Experimental restraint
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Swiss ID: mc4r_human
Protein Name: Melanocortin 4 (MC4-R)
Organism: Human
Seqeunce Length: 332
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Multiple Sequence Alignment
Experimental Restraints:
Contact Restraint: E61-D90  PMID of associated paper:  11101306
Contact Restraint: V50-I102  PMID of associated paper:  12499395
Contact Restraint: I125-F184  PMID of associated paper:  12604699
Contact Restraint: D126-C196  PMID of associated paper:  11101306
MSA  PMID of associated paper:  0
Orientation Restraint: F51  PMID of associated paper:  12646666
Orientation Restraint: S58  PMID of associated paper:  12499395
Orientation Restraint: N62  PMID of associated paper:  12499395
Orientation Restraint: E100  PMID of associated paper:  11101306
Orientation Restraint: I103  PMID of associated paper:  12499395
Orientation Restraint: D126  PMID of associated paper:  11101306
Orientation Restraint: S127  PMID of associated paper:  12499395
Orientation Restraint: C130  PMID of associated paper:  11101306
Orientation Restraint: C196  PMID of associated paper:  11101306
Orientation Restraint: T199  PMID of associated paper:  11101306
Orientation Restraint: F202  PMID of associated paper:  16030156
Orientation Restraint: M204  PMID of associated paper:  11101306
Orientation Restraint: L250  PMID of associated paper:  10903341
Orientation Restraint: I251  PMID of associated paper:  10508193
Orientation Restraint: W258  PMID of associated paper:  11101306
Orientation Restraint: F261  PMID of associated paper:  11101306
Orientation Restraint: F262  PMID of associated paper:  16114870
Orientation Restraint: F284  PMID of associated paper:  12604699
Orientation Restraint: N285  PMID of associated paper:  11101306
Orientation Restraint: S295  PMID of associated paper:  16030156
Orientation Restraint: D298  PMID of associated paper:  11101306
Orientation Restraint: P299  PMID of associated paper:  12499395
Orientation Restraint: I301  PMID of associated paper:  10903341
Experimental Data:
Experimental Data: H6A  PMID of associated paper:  11101306
Experimental Data: H6R  PMID of associated paper:  16114870
Experimental Data: T11A  PMID of associated paper:  12646666
Experimental Data: T11S  PMID of associated paper:  10903341
Experimental Data: R18C  PMID of associated paper:  10903341
Experimental Data: S30F  PMID of associated paper:  10508193
Experimental Data: S30P  PMID of associated paper:  12499395
Experimental Data: Y35X  PMID of associated paper:  15951321
Experimental Data: D37V  PMID of associated paper:  10508193
Experimental Data: P48S  PMID of associated paper:  12959994
Experimental Data: E49A  PMID of associated paper:  11101306
Experimental Data: F51L  PMID of associated paper:  12646666
Experimental Data: S58C  PMID of associated paper:  12499395
Experimental Data: N62S  PMID of associated paper:  12499395
Experimental Data: P78L  PMID of associated paper:  10508193
Experimental Data: E100A  PMID of associated paper:  11101306
Experimental Data: I103V  PMID of associated paper:  12499395
Experimental Data: V103I  PMID of associated paper:  16030156
Experimental Data: T112M  PMID of associated paper:  10508193
Experimental Data: D122A  PMID of associated paper:  11101306
Experimental Data: D122N  PMID of associated paper:  11101306
Experimental Data: D126A  PMID of associated paper:  11101306
Experimental Data: D126L  PMID of associated paper:  11101306
Experimental Data: D126N  PMID of associated paper:  11101306
Experimental Data: D126S  PMID of associated paper:  11101306
Experimental Data: S127L  PMID of associated paper:  12499395
Experimental Data: C130A  PMID of associated paper:  11101306
Experimental Data: T150I  PMID of associated paper:  10903341
Experimental Data: A154D  PMID of associated paper:  16030156
Experimental Data: Y157S  PMID of associated paper:  12959994
Experimental Data: K164A  PMID of associated paper:  11101306
Experimental Data: R165A  PMID of associated paper:  11101306
Experimental Data: R165Q  PMID of associated paper:  12499395
Experimental Data: R165W  PMID of associated paper:  10508193
Experimental Data: S190A  PMID of associated paper:  12604699
Experimental Data: S191A  PMID of associated paper:  12604699
Experimental Data: C196A  PMID of associated paper:  11101306
Experimental Data: T199A  PMID of associated paper:  11101306
Experimental Data: F202L  PMID of associated paper:  16030156
Experimental Data: M204A  PMID of associated paper:  11101306
Experimental Data: N240S  PMID of associated paper:  16030156
Experimental Data: A244E  PMID of associated paper:  12499395
Experimental Data: L250Q  PMID of associated paper:  10903341
Experimental Data: I251L  PMID of associated paper:  10508193
Experimental Data: W258A  PMID of associated paper:  11101306
Experimental Data: F261A  PMID of associated paper:  11101306
Experimental Data: F262A  PMID of associated paper:  16114870
Experimental Data: Y268A  PMID of associated paper:  11101306
Experimental Data: C271A  PMID of associated paper:  15115780
Experimental Data: C271T  PMID of associated paper:  12690102
Experimental Data: C271Y  PMID of associated paper:  12499395
