SSIPe is a method to calculate binding affinity changes
(ΔΔGbind) of protein-protein interactions (PPIs)
upon mutations at protein-protein interface.
Starting from a PPI complex structure, SSPIe first generates
multple structure and sequence alignments from
STRING databases separately.
The structural and sequence profiles are then combined with
the physical energy function
to predict the impact of the mutations on PPI binding free energies.
SSIPe can be used to guide the designing and engineering of
protein-protein interactions with enhanced binding affinity, and/or
for understanding the roles of disease-related mutations
associated with protein-protein interactions.
(>> Read more about SSIPe).
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