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I-TASSER results for job id S205619

[Click on S205619_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

(Click on Annotation of I-TASSER Output to read the instructions for how to interpret the results on this page)

  Submitted Sequence in FASTA format

>protein
DFILLGFSDHPRLEAVLFVFVLFFYLLTLVGNFTIIIISYLDPPLHTPMYFFLSNLSLLD
ICFTTSLAPQTLVNLQRPKKTITYGGCVAQLYISLALGSTECILLADMALDRYIAVCKPL
HYVVIMNPRLCQQLASISWLSGLASSLIHATFTLQLPLCGNHRLDHFICEVPALLKLACV
DTTVNELVLFVVSVLFVVIPPALISISYGFITQAVLRIKSVEARHKAFSTCSSHLTVVII
FYGTIIYVYLQPSDSYAQDQGKFISLFYTMVTPTLNPIIYTLRNKDMKEALRKLLSGK

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                  
DFILLGFSDHPRLEAVLFVFVLFFYLLTLVGNFTIIIISYLDPPLHTPMYFFLSNLSLLDICFTTSLAPQTLVNLQRPKKTITYGGCVAQLYISLALGSTECILLADMALDRYIAVCKPLHYVVIMNPRLCQQLASISWLSGLASSLIHATFTLQLPLCGNHRLDHFICEVPALLKLACVDTTVNELVLFVVSVLFVVIPPALISISYGFITQAVLRIKSVEARHKAFSTCSSHLTVVIIFYGTIIYVYLQPSDSYAQDQGKFISLFYTMVTPTLNPIIYTLRNKDMKEALRKLLSGK
PredictionCSSSSSCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCSSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHSSCCCCCCCCCCCSSCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHSSSSCCCCCCCCCCCCSSSSSHHCHHHCCCCHHHCCCCHHHHHHHHHHHCCC
Conf.Score9499727998517999999999999999998899989887388766748888667998778876247899989846899667189999999999999999999999998650666255445871468879999999999999999999999991438999894789714838999997037529999999999999999799999999999999930866044650421558689979998600314781789999887881898535064433123754155299999999985259
H:Helix; S:Strand; C:Coil

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                  
DFILLGFSDHPRLEAVLFVFVLFFYLLTLVGNFTIIIISYLDPPLHTPMYFFLSNLSLLDICFTTSLAPQTLVNLQRPKKTITYGGCVAQLYISLALGSTECILLADMALDRYIAVCKPLHYVVIMNPRLCQQLASISWLSGLASSLIHATFTLQLPLCGNHRLDHFICEVPALLKLACVDTTVNELVLFVVSVLFVVIPPALISISYGFITQAVLRIKSVEARHKAFSTCSSHLTVVIIFYGTIIYVYLQPSDSYAQDQGKFISLFYTMVTPTLNPIIYTLRNKDMKEALRKLLSGK
Prediction7000000043240011002303331331333332002002001300000001020000000101002003000001166230101002201220130021002000100300000002102000000330000001100110021031001000201101423010000032100100021033001102331333133122102201320020001031362231011000001000101220020000104263255230000021033213300310101032013002301658
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. Click here to read more about predicted normalized B-factor)


  Top 10 threading templates used by I-TASSER

(I-TASSER modeling starts from the structure templates identified by LOMETS from the PDB library. LOMETS is a meta-server threading approach containing multiple threading programs, where each threading program can generate tens of thousands of template alignments. I-TASSER only uses the templates of the highest significance in the threading alignments, the significance of which are measured by the Z-score, i.e. the difference between the raw and average scores in the unit of standard deviation. The templates in this section are the 10 best templates selected from the LOMETS threading programs. Usually, one template of the highest Z-score is selected from each threading program, where the threading programs are sorted by the average performance in the large-scale benchmark test experiments.)

