is a computational method designed for 3D structure
prediction of G protein-coupled receptors.
The target sequence is first threaded through the PDB libary
to search for putative templates.
If homologous templates are identified, a template-based fragment
assembly procedure is used to construct full-length models. This
procedure is extended from
but with a GPCR-specific, knowledge-based force field to guide
the structure assembly simulations.
In case that no homologous templates are available, an
TM-helix folding procedure is used to
assembly the 7 transmembrane helix bundle from scratch, followed
by GPCR-I-TASSER structure reassembly simulation that is
assisted with the sparse mutagensis restraints from GPCR-RD
The final structue models are refined at atomic-level by
the fragment-guided molecular dynamic
Please report problems and questions at
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Note: This server is only for modeling GPCRs. For non-GPCR
sequences, please submit the sequences to the
If your sequence is a human GPCR, you can quickly retreive the model
results from the
All experimentally solved GPCRs can be found in the
J Zhang, J Yang, R Jang, Y Zhang.
GPCR-I-TASSER: A hybrid approach to G protein-coupled receptor
structure modeling and the application to the human genome, Structure, 23: 1538-1549, 2015
(Download PDF and