COFACTOR generates protein function annotation using three independent sequence,structure, and PPI function library.
The user must upload a PDB formatted structure file of query protein. User's have the option to either copy the PDB file in the provided form or upload the file using the browse button. If the PDB file contains multiple protein chains and/or multiple models, first protein chain of the first model will be automatically selected by the program. Providing an e-mail address is recommended for recieving the prediction results.
Gene Ontology (GO) terms
Predicted GO terms for Molecular Function (MF), Biological Process (BP), and Cellular Component (CC) are enlisted separated in this section, with graphic representation of relation between predicted terms.
Enzyme Commission (EC) numbers
The section enlists top 5 enzyme homologs detected in PDB using COFACTOR global-local structure alignment procedure. Catalytic residues in query protein are also predicted based on active-site match of query and template proteins.
Protein-ligand binding site predictions
This section contains top 10 predicted ligand binding sites in query protein.