Rank PDB
Hit
Iden1Iden2CovNorm.
Z-score
Download
Align.
                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                  
Sec.Str
Seq
CSSSSSCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCSSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHSSCCCCCCCCCCCSSCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHSSSSCCCCCCCCCCCCSSSSSHHCHHHCCCCHHHCCCCHHHHHHHHHHHCCC
DFILLGFSDHPRLEAVLFVFVLFFYLLTLVGNFTIIIISYLDPPLHTPMYFFLSNLSLLDICFTTSLAPQTLVNLQRPKKTITYGGCVAQLYISLALGSTECILLADMALDRYIAVCKPLHYVVIMNPRLCQQLASISWLSGLASSLIHATFTLQLPLCGNHRLDHFICEVPALLKLACVDTTVNELVLFVVSVLFVVIPPALISISYGFITQAVLRIKSVEARHKAFSTCSSHLTVVIIFYGTIIYVYLQPSDSYAQDQGKFISLFYTMVTPTLNPIIYTLRNKDMKEALRKLLSGK
13emlA 0.19 0.23 0.92 3.90Download ----------IMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTG--FCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGGCGEGQVACLFEDVVP-----------MNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLVHAAKSLAIIVGLFALCWLPLHI-INCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSH
23v2yA 0.20 0.24 0.89 2.13Download --------DKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYK-LTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKN--------NFRLFLLISACWVISLILGG--------LPIMGWNCISA--------LSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRNSRSSEVALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMGRP
33pblA 0.18 0.21 0.87 2.27Download ----------------YALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGV---WICCDVFVTLDVMMCTASIWNLCAISIDRYTAVVMPVHYQHGTSCRRVALMITAVWVLAFAVSCPLLF--GFNTTGDPTV-----CSI---------SNPDFVIYSSVVSFY---LPFGVTVLVYARIYVVLKQRRVPLREKKATQMVAIVLGAFIVCWLPFFLTHVHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC-
42rh1A 0.17 0.18 0.94 2.52Download ---------DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRA----THQEAINCYAEET----CCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNKLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVINLIRKEVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQELLCL-
54bvnA 0.18 0.26 0.92 2.08Download ---------SQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASVETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMM----HWWRDEDPQALKCYQDP----GCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKE-----REHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNLVPKWLFVAFNWLGYANSAMNPIILC-RSPDFRKAFKRLLA--
63emlA 0.19 0.23 0.92 4.24Download -----------MGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGGCGEGQVACLFEDVVP-----------MNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLVHAAKSLAIIVGLFALCWLPLHIINCF-TFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSH
74bvnA 0.17 0.26 0.93 2.95Download --------LSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASVETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWR----DEDPQALKCYQDP----GCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKEQ---MREHKALKTLGIIMGVFTLCWLPFFLVNIVNNRDLVPKWLFVAFNWLGYANSAMNPIILC-RSPDFRKAFKRLLA--
84ea3A 0.17 0.21 0.90 2.75Download ---------PLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLT-LPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPTSSKAQAVNVAIWALASVVGVPVAIMGSAQ---------VEDEEIDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLG-----VQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFR------
93emlA 0.20 0.23 0.92 5.38Download ----------IMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIS--TGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLNCGQSQGCGEGQVACLFEDVVP-----------MNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLVHAAKSLAIIVGLFALCWLPLHI-INCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSH
102ydoA 0.17 0.21 0.95 6.15Download -------------SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSAAAADILVGVLAIPFAIA--ISTGFCAACHGCLFIACFVLVLTASSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKAHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESTLQKEVHAAKSLAIIVGLFALCWLTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSH
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: MUSTER   2: FFAS-3D   3: SPARKS-X   4: HHSEARCH2   5: HHSEARCH I   6: Neff-PPAS   7: HHSEARCH   8: pGenTHREADER   9: wdPPAS   10: cdPPAS   

  Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)
(By right-clicking on the images, you can change the configurations, e.g. modifying the background color or stopping the spin of your models)
  • Download Model 1
  • C-score=-0.08
  • Estimated TM-score = 0.70±0.12
  • Estimated RMSD = 6.3±3.9Å
  • Download Model 2
  • C-score=-0.78


