TACOS (Template-based Assembly of Complex Structures) is designed to model the structures of protein-protein complexes based on a hierarchical approach of template identification and structural refinement. First, protein complex templates are identified by the multi-chain threading algorithms COTH and SPRING. The fragments excised from the multple threading alignments are then used to reassemble the complex structure by replica-exchange Monte Carlo simulations based on a composite knowledge-based force field. Final models are selected based on structure clustering by SPICKER and refined into full-atomic models by ModRefiner.
From May. 10 to Jul. 30, 2020 (CASP14 season), the TACOS server will be closed to external users. Jobs submitted during this period will be run after CASP. We apologize for any inconvenience this may cause.
The output of the TACOS server include (An example of the TACOS output):
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