Experimental Data: N274S  PMID of associated paper:  12959994
Experimental Data: F284A  PMID of associated paper:  12604699
Experimental Data: N285A  PMID of associated paper:  11101306
Experimental Data: S295P  PMID of associated paper:  16030156
Experimental Data: D298A  PMID of associated paper:  11101306
Experimental Data: P299H  PMID of associated paper:  12499395
Experimental Data: I301T  PMID of associated paper:  10903341
Experimental Data: R305A  PMID of associated paper:  11101306
Experimental Data: S306A  PMID of associated paper:  12639913
Experimental Data: R310A  PMID of associated paper:  15865442
Experimental Data: K311A  PMID of associated paper:  15865442
Experimental Data: T312A  PMID of associated paper:  12639913
Experimental Data: F313A  PMID of associated paper:  15865442
Experimental Data: K314A  PMID of associated paper:  15865442
Experimental Data: E315A  PMID of associated paper:  15865442
Experimental Data: I316A  PMID of associated paper:  15865442
Experimental Data: I316T  PMID of associated paper:  12594226
Experimental Data: I317A  PMID of associated paper:  15865442
Experimental Data: I317T  PMID of associated paper:  10508193
Experimental Data: S329A  PMID of associated paper:  12639913
Experimental Data: S330A  PMID of associated paper:  12639913
Experimental Data: Y268I  PMID of associated paper:  10358030
Experimental Data: C271  PMID of associated paper:  10318826
Experimental Data: S270T  PMID of associated paper:  10358030
Experimental Data: M281T  PMID of associated paper:  10358030
Experimental Data: E61-D90  PMID of associated paper:  11101306
Experimental Data: V50-I102  PMID of associated paper:  12499395
Experimental Data: I125-F184  PMID of associated paper:  12604699
Experimental Data: D126-C196  PMID of associated paper:  11101306
Experimental Data: V50M  PMID of associated paper:  12499395
Experimental Data: F51L  PMID of associated paper:  12646666
Experimental Data: S58C  PMID of associated paper:  12499395
Experimental Data: E61A  PMID of associated paper:  11101306
Experimental Data: N62S  PMID of associated paper:  12499395
Experimental Data: D90A  PMID of associated paper:  11101306
Experimental Data: G98R  PMID of associated paper:  12959994
Experimental Data: E100A  PMID of associated paper:  11101306
Experimental Data: I102S  PMID of associated paper:  12499395
Experimental Data: I102T  PMID of associated paper:  16030156
Experimental Data: I103V  PMID of associated paper:  12499395
Experimental Data: V103I  PMID of associated paper:  16030156
Experimental Data: I125F  PMID of associated paper:  12604699
Experimental Data: D126A  PMID of associated paper:  11101306
Experimental Data: D126L  PMID of associated paper:  11101306
Experimental Data: D126N  PMID of associated paper:  11101306
Experimental Data: D126S  PMID of associated paper:  11101306
Experimental Data: S127L  PMID of associated paper:  12499395
Experimental Data: I129A  PMID of associated paper:  16114870
Experimental Data: C130A  PMID of associated paper:  11101306
Experimental Data: I137T  PMID of associated paper:  10903341
Experimental Data: I170V  PMID of associated paper:  10903341
Experimental Data: F184L  PMID of associated paper:  12604699
Experimental Data: F184M  PMID of associated paper:  12604699
Experimental Data: F184S  PMID of associated paper:  12604699
Experimental Data: C196A  PMID of associated paper:  11101306
Experimental Data: T199A  PMID of associated paper:  11101306
Experimental Data: M200A  PMID of associated paper:  11101306
Experimental Data: M200V  PMID of associated paper:  12646666
Experimental Data: F202L  PMID of associated paper:  16030156
Experimental Data: T203A  PMID of associated paper:  11101306
Experimental Data: M204A  PMID of associated paper:  11101306
Experimental Data: H214A  PMID of associated paper:  11101306
Experimental Data: L250Q  PMID of associated paper:  10903341
Experimental Data: I251L  PMID of associated paper:  10508193
Experimental Data: G252S  PMID of associated paper:  10508193
Experimental Data: V253I  PMID of associated paper:  12499395
Experimental Data: W258A  PMID of associated paper:  11101306
Experimental Data: F261A  PMID of associated paper:  11101306
Experimental Data: F262A  PMID of associated paper:  16114870
Experimental Data: H264A  PMID of associated paper:  11101306
Experimental Data: F267A  PMID of associated paper:  11101306
Experimental Data: F267L  PMID of associated paper:  12604699
Experimental Data: H283A  PMID of associated paper:  11101306
Experimental Data: F284A  PMID of associated paper:  12604699
Experimental Data: N285A  PMID of associated paper:  11101306
Experimental Data: S295P  PMID of associated paper:  16030156
Experimental Data: D298A  PMID of associated paper:  11101306
Experimental Data: P299H  PMID of associated paper:  12499395
Experimental Data: I301T  PMID of associated paper:  10903341
Experimental Data: V67  PMID of associated paper:  10358030
Experimental Data: F267  PMID of associated paper:  10358030
Experimental Data: F202  PMID of associated paper:  10358030
Experimental Data: MSA  PMID of associated paper:  0
GPCR Related Corss-reference Links:
GPCRDB
GPCR-OKB
UniProt_P32245