  • Download Model 3
  • C-score=-0.92


  • Download Model 4
  • C-score=-2.36


  • Download Model 5
  • C-score=-2.56



  •   Proteins structurally close to the target in the PDB (as identified by TM-align)

    (After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)


    Top 10 Identified stuctural analogs in PDB

    Click
    to view
    RankPDB HitTM-scoreRMSDaIDENaCovAlignment
    14bvnA0.905 1.310.1650.936Download
    22rh1A0.895 1.630.1680.936Download
    33uonA0.848 2.140.1760.916Download
    42vt4C0.847 1.260.1720.876Download
    53emlA0.846 2.350.1730.923Download
    62ksbA0.844 2.620.1430.923Download
    74iaqA0.843 2.000.1960.903Download
    83pblA0.843 1.430.1760.879Download
    93p0gA0.842 2.470.1570.926Download
    103rzeA0.827 1.920.1710.883Download

    (a)Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
    (b)Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
    (c)RMSDa is the RMSD between residues that are structurally aligned by TM-align.
    (d)IDENa is the percentage sequence identity in the structurally aligned region.
    (e)Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.


      Predicted function using COFACTOR and COACH

    (This section reports biological annotations of the target protein by COFACTOR and COACH based on the I-TASSER structure prediction. While COFACTOR deduces protein functions (ligand-binding sites, EC and GO) using structure comparison and protein-protein networks, COACH is a meta-server approach that combines multiple function annotation results (on ligand-binding sites) from the COFACTOR, TM-SITE and S-SITE programs.)

      Ligand binding sites


    Click
    to view
    RankC-scoreCluster
    size
    PDB
    Hit
    Lig
    Name
    Download
    Complex
    Ligand Binding Site Residues
    10.29 53 4amiA G90 Rep, Mult 90,91,94,95,98,180,181,182,192,196,242,245,246,262,263,266,270
    20.16 36 2y04A Y01 Rep, Mult 51,55,58,96,128,132,135,139
    30.08 24 4ea3A 0NN Rep, Mult 71,91,94,95,98,99,192,196,242,246,249,266,270
    40.05 12 3dqbA PEPTIDE Rep, Mult 48,112,115,116,118,211,215,218,221,284,286
    50.04 18 2ycwA 2CV Rep, Mult 208,211,212,225,228,229,235


    Download the residue-specific ligand binding probability, which is estimated by SVM.
    Download the all possible binding ligands and detailed prediction summary.
    Download the templates clustering results.
    (a)C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
    (b)Cluster size is the total number of templates in a cluster.
    (c)Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
    (d)Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column.
    Mult is the complex structures with all potential binding ligands in the cluster.

      Enzyme Commission (EC) numbers and active sites


    Click
    to view
    RankCscoreECPDB
    Hit
    TM-scoreRMSDaIDENaCovEC NumberActive Site Residues
    10.3393d4sA0.882 1.690.1670.926 3.2.1.17  NA
    20.2291xmeA0.518 5.750.0800.815 1.9.3.1  NA
    30.2232occN0.542 5.730.0610.826 1.9.3.1  NA
    40.2181occA0.542 5.740.0620.822 1.9.3.1  NA
    50.2041qleA0.477 6.390.0620.822 1.9.3.1  NA

     Click on the radio buttons to visualize predicted active site residues.
    (a)CscoreEC is the confidence score for the EC number prediction. CscoreEC values range in between [0-1];
    where a higher score indicates a more reliable EC number prediction.
    (b)TM-score is a measure of global structural similarity between query and template protein.
    (c)RMSDa is the RMSD between residues that are structurally aligned by TM-align.
    (d)IDENa is the percentage sequence identity in the structurally aligned region.
    (e)Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided
    by length of the query protein.

