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I-TASSER QUARK LOMETS COACH COFACTOR MetaGO MUSTER SEGMER FG-MD ModRefiner REMO SPRING COTH BSpred SVMSEQ ANGLOR BSP-SLIM SAXSTER ThreaDom ThreaDomEx EvoDesign GPCR-I-TASSER BindProf BindProfX ResQ IonCom STRUM DAMpred

TM-score TM-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR NeBcon WDL-RF ATPbind

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13


TACOS (Template-based Assembly of Complex Structures) is designed to model the structures of protein-protein complexes based on a hierarchical approach of template identification and structural refinement. First, protein complex templates are identified by the multi-chain threading algorithms COTH and SPRING. The fragments excised from the multple threading alignments are then used to reassemble the complex structure by replica-exchange Monte Carlo simulations based on a composite knowledge-based force field. Final models are selected based on structure clustering by SPICKER and refined into full-atomic models by ModRefiner.

The output of the TACOS server include (An example of the TACOS output):

Input your first sequence below ([30,1000] residues in FASTA format). Example input:

Or upload the sequence from your local computer:

Input your second sequence below ([30,1000] residues in FASTA format). Example input:

Or upload the sequence from your local computer:

Email: (mandatory, where results will be sent to)

ID: (optional, your given name of the protein)




Reference:

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