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ThreaDom (Threading-based Protein Domain Prediction) is a template-based algorithm for protein domain boundary prediction. Given a protein sequence, ThreaDom first threads the target through the PDB library to identify protein template that have similar structure fold. A domain conservation score (DCS) will be calculated for each residue which combines information from template domain structure, terminal and internal gaps and insertions. Finally, the domain boundary information is derived from the DCS profile distributions. ThreaDom is designed to predict both continuous and discontinuous domains.

Note:
Recently, we constructed a new server, ThreaDomEx, which combining ThreaDom and DomEx into a unified on-line server system for more accurate and user-friendly domain predictions on sequences of both continuous and discontinuous domain structures. Users can find it at http://zhanglab.ccmb.med.umich.edu/ThreaDomEx/index.html.


ThreaDom online

Copy and paste your sequence here (<4,000 residues, in FASTA format):

Or upload the sequence from your local computer:

Email: (mandatory, where results will be sent to)

ID: (optional, your given name of the protein)



  • Click ThreaDom Dataset to download the dataset of training and testing proteins.
  • Click Prediction of CASP8 to download the domain prediction of CASP8 targets.
  • Click The source code package to download the source code of ThreaDom.
    References:
    Z Xue, D Xu, Y Wang, Y Zhang. ThreaDom: Extracting Protein Domain Boundary Information from Multiple Threading Alignments. Bioinformatics, 29: i247-i256 (2013) (Download the PDF file).

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