      Gene Ontology (GO) terms
    Top 10 homologous GO templates in PDB 
    RankCscoreGOTM-scoreRMSDaIDENaCovPDB HitAssociated GO Terms
    1 0.480.9034 1.68 0.18 0.942y00B GO:0004935 GO:0007186 GO:0016021 GO:0071875 GO:0004940
    2 0.350.8417 2.47 0.16 0.933p0gA GO:0016998 GO:0016787 GO:0003824 GO:0009253 GO:0003796 GO:0016798 GO:0008152 GO:0042742 GO:0019835 GO:0007186 GO:0016021
    3 0.350.8947 1.63 0.17 0.942rh1A GO:0003796 GO:0007186 GO:0009253 GO:0016021 GO:0016998 GO:0042742 GO:0008152 GO:0016798 GO:0003824 GO:0016787 GO:0019835
    4 0.350.6645 1.59 0.18 0.693kj6A GO:0004935 GO:0004941 GO:0007186 GO:0016021 GO:0071875
    5 0.330.8439 2.62 0.14 0.922ks9A GO:0004995 GO:0005886 GO:0007186 GO:0016021
    6 0.330.8427 1.43 0.18 0.883pblA GO:0019835 GO:0016998 GO:0016798 GO:0016787 GO:0008152 GO:0003824 GO:0003796 GO:0009253 GO:0042742 GO:0007186 GO:0016021
    7 0.330.8459 2.35 0.17 0.923emlA GO:0003796 GO:0007186 GO:0009253 GO:0016021 GO:0016998 GO:0016798 GO:0008152 GO:0042742 GO:0019835 GO:0016787 GO:0003824
    8 0.320.8270 1.92 0.17 0.883rzeA GO:0005737 GO:0004872 GO:0007186 GO:0016021 GO:0010894 GO:0042742 GO:0008152 GO:0016798 GO:0003796 GO:0019835 GO:0003824 GO:0009253 GO:0016787 GO:0016998 GO:0004930 GO:0009629 GO:0045907 GO:0005887 GO:0045429 GO:0006954 GO:0005730 GO:0004969 GO:0051381 GO:0007165 GO:0007200 GO:0004871 GO:0005634 GO:0016020 GO:0005624 GO:0007268 GO:0005886
    9 0.320.8131 2.97 0.17 0.942ydvA GO:0001609 GO:0001973 GO:0007186 GO:0016021
    10 0.240.2368 4.71 0.03 0.331jtnA GO:0042742 GO:0008152 GO:0016798 GO:0019835 GO:0009253 GO:0003824 GO:0016787 GO:0016998 GO:0003796


    Consensus prediction of GO terms
     
    Molecular Function GO:0003796 GO:0004940 GO:0004941 GO:0004995
    GO-Score 0.58 0.48 0.35 0.33
    Biological Process GO:0071875 GO:0019835 GO:0009253 GO:0042742 GO:0016998
    GO-Score 0.66 0.58 0.58 0.58 0.58
    Cellular Component GO:0016021 GO:0005886
    GO-Score 0.90 0.33

    (a)CscoreGO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
    (b)TM-score is a measure of global structural similarity between query and template protein.
    (c)RMSDa is the RMSD between residues that are structurally aligned by TM-align.
    (d)IDENa is the percentage sequence identity in the structurally aligned region.
    (e)Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
    (f)The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on CscoreGO of the template.


    [Click on S205619_results.tar.bz2 to download the tarball file including all modeling results listed on this page]



    Please cite the following articles when you use the I-TASSER server:
    1.Yang Zhang. I-TASSER: Fully automated protein structure prediction in CASP8. Proteins, 77 (Suppl 9): 100-113, 2009.
    2.Ambrish Roy, Jianyi Yang, Yang Zhang. COFACTOR: an accurate comparative algorithm for structure-based protein function annotation. Nucleic Acids Research, 40: W471-W477, 2012.
    3. Jianyi Yang, Yang Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.