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I-TASSER QUARK LOMETS COACH COFACTOR MUSTER SEGMER FG-MD ModRefiner REMO SPRING COTH BSpred SVMSEQ ANGLOR BSP-SLIM SAXSTER ThreaDom EvoDesign GPCR-I-TASSER BindProf BindProfX ResQ IonCom STRUM

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About COFACTOR

COFACTOR generates protein function annotation using three independent sequence,structure, and PPI function library.


User Input

The user must upload a PDB formatted structure file of query protein. User's have the option to either copy the PDB file in the provided form or upload the file using the browse button. If the PDB file contains multiple protein chains and/or multiple models, first protein chain of the first model will be automatically selected by the program. Providing an e-mail address is recommended for recieving the prediction results.


Prediction results

Gene Ontology (GO) terms

Predicted GO terms for Molecular Function (MF), Biological Process (BP), and Cellular Component (CC) are enlisted separated in this section, with graphic representation of relation between predicted terms.



Enzyme Commission (EC) numbers

The section enlists top 5 enzyme homologs detected in PDB using COFACTOR global-local structure alignment procedure. Catalytic residues in query protein are also predicted based on active-site match of query and template proteins.



Protein-ligand binding site predictions

This section contains top 10 predicted ligand binding sites in query protein.



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