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I-TASSER QUARK LOMETS COACH COFACTOR MetaGO MUSTER SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH BSpred SVMSEQ ANGLOR BSP-SLIM SAXSTER ThreaDom ThreaDomEx EvoDesign GPCR-I-TASSER BindProf BindProfX ResQ IonCom STRUM DAMpred

TM-score TM-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR NeBcon WDL-RF ATPbind DockRMSD

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13




SPRING is a template-base algorithm for protein-protein complex structure prediction. The pipeline first threads one chain of the protein complex through the PDB library with the binding parters retrieved from the original oligomer entries. The complex models for the query are then deduced from the template binding partner associations through a pre-calculated look-up table. The model of the best orientation is finally selected by the SPRING-score that is a combination of threading Z-score, interface contacts, and TM-align match between monomer-to-dimer templates.

The output of the SPRING server include (An example of the SPRING output):



SPRING On-Line Server



SPRING Download



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