Hi, I'm working with several hundred structures I've generated from a local install of I-TASSER. I was wondering if there are any necessary or recommended downstream steps?
For example, I know its common to refine models via molecular dynamics after generation of the initial homology models using other software, but does ITASSER already incorporate a step like this in to the work flow? Is there any need to refine further the models that ITASSER produces?
Some of the models I have already have very good RMSDs/scores, but some of the others (with less optimal template proteins) often score badly. I'm wondering if its worth refining some of these at least?