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I-TASSER QUARK LOMETS COACH COFACTOR MetaGO MUSTER SEGMER FG-MD ModRefiner REMO SPRING COTH BSpred SVMSEQ ANGLOR BSP-SLIM SAXSTER ThreaDom ThreaDomEx EvoDesign GPCR-I-TASSER BindProf BindProfX ResQ IonCom STRUM DAMpred

TM-score TM-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR NeBcon WDL-RF ATPbind

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

TM-align is an algorithm for sequence independent protein structure comparisons. For two protein structures of unknown equivalence, TM-align first generates optimized residue-to-residue alignment based on structural similarity using heuristic dynamic programming iterations. An optimal superposition of the two structures built on the detected alignment, as well as the TM-score value which scales the structural similarity, will be returned. TM-score has the value in (0,1], where 1 indicates a perfect match between two structures. Following strict statistics of structures in the PDB, scores below 0.2 correspond to randomly chosen unrelated proteins while those higher than 0.5 assume generally the same fold in SCOP/CATH.


TM-align on-line (view an example of output)

Note: This server is only for pair-wise structure comparison. If you want to match one protein structure with all proteins in the PDB library, you can do it in COFACTOR Server.


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TM-align